Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Vpr
|
vpr
|
Prolonged cell cycle arrest in the G2 phase induced by HIV-1 Vpr results in the depletion of Wee1 kinase |
PubMed
|
|
vpr
|
HIV-1 Vpr binds to Wee1. Amino acids 291-369 in Wee1 are required for the binding between Vpr and Wee1. Vpr stimulates Wee1 kinase activity |
PubMed
|
|
vpr
|
HIV-1 Vpr-induced cell cycle arrest results in increased levels of Wee-1 kinase in synchronized HeLa cells; G2 arrest by Vpr is correlated with delayed degradation of Wee-1, and Cdc2 activity is reduced at G2/M in the presence of Vpr |
PubMed
|
|
vpr
|
HIV-1 Vpr induced cell cycle arrest in the G2 phase is mediated predominately through the Wee1 kinase in fission yeast |
PubMed
|
|
vpr
|
Overexpression of Wee-1 kinase suppresses HIV-1 Vpr-mediated apoptosis |
PubMed
|
|
vpr
|
Rupture of HIV-1 Vpr-induced nuclear envelope herniations produces transient loss of the subcellular compartmentalization of Wee1, Cdc25C, cyclin B1, and presumably other soluble cellular components, resulting in their release into the cytoplasm |
PubMed
|
Go to the HIV-1, Human Interaction Database