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T-cell surface glycoprotein CD1c precursor [Homo sapiens]

NCBI Reference Sequence: NP_001756.2

Identical Proteins FASTA Graphics 

LOCUS       NP_001756                333 aa            linear   PRI 06-JUN-2024
DEFINITION  T-cell surface glycoprotein CD1c precursor [Homo sapiens].
ACCESSION   NP_001756
VERSION     NP_001756.2
DBSOURCE    REFSEQ: accession NM_001765.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 333)
  AUTHORS   Xiang,X., Gao,L.M., Zhang,Y., Zhu,Q., Zhao,S., Liu,W., Ye,Y.,
            Tang,Y. and Zhang,W.
  TITLE     Identifying CD1c as a potential biomarker by the comprehensive
            exploration of tumor mutational burden and immune infiltration in
            diffuse large B cell lymphoma
  JOURNAL   PeerJ 11, e16618 (2023)
   PUBMED   38099311
  REMARK    GeneRIF: Identifying CD1c as a potential biomarker by the
            comprehensive exploration of tumor mutational burden and immune
            infiltration in diffuse large B cell lymphoma.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 333)
  AUTHORS   Chen,X., Zhang,J., Lei,X., Yang,L., Li,W., Zheng,L., Zhang,S.,
            Ding,Y., Shi,J., Zhang,L., Li,J., Tang,T. and Jia,W.
  TITLE     CD1C is associated with breast cancer prognosis and immune
            infiltrates
  JOURNAL   BMC Cancer 23 (1), 129 (2023)
   PUBMED   36755259
  REMARK    GeneRIF: CD1C is associated with breast cancer prognosis and immune
            infiltrates.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 333)
  AUTHORS   Reijneveld,J.F., Marino,L., Cao,T.P., Cheng,T.Y., Dam,D.,
            Shahine,A., Witte,M.D., Filippov,D.V., Suliman,S., van der
            Marel,G.A., Moody,D.B., Minnaard,A.J., Rossjohn,J., Codee,J.D.C.
            and Van Rhijn,I.
  TITLE     Rational design of a hydrolysis-resistant mycobacterial
            phosphoglycolipid antigen presented by CD1c to T cells
  JOURNAL   J Biol Chem 297 (4), 101197 (2021)
   PUBMED   34536421
  REMARK    GeneRIF: Rational design of a hydrolysis-resistant mycobacterial
            phosphoglycolipid antigen presented by CD1c to T cells.
REFERENCE   4  (residues 1 to 333)
  AUTHORS   Eckhardt,E. and Bastian,M.
  TITLE     Animal models for human group 1 CD1 protein function
  JOURNAL   Mol Immunol 130, 159-163 (2021)
   PUBMED   33384157
  REMARK    GeneRIF: Animal models for human group 1 CD1 protein function.
            Review article
REFERENCE   5  (residues 1 to 333)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (residues 1 to 333)
  AUTHORS   Woolfson,A. and Milstein,C.
  TITLE     Alternative splicing generates secretory isoforms of human CD1
  JOURNAL   Proc Natl Acad Sci U S A 91 (14), 6683-6687 (1994)
   PUBMED   7517559
REFERENCE   7  (residues 1 to 333)
  AUTHORS   Yu,C.Y. and Milstein,C.
  TITLE     A physical map linking the five CD1 human thymocyte differentiation
            antigen genes
  JOURNAL   EMBO J 8 (12), 3727-3732 (1989)
   PUBMED   2583117
REFERENCE   8  (residues 1 to 333)
  AUTHORS   Aruffo,A. and Seed,B.
  TITLE     Expression of cDNA clones encoding the thymocyte antigens CD1a, b,
            c demonstrates a hierarchy of exclusion in fibroblasts
  JOURNAL   J Immunol 143 (5), 1723-1730 (1989)
   PUBMED   2701945
REFERENCE   9  (residues 1 to 333)
  AUTHORS   Martin,L.H., Calabi,F., Lefebvre,F.A., Bilsland,C.A. and
            Milstein,C.
  TITLE     Structure and expression of the human thymocyte antigens CD1a,
            CD1b, and CD1c
  JOURNAL   Proc Natl Acad Sci U S A 84 (24), 9189-9193 (1987)
   PUBMED   2447586
REFERENCE   10 (residues 1 to 333)
  AUTHORS   Martin,L.H., Calabi,F. and Milstein,C.
  TITLE     Isolation of CD1 genes: a family of major histocompatibility
            complex-related differentiation antigens
  JOURNAL   Proc Natl Acad Sci U S A 83 (23), 9154-9158 (1986)
   PUBMED   3097645
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121986.12, M28827.1 and
            AA824381.1.
            
            On Jul 21, 2006 this sequence version replaced NP_001756.1.
            
            Summary: This gene encodes a member of the CD1 family of
            transmembrane glycoproteins, which are structurally related to the
            major histocompatibility complex (MHC) proteins and form
            heterodimers with beta-2-microglobulin. The CD1 proteins mediate
            the presentation of primarily lipid and glycolipid antigens of self
            or microbial origin to T cells. The human genome contains five CD1
            family genes organized in a cluster on chromosome 1. The CD1 family
            members are thought to differ in their cellular localization and
            specificity for particular lipid ligands. The protein encoded by
            this gene is broadly distributed throughout the endocytic system
            via a tyrosine-based motif in the cytoplasmic tail. Alternatively
            spliced transcript variants of this gene have been observed, but
            their full-length nature is not known. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.131085.1,
                                           SRR1163657.175873.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368170.8/ ENSP00000357152.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..333
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     Protein         1..333
                     /product="T-cell surface glycoprotein CD1c precursor"
                     /note="CD1C antigen, c polypeptide; T-cell surface
                     glycoprotein CD1c; differentiation antigen CD1-alpha-3;
                     cortical thymocyte antigen CD1C"
                     /calculated_mol_wt=35798
     sig_peptide     1..17
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P29017.2)"
                     /calculated_mol_wt=1874
     mat_peptide     18..333
                     /product="T-cell surface glycoprotein CD1c.
                     /id=PRO_0000014580"
                     /note="propagated from UniProtKB/Swiss-Prot (P29017.2)"
                     /calculated_mol_wt=35798
     Region          19..197
                     /region_name="MHC_I_3"
                     /note="MHC-I family domain; pfam16497"
                     /db_xref="CDD:465144"
     Site            38
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973,
                     ECO:0000269|PubMed:21167756; propagated from
                     UniProtKB/Swiss-Prot (P29017.2)"
     Site            70
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P29017.2)"
     Site            75
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (P29017.2)"
     Site            146
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P29017.2)"
     Region          204..296
                     /region_name="IgC1_CD1"
                     /note="Immunoglobulin domain of Cluster of Differentiation
                     (CD) 1; member of the C1-set of Ig superfamily (IgSF)
                     domains; cd21029"
                     /db_xref="CDD:409620"
     Region          205..213
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409620"
     Region          220..230
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409620"
     Site            order(231..233,260,285)
                     /site_type="other"
                     /note="MHC binding domain interface [polypeptide binding]"
                     /db_xref="CDD:409620"
     Region          235..241
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409620"
     Region          243..246
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409620"
     Region          249..257
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409620"
     Region          260..270
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409620"
     Region          277..284
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409620"
     Region          292..295
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409620"
     Site            303..323
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P29017.2)"
     Region          329..332
                     /region_name="Internalization signal"
                     /note="propagated from UniProtKB/Swiss-Prot (P29017.2)"
     CDS             1..333
                     /gene="CD1C"
                     /gene_synonym="BDCA1; CD1; CD1A; R7"
                     /coded_by="NM_001765.3:143..1144"
                     /db_xref="CCDS:CCDS1175.1"
                     /db_xref="GeneID:911"
                     /db_xref="HGNC:HGNC:1636"
                     /db_xref="MIM:188340"
ORIGIN      
        1 mlflqfllla lllpggdnad asqehvsfhv iqifsfvnqs wargqgsgwl delqthgwds
       61 esgtiiflhn wskgnfsnee lsdlellfrf ylfgltreiq dhasqdysky pfevqvkagc
      121 elhsgkspeg ffqvafngld llsfqnttwv pspgcgslaq svchllnhqy egvtetvynl
      181 irstcprfll glldagkmyv hrqvrpeawl ssrpslgsgq lllvchasgf ypkpvwvtwm
      241 rneqeqlgtk hgdilpnadg twylqvilev aseepaglsc rvrhsslggq diilywghhf
      301 smnwialvvi vplvilivlv lwfkkhcsyq dil
//
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