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Snip1 Smad nuclear interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 76793, updated on 4-Jan-2025

Summary

Official Symbol
Snip1provided by MGI
Official Full Name
Smad nuclear interacting protein 1provided by MGI
Primary source
MGI:MGI:2156003
See related
Ensembl:ENSMUSG00000050213 AllianceGenome:MGI:2156003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410133M08Rik
Summary
Enables transcription regulator inhibitor activity. Involved in negative regulation of canonical NF-kappaB signal transduction. Is active in nucleus. Is expressed in several structures, including branchial arch; cerebral cortex; gut epithelium; metanephros; and sensory organ. Orthologous to human SNIP1 (Smad nuclear interacting protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in testis adult (RPKM 7.6), CNS E11.5 (RPKM 7.1) and 28 other tissues See more
Orthologs
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Genomic context

See Snip1 in Genome Data Viewer
Location:
4 D2.2; 4 57.99 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124960465..124967836)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (125066672..125074043)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38472 Neighboring gene STARR-positive B cell enhancer ABC_E7987 Neighboring gene guanine nucleotide binding protein nucleolar 2 Neighboring gene dynein, axonemal, light intermediate polypeptide 1 Neighboring gene STARR-positive B cell enhancer ABC_E6215 Neighboring gene splicing factor 3a, subunit 2 pseudogene Neighboring gene MYST/Esa1-associated factor 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

General gene information

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome  
involved_in mRNA splicing, via spliceosome  
involved_in miRNA processing  
involved_in miRNA processing  
involved_in miRNA processing  
involved_in negative regulation of canonical NF-kappaB signal transduction PubMed 
Component Evidence Code Pubs
part_of U2-type precatalytic spliceosome  
part_of U2-type precatalytic spliceosome  
located_in cytosol  
located_in cytosol  
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in nucleus  
is_active_in nucleus PubMed 
located_in nucleus  

General protein information

Preferred Names
smad nuclear-interacting protein 1
Names
Smad nuclear interacting protein 1 Snip1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356560.1NP_001343489.1  smad nuclear-interacting protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK078163, AL626775, BB636252, BE336211
    Conserved Domains (2) summary
    cd00060
    Location:150253
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl28310
    Location:397
    Rho; Transcription termination factor Rho [Transcription]
  2. NM_175246.5NP_780455.2  smad nuclear-interacting protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK040571, AL626775, BE336211
    Consensus CDS
    CCDS18636.1
    UniProtKB/Swiss-Prot
    Q3V106, Q8BIZ4, Q8BIZ6
    Related
    ENSMUSP00000060721.7, ENSMUST00000052183.7
    Conserved Domains (2) summary
    COG1716
    Location:262353
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:245360
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    124960465..124967836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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