| | The following method definition consists of one or more |
| | protocols used in The SNP Consortium project by the |
| | participating laboratory CSHL. |
| | See the TSC website (http://snp.cshl.org/cgi-bin/protocol) |
| | for a complete list of TSC protocols. |
| | \\--------------------------------------- |
| | SNP detection protocol TSCM0031 ( |
| | http://snp.cshl.org/cgi-bin/protocol?id=TSCM0031) |
| | Title: SNP detection method using PolyBayes program performed over preselected set of trace files from all participating labs |
| | Lab: Cold Spring Harbor Laboratory |
| | Contact: [email protected] |
| | Description: |
| | A Bayesian statistical approach (implemented in PolyYayes program) was applied |
| | to clusters of high quality reads representing unique genomic locations. The |
| | method then determined if a part of such multiple alignment contains polimorphic |
| | nucleotides based on quality score of the base call from every sequence |
| | contributing to the cluster |
