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Nme2 NME/NM23 nucleoside diphosphate kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 18103, updated on 13-Jan-2025

Summary

Official Symbol
Nme2provided by MGI
Official Full Name
NME/NM23 nucleoside diphosphate kinase 2provided by MGI
Primary source
MGI:MGI:97356
See related
Ensembl:ENSMUSG00000020857 AllianceGenome:MGI:97356
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NM23B; NM23-H2; nm23-M2
Summary
Predicted to enable several functions, including G-quadruplex DNA binding activity; anion binding activity; and kinase activity. Predicted to be involved in several processes, including integrin-mediated signaling pathway; negative regulation of myeloid leukocyte differentiation; and ribonucleoside triphosphate biosynthetic process. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in teratoma. Orthologous to several human genes including NME2 (NME/NM23 nucleoside diphosphate kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in placenta adult (RPKM 169.6), liver E18 (RPKM 106.9) and 28 other tissues See more
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Genomic context

See Nme2 in Genome Data Viewer
Location:
11 D; 11 58.88 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (93840640..93847082, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (93949814..93956256, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene UTP18 small subunit processome component Neighboring gene ES cell cis-regulatory motifs 1a, 3b and 9b Neighboring gene STARR-seq mESC enhancer starr_30442 Neighboring gene mbt domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E1144 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:93829571-93829796 Neighboring gene STARR-seq mESC enhancer starr_30446 Neighboring gene predicted gene, 35198 Neighboring gene NME/NM23 nucleoside diphosphate kinase 1 Neighboring gene STARR-seq mESC enhancer starr_30447 Neighboring gene sperm associated antigen 9 Neighboring gene ribosomal protein L27 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2) 
  • Targeted (2) 

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC107562, MGC107563

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding  
enables DNA binding  
enables DNA binding  
enables G-quadruplex DNA binding  
enables G-quadruplex DNA binding  
enables GDP binding  
enables GDP binding  
enables enzyme binding  
enables fatty acid binding  
enables heterocyclic compound binding  
enables identical protein binding  
enables identical protein binding  
enables intermediate filament binding  
enables metal ion binding  
enables nucleoside diphosphate kinase activity  
enables nucleoside diphosphate kinase activity PubMed 
enables phosphorelay sensor kinase activity  
enables protein binding PubMed 
enables protein serine/threonine kinase activity  
enables transcription coactivator activity  
enables transcription coactivator activity  
Process Evidence Code Pubs
involved_in CTP biosynthetic process  
involved_in CTP biosynthetic process  
involved_in GTP biosynthetic process  
involved_in GTP biosynthetic process  
involved_in UTP biosynthetic process  
involved_in UTP biosynthetic process  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in dTMP biosynthetic process PubMed 
involved_in integrin-mediated signaling pathway  
involved_in negative regulation of apoptotic process  
involved_in negative regulation of myeloid leukocyte differentiation  
involved_in phosphorelay signal transduction system  
involved_in positive regulation of DNA-templated transcription  
involved_in positive regulation of epithelial cell proliferation  
involved_in positive regulation of keratinocyte differentiation  
involved_in positive regulation of neuron projection development  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in regulation of apoptotic process  
Component Evidence Code Pubs
located_in cell periphery  
located_in cell periphery  
located_in cytoplasm  
located_in cytoplasm  
NOT located_in focal adhesion  
located_in intermediate filament  
located_in lamellipodium  
located_in lamellipodium  
located_in mitochondrial membrane  
located_in mitochondrion PubMed 
located_in myelin sheath PubMed 
located_in nucleus  
located_in perinuclear region of cytoplasm  
located_in ruffle  
located_in ruffle  

General protein information

Preferred Names
nucleoside diphosphate kinase B
Names
NDK B
NDP kinase B
P18
expressed in non-metastatic cells 2 protein
histidine protein kinase NDKB
non-metastatic cells 2, protein (NM23B) expressed in
nucleoside-diphosphate kinase 2
NP_001070997.1
NP_032731.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077529.2NP_001070997.1  nucleoside diphosphate kinase B

    See identical proteins and their annotated locations for NP_001070997.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK216511, AV458476, BC086892
    Consensus CDS
    CCDS25246.1
    UniProtKB/Swiss-Prot
    Q01768
    UniProtKB/TrEMBL
    B0LAA8, Q5NC82
    Related
    ENSMUSP00000103476.2, ENSMUST00000072566.5
    Conserved Domains (1) summary
    PTZ00093
    Location:3151
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional
  2. NM_008705.5NP_032731.1  nucleoside diphosphate kinase B

    See identical proteins and their annotated locations for NP_032731.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    BC066995, BC086893
    Consensus CDS
    CCDS25246.1
    UniProtKB/Swiss-Prot
    Q01768
    UniProtKB/TrEMBL
    B0LAA8, Q5NC82
    Related
    ENSMUSP00000021217.5, ENSMUST00000021217.11
    Conserved Domains (1) summary
    PTZ00093
    Location:3151
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    93840640..93847082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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