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IQCF1 IQ motif containing F1 [ Homo sapiens (human) ]

Gene ID: 132141, updated on 4-Jan-2025

Summary

Official Symbol
IQCF1provided by HGNC
Official Full Name
IQ motif containing F1provided by HGNC
Primary source
HGNC:HGNC:28607
See related
Ensembl:ENSG00000173389 AllianceGenome:HGNC:28607
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable calmodulin binding activity. Predicted to be involved in positive regulation of acrosome reaction and positive regulation of flagellated sperm motility involved in capacitation. Located in acrosomal vesicle. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward testis (RPKM 24.8) See more
Orthologs
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Genomic context

See IQCF1 in Genome Data Viewer
Location:
3p21.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (51894876..51903353, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (51927807..51936279, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (51928892..51937369, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 504, pseudogene Neighboring gene IQCF5 antisense RNA 1 Neighboring gene IQ motif containing F5 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:51935927-51937126 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:51975282-51975930 Neighboring gene ribosomal RNA processing 9, U3 small nucleolar RNA binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19921 Neighboring gene poly(ADP-ribose) polymerase family member 3

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Interactions

General gene information

Clone Names

  • FLJ27508, MGC39725

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calmodulin binding  
enables protein binding PubMed 
Component Evidence Code Pubs
is_active_in acrosomal vesicle  
located_in acrosomal vesicle PubMed 

General protein information

Preferred Names
IQ domain-containing protein F1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152397.3NP_689610.2  IQ domain-containing protein F1

    See identical proteins and their annotated locations for NP_689610.2

    Status: VALIDATED

    Source sequence(s)
    AC097636, BC029595
    Consensus CDS
    CCDS2836.1
    UniProtKB/Swiss-Prot
    Q8N6M8, Q8N711
    Related
    ENSP00000307958.5, ENST00000310914.10
    Conserved Domains (1) summary
    pfam11374
    Location:86143
    DUF3176; Protein of unknown function (DUF3176)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    51894876..51903353 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005729.1XP_016861218.1  IQ domain-containing protein F1 isoform X1

    Conserved Domains (1) summary
    pfam11374
    Location:51108
    DUF3176; Protein of unknown function (DUF3176)
  2. XM_011533366.2XP_011531668.1  IQ domain-containing protein F1 isoform X2

    See identical proteins and their annotated locations for XP_011531668.1

    Conserved Domains (1) summary
    pfam11374
    Location:51108
    DUF3176; Protein of unknown function (DUF3176)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    51927807..51936279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345278.1XP_054201253.1  IQ domain-containing protein F1 isoform X1

  2. XM_054345279.1XP_054201254.1  IQ domain-containing protein F1 isoform X2

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