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F2RL1 F2R like trypsin receptor 1 [ Homo sapiens (human) ]

Gene ID: 2150, updated on 4-Jan-2025

Summary

Official Symbol
F2RL1provided by HGNC
Official Full Name
F2R like trypsin receptor 1provided by HGNC
Primary source
HGNC:HGNC:3538
See related
Ensembl:ENSG00000164251 MIM:600933; AllianceGenome:HGNC:3538
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAR2; GPR11
Summary
This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered ligand that binds to an extracellular loop domain. Activation of the receptor has been shown to stimulate vascular smooth muscle relaxation, dilate blood vessels, increase blood flow, and lower blood pressure. This protein is also important in the inflammatory response, as well as innate and adaptive immunity. [provided by RefSeq, Jun 2016]
Expression
Broad expression in colon (RPKM 30.3), duodenum (RPKM 21.7) and 16 other tissues See more
Orthologs
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Genomic context

See F2RL1 in Genome Data Viewer
Location:
5q13.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (76819030..76835315)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (77300842..77317122)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (76114855..76131140)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:76013800-76014300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:76014301-76014801 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22695 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22696 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22697 Neighboring gene coagulation factor II thrombin receptor Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:76068685-76069184 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:76074968-76075586 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:76094678-76095178 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:76099560-76100759 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:76101363-76101946 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:76101947-76102528 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:76103693-76104276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:76110384-76111038 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:76114571-76115188 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:76115189-76115806 Neighboring gene RNA, 7SL, cytoplasmic 208, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22698 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:76166173-76166870 Neighboring gene S100 calcium binding protein Z Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:76184471-76184971 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:76221500-76221673 Neighboring gene RNA, U6atac small nuclear 36, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity  
enables G protein-coupled receptor activity PubMed 
enables G protein-coupled receptor activity  
enables G-protein alpha-subunit binding  
enables G-protein beta-subunit binding  
enables protease binding PubMed 
enables protein binding PubMed 
enables signaling receptor activity PubMed 
enables signaling receptor binding PubMed 
enables thrombin-activated receptor activity  
Items 1 - 25 of 61
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway  
involved_in G protein-coupled receptor signaling pathway PubMed 
involved_in T cell activation involved in immune response  
involved_in blood coagulation  
involved_in cell-cell junction maintenance PubMed 
involved_in defense response to virus PubMed 
involved_in establishment of endothelial barrier PubMed 
involved_in inflammatory response  
involved_in innate immune response  
involved_in leukocyte migration PubMed 
involved_in leukocyte proliferation  
involved_in mature conventional dendritic cell differentiation PubMed 
involved_in mature conventional dendritic cell differentiation  
involved_in negative regulation of JNK cascade PubMed 
involved_in negative regulation of chemokine production PubMed 
involved_in negative regulation of insulin secretion  
involved_in negative regulation of toll-like receptor 3 signaling pathway PubMed 
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway PubMed 
involved_in neutrophil activation PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of GTPase activity PubMed 
involved_in positive regulation of JNK cascade PubMed 
involved_in positive regulation of Rho protein signal transduction  
involved_in positive regulation of Rho protein signal transduction PubMed 
involved_in positive regulation of Rho protein signal transduction  
involved_in positive regulation of actin filament depolymerization PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
involved_in positive regulation of cell migration  
involved_in positive regulation of chemokine production PubMed 
involved_in positive regulation of chemotaxis  
involved_in positive regulation of cytokine production involved in immune response PubMed 
involved_in positive regulation of cytosolic calcium ion concentration PubMed 
involved_in positive regulation of cytosolic calcium ion concentration  
involved_in positive regulation of eosinophil degranulation PubMed 
involved_in positive regulation of glomerular filtration  
involved_in positive regulation of interleukin-1 beta production PubMed 
involved_in positive regulation of interleukin-10 production PubMed 
involved_in positive regulation of interleukin-6 production PubMed 
involved_in positive regulation of interleukin-8 production PubMed 
involved_in positive regulation of leukocyte chemotaxis PubMed 
involved_in positive regulation of neutrophil mediated killing of gram-negative bacterium PubMed 
involved_in positive regulation of phagocytosis, engulfment PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of positive chemotaxis PubMed 
involved_in positive regulation of pseudopodium assembly  
involved_in positive regulation of renin secretion into blood stream  
involved_in positive regulation of superoxide anion generation PubMed 
involved_in positive regulation of toll-like receptor 2 signaling pathway PubMed 
involved_in positive regulation of toll-like receptor 3 signaling pathway PubMed 
involved_in positive regulation of toll-like receptor 4 signaling pathway PubMed 
involved_in positive regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of type II interferon production  
involved_in potassium channel activating, G protein-coupled receptor signaling pathway  
involved_in regulation of JNK cascade PubMed 
involved_in regulation of blood coagulation PubMed 
involved_in regulation of canonical NF-kappaB signal transduction PubMed 
involved_in regulation of chemokine (C-X-C motif) ligand 2 production PubMed 
involved_in thrombin-activated receptor signaling pathway  
acts_upstream_of_or_within_positive_effect vasodilation  
Items 1 - 25 of 61
Component Evidence Code Pubs
located_in Golgi apparatus PubMed 
located_in early endosome PubMed 
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in pseudopodium  

General protein information

Preferred Names
proteinase-activated receptor 2
Names
G-protein coupled receptor 11
coagulation factor II (thrombin) receptor-like 1
protease-activated receptor 2
thrombin receptor-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005242.6NP_005233.4  proteinase-activated receptor 2 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC010621
    Consensus CDS
    CCDS4033.1
    UniProtKB/Swiss-Prot
    P55085, Q13317, Q13346, Q53XJ8
    Related
    ENSP00000296677.4, ENST00000296677.5
    Conserved Domains (1) summary
    cd15370
    Location:76355
    7tmA_PAR2; protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    76819030..76835315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    77300842..77317122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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