LOCUS NP_001756 333 aa linear PRI 06-JUN-2024
DEFINITION T-cell surface glycoprotein CD1c precursor [Homo sapiens].
ACCESSION NP_001756
VERSION NP_001756.2
DBSOURCE REFSEQ: accession NM_001765.3
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 333)
AUTHORS Xiang,X., Gao,L.M., Zhang,Y., Zhu,Q., Zhao,S., Liu,W., Ye,Y.,
Tang,Y. and Zhang,W.
TITLE Identifying CD1c as a potential biomarker by the comprehensive
exploration of tumor mutational burden and immune infiltration in
diffuse large B cell lymphoma
JOURNAL PeerJ 11, e16618 (2023)
PUBMED 38099311
REMARK GeneRIF: Identifying CD1c as a potential biomarker by the
comprehensive exploration of tumor mutational burden and immune
infiltration in diffuse large B cell lymphoma.
Publication Status: Online-Only
REFERENCE 2 (residues 1 to 333)
AUTHORS Chen,X., Zhang,J., Lei,X., Yang,L., Li,W., Zheng,L., Zhang,S.,
Ding,Y., Shi,J., Zhang,L., Li,J., Tang,T. and Jia,W.
TITLE CD1C is associated with breast cancer prognosis and immune
infiltrates
JOURNAL BMC Cancer 23 (1), 129 (2023)
PUBMED 36755259
REMARK GeneRIF: CD1C is associated with breast cancer prognosis and immune
infiltrates.
Publication Status: Online-Only
REFERENCE 3 (residues 1 to 333)
AUTHORS Reijneveld,J.F., Marino,L., Cao,T.P., Cheng,T.Y., Dam,D.,
Shahine,A., Witte,M.D., Filippov,D.V., Suliman,S., van der
Marel,G.A., Moody,D.B., Minnaard,A.J., Rossjohn,J., Codee,J.D.C.
and Van Rhijn,I.
TITLE Rational design of a hydrolysis-resistant mycobacterial
phosphoglycolipid antigen presented by CD1c to T cells
JOURNAL J Biol Chem 297 (4), 101197 (2021)
PUBMED 34536421
REMARK GeneRIF: Rational design of a hydrolysis-resistant mycobacterial
phosphoglycolipid antigen presented by CD1c to T cells.
REFERENCE 4 (residues 1 to 333)
AUTHORS Eckhardt,E. and Bastian,M.
TITLE Animal models for human group 1 CD1 protein function
JOURNAL Mol Immunol 130, 159-163 (2021)
PUBMED 33384157
REMARK GeneRIF: Animal models for human group 1 CD1 protein function.
Review article
REFERENCE 5 (residues 1 to 333)
AUTHORS Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
TITLE Interactome Mapping Provides a Network of Neurodegenerative Disease
Proteins and Uncovers Widespread Protein Aggregation in Affected
Brains
JOURNAL Cell Rep 32 (7), 108050 (2020)
PUBMED 32814053
REFERENCE 6 (residues 1 to 333)
AUTHORS Woolfson,A. and Milstein,C.
TITLE Alternative splicing generates secretory isoforms of human CD1
JOURNAL Proc Natl Acad Sci U S A 91 (14), 6683-6687 (1994)
PUBMED 7517559
REFERENCE 7 (residues 1 to 333)
AUTHORS Yu,C.Y. and Milstein,C.
TITLE A physical map linking the five CD1 human thymocyte differentiation
antigen genes
JOURNAL EMBO J 8 (12), 3727-3732 (1989)
PUBMED 2583117
REFERENCE 8 (residues 1 to 333)
AUTHORS Aruffo,A. and Seed,B.
TITLE Expression of cDNA clones encoding the thymocyte antigens CD1a, b,
c demonstrates a hierarchy of exclusion in fibroblasts
JOURNAL J Immunol 143 (5), 1723-1730 (1989)
PUBMED 2701945
REFERENCE 9 (residues 1 to 333)
AUTHORS Martin,L.H., Calabi,F., Lefebvre,F.A., Bilsland,C.A. and
Milstein,C.
TITLE Structure and expression of the human thymocyte antigens CD1a,
CD1b, and CD1c
JOURNAL Proc Natl Acad Sci U S A 84 (24), 9189-9193 (1987)
PUBMED 2447586
REFERENCE 10 (residues 1 to 333)
AUTHORS Martin,L.H., Calabi,F. and Milstein,C.
TITLE Isolation of CD1 genes: a family of major histocompatibility
complex-related differentiation antigens
JOURNAL Proc Natl Acad Sci U S A 83 (23), 9154-9158 (1986)
PUBMED 3097645
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL121986.12, M28827.1 and
AA824381.1.
On Jul 21, 2006 this sequence version replaced NP_001756.1.
Summary: This gene encodes a member of the CD1 family of
transmembrane glycoproteins, which are structurally related to the
major histocompatibility complex (MHC) proteins and form
heterodimers with beta-2-microglobulin. The CD1 proteins mediate
the presentation of primarily lipid and glycolipid antigens of self
or microbial origin to T cells. The human genome contains five CD1
family genes organized in a cluster on chromosome 1. The CD1 family
members are thought to differ in their cellular localization and
specificity for particular lipid ligands. The protein encoded by
this gene is broadly distributed throughout the endocytic system
via a tyrosine-based motif in the cytoplasmic tail. Alternatively
spliced transcript variants of this gene have been observed, but
their full-length nature is not known. [provided by RefSeq, Jul
2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1163657.131085.1,
SRR1163657.175873.1 [ECO:0000332]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000368170.8/ ENSP00000357152.3
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..333
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q23.1"
Protein 1..333
/product="T-cell surface glycoprotein CD1c precursor"
/note="CD1C antigen, c polypeptide; T-cell surface
glycoprotein CD1c; differentiation antigen CD1-alpha-3;
cortical thymocyte antigen CD1C"
/calculated_mol_wt=35798
sig_peptide 1..17
/note="/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P29017.2)"
/calculated_mol_wt=1874
mat_peptide 18..333
/product="T-cell surface glycoprotein CD1c.
/id=PRO_0000014580"
/note="propagated from UniProtKB/Swiss-Prot (P29017.2)"
/calculated_mol_wt=35798
Region 19..197
/region_name="MHC_I_3"
/note="MHC-I family domain; pfam16497"
/db_xref="CDD:465144"
Site 38
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000269|PubMed:19349973,
ECO:0000269|PubMed:21167756; propagated from
UniProtKB/Swiss-Prot (P29017.2)"
Site 70
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P29017.2)"
Site 75
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000269|PubMed:19349973; propagated from
UniProtKB/Swiss-Prot (P29017.2)"
Site 146
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P29017.2)"
Region 204..296
/region_name="IgC1_CD1"
/note="Immunoglobulin domain of Cluster of Differentiation
(CD) 1; member of the C1-set of Ig superfamily (IgSF)
domains; cd21029"
/db_xref="CDD:409620"
Region 205..213
/region_name="Ig strand A"
/note="Ig strand A [structural motif]"
/db_xref="CDD:409620"
Region 220..230
/region_name="Ig strand B"
/note="Ig strand B [structural motif]"
/db_xref="CDD:409620"
Site order(231..233,260,285)
/site_type="other"
/note="MHC binding domain interface [polypeptide binding]"
/db_xref="CDD:409620"
Region 235..241
/region_name="Ig strand C"
/note="Ig strand C [structural motif]"
/db_xref="CDD:409620"
Region 243..246
/region_name="Ig strand C'"
/note="Ig strand C' [structural motif]"
/db_xref="CDD:409620"
Region 249..257
/region_name="Ig strand D"
/note="Ig strand D [structural motif]"
/db_xref="CDD:409620"
Region 260..270
/region_name="Ig strand E"
/note="Ig strand E [structural motif]"
/db_xref="CDD:409620"
Region 277..284
/region_name="Ig strand F"
/note="Ig strand F [structural motif]"
/db_xref="CDD:409620"
Region 292..295
/region_name="Ig strand G"
/note="Ig strand G [structural motif]"
/db_xref="CDD:409620"
Site 303..323
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (P29017.2)"
Region 329..332
/region_name="Internalization signal"
/note="propagated from UniProtKB/Swiss-Prot (P29017.2)"
CDS 1..333
/gene="CD1C"
/gene_synonym="BDCA1; CD1; CD1A; R7"
/coded_by="NM_001765.3:143..1144"
/db_xref="CCDS:CCDS1175.1"
/db_xref="GeneID:911"
/db_xref="HGNC:HGNC:1636"
/db_xref="MIM:188340"
ORIGIN
1 mlflqfllla lllpggdnad asqehvsfhv iqifsfvnqs wargqgsgwl delqthgwds
61 esgtiiflhn wskgnfsnee lsdlellfrf ylfgltreiq dhasqdysky pfevqvkagc
121 elhsgkspeg ffqvafngld llsfqnttwv pspgcgslaq svchllnhqy egvtetvynl
181 irstcprfll glldagkmyv hrqvrpeawl ssrpslgsgq lllvchasgf ypkpvwvtwm
241 rneqeqlgtk hgdilpnadg twylqvilev aseepaglsc rvrhsslggq diilywghhf
301 smnwialvvi vplvilivlv lwfkkhcsyq dil
//