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ADAM8 ADAM metallopeptidase domain 8 [ Homo sapiens (human) ]

Gene ID: 101, updated on 4-Jan-2025

Summary

Official Symbol
ADAM8provided by HGNC
Official Full Name
ADAM metallopeptidase domain 8provided by HGNC
Primary source
HGNC:HGNC:215
See related
Ensembl:ENSG00000151651 MIM:602267; AllianceGenome:HGNC:215
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MS2; CD156; CD156a
Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]
Expression
Biased expression in bone marrow (RPKM 22.3), spleen (RPKM 13.4) and 12 other tissues See more
Orthologs
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Genomic context

See ADAM8 in Genome Data Viewer
Location:
10q26.3
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (133262423..133276868, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (134218053..134232489, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (135075927..135090372, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135050938-135051542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135051543-135052146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135056640-135057492 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:135057814-135059013 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2970 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135060766-135061280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135061797-135062311 Neighboring gene VENT homeobox Neighboring gene MIR202 host gene Neighboring gene microRNA 202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4238 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2971 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135075828-135076804 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135084013-135084769 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135087865-135088514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4240 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135089815-135090462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4241 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4242 Neighboring gene tubulin gamma complex component 2 Neighboring gene uncharacterized LOC124902562 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:135106330-135107529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4243 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135122506-135123201 Neighboring gene ZNF511-PRAP1 readthrough Neighboring gene zinc finger protein 511

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC134985

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding  
enables cell adhesion molecule binding  
enables immunoglobulin receptor binding PubMed 
enables metalloendopeptidase activity  
enables metallopeptidase activity PubMed 
enables protein binding PubMed 
enables serine-type endopeptidase activity  
enables tumor necrosis factor receptor superfamily binding PubMed 
enables zinc ion binding PubMed 
Items 1 - 25 of 33
Process Evidence Code Pubs
involved_in angiogenesis  
involved_in canonical NF-kappaB signal transduction  
involved_in cell morphogenesis  
involved_in cell-cell adhesion  
involved_in cellular response to hypoxia PubMed 
involved_in extracellular matrix disassembly  
involved_in inflammatory response  
involved_in inflammatory response PubMed 
involved_in leukocyte migration involved in inflammatory response  
involved_in lymphocyte chemotaxis  
involved_in negative regulation of neuron apoptotic process  
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of T cell differentiation in thymus  
involved_in positive regulation of acute inflammatory response  
involved_in positive regulation of bone resorption  
involved_in positive regulation of cell adhesion  
involved_in positive regulation of cellular extravasation  
involved_in positive regulation of eosinophil migration  
involved_in positive regulation of epithelial to mesenchymal transition  
involved_in positive regulation of fibronectin-dependent thymocyte migration  
involved_in positive regulation of innate immune response  
involved_in positive regulation of membrane protein ectodomain proteolysis  
involved_in positive regulation of membrane protein ectodomain proteolysis PubMed 
involved_in positive regulation of neutrophil extravasation PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of protein processing PubMed 
involved_in positive regulation of protein secretion PubMed 
involved_in positive regulation of thymocyte apoptotic process  
involved_in positive regulation of tumor necrosis factor (ligand) superfamily member 11 production  
involved_in proteolysis  
involved_in regulation of cell-cell adhesion  
involved_in regulation of cell-cell adhesion PubMed 
involved_in signal release PubMed 
Items 1 - 25 of 33
Component Evidence Code Pubs
part_of alpha9-beta1 integrin-ADAM8 complex  
located_in cell surface PubMed 
located_in cytoplasm PubMed 
located_in dense core granule membrane PubMed 
located_in ficolin-1-rich granule membrane  
located_in phagolysosome PubMed 
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in podosome PubMed 
located_in specific granule PubMed 
located_in specific granule membrane  
located_in tertiary granule PubMed 
located_in tertiary granule membrane  

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 8
Names
a disintegrin and metalloproteinase domain 8
cell surface antigen MS2
human leukocyte differentiation antigen
NP_001100.3
NP_001157961.1
NP_001157962.1
XP_047280379.1
XP_047280380.1
XP_047280381.1
XP_047280382.1
XP_054220443.1
XP_054220444.1
XP_054220445.1
XP_054220446.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109.5NP_001100.3  disintegrin and metalloproteinase domain-containing protein 8 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001100.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK312834, AL592071, BQ007791, DA936506, DC408787
    Consensus CDS
    CCDS31319.2
    UniProtKB/Swiss-Prot
    B4DVM6, H0YL36, H0YLR0, H0YN39, P78325
    UniProtKB/TrEMBL
    Q14C66
    Related
    ENSP00000453302.1, ENST00000445355.8
    Conserved Domains (5) summary
    smart00050
    Location:417491
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:494605
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:200398
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:200400
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:43154
    Pep_M12B_propep; Reprolysin family propeptide
  2. NM_001164489.2NP_001157961.1  disintegrin and metalloproteinase domain-containing protein 8 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon and uses an alternate splice site, which causes a frameshift in the 3' coding region, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL592071, BC064500, BQ007791, DA936506, DC401057, DC408787
    Consensus CDS
    CCDS58103.1
    UniProtKB/Swiss-Prot
    P78325
    Related
    ENSP00000453855.1, ENST00000415217.7
    Conserved Domains (5) summary
    smart00050
    Location:417491
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:494605
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:200398
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:200400
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:43154
    Pep_M12B_propep; Reprolysin family propeptide
  3. NM_001164490.2NP_001157962.1  disintegrin and metalloproteinase domain-containing protein 8 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks three alternate exons and uses an alternate splice site in the coding region, which results in a frameshifted segment, compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter than isoform 1.
    Source sequence(s)
    AK301147, AL592071, BI908229, BQ007791, DA936506, DC408787
    Consensus CDS
    CCDS58102.1
    UniProtKB/TrEMBL
    Q14C66
    Related
    ENSP00000453043.1, ENST00000485491.6
    Conserved Domains (4) summary
    smart00050
    Location:378452
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:455562
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:161359
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:161361
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    133262423..133276868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424426.1XP_047280382.1  disintegrin and metalloproteinase domain-containing protein 8 isoform X4

    UniProtKB/TrEMBL
    Q14C66
  2. XM_047424425.1XP_047280381.1  disintegrin and metalloproteinase domain-containing protein 8 isoform X3

    UniProtKB/TrEMBL
    Q14C66
  3. XM_047424424.1XP_047280380.1  disintegrin and metalloproteinase domain-containing protein 8 isoform X2

    UniProtKB/TrEMBL
    Q14C66
  4. XM_047424423.1XP_047280379.1  disintegrin and metalloproteinase domain-containing protein 8 isoform X1

    UniProtKB/TrEMBL
    Q14C66

RNA

  1. XR_007061938.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    134218053..134232489 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364471.1XP_054220446.1  disintegrin and metalloproteinase domain-containing protein 8 isoform X4

    UniProtKB/TrEMBL
    Q14C66
  2. XM_054364470.1XP_054220445.1  disintegrin and metalloproteinase domain-containing protein 8 isoform X3

    UniProtKB/TrEMBL
    Q14C66
  3. XM_054364469.1XP_054220444.1  disintegrin and metalloproteinase domain-containing protein 8 isoform X2

    UniProtKB/TrEMBL
    Q14C66
  4. XM_054364468.1XP_054220443.1  disintegrin and metalloproteinase domain-containing protein 8 isoform X1

    UniProtKB/TrEMBL
    Q14C66

RNA

  1. XR_008488152.1 RNA Sequence

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