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CFLAR CASP8 and FADD like apoptosis regulator [ Bos taurus (domestic cattle) ]

Gene ID: 497199, updated on 1-Jan-2025

Summary

Official Symbol
CFLARprovided by VGNC
Official Full Name
CASP8 and FADD like apoptosis regulatorprovided by VGNC
Primary source
VGNC:VGNC:27255
See related
BGD:BT15630; Ensembl:ENSBTAG00000010998
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
FLIP
Orthologs
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Genomic context

See CFLAR in Genome Data Viewer
Location:
chromosome: 2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (89704174..89762443)

Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene hyccin PI4KA lipid kinase complex subunit 2 Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 Neighboring gene caspase-10 Neighboring gene flagellum associated containing coiled-coil domains 1 Neighboring gene caspase 8

Genomic regions, transcripts, and products

Genomic Sequence:
NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Expression

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Pathways from PubChem

General gene information

Gene Ontology Provided by RefSeq

General protein information

Preferred Names
CASP8 and FADD-like apoptosis regulator
Names
FLICE-like inhibitory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012281.2NP_001012281.2  CASP8 and FADD-like apoptosis regulator

    Status: VALIDATED

    Source sequence(s)
    NKLS02000002
    UniProtKB/TrEMBL
    A0A3Q1MFY0, F1N346, Q5FX62
    Related
    ENSBTAP00000073134.1, ENSBTAT00000085853.2

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    89704174..89762443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005202603.5XP_005202660.1  CASP8 and FADD-like apoptosis regulator isoform X1

    See identical proteins and their annotated locations for XP_005202660.1

    UniProtKB/TrEMBL
    A0A3Q1MFY0, F1N346, Q5FX62
    Conserved Domains (3) summary
    cd08337
    Location:28107
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:118198
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    cl00042
    Location:273510
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
  2. XM_024999538.2XP_024855306.1  CASP8 and FADD-like apoptosis regulator isoform X2

    UniProtKB/TrEMBL
    A0A3Q1MLX3, A0A3Q1N3I3
    Related
    ENSBTAP00000064085.1, ENSBTAT00000076795.2
    Conserved Domains (3) summary
    cd08337
    Location:28107
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:118198
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    cl00042
    Location:247466
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
  3. XM_010802165.4XP_010800467.1  CASP8 and FADD-like apoptosis regulator isoform X3

    UniProtKB/TrEMBL
    F1N346, Q5FX62
    Conserved Domains (2) summary
    cd08340
    Location:175
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    cl00042
    Location:150387
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
  4. XM_024999533.2XP_024855301.1  CASP8 and FADD-like apoptosis regulator isoform X1

    UniProtKB/TrEMBL
    A0A3Q1MFY0, F1N346, Q5FX62
    Conserved Domains (3) summary
    cd08337
    Location:28107
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:118198
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    cl00042
    Location:273510
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
  5. XM_005202605.5XP_005202662.1  CASP8 and FADD-like apoptosis regulator isoform X1

    See identical proteins and their annotated locations for XP_005202662.1

    UniProtKB/TrEMBL
    A0A3Q1MFY0, F1N346, Q5FX62
    Conserved Domains (3) summary
    cd08337
    Location:28107
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:118198
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    cl00042
    Location:273510
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
  6. XM_005202604.5XP_005202661.1  CASP8 and FADD-like apoptosis regulator isoform X1

    See identical proteins and their annotated locations for XP_005202661.1

    UniProtKB/TrEMBL
    A0A3Q1MFY0, F1N346, Q5FX62
    Conserved Domains (3) summary
    cd08337
    Location:28107
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:118198
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    cl00042
    Location:273510
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
  7. XM_059892075.1XP_059748058.1  CASP8 and FADD-like apoptosis regulator isoform X4

  8. XM_024999561.2XP_024855329.1  CASP8 and FADD-like apoptosis regulator isoform X4

    Conserved Domains (1) summary
    cl00042
    Location:57294
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
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