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crn-2 Deoxyribonuclease TATDN1 [ Caenorhabditis elegans ]

Gene ID: 178945, updated on 27-Dec-2024

Summary

Official Symbol
crn-2
Official Full Name
Deoxyribonuclease TATDN1
Primary source
WormBase:WBGene00000795
Locus tag
CELE_CD4.2
See related
AllianceGenome:WB:WBGene00000795
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DNA nuclease activity. Involved in apoptotic DNA fragmentation and apoptotic cell clearance. Is expressed in head; intestine; and tail. Orthologous to human TATDN1 (TatD DNase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See crn-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (5594615..5595842)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene VPS37 C-terminal domain-containing protein Neighboring gene Small ribosomal subunit protein uS10 domain-containing protein Neighboring gene HIT-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SPK domain-containing protein

Interactions

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA nuclease activity PubMed 
enables hydrolase activity, acting on ester bonds  
enables metal ion binding  
enables nuclease activity  

General protein information

Preferred Names
Deoxyribonuclease TATDN1
NP_504476.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    5594615..5595842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072075.8NP_504476.1  Deoxyribonuclease TATDN1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504476.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EG18
    Conserved Domains (2) summary
    cd01310
    Location:6284
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.
    pfam00702
    Location:2196
    Hydrolase; haloacid dehalogenase-like hydrolase
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