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    Usp7 ubiquitin specific peptidase 7 [ Mus musculus (house mouse) ]

    Gene ID: 252870, updated on 4-Jan-2025

    Summary

    Official Symbol
    Usp7provided by MGI
    Official Full Name
    ubiquitin specific peptidase 7provided by MGI
    Primary source
    MGI:MGI:2182061
    See related
    Ensembl:ENSMUSG00000022710 AllianceGenome:MGI:2182061
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hausp; 2210010O09Rik
    Summary
    Enables cysteine-type deubiquitinase activity and cysteine-type endopeptidase activity. Involved in several processes, including protein deubiquitination; regulation of protein stability; and transcription elongation-coupled chromatin remodeling. Located in XY body; cytoplasm; and nucleus. Is expressed in blastocyst; embryo; inner cell mass; and trophectoderm. Orthologous to human USP7 (ubiquitin specific peptidase 7). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 25.2), liver E14 (RPKM 24.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Usp7 in Genome Data Viewer
    Location:
    16 A1; 16 4.28 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (8506586..8574931, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (8688722..8757067, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 186 Neighboring gene phosphomannomutase 2 Neighboring gene calcium regulated heat stable protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E8616 Neighboring gene LITAF domain containing Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:8745912-8746157 Neighboring gene STARR-seq mESC enhancer starr_40018 Neighboring gene STARR-seq mESC enhancer starr_40019 Neighboring gene STARR-positive B cell enhancer ABC_E8906 Neighboring gene STARR-seq mESC enhancer starr_40021 Neighboring gene predicted gene, 25805 Neighboring gene STARR-seq mESC enhancer starr_40028 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:8829797-8829906 Neighboring gene STARR-seq mESC enhancer starr_40031 Neighboring gene HUWE1 associated protein modifying stress responses Neighboring gene predicted gene, 52232

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity  
    enables K48-linked deubiquitinase activity  
    enables cysteine-type deubiquitinase activity  
    enables cysteine-type deubiquitinase activity PubMed 
    enables cysteine-type deubiquitinase activity PubMed 
    enables cysteine-type deubiquitinase activity PubMed 
    enables cysteine-type deubiquitinase activity  
    enables cysteine-type endopeptidase activity PubMed 
    enables cysteine-type endopeptidase activity  
    enables deubiquitinase activity  
    enables deubiquitinase activity  
    enables identical protein binding  
    enables p53 binding  
    enables protein binding PubMed 
    Items 1 - 25 of 29
    Process Evidence Code Pubs
    involved_in DNA alkylation repair  
    involved_in DNA alkylation repair  
    acts_upstream_of_or_within monoubiquitinated protein deubiquitination PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity  
    involved_in negative regulation of TORC1 signaling  
    involved_in negative regulation of gene expression via chromosomal CpG island methylation  
    involved_in negative regulation of gluconeogenesis  
    involved_in negative regulation of gluconeogenesis  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of apoptotic process  
    involved_in protein deubiquitination PubMed 
    involved_in protein deubiquitination  
    involved_in protein deubiquitination  
    involved_in protein stabilization  
    involved_in protein stabilization  
    involved_in proteolysis  
    involved_in regulation of DNA-binding transcription factor activity  
    involved_in regulation of DNA-binding transcription factor activity  
    involved_in regulation of circadian rhythm PubMed 
    involved_in regulation of circadian rhythm  
    involved_in regulation of protein stability  
    involved_in regulation of protein stability PubMed 
    involved_in regulation of protein stability  
    involved_in regulation of retrograde transport, endosome to Golgi  
    involved_in rhythmic process  
    involved_in symbiont-mediated disruption of host cell PML body  
    involved_in transcription elongation-coupled chromatin remodeling PubMed 
    involved_in transcription-coupled nucleotide-excision repair  
    involved_in transcription-coupled nucleotide-excision repair  
    Items 1 - 25 of 29
    Component Evidence Code Pubs
    located_in PML body  
    is_active_in PML body  
    located_in XY body PubMed 
    located_in cytoplasm PubMed 
    is_active_in cytosol  
    located_in cytosol  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 7
    Names
    deubiquitinating enzyme 7
    herpesvirus-associated ubiquitin-specific protease
    mHAUSP
    ubiquitin specific protease 7
    ubiquitin thioesterase 7
    ubiquitin thiolesterase 7
    ubiquitin-specific-processing protease 7
    NP_001003918.2
    XP_006522201.1
    XP_006522202.1
    XP_006522204.1
    XP_030104976.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003918.2NP_001003918.2  ubiquitin carboxyl-terminal hydrolase 7

      Status: VALIDATED

      Source sequence(s)
      AC115005, AC156026, AF548565, AK135814
      Consensus CDS
      CCDS49755.1
      UniProtKB/Swiss-Prot
      Q3UX92, Q496Y5, Q6A4J8, Q8BW01
      UniProtKB/TrEMBL
      F8VPX1
      Related
      ENSMUSP00000124093.3, ENSMUST00000161046.9
      Conserved Domains (5) summary
      COG5077
      Location:561101
      COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02659
      Location:213524
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd03772
      Location:68203
      MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...
      pfam12436
      Location:621866
      USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7
      pfam14533
      Location:8761087
      USP7_C2; Ubiquitin-specific protease C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      8506586..8574931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522138.4XP_006522201.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X1

      UniProtKB/Swiss-Prot
      Q3UX92, Q496Y5, Q6A4J8, Q8BW01
      UniProtKB/TrEMBL
      E9PXY8
      Related
      ENSMUSP00000124382.2, ENSMUST00000160405.8
      Conserved Domains (1) summary
      COG5077
      Location:961141
      COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    2. XM_006522141.4XP_006522204.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X3

      UniProtKB/Swiss-Prot
      Q3UX92, Q496Y5, Q6A4J8, Q8BW01
      Conserved Domains (1) summary
      COG5077
      Location:61001
      COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    3. XM_030249116.2XP_030104976.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X3

      UniProtKB/Swiss-Prot
      Q3UX92, Q496Y5, Q6A4J8, Q8BW01
      Conserved Domains (1) summary
      COG5077
      Location:61001
      COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    4. XM_006522139.4XP_006522202.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X2

      UniProtKB/Swiss-Prot
      Q3UX92, Q496Y5, Q6A4J8, Q8BW01
      Conserved Domains (1) summary
      COG5077
      Location:391084
      COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
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