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Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 [ Mus musculus (house mouse) ]

Gene ID: 15486, updated on 4-Jan-2025

Summary

Official Symbol
Hsd17b2provided by MGI
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 2provided by MGI
Primary source
MGI:MGI:1096386
See related
Ensembl:ENSMUSG00000031844 AllianceGenome:MGI:1096386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable estradiol 17-beta-dehydrogenase [NAD(P)+] activity and testosterone dehydrogenase (NAD+) activity. Acts upstream of or within in utero embryonic development and placenta development. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including adrenal gland; genitourinary system; gut; labyrinthine zone; and liver. Orthologous to human HSD17B2 (hydroxysteroid 17-beta dehydrogenase 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in liver adult (RPKM 84.5), colon adult (RPKM 79.8) and 9 other tissues See more
Orthologs
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Genomic context

See Hsd17b2 in Genome Data Viewer
Location:
8 E1; 8 64.82 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (118427752..118485767)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (117700982..117759030)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31717 Neighboring gene predicted gene, 38416 Neighboring gene predicted gene, 31774 Neighboring gene predicted gene, 39261 Neighboring gene STARR-positive B cell enhancer mm9_chr8:120303396-120303696 Neighboring gene STARR-positive B cell enhancer ABC_E9744 Neighboring gene M phase phosphoprotein 6 Neighboring gene STARR-positive B cell enhancer ABC_E1377

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in androgen biosynthetic process  
involved_in androgen metabolic process  
involved_in androgen metabolic process  
involved_in estrogen biosynthetic process  
involved_in estrogen biosynthetic process  
acts_upstream_of_or_within in utero embryonic development PubMed 
acts_upstream_of_or_within placenta development PubMed 
involved_in response to retinoic acid  
involved_in response to retinoic acid  
involved_in steroid metabolic process  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane  
located_in endoplasmic reticulum membrane  
is_active_in intracellular membrane-bounded organelle  

General protein information

Preferred Names
estradiol 17-beta-dehydrogenase 2
Names
17 HSD type 2
17-beta-HSD 2
17-beta-hydroxysteroid dehydrogenase 2
17-beta-hydroxysteroid dehydrogenase type 2
testosterone 17-beta-dehydrogenase
NP_001411758.1
NP_032316.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424829.1NP_001411758.1  estradiol 17-beta-dehydrogenase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC112964, AC122036
  2. NM_008290.3NP_032316.2  estradiol 17-beta-dehydrogenase 2 isoform 1

    See identical proteins and their annotated locations for NP_032316.2

    Status: VALIDATED

    Source sequence(s)
    AC112964, AC122036
    Consensus CDS
    CCDS40491.1
    UniProtKB/Swiss-Prot
    O08898, P51658
    Related
    ENSMUSP00000034304.8, ENSMUST00000034304.9
    Conserved Domains (2) summary
    cd09805
    Location:84364
    type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
    pfam00106
    Location:84279
    adh_short; short chain dehydrogenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    118427752..118485767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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