RecName: Full=Cholinesterase; AltName: Full=Acylcholine acylhydrolase; - Protein

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Protein 3D Structure

Crystal structure of human butyrylcholinesterase in complex with 2-{1-[4-(12-Amino-3-chloro-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinolin-9-yl)butyl]-1H-1,2,3-triazol-4-yl}-N-[4-hydroxy-3-methoxybenzyl]acetamide

PDB: 7AIY

Source: Homo sapiens

Method: X-ray Diffraction

Resolution: 2.937 Å

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Articles about the BCHE gene

Butyrylcholinesterase activity in patients with postoperative delirium after cardiothoracic surgery or percutaneous valve replacement- an observational interdisciplinary cohort study. [BMC Neurol. 2024]
Butyrylcholinesterase activity in patients with postoperative delirium after cardiothoracic surgery or percutaneous valve replacement- an observational interdisciplinary cohort study.
Schlake K, Teller J, Hinken L, Laser H, Lichtinghagen R, Schäfer A, Fegbeutel C, Weissenborn K, Jung C, Worthmann H, et al. BMC Neurol. 2024 Mar 1; 24(1):80. Epub 2024 Mar 1.
Progressions of the correlation between lipid metabolism and immune infiltration characteristics in gastric cancer and identification of BCHE as a potential biomarker. [Front Immunol. 2024]
Progressions of the correlation between lipid metabolism and immune infiltration characteristics in gastric cancer and identification of BCHE as a potential biomarker.
Wang S, Huang X, Zhao S, Lv J, Li Y, Wang S, Guo J, Wang Y, Wang R, Zhang M, et al. Front Immunol. 2024; 15:1327565. Epub 2024 Jan 31.
Human Butyrylcholinesterase Mutants for (-)-Cocaine Hydrolysis: A Correlation Relationship between Catalytic Efficiency and Total Hydrogen Bonding Energy with an Oxyanion Hole. [J Phys Chem B. 2023]
Human Butyrylcholinesterase Mutants for (-)-Cocaine Hydrolysis: A Correlation Relationship between Catalytic Efficiency and Total Hydrogen Bonding Energy with an Oxyanion Hole.
Zheng F, Hou S, Xue L, Yang W, Zhan CG. J Phys Chem B. 2023 Dec 21; 127(50):10723-10729. Epub 2023 Dec 8.

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Reference sequence information

RefSeq genomic sequence
See the genomic reference sequence for the BCHE gene (NG_009031.1).
RefSeq protein
See the reference protein sequence for cholinesterase precursor (NP_000046.1).

More about the BCHE gene

This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/lipase family of proteins. The encoded enzyme exhibits b...
Also Known As: BCHED, CHE1, CHE2, E1

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LinkOut to external resources

P06276 [Domain Mapping of Disease Mut...]
P06276
Domain Mapping of Disease Mutations
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF) [MODBASE, Database of Comparat...]
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF)
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
Reactome [Reactome]
Reactome
reagent reviews [ExactAntigen/Labome]
reagent reviews
ExactAntigen/Labome
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome
Evolutionary Trace of Functional Site [Evolutionary Trace of Functio...]
Evolutionary Trace of Functional Site

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RecName: Full=Cholinesterase; AltName: Full=Acylcholine acylhydrolase; AltName: ...
RecName: Full=Cholinesterase; AltName: Full=Acylcholine acylhydrolase; AltName: Full=Butyrylcholine esterase; AltName: Full=Choline esterase II; AltName: Full=Pseudocholinesterase; Flags: Precursor
gi|116353|sp|P06276.1|CHLE_HUMAN

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RecName: Full=Cholinesterase; AltName: Full=Acylcholine acylhydrolase; AltName: Full=Butyrylcholine esterase; AltName: Full=Choline esterase II; AltName: Full=Pseudocholinesterase; Flags: Precursor

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