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ISG15 ISG15 ubiquitin like modifier [ Homo sapiens (human) ]

Gene ID: 9636, updated on 4-Jan-2025

Summary

Official Symbol
ISG15provided by HGNC
Official Full Name
ISG15 ubiquitin like modifierprovided by HGNC
Primary source
HGNC:HGNC:4053
See related
Ensembl:ENSG00000187608 MIM:147571; AllianceGenome:HGNC:4053
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G1P2; IP17; UCRP; IFI15; IMD38; hUCRP
Summary
The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012]
Expression
Broad expression in salivary gland (RPKM 43.3), spleen (RPKM 35.3) and 22 other tissues See more
Orthologs
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Genomic context

See ISG15 in Genome Data Viewer
Location:
1p36.33
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1013497..1014540)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (443628..444671)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (948877..949920)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:941508-942493 Neighboring gene hes family bHLH transcription factor 4 Neighboring gene ribosomal protein L39 pseudogene 12 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:948847-949738 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:949739-950630 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:950916-951136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:956772-957971 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:959156-960132 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:960133-961108 Neighboring gene agrin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:965235-966104 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:967845-968714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 22 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:974926-975604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 23 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 24 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:989815-989997 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:994105-994948 Neighboring gene uncharacterized LOC100288175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:995794-996637 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:997280-997780 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 26 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1000356-1000856 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1000857-1001357 Neighboring gene uncharacterized LOC105378948

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HERC5 restricts HIV-1 Gag particle production by a mechanism dependent on its E3 ligase activity. This restriction correlates with the conjugation of ISG15 to Gag by HERC5 PubMed
gag ISG15 inhibits budding of HIV-1 by disrupting the association between Vps4 and the Gag budding complex PubMed
Tat tat HIV-1 and the viral protein Tat modulate the expression of ISG15 ubiquitin-like modifier (ISG15) in immature dendritic cells and monocyte-derived macrophages PubMed
tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including ISG15, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
Vpr vpr HIV-1 Vpr upregulates the expression of ISG15 in human monocyte-derived dendritic cells PubMed
vpr HIV-1 Vpr upregulates the expression of ISG15 in human monocyte-derived macrophages PubMed
Vpu vpu The expression of ISG15 ubiquitin-like modifier is enhanced in Vpu-deficient HIV-1-infected cells as compared to that in wild-type-infected cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables integrin binding PubMed 
enables protein binding PubMed 
enables protein tag activity  
enables protein tag activity PubMed 
enables ubiquitin protein ligase binding  
Process Evidence Code Pubs
involved_in ISG15-protein conjugation  
involved_in ISG15-protein conjugation PubMed 
involved_in ISG15-protein conjugation PubMed 
involved_in defense response to bacterium PubMed 
involved_in defense response to virus PubMed 
involved_in defense response to virus PubMed 
involved_in innate immune response PubMed 
involved_in integrin-mediated signaling pathway PubMed 
involved_in modification-dependent protein catabolic process  
involved_in negative regulation of protein ubiquitination PubMed 
involved_in negative regulation of type I interferon-mediated signaling pathway PubMed 
involved_in negative regulation of viral genome replication PubMed 
involved_in negative regulation of viral genome replication PubMed 
involved_in positive regulation of bone mineralization  
involved_in positive regulation of erythrocyte differentiation  
involved_in positive regulation of interferon-beta production PubMed 
involved_in positive regulation of interleukin-10 production PubMed 
involved_in positive regulation of protein oligomerization PubMed 
involved_in positive regulation of type II interferon production PubMed 
involved_in protein localization to mitochondrion PubMed 
NOT involved_in protein ubiquitination  
involved_in regulation of type II interferon production PubMed 
involved_in response to type I interferon PubMed 
involved_in response to virus PubMed 
involved_in response to virus PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm  
is_active_in cytoplasm PubMed 
located_in cytosol  
located_in extracellular region PubMed 
located_in nucleoplasm  
is_active_in nucleus  

General protein information

Preferred Names
ubiquitin-like protein ISG15
Names
interferon, alpha-inducible protein (clone IFI-15K)
interferon-induced 17-kDa/15-kDa protein
interferon-stimulated protein, 15 kDa
ubiquitin cross-reactive protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033033.2 RefSeqGene

    Range
    17360..18403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1231

mRNA and Protein(s)

  1. NM_005101.4NP_005092.1  ubiquitin-like protein ISG15

    See identical proteins and their annotated locations for NP_005092.1

    Status: REVIEWED

    Source sequence(s)
    AL645608, BC009507, BU161226, M13755
    Consensus CDS
    CCDS6.1
    UniProtKB/Swiss-Prot
    P05161, Q5SVA4, Q7Z2G2, Q96GF0
    UniProtKB/TrEMBL
    A0A096LPJ4
    Related
    ENSP00000496832.1, ENST00000649529.1
    Conserved Domains (3) summary
    cd01792
    Location:180
    ISG15_repeat1; ISG15 ubiquitin-like protein, first repeat of 2
    smart00213
    Location:82153
    UBQ; Ubiquitin homologues
    cl00155
    Location:84157
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    1013497..1014540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    443628..444671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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