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thiI tRNA uridine 4-sulfurtransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945067, updated on 17-Dec-2024

Summary

Official Symbol
thiI
Official Full Name
tRNA uridine 4-sulfurtransferase
Primary source
ECOCYC:G6238
Locus tag
b0423
See related
ASAP:ABE-0001470
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0417; nuvA; yajK
Summary
The 4-thiouridine modification of tRNA acts as a near UV sensor because it makes tRNA near-UV labile, blocking translation, inducing the stringent response and stopping growth. [More information is available at EcoGene: EG13273]. ThiI is required for the synthesis of the thiazole moiety of thiamine and plays a role in the conversion of uridine to 4-thiouridine at position 8 in tRNA . [More information is available at EcoCyc: G6238].
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Genomic context

Sequence:
NC_000913.3 (441549..442997)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene geranyl diphosphate/farnesyl diphosphate synthase Neighboring gene exodeoxyribonuclease VII subunit XseB Neighboring gene protein/nucleic acid deglycase 3 Neighboring gene 2-dehydropantoate 2-reductase Neighboring gene nucleotide binding protein YajQ

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding  
enables CCA tRNA nucleotidyltransferase activity  
enables RNA binding  
enables protein binding PubMed 
enables sulfur carrier activity PubMed 
enables sulfurtransferase activity PubMed 
enables sulfurtransferase activity  
enables tRNA binding  
enables tRNA-uracil-4 sulfurtransferase activity  
enables transferase activity  
Component Evidence Code Pubs
part_of L-cysteine desulfurase complex PubMed 
located_in cytoplasm  
is_active_in cytosol  
located_in cytosol PubMed 
part_of sulfurtransferase complex PubMed 

General protein information

Preferred Names
tRNA uridine 4-sulfurtransferase
NP_414957.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    441549..442997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414957.1 tRNA uridine 4-sulfurtransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414957.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1V2GJV7
    Conserved Domains (1) summary
    PRK01269
    Location:1482
    PRK01269; tRNA s(4)U8 sulfurtransferase; Provisional
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