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RIOX2 ribosomal oxygenase 2 [ Homo sapiens (human) ]

Gene ID: 84864, updated on 4-Jan-2025

Summary

Official Symbol
RIOX2provided by HGNC
Official Full Name
ribosomal oxygenase 2provided by HGNC
Primary source
HGNC:HGNC:19441
See related
Ensembl:ENSG00000170854 MIM:612049; AllianceGenome:HGNC:19441
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ROX; MDIG; MINA; NO52; JMJD10; MINA53
Summary
MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]
Expression
Ubiquitous expression in thyroid (RPKM 23.6), skin (RPKM 10.0) and 24 other tissues See more
Orthologs
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Genomic context

See RIOX2 in Genome Data Viewer
Location:
3q11.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (97941818..97972431, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (100645556..100676171, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (97660662..97691275, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ARF like GTPase 6 Neighboring gene uncharacterized LOC101929298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14552 Neighboring gene uncharacterized LOC105373994 Neighboring gene crystallin beta-gamma domain containing 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:97614773-97615564 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:97628706-97629296 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:97629297-97629886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14553 Neighboring gene uncharacterized LOC124909398 Neighboring gene Sharpr-MPRA regulatory region 5379 Neighboring gene gamma-aminobutyric acid type A receptor subunit rho3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20129 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20130

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ14393, DKFZp762O1912

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone H3K36 demethylase activity  
enables histone H3K4 demethylase activity  
enables histone demethylase activity  
enables identical protein binding PubMed 
enables metal ion binding  
enables peptidyl-histidine dioxygenase activity PubMed 
enables peptidyl-histidine dioxygenase activity PubMed 
enables protein binding PubMed 
enables transcription corepressor activity  
Component Evidence Code Pubs
located_in cytosol  
is_active_in nucleolus  
located_in nucleolus  
located_in nucleoplasm  
located_in nucleoplasm  
part_of transcription regulator complex  

General protein information

Preferred Names
ribosomal oxygenase 2
Names
60S ribosomal protein L27a histidine hydroxylase
MYC induced nuclear antigen
MYC-induced nuclear antigen 53
bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA
histone lysine demethylase MINA
mineral dust induced gene protein
myc-induced nuclear antigen, 53 kDa
nucleolar protein 52
ribosomal oxygenase MINA
NP_001035998.1
NP_001248758.1
NP_116167.3
NP_694822.2
XP_005247895.1
XP_011511546.1
XP_047305041.1
XP_047305042.1
XP_047305043.1
XP_054204117.1
XP_054204118.1
XP_054204119.1
XP_054204120.1
XP_054204121.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042533.3NP_001035998.1  ribosomal oxygenase 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (A). Variants 1 and 2 encode the same protein (isoform A).
    Source sequence(s)
    AC110491, AL550737, AY302110, DA310030
    Consensus CDS
    CCDS43114.1
    UniProtKB/Swiss-Prot
    D3DN35, Q6AHW4, Q6SKS0, Q8IU69, Q8IUF6, Q8IUF7, Q8IUF8, Q96C17, Q96KB0
    UniProtKB/TrEMBL
    A0A6M8YDW1, A0A6M8YDW2
    Related
    ENSP00000328251.6, ENST00000333396.11
    Conserved Domains (1) summary
    pfam08007
    Location:52364
    Cupin_4; Cupin superfamily protein
  2. NM_001261829.2NP_001248758.1  ribosomal oxygenase 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses alternate splice sites in the 5' UTR and 3' coding region, compared to variant 1, and encodes a shorter protein (isoform B), compared to isoform A. Variants 3 and 4 encode the same protein (isoform B).
    Source sequence(s)
    AC026100, AC110491, AK027299, DA310030
    Consensus CDS
    CCDS2929.1
    UniProtKB/TrEMBL
    A0A6M8YDW2
    Conserved Domains (1) summary
    pfam08007
    Location:52363
    Cupin_4; Cupin superfamily protein
  3. NM_032778.6NP_116167.3  ribosomal oxygenase 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, compared to variant 1, and encodes a shorter protein (isoform B), compared to isoform A. Variants 3 and 4 encode the same protein (isoform B).
    Source sequence(s)
    AB083190, AC026100, AC110491, AL550737, DA310030
    Consensus CDS
    CCDS2929.1
    UniProtKB/TrEMBL
    A0A6M8YDW2
    Related
    ENSP00000353395.4, ENST00000360258.8
    Conserved Domains (1) summary
    pfam08007
    Location:52363
    Cupin_4; Cupin superfamily protein
  4. NM_153182.4NP_694822.2  ribosomal oxygenase 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1, and encodes isoform A. Variants 1 and 2 encode the same protein (isoform A).
    Source sequence(s)
    AC110491, DA310030, DQ453796
    Consensus CDS
    CCDS43114.1
    UniProtKB/Swiss-Prot
    D3DN35, Q6AHW4, Q6SKS0, Q8IU69, Q8IUF6, Q8IUF7, Q8IUF8, Q96C17, Q96KB0
    UniProtKB/TrEMBL
    A0A6M8YDW1, A0A6M8YDW2
    Related
    ENSP00000377748.2, ENST00000394198.7
    Conserved Domains (1) summary
    pfam08007
    Location:52364
    Cupin_4; Cupin superfamily protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    97941818..97972431 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449085.1XP_047305041.1  ribosomal oxygenase 2 isoform X2

    UniProtKB/TrEMBL
    A0A6M8YDW2
  2. XM_005247838.5XP_005247895.1  ribosomal oxygenase 2 isoform X1

    UniProtKB/Swiss-Prot
    D3DN35, Q6AHW4, Q6SKS0, Q8IU69, Q8IUF6, Q8IUF7, Q8IUF8, Q96C17, Q96KB0
    UniProtKB/TrEMBL
    A0A6M8YDW1, A0A6M8YDW2
    Conserved Domains (1) summary
    pfam08007
    Location:52364
    Cupin_4; Cupin superfamily protein
  3. XM_011513244.4XP_011511546.1  ribosomal oxygenase 2 isoform X5

    Conserved Domains (1) summary
    cl21464
    Location:7133
    cupin_like; Conserved domain found in cupin and related proteins
  4. XM_047449086.1XP_047305042.1  ribosomal oxygenase 2 isoform X3

  5. XM_047449087.1XP_047305043.1  ribosomal oxygenase 2 isoform X4

    Related
    ENSP00000424955.1, ENST00000514314.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    100645556..100676171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348142.1XP_054204117.1  ribosomal oxygenase 2 isoform X1

    UniProtKB/TrEMBL
    A0A6M8YDW2, A0A6M8YHF9
  2. XM_054348143.1XP_054204118.1  ribosomal oxygenase 2 isoform X2

    UniProtKB/TrEMBL
    A0A6M8YDW2
  3. XM_054348146.1XP_054204121.1  ribosomal oxygenase 2 isoform X5

  4. XM_054348144.1XP_054204119.1  ribosomal oxygenase 2 isoform X3

  5. XM_054348145.1XP_054204120.1  ribosomal oxygenase 2 isoform X4

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