U.S. flag

An official website of the United States government

Lamtor2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 [ Mus musculus (house mouse) ]

Gene ID: 83409, updated on 4-Jan-2025

Summary

Official Symbol
Lamtor2provided by MGI
Official Full Name
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2provided by MGI
Primary source
MGI:MGI:1932697
See related
Ensembl:ENSMUSG00000028062 AllianceGenome:MGI:1932697
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P14; Rab25; Robld3; Mapbpip; 2010111E04Rik
Summary
Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Acts upstream of or within several processes, including fibroblast migration; positive regulation of MAPK cascade; and regulation of cell-substrate junction organization. Located in late endosome. Orthologous to human LAMTOR2 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in kidney adult (RPKM 88.5), colon adult (RPKM 83.4) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Lamtor2 in Genome Data Viewer
Location:
3 F1; 3 38.87 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88457126..88460258, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88549819..88552951, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene mex3 RNA binding family member A Neighboring gene microRNA 1905 Neighboring gene RAB25, member RAS oncogene family Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:88356947-88357056 Neighboring gene STARR-positive B cell enhancer ABC_E8803 Neighboring gene ubiquilin 4 Neighboring gene STARR-seq mESC enhancer starr_08200 Neighboring gene STARR-seq mESC enhancer starr_08201 Neighboring gene RNA transcription, translation and transport factor, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to guanyl-nucleotide exchange factor activity  
contributes_to guanyl-nucleotide exchange factor activity  
contributes_to molecular adaptor activity  
contributes_to molecular adaptor activity  
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in TORC1 signaling PubMed 
involved_in cellular response to amino acid stimulus  
involved_in cellular response to amino acid stimulus  
involved_in cellular response to amino acid stimulus  
acts_upstream_of_or_within fibroblast migration PubMed 
acts_upstream_of_or_within fibroblast migration PubMed 
acts_upstream_of_or_within fibroblast migration PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade PubMed 
involved_in positive regulation of TOR signaling  
involved_in positive regulation of TOR signaling  
involved_in positive regulation of TOR signaling  
involved_in positive regulation of TORC1 signaling  
involved_in positive regulation of TORC1 signaling  
involved_in protein localization  
involved_in protein localization  
acts_upstream_of_or_within protein localization to cell junction PubMed 
involved_in regulation of cell growth  
involved_in regulation of cell growth  
acts_upstream_of_or_within regulation of cell-substrate junction organization PubMed 
acts_upstream_of_or_within regulation of cell-substrate junction organization PubMed 
acts_upstream_of_or_within regulation of cell-substrate junction organization PubMed 
Component Evidence Code Pubs
part_of FNIP-folliculin RagC/D GAP  
part_of FNIP-folliculin RagC/D GAP  
part_of Ragulator complex  
part_of Ragulator complex  
part_of Ragulator complex  
located_in late endosome PubMed 
located_in late endosome membrane PubMed 
is_active_in lysosomal membrane  
is_active_in lysosomal membrane  
located_in lysosomal membrane PubMed 

General protein information

Preferred Names
ragulator complex protein LAMTOR2
Names
endosomal adaptor protein p14
late endosomal/lysosomal MP1 interacting protein
late endosomal/lysosomal adaptor and MAPK and MTOR activator 2
mitogen-activated protein-binding protein-interacting protein
roadblock domain-containing protein 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362368.1NP_001349297.1  ragulator complex protein LAMTOR2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    BE629197, BY062676
    Conserved Domains (1) summary
    pfam03259
    Location:877
    Robl_LC7; Roadblock/LC7 domain
  2. NM_031248.4NP_112538.1  ragulator complex protein LAMTOR2 isoform 1

    See identical proteins and their annotated locations for NP_112538.1

    Status: VALIDATED

    Source sequence(s)
    AA250375, BE947263, BY062676
    Consensus CDS
    CCDS17478.1
    UniProtKB/Swiss-Prot
    Q9JHS3
    Related
    ENSMUSP00000029698.9, ENSMUST00000029698.15
    Conserved Domains (1) summary
    pfam03259
    Location:595
    Robl_LC7; Roadblock/LC7 domain

RNA

  1. NR_155541.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC145168
  2. NR_155542.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC145168
    Related
    ENSMUST00000156421.2
  3. NR_155543.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AW988728, BE947263, BY062676
    Related
    ENSMUST00000119002.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    88457126..88460258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.