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    Cldn1 claudin 1 [ Mus musculus (house mouse) ]

    Gene ID: 12737, updated on 14-Jan-2025

    Summary

    Official Symbol
    Cldn1provided by MGI
    Official Full Name
    claudin 1provided by MGI
    Primary source
    MGI:MGI:1276109
    See related
    Ensembl:ENSMUSG00000022512 AllianceGenome:MGI:1276109
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The knockout mice lacking this gene die soon after birth as a consequence of dehydration from trandermal water loss, indicating that this gene is indispensable for creating and maintaining the epidermal barrier. The protein encoded by this gene also has gastric tumor suppressive activity, and is a key factor for hepatitis C virus (HCV) entry. [provided by RefSeq, Aug 2010]
    Expression
    Biased expression in liver E18 (RPKM 82.6), liver adult (RPKM 15.9) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Cldn1 in Genome Data Viewer
    Location:
    16 B2; 16 18.0 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (26175395..26190589, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (26356645..26371839, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene prolyl 3-hydroxylase 2 Neighboring gene VISTA enhancer mm1097 Neighboring gene expressed sequence AU015336 Neighboring gene STARR-seq mESC enhancer starr_40483 Neighboring gene STARR-seq mESC enhancer starr_40484 Neighboring gene predicted gene, 41436 Neighboring gene STARR-seq mESC enhancer starr_40485 Neighboring gene claudin 16 Neighboring gene STARR-seq mESC enhancer starr_40486 Neighboring gene transmembrane protein 207

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding PubMed 
    enables identical protein binding  
    enables protein binding PubMed 
    enables structural molecule activity  
    enables virus receptor activity  
    enables virus receptor activity  
    Items 1 - 25 of 38
    Process Evidence Code Pubs
    involved_in bicellular tight junction assembly  
    involved_in bicellular tight junction assembly  
    involved_in bicellular tight junction assembly  
    involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules PubMed 
    involved_in cell adhesion  
    involved_in cell junction maintenance PubMed 
    acts_upstream_of_or_within cell-cell junction organization  
    involved_in cellular response to butyrate  
    involved_in cellular response to lead ion  
    involved_in cellular response to transforming growth factor beta stimulus  
    involved_in cellular response to tumor necrosis factor  
    involved_in cellular response to type II interferon  
    involved_in establishment of blood-nerve barrier  
    involved_in establishment of blood-nerve barrier  
    involved_in establishment of endothelial intestinal barrier  
    involved_in establishment of endothelial intestinal barrier  
    involved_in establishment of skin barrier PubMed 
    involved_in establishment of skin barrier  
    involved_in liver regeneration  
    involved_in positive regulation of bicellular tight junction assembly  
    involved_in positive regulation of bicellular tight junction assembly  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of epithelial cell proliferation involved in wound healing  
    involved_in positive regulation of epithelial cell proliferation involved in wound healing  
    involved_in positive regulation of wound healing  
    involved_in positive regulation of wound healing  
    involved_in protein complex oligomerization  
    involved_in protein complex oligomerization  
    involved_in response to dexamethasone  
    involved_in response to ethanol  
    involved_in response to interleukin-18  
    involved_in response to interleukin-18  
    involved_in response to lipopolysaccharide  
    involved_in response to toxic substance  
    involved_in symbiont entry into host cell  
    involved_in xenobiotic transport across blood-nerve barrier  
    involved_in xenobiotic transport across blood-nerve barrier  
    Items 1 - 25 of 38
    Items 1 - 20 of 21
    Component Evidence Code Pubs
    located_in apical plasma membrane PubMed 
    located_in apical plasma membrane  
    located_in basolateral plasma membrane  
    located_in basolateral plasma membrane  
    is_active_in bicellular tight junction  
    located_in bicellular tight junction PubMed 
    located_in bicellular tight junction  
    located_in cell junction PubMed 
    located_in cell junction  
    located_in cell-cell junction PubMed 
    located_in lateral plasma membrane PubMed 
    located_in lateral plasma membrane  
    located_in membrane PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    part_of protein-containing complex  
    part_of protein-containing complex  
    located_in tight junction PubMed 
    located_in tight junction  
    Items 1 - 20 of 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016674.4NP_057883.1  claudin-1

      See identical proteins and their annotated locations for NP_057883.1

      Status: REVIEWED

      Source sequence(s)
      AK036780, CK626537
      Consensus CDS
      CCDS28087.1
      UniProtKB/Swiss-Prot
      O88551
      UniProtKB/TrEMBL
      A7UKX1, Q4FJV3
      Related
      ENSMUSP00000023154.3, ENSMUST00000023154.3
      Conserved Domains (1) summary
      pfam00822
      Location:5182
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      26175395..26190589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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