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Zmynd10 zinc finger, MYND domain containing 10 [ Mus musculus (house mouse) ]

Gene ID: 114602, updated on 4-Jan-2025

Summary

Official Symbol
Zmynd10provided by MGI
Official Full Name
zinc finger, MYND domain containing 10provided by MGI
Primary source
MGI:MGI:2387863
See related
Ensembl:ENSMUSG00000010044 AllianceGenome:MGI:2387863
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Blu
Summary
Enables molecular adaptor activity and protein folding chaperone. Involved in inner dynein arm assembly; outer dynein arm assembly; and positive regulation of motile cilium assembly. Acts upstream of or within several processes, including motile cilium assembly; protein folding; and protein localization to cilium. Located in apical plasma membrane and cytoplasm. Is expressed in lung; nasal cavity epithelium; and testis. Used to study primary ciliary dyskinesia 22. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 22. Orthologous to human ZMYND10 (zinc finger MYND-type containing 10). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in testis adult (RPKM 56.3) and kidney adult (RPKM 6.2) See more
Orthologs
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Genomic context

See Zmynd10 in Genome Data Viewer
Location:
9 F1; 9 58.12 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107424067..107428520)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107546872..107551321)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene cytochrome b-561 domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E10584 Neighboring gene NPR2 like, GATOR1 complex subunit Neighboring gene STARR-positive B cell enhancer ABC_E3857 Neighboring gene predicted gene, 34106 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107453431-107453584 Neighboring gene Ras association (RalGDS/AF-6) domain family member 1 Neighboring gene STARR-positive B cell enhancer ABC_E9335 Neighboring gene predicted gene 9917 Neighboring gene tumor suppressor 2, mitochondrial calcium regulator

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5)  1 citation
  • Targeted (1) 

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding  
enables molecular adaptor activity PubMed 
enables protein binding PubMed 
enables protein folding chaperone PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cilium movement PubMed 
involved_in inner dynein arm assembly  
acts_upstream_of_or_within inner dynein arm assembly PubMed 
involved_in inner dynein arm assembly PubMed 
involved_in inner dynein arm assembly  
involved_in inner dynein arm assembly  
involved_in motile cilium assembly  
acts_upstream_of_or_within motile cilium assembly PubMed 
involved_in motile cilium assembly  
involved_in motile cilium assembly  
involved_in outer dynein arm assembly  
acts_upstream_of_or_within outer dynein arm assembly PubMed 
involved_in outer dynein arm assembly PubMed 
involved_in outer dynein arm assembly  
involved_in outer dynein arm assembly  
involved_in positive regulation of motile cilium assembly PubMed 
acts_upstream_of_or_within protein folding PubMed 
acts_upstream_of_or_within protein localization to cilium PubMed 
acts_upstream_of_or_within sperm motility PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane PubMed 
is_active_in centriolar satellite  
located_in centriolar satellite  
located_in centriolar satellite  
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytoplasm  
located_in dynein axonemal particle  

General protein information

Preferred Names
zinc finger MYND domain-containing protein 10
Names
protein BLu

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379079.1NP_001366008.1  zinc finger MYND domain-containing protein 10 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variant 4, encodes isoform 3.
    Source sequence(s)
    AL672219
    Conserved Domains (1) summary
    pfam01753
    Location:351387
    zf-MYND; MYND finger
  2. NM_001379080.1NP_001366009.1  zinc finger MYND domain-containing protein 10 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variant 3, encodes isoform 3.
    Source sequence(s)
    AL672219
    Conserved Domains (1) summary
    pfam01753
    Location:351387
    zf-MYND; MYND finger
  3. NM_001404947.1NP_001391876.1  zinc finger MYND domain-containing protein 10 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL672219
  4. NM_053253.4NP_444483.2  zinc finger MYND domain-containing protein 10 isoform 1

    See identical proteins and their annotated locations for NP_444483.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL672219, BC052357, BY284492
    Consensus CDS
    CCDS23493.1
    UniProtKB/Swiss-Prot
    Q3V1P0, Q80W73, Q99ML0
    Related
    ENSMUSP00000010188.8, ENSMUST00000010188.9
    Conserved Domains (1) summary
    pfam01753
    Location:394430
    zf-MYND; MYND finger

RNA

  1. NR_166465.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL672219
    Related
    ENSMUST00000193303.6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    107424067..107428520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511630.4XP_006511693.1  zinc finger MYND domain-containing protein 10 isoform X1

    Conserved Domains (1) summary
    pfam01753
    Location:432468
    zf-MYND; MYND finger
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