U.S. flag

An official website of the United States government

Tpte transmembrane phosphatase with tensin homology [ Mus musculus (house mouse) ]

Gene ID: 234129, updated on 4-Jan-2025

Summary

Official Symbol
Tpteprovided by MGI
Official Full Name
transmembrane phosphatase with tensin homologyprovided by MGI
Primary source
MGI:MGI:2446460
See related
Ensembl:ENSMUSG00000031481 AllianceGenome:MGI:2446460
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vsp; Pten2
Summary
Predicted to enable phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity. Predicted to be located in Golgi apparatus and endoplasmic reticulum membrane. Predicted to be active in cytosol. Is expressed in brain; eye; future spinal cord; surface ectoderm; and testis. Orthologous to several human genes including TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in testis adult (RPKM 1.2), kidney adult (RPKM 0.2) and 6 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Tpte in Genome Data Viewer
Location:
8 A2; 8 11.2 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22773457..22861432)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22283315..22371418)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 36 Neighboring gene ribosomal protein L30, pseudogene 2 Neighboring gene thrombospondin, type I, domain 1 Neighboring gene predicted gene, 46035 Neighboring gene solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15 Neighboring gene RIKEN cDNA 1810012K16 gene Neighboring gene STARR-positive B cell enhancer ABC_E6625

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Clone Names

  • MGC130293

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in Golgi apparatus PubMed 
located_in cytoplasm  
is_active_in cytosol  
located_in endoplasmic reticulum membrane  

General protein information

Preferred Names
transmembrane phosphatase with tensin homology
NP_954866.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199257.3NP_954866.2  transmembrane phosphatase with tensin homology

    See identical proteins and their annotated locations for NP_954866.2

    Status: VALIDATED

    Source sequence(s)
    AC121933, AC140326
    Consensus CDS
    CCDS22173.1
    UniProtKB/TrEMBL
    G5E8H5, Q3KNE1
    Related
    ENSMUSP00000076435.2, ENSMUST00000077194.2
    Conserved Domains (2) summary
    smart00404
    Location:413478
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:529663
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    22773457..22861432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

External link. Please review our privacy policy.