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Entpd8 ectonucleoside triphosphate diphosphohydrolase 8 [ Mus musculus (house mouse) ]

Gene ID: 72090, updated on 4-Jan-2025

Summary

Official Symbol
Entpd8provided by MGI
Official Full Name
ectonucleoside triphosphate diphosphohydrolase 8provided by MGI
Primary source
MGI:MGI:1919340
See related
Ensembl:ENSMUSG00000036813 AllianceGenome:MGI:1919340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables nucleoside diphosphate phosphatase activity and ribonucleoside triphosphate phosphatase activity. Acts upstream of or within nucleoside diphosphate biosynthetic process and nucleoside monophosphate biosynthetic process. Located in membrane. Is expressed in esophagus; intestine; lung; and reproductive system. Orthologous to human ENTPD8 (ectonucleoside triphosphate diphosphohydrolase 8). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in colon adult (RPKM 99.7), small intestine adult (RPKM 77.6) and 5 other tissues See more
Orthologs
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Genomic context

See Entpd8 in Genome Data Viewer
Location:
2 A3; 2 16.97 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (24969308..24975731)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25079296..25085719)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene NMDA receptor synaptonuclear signaling and neuronal migration factor Neighboring gene microRNA 7664 Neighboring gene STARR-seq mESC enhancer starr_03956 Neighboring gene predicted gene, 39770 Neighboring gene NADPH oxidase activator 1 Neighboring gene STARR-seq mESC enhancer starr_03957 Neighboring gene VISTA enhancer mm1454 Neighboring gene predicted gene 13387 Neighboring gene Notch-regulated ankyrin repeat protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding  
enables GDP phosphatase activity  
enables UDP phosphatase activity  
enables apyrase activity  
enables metal ion binding  
enables nucleoside diphosphate phosphatase activity PubMed 
enables ribonucleoside triphosphate phosphatase activity  
enables ribonucleoside triphosphate phosphatase activity PubMed 
Component Evidence Code Pubs
located_in membrane PubMed 
is_active_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
ectonucleoside triphosphate diphosphohydrolase 8
Names
E-NTPDase 8
NTPDase 8
NTPDase8
NP_082369.1
XP_011237493.1
XP_030107962.1
XP_030107963.1
XP_030107964.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028093.1NP_082369.1  ectonucleoside triphosphate diphosphohydrolase 8

    See identical proteins and their annotated locations for NP_082369.1

    Status: VALIDATED

    Source sequence(s)
    AV026718, AY364442, BB610017
    Consensus CDS
    CCDS15748.1
    UniProtKB/Swiss-Prot
    A2AJ99, Q6UQ22, Q8K0L2
    Related
    ENSMUSP00000110022.3, ENSMUST00000114380.9
    Conserved Domains (1) summary
    cl17037
    Location:34459
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    24969308..24975731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239191.2XP_011237493.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X1

    Conserved Domains (1) summary
    cl17037
    Location:34347
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. XM_030252103.2XP_030107963.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X3

    Related
    ENSMUST00000152326.8
    Conserved Domains (1) summary
    cl17037
    Location:3262
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  3. XM_030252104.2XP_030107964.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X4

    Conserved Domains (1) summary
    cl17037
    Location:34261
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  4. XM_030252102.2XP_030107962.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X2

    Conserved Domains (1) summary
    cl17037
    Location:1332
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
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