U.S. flag

An official website of the United States government

Atp13a2 ATPase type 13A2 [ Mus musculus (house mouse) ]

Gene ID: 74772, updated on 4-Jan-2025

Summary

Official Symbol
Atp13a2provided by MGI
Official Full Name
ATPase type 13A2provided by MGI
Primary source
MGI:MGI:1922022
See related
Ensembl:ENSMUSG00000036622 AllianceGenome:MGI:1922022
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110012E06Rik
Summary
Predicted to enable ATPase-coupled monoatomic cation transmembrane transporter activity; phospholipid binding activity; and polyamine transmembrane transporter activity. Involved in several processes, including autophagosome-lysosome fusion; positive regulation of exosomal secretion; and regulation of glucosylceramidase activity. Located in neuron projection; neuronal cell body; and vesicle membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Used to study Kufor-Rakeb syndrome. Human ortholog(s) of this gene implicated in Kufor-Rakeb syndrome; Parkinson's disease; and hereditary spastic paraplegia 78. Orthologous to human ATP13A2 (ATPase cation transporting 13A2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in spleen adult (RPKM 76.5), ovary adult (RPKM 68.9) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Atp13a2 in Genome Data Viewer
Location:
4 D3; 4 73.29 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (140711812..140734641)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (140986216..141007330)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene peptidyl arginine deiminase, type II Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:140508500-140508683 Neighboring gene predicted gene 13031 Neighboring gene STARR-seq mESC enhancer starr_11883 Neighboring gene STARR-positive B cell enhancer ABC_E10271 Neighboring gene succinate dehydrogenase complex, subunit B, iron sulfur (Ip) Neighboring gene STARR-positive B cell enhancer ABC_E6248 Neighboring gene microfibrillar-associated protein 2 Neighboring gene ciliary rootlet coiled-coil, rootletin Neighboring gene STARR-seq mESC enhancer starr_11885

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (7)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type polyamine transporter activity  
enables ATP binding  
enables ATP hydrolysis activity  
enables ATPase-coupled monoatomic cation transmembrane transporter activity  
enables ATPase-coupled monoatomic cation transmembrane transporter activity  
enables P-type ion transporter activity  
enables metal ion binding  
enables phosphatidic acid binding  
enables phosphatidic acid binding  
enables phosphatidylinositol-3,5-bisphosphate binding  
enables phosphatidylinositol-3,5-bisphosphate binding  
enables polyamine transmembrane transporter activity  
enables polyamine transmembrane transporter activity  
enables polyamine transmembrane transporter activity  
Items 1 - 25 of 54
Process Evidence Code Pubs
involved_in autophagosome organization  
involved_in autophagosome-lysosome fusion  
involved_in autophagosome-lysosome fusion PubMed 
involved_in autophagosome-lysosome fusion  
involved_in autophagy PubMed 
involved_in autophagy  
involved_in cellular response to manganese ion  
involved_in cellular response to manganese ion  
involved_in cellular response to oxidative stress PubMed 
involved_in cellular response to oxidative stress  
involved_in extracellular exosome biogenesis  
involved_in extracellular exosome biogenesis  
involved_in intracellular calcium ion homeostasis  
involved_in intracellular calcium ion homeostasis  
involved_in intracellular calcium ion homeostasis  
involved_in intracellular iron ion homeostasis  
involved_in intracellular iron ion homeostasis  
involved_in intracellular zinc ion homeostasis PubMed 
involved_in intracellular zinc ion homeostasis  
involved_in lipid homeostasis  
involved_in lipid homeostasis  
involved_in lysosomal transport  
involved_in lysosomal transport  
involved_in monoatomic cation transmembrane transport  
involved_in peptidyl-aspartic acid autophosphorylation  
involved_in polyamine transmembrane transport  
involved_in polyamine transmembrane transport  
involved_in positive regulation of exosomal secretion PubMed 
involved_in positive regulation of exosomal secretion  
involved_in positive regulation of gene expression  
involved_in positive regulation of gene expression  
involved_in positive regulation of protein secretion  
involved_in positive regulation of protein secretion  
involved_in protein localization to lysosome PubMed 
involved_in protein localization to lysosome  
involved_in regulation of autophagosome size  
involved_in regulation of autophagosome size  
involved_in regulation of autophagosome size  
involved_in regulation of endopeptidase activity  
involved_in regulation of glucosylceramidase activity PubMed 
involved_in regulation of intracellular protein transport PubMed 
involved_in regulation of lysosomal protein catabolic process PubMed 
involved_in regulation of lysosomal protein catabolic process  
involved_in regulation of macroautophagy  
involved_in regulation of macroautophagy  
involved_in regulation of mitochondrion organization  
involved_in regulation of mitochondrion organization PubMed 
involved_in regulation of mitochondrion organization  
involved_in regulation of protein localization to nucleus PubMed 
involved_in regulation of protein localization to nucleus  
involved_in regulation of ubiquitin-specific protease activity  
involved_in regulation of ubiquitin-specific protease activity  
involved_in spermine transmembrane transport  
involved_in spermine transmembrane transport  
Items 1 - 25 of 54
Component Evidence Code Pubs
located_in autophagosome  
located_in autophagosome membrane  
located_in late endosome  
is_active_in late endosome membrane  
located_in late endosome membrane  
located_in late endosome membrane  
located_in lysosomal membrane  
located_in lysosomal membrane  
located_in lysosome  
located_in lysosome  
located_in multivesicular body  
located_in multivesicular body membrane  
located_in neuron projection PubMed 
located_in neuron projection  
located_in neuronal cell body PubMed 
located_in neuronal cell body  
located_in transport vesicle  
located_in transport vesicle  
located_in vesicle  
located_in vesicle membrane PubMed 

General protein information

Preferred Names
polyamine-transporting ATPase 13A2
Names
cation-transporting ATPase 13A2
probable cation-transporting ATPase 13A2
NP_001157838.1
NP_001366548.1
NP_001366549.1
NP_001366550.1
NP_001366551.1
NP_083373.2
XP_006539299.1
XP_006539300.1
XP_036020402.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164366.2NP_001157838.1  polyamine-transporting ATPase 13A2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL645625
    Consensus CDS
    CCDS51345.1
    UniProtKB/TrEMBL
    E9Q2A4
    Related
    ENSMUSP00000132183.2, ENSMUST00000127833.3
    Conserved Domains (6) summary
    COG4087
    Location:839888
    COG4087; Soluble P-type ATPase [General function prediction only]
    TIGR01657
    Location:351067
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
    pfam00122
    Location:258493
    E1-E2_ATPase; E1-E2 ATPase
    pfam12409
    Location:35161
    P5-ATPase; P5-type ATPase cation transporter
    pfam13246
    Location:621658
    Cation_ATPase; Cation transport ATPase (P-type)
    cl02930
    Location:188260
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
  2. NM_001379619.1NP_001366548.1  polyamine-transporting ATPase 13A2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL645625
    Conserved Domains (1) summary
    TIGR01657
    Location:351111
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
  3. NM_001379620.1NP_001366549.1  polyamine-transporting ATPase 13A2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL645625
    Conserved Domains (1) summary
    TIGR01657
    Location:351066
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
  4. NM_001379621.1NP_001366550.1  polyamine-transporting ATPase 13A2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL645625
    UniProtKB/TrEMBL
    E9PYX5
    Conserved Domains (1) summary
    TIGR01657
    Location:35941
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
  5. NM_001379622.1NP_001366551.1  polyamine-transporting ATPase 13A2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL645625
    UniProtKB/TrEMBL
    E9PYX5
    Related
    ENSMUSP00000126461.2, ENSMUST00000168047.8
    Conserved Domains (1) summary
    TIGR01657
    Location:35942
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
  6. NM_029097.3NP_083373.2  polyamine-transporting ATPase 13A2 isoform 1

    See identical proteins and their annotated locations for NP_083373.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL645625
    Consensus CDS
    CCDS18859.1
    UniProtKB/Swiss-Prot
    A2AA78, Q8CG98, Q9CTG6
    Related
    ENSMUSP00000039648.8, ENSMUST00000037055.14
    Conserved Domains (6) summary
    COG4087
    Location:839888
    COG4087; Soluble P-type ATPase [General function prediction only]
    TIGR01657
    Location:351112
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
    pfam00122
    Location:258493
    E1-E2_ATPase; E1-E2 ATPase
    pfam12409
    Location:35161
    P5-ATPase; P5-type ATPase cation transporter
    pfam13246
    Location:621658
    Cation_ATPase; Cation transport ATPase (P-type)
    cl02930
    Location:188260
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    140711812..140734641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164509.1XP_036020402.1  polyamine-transporting ATPase 13A2 isoform X3

    Conserved Domains (1) summary
    TIGR01657
    Location:351118
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
  2. XM_006539236.3XP_006539299.1  polyamine-transporting ATPase 13A2 isoform X1

    Conserved Domains (1) summary
    TIGR01657
    Location:351195
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
  3. XM_006539237.3XP_006539300.1  polyamine-transporting ATPase 13A2 isoform X2

    UniProtKB/TrEMBL
    E9PYX5
    Conserved Domains (1) summary
    TIGR01657
    Location:351150
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
External link. Please review our privacy policy.