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Adam10 a disintegrin and metallopeptidase domain 10 [ Mus musculus (house mouse) ]

Gene ID: 11487, updated on 13-Jan-2025

Summary

Official Symbol
Adam10provided by MGI
Official Full Name
a disintegrin and metallopeptidase domain 10provided by MGI
Primary source
MGI:MGI:109548
See related
Ensembl:ENSMUSG00000054693 AllianceGenome:MGI:109548
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
kuz; MADM; kuzbanian; 1700031C13Rik
Summary
This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that is involved in the proteolytic release of membrane-bound proteins in a process called ectodomain shedding. Mice lacking the encoded protein die in utero with multiple defects of the developing central nervous system, somites, and cardiovascular system. [provided by RefSeq, May 2016]
Expression
Ubiquitous expression in liver E14 (RPKM 28.0), liver E14.5 (RPKM 23.2) and 27 other tissues See more
Orthologs
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Genomic context

See Adam10 in Genome Data Viewer
Location:
9 D; 9 39.53 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (70586133..70687511)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (70678944..70780229)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene MINDY lysine 48 deubiquitinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E2903 Neighboring gene predicted gene 10642 Neighboring gene predicted gene, 31872 Neighboring gene cytochrome c, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_24559 Neighboring gene STARR-seq mESC enhancer starr_24560 Neighboring gene VISTA enhancer mm190 Neighboring gene lipase, hepatic Neighboring gene ribosomal RNA processing 7 homolog A pseudogene Neighboring gene STARR-seq mESC enhancer starr_24562 Neighboring gene STARR-seq mESC enhancer starr_24564 Neighboring gene predicted gene, 32017

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH2 domain binding PubMed 
enables SH3 domain binding  
enables endopeptidase activity PubMed 
enables endopeptidase activity PubMed 
enables endopeptidase activity  
enables metal ion binding  
enables metallodipeptidase activity PubMed 
enables metalloendopeptidase activity  
enables metalloendopeptidase activity  
enables metalloendopeptidase activity  
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process  
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process  
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process  
enables metallopeptidase activity PubMed 
enables metallopeptidase activity PubMed 
enables metallopeptidase activity PubMed 
enables molecular adaptor activity  
enables protein binding PubMed 
enables protein homodimerization activity PubMed 
enables protein kinase binding PubMed 
Items 1 - 25 of 56
Process Evidence Code Pubs
involved_in Notch receptor processing PubMed 
involved_in Notch signaling pathway  
involved_in Notch signaling pathway PubMed 
involved_in adherens junction organization PubMed 
involved_in amyloid precursor protein catabolic process  
involved_in amyloid precursor protein catabolic process  
involved_in amyloid-beta formation  
involved_in cochlea development PubMed 
involved_in constitutive protein ectodomain proteolysis  
involved_in constitutive protein ectodomain proteolysis  
involved_in epidermal growth factor receptor ligand maturation PubMed 
involved_in in utero embryonic development PubMed 
involved_in membrane protein ectodomain proteolysis  
involved_in membrane protein ectodomain proteolysis PubMed 
involved_in membrane protein ectodomain proteolysis PubMed 
acts_upstream_of_or_within membrane protein ectodomain proteolysis  
involved_in membrane protein ectodomain proteolysis  
involved_in membrane protein ectodomain proteolysis  
involved_in monocyte activation  
involved_in monocyte activation  
involved_in negative regulation of cell adhesion  
involved_in negative regulation of cell adhesion  
involved_in negative regulation of gene expression  
acts_upstream_of_or_within negative regulation of gene expression  
involved_in nucleocytoplasmic transport PubMed 
involved_in pore complex assembly PubMed 
involved_in pore complex assembly  
involved_in positive regulation of T cell chemotaxis  
involved_in positive regulation of T cell chemotaxis  
involved_in positive regulation of apoptotic process  
involved_in positive regulation of cell growth  
involved_in positive regulation of cell growth  
involved_in positive regulation of cell migration  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of cell population proliferation  
involved_in postsynapse organization PubMed 
involved_in postsynapse organization PubMed 
involved_in protein catabolic process at postsynapse PubMed 
involved_in protein catabolic process at postsynapse PubMed 
involved_in protein catabolic process at postsynapse PubMed 
involved_in protein catabolic process at postsynapse PubMed 
involved_in protein phosphorylation PubMed 
acts_upstream_of_or_within protein processing PubMed 
involved_in regulation of Notch signaling pathway PubMed 
involved_in regulation of dendritic spine morphogenesis  
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane PubMed 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane PubMed 
involved_in regulation of postsynapse organization PubMed 
involved_in regulation of postsynapse organization PubMed 
involved_in regulation of postsynapse organization PubMed 
involved_in regulation of postsynapse organization PubMed 
involved_in regulation of vasculature development PubMed 
involved_in response to tumor necrosis factor  
involved_in response to tumor necrosis factor  
involved_in signaling receptor ligand precursor processing PubMed 
involved_in signaling receptor ligand precursor processing PubMed 
Items 1 - 25 of 56
Items 1 - 20 of 45
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in Golgi apparatus  
located_in Golgi membrane  
located_in Golgi-associated vesicle  
located_in Golgi-associated vesicle  
located_in adherens junction  
located_in axon  
located_in cell surface PubMed 
located_in cell surface  
located_in cell surface  
located_in clathrin-coated vesicle  
located_in collagen-containing extracellular matrix PubMed 
located_in cytoplasm PubMed 
located_in dendrite  
located_in dendrite  
located_in dendritic spine  
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse  
located_in intracellular membrane-bounded organelle  
located_in neuronal cell body  
located_in nucleus PubMed 
located_in perinuclear endoplasmic reticulum  
located_in perinuclear endoplasmic reticulum  
is_active_in plasma membrane  
located_in plasma membrane PubMed 
is_active_in plasma membrane PubMed 
is_active_in plasma membrane PubMed 
located_in plasma membrane  
located_in plasma membrane  
part_of pore complex PubMed 
part_of pore complex  
is_active_in postsynapse  
located_in postsynapse  
located_in postsynaptic density PubMed 
located_in postsynaptic membrane  
is_active_in synaptic membrane  
located_in synaptic membrane PubMed 
located_in synaptic membrane  
located_in synaptic vesicle  
located_in tetraspanin-enriched microdomain  
located_in tetraspanin-enriched microdomain  
located_in trans-Golgi network  
Items 1 - 20 of 45

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 10
Names
a disintegrin and metalloprotease domain (ADAM) 10
kuzbanian protein homolog
mammalian disintegrin-metalloprotease
NP_031425.2
XP_030099887.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007399.4NP_031425.2  disintegrin and metalloproteinase domain-containing protein 10 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC160636, AK031857, BC057346, BC066207, BE654195, BY205591
    Consensus CDS
    CCDS23323.1
    UniProtKB/Swiss-Prot
    B8JJJ0, O35598
    Related
    ENSMUSP00000063839.7, ENSMUST00000067880.13
    Conserved Domains (4) summary
    smart00050
    Location:467546
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:221460
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:46146
    Pep_M12B_propep; Reprolysin family propeptide
    pfam13574
    Location:241445
    Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    70586133..70687511
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244027.2XP_030099887.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X1

    Conserved Domains (2) summary
    smart00050
    Location:393472
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:147386
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
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