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Etnk2 ethanolamine kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 214253, updated on 9-Dec-2024

Summary

Official Symbol
Etnk2provided by MGI
Official Full Name
ethanolamine kinase 2provided by MGI
Primary source
MGI:MGI:2443760
See related
Ensembl:ENSMUSG00000070644 AllianceGenome:MGI:2443760
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eki2; Tuc1; EKI 2; 4933417N20Rik
Summary
Enables ethanolamine kinase activity. Involved in phosphorylation. Acts upstream of or within several processes, including in utero embryonic development; phosphatidylethanolamine biosynthetic process; and placenta development. Predicted to be active in cytoplasm. Is expressed in several structures, including genitourinary system; heart; intestine; liver; and lung. Orthologous to human ETNK2 (ethanolamine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in liver adult (RPKM 89.4), ovary adult (RPKM 18.3) and 3 other tissues See more
Orthologs
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Genomic context

See Etnk2 in Genome Data Viewer
Location:
1 E4; 1 57.91 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (133291308..133308056)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (133363463..133380318)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene golgi transport 1A Neighboring gene KiSS-1 metastasis-suppressor Neighboring gene Ren1 promoter and enhancer region Neighboring gene STARR-positive B cell enhancer ABC_E11089 Neighboring gene renin 1 structural Neighboring gene STARR-seq mESC enhancer starr_02283 Neighboring gene SRY (sex determining region Y)-box 13 Neighboring gene STARR-seq mESC enhancer starr_02289 Neighboring gene VISTA enhancer mm573 Neighboring gene STARR-seq mESC enhancer starr_02292 Neighboring gene ribosomal protein L7A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
NOT enables choline kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ethanolamine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ethanolamine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ethanolamine kinase 2
Names
ethanolamine kinase-like protein
putative ethanolamine kinase
NP_001406522.1
NP_780652.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419593.1NP_001406522.1  ethanolamine kinase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC068906
  2. NM_175443.6NP_780652.2  ethanolamine kinase 2

    See identical proteins and their annotated locations for NP_780652.2

    Status: VALIDATED

    Source sequence(s)
    AC068906
    Consensus CDS
    CCDS15296.2
    UniProtKB/Swiss-Prot
    A7MCT6, B7ZNN6, D3Z771, Q6XRG2
    Related
    ENSMUSP00000114272.3, ENSMUST00000135222.9
    Conserved Domains (2) summary
    PLN02236
    Location:60378
    PLN02236; choline kinase
    cd05157
    Location:82374
    ETNK_euk; Euykaryotic Ethanolamine kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    133291308..133308056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)