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Gna13 guanine nucleotide binding protein, alpha 13 [ Mus musculus (house mouse) ]

Gene ID: 14674, updated on 4-Jan-2025

Summary

Official Symbol
Gna13provided by MGI
Official Full Name
guanine nucleotide binding protein, alpha 13provided by MGI
Primary source
MGI:MGI:95768
See related
Ensembl:ENSMUSG00000020611 AllianceGenome:MGI:95768
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Galpha13
Summary
Predicted to enable D5 dopamine receptor binding activity; G protein activity; and G-protein beta/gamma-subunit complex binding activity. Involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway; regulation of blood pressure; and regulation of postsynapse assembly. Acts upstream of or within several processes, including Rho protein signal transduction; branching involved in blood vessel morphogenesis; and platelet activation. Located in cytoplasm and nucleus. Is active in postsynapse. Is expressed in several structures, including branchial arch; genitourinary system; gut gland; nervous system; and sensory organ. Orthologous to human GNA13 (G protein subunit alpha 13). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in colon adult (RPKM 6.4), thymus adult (RPKM 6.4) and 28 other tissues See more
Orthologs
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Genomic context

See Gna13 in Genome Data Viewer
Location:
11 E1; 11 71.88 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (109253620..109292195)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (109362794..109401369)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1600015H23 gene Neighboring gene RIKEN cDNA 1700096J18 gene Neighboring gene STARR-seq mESC enhancer starr_31020 Neighboring gene STARR-positive B cell enhancer ABC_E7086 Neighboring gene predicted gene 11696 Neighboring gene STARR-positive B cell enhancer ABC_E5291 Neighboring gene STARR-positive B cell enhancer ABC_E4009 Neighboring gene STARR-positive B cell enhancer ABC_E7087 Neighboring gene STARR-positive B cell enhancer mm9_chr11:109281499-109281800 Neighboring gene STARR-positive B cell enhancer ABC_E380 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:109287298-109287521 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:109293875-109294028 Neighboring gene archaelysin family metallopeptidase 2 Neighboring gene STARR-positive B cell enhancer ABC_E10727 Neighboring gene STARR-positive B cell enhancer ABC_E5293 Neighboring gene predicted gene, 45916 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D5 dopamine receptor binding  
enables D5 dopamine receptor binding  
enables D5 dopamine receptor binding  
enables G protein activity  
enables G protein activity  
enables G-protein beta/gamma-subunit complex binding  
enables G-protein beta/gamma-subunit complex binding  
enables GTP binding  
enables GTPase activity  
enables GTPase activity PubMed 
enables GTPase activity PubMed 
enables metal ion binding  
enables protein binding PubMed 
Items 1 - 25 of 26
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway PubMed 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway PubMed 
involved_in G protein-coupled receptor signaling pathway  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway PubMed 
involved_in Rho protein signal transduction  
acts_upstream_of_or_within Rho protein signal transduction PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway PubMed 
acts_upstream_of_or_within angiogenesis PubMed 
acts_upstream_of_or_within branching involved in blood vessel morphogenesis PubMed 
acts_upstream_of_or_within cell differentiation PubMed 
acts_upstream_of_or_within in utero embryonic development PubMed 
acts_upstream_of_or_within intracellular signal transduction PubMed 
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell migration PubMed 
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation PubMed 
acts_upstream_of_or_within platelet activation PubMed 
involved_in positive regulation of cytosolic calcium ion concentration  
involved_in positive regulation of cytosolic calcium ion concentration  
involved_in regulation of blood pressure PubMed 
acts_upstream_of_or_within regulation of cell shape PubMed 
acts_upstream_of_or_within regulation of fibroblast migration PubMed 
involved_in regulation of postsynapse assembly PubMed 
involved_in regulation of postsynapse assembly PubMed 
involved_in regulation of postsynapse assembly PubMed 
involved_in regulation of postsynapse assembly PubMed 
Items 1 - 25 of 26
Component Evidence Code Pubs
is_active_in brush border membrane  
located_in brush border membrane  
located_in brush border membrane  
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytoplasm  
located_in cytosol  
located_in cytosol  
part_of heterotrimeric G-protein complex  
part_of heterotrimeric G-protein complex PubMed 
part_of heterotrimeric G-protein complex PubMed 
located_in melanosome  
located_in nucleus PubMed 
located_in nucleus  
located_in plasma membrane  
is_active_in postsynapse PubMed 
is_active_in postsynapse PubMed 
is_active_in postsynapse PubMed 
is_active_in postsynapse PubMed 

General protein information

Preferred Names
guanine nucleotide-binding protein subunit alpha-13
Names
G-protein subunit alpha-13
g alpha-13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359034.1NP_001345963.1  guanine nucleotide-binding protein subunit alpha-13 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate 3' terminal exon, resulting in novel 3' UTR and 3' coding region. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK011851, BE943634, BY711071, BY742974
    Consensus CDS
    CCDS88277.1
    UniProtKB/TrEMBL
    Q9D034
    Related
    ENSMUSP00000102313.4, ENSMUST00000106702.4
    Conserved Domains (1) summary
    smart00275
    Location:29172
    G_alpha; G protein alpha subunit
  2. NM_010303.3NP_034433.3  guanine nucleotide-binding protein subunit alpha-13 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant 1 represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK011851, AK149766, AL645791, BC032937, CJ180381
    Consensus CDS
    CCDS25577.1
    UniProtKB/Swiss-Prot
    P27601, Q6PF99
    UniProtKB/TrEMBL
    Q3UE40
    Related
    ENSMUSP00000020930.8, ENSMUST00000020930.14
    Conserved Domains (2) summary
    cd00066
    Location:49371
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:29375
    G_alpha; G protein alpha subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    109253620..109292195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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