Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Pr55(Gag)
|
gag
|
HERC5 restricts HIV-1 Gag particle production by a mechanism dependent on its E3 ligase activity. This restriction correlates with the conjugation of ISG15 to Gag by HERC5 |
PubMed
|
|
gag
|
ISG15 inhibits budding of HIV-1 by disrupting the association between Vps4 and the Gag budding complex |
PubMed
|
Tat
|
tat
|
HIV-1 and the viral protein Tat modulate the expression of ISG15 ubiquitin-like modifier (ISG15) in immature dendritic cells and monocyte-derived macrophages |
PubMed
|
|
tat
|
Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including ISG15, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection |
PubMed
|
Vpr
|
vpr
|
HIV-1 Vpr upregulates the expression of ISG15 in human monocyte-derived dendritic cells |
PubMed
|
|
vpr
|
HIV-1 Vpr upregulates the expression of ISG15 in human monocyte-derived macrophages |
PubMed
|
Vpu
|
vpu
|
The expression of ISG15 ubiquitin-like modifier is enhanced in Vpu-deficient HIV-1-infected cells as compared to that in wild-type-infected cells |
PubMed
|
Go to the HIV-1, Human Interaction Database