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Nlrp2 NLR family, pyrin domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 232827, updated on 4-Jan-2025

Summary

Official Symbol
Nlrp2provided by MGI
Official Full Name
NLR family, pyrin domain containing 2provided by MGI
Primary source
MGI:MGI:3041206
See related
Ensembl:ENSMUSG00000035177 AllianceGenome:MGI:3041206
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NBS1; PAN1; Nalp2; PYPAF2; E330007A02Rik
Summary
Predicted to enable several functions, including Pyrin domain binding activity; aspartic-type endopeptidase inhibitor activity; and caspase binding activity. Predicted to be involved in regulation of inflammatory response. Predicted to be located in Golgi apparatus and cytosol. Predicted to be active in cytoplasm. Predicted to colocalize with chromosome, telomeric region. Is expressed in early conceptus and gonad. Human ortholog(s) of this gene implicated in gestational trophoblastic neoplasm. Orthologous to human NLRP2 (NLR family pyrin domain containing 2) and NLRP7 (NLR family pyrin domain containing 7). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Low expression observed in reference dataset See more
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Genomic context

See Nlrp2 in Genome Data Viewer
Location:
7 A1; 7 3.07 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (5301546..5354034, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (5298547..5351035, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 57 Neighboring gene predicted gene, 23942 Neighboring gene predicted gene, 18757 Neighboring gene galectin like 2 Neighboring gene vomeronasal 1 receptor 58 Neighboring gene vomeronasal 1 receptor, pseudogene 39

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Pyrin domain binding  
enables aspartic-type endopeptidase inhibitor activity  
enables caspase binding  
enables identical protein binding  
enables interleukin-1 binding  
Component Evidence Code Pubs
located_in Golgi apparatus  
colocalizes_with chromosome, telomeric region  
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytosol  
located_in intracellular membrane-bounded organelle  

General protein information

Preferred Names
NACHT, LRR and PYD domains-containing protein 2
Names
NACHT, leucine rich repeat and PYD containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177690.3NP_808358.2  NACHT, LRR and PYD domains-containing protein 2

    See identical proteins and their annotated locations for NP_808358.2

    Status: VALIDATED

    Source sequence(s)
    AC155171, DQ066881
    Consensus CDS
    CCDS39746.1
    UniProtKB/TrEMBL
    Q4PLS0
    Related
    ENSMUSP00000045077.8, ENSMUST00000045022.9
    Conserved Domains (4) summary
    cd00116
    Location:7691008
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd08320
    Location:1194
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    sd00033
    Location:743766
    LRR_RI; leucine-rich repeat [structural motif]
    cl21455
    Location:182345
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    5301546..5354034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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