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Mc1r melanocortin 1 receptor [ Mus musculus (house mouse) ]

Gene ID: 17199, updated on 4-Jan-2025

Summary

Official Symbol
Mc1rprovided by MGI
Official Full Name
melanocortin 1 receptorprovided by MGI
Primary source
MGI:MGI:99456
See related
Ensembl:ENSMUSG00000074037 AllianceGenome:MGI:99456
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
e; Tob; Mcr1; Mshra
Summary
Enables melanocyte-stimulating hormone receptor activity. Involved in several processes, including phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cAMP/PKA signal transduction; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within melanin biosynthetic process; pigmentation; and sensory perception of pain. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including central nervous system; foregut; musculature; sensory organ; and skin. Human ortholog(s) of this gene implicated in familial melanoma; major depressive disorder; melanoma; oculocutaneous albinism type II; and pigmentation disease. Orthologous to human MC1R (melanocortin 1 receptor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Mc1r in Genome Data Viewer
Location:
8 E1; 8 72.1 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (124133839..124137483)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (123407082..123410744)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22969 Neighboring gene STARR-seq mESC enhancer starr_22970 Neighboring gene spire type actin nucleation factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E2278 Neighboring gene transcription factor 25 (basic helix-loop-helix) Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:125928490-125928752 Neighboring gene STARR-seq mESC enhancer starr_22972 Neighboring gene tubulin, beta 3 class III Neighboring gene differentially expressed in FDCP 8

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in UV-damage excision repair  
involved_in UV-damage excision repair  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in intracellular signal transduction PubMed 
acts_upstream_of_or_within melanin biosynthetic process PubMed 
involved_in negative regulation of tumor necrosis factor production  
involved_in negative regulation of tumor necrosis factor production  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway PubMed 
acts_upstream_of_or_within pigmentation  
involved_in positive regulation of cAMP/PKA signal transduction PubMed 
involved_in positive regulation of feeding behavior  
involved_in positive regulation of transcription by RNA polymerase II PubMed 
involved_in regulation of metabolic process  
acts_upstream_of_or_within sensory perception of pain PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm  
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
melanocyte-stimulating hormone receptor
Names
MC1-R
MSH-R
extension recessive yellow
melanocortin receptor 1
tobacco darkening

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008559.3NP_032585.2  melanocyte-stimulating hormone receptor

    See identical proteins and their annotated locations for NP_032585.2

    Status: VALIDATED

    Source sequence(s)
    AC122266
    Consensus CDS
    CCDS22756.1
    UniProtKB/Swiss-Prot
    Q01727, Q75NA3
    UniProtKB/TrEMBL
    A0A0B6VKM9, A0A0B6VKP5, A0A0B6VKR0, A0A0B6VNE1, A0A0B6VTI1, A0A0B6VTI5, A0A0B6VTJ4, A0A0B6VTK2, Q75NA2
    Related
    ENSMUSP00000095929.3, ENSMUST00000098324.4
    Conserved Domains (2) summary
    pfam00001
    Location:53296
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:43172
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    124133839..124137483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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