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RecName: Full=Coronin-6; AltName: Full=Coronin-like protein E; Short=Clipin-E

UniProtKB/Swiss-Prot: Q6QEF8.2

Identical Proteins FASTA Graphics 

LOCUS       CORO6_HUMAN              472 aa            linear   PRI 27-NOV-2024
DEFINITION  RecName: Full=Coronin-6; AltName: Full=Coronin-like protein E;
            Short=Clipin-E.
ACCESSION   Q6QEF8
VERSION     Q6QEF8.2
DBSOURCE    UniProtKB: locus CORO6_HUMAN, accession Q6QEF8;
            class: standard.
            extra accessions:B3KU26,Q71MF3,Q8WYH7,Q96K02
            created: Oct 31, 2006.
            sequence updated: Oct 31, 2006.
            annotation updated: Nov 27, 2024.
            xrefs: AF193039.1, AAG22467.1, AF447884.1, AAQ04659.1, AF447885.1,
            AAQ04660.1, AY545070.1, AAS48630.1, AK027777.1, BAB55360.1,
            AK096431.1, BAG53288.1, AC104564.11, BC064514.1, AAH64514.1,
            NP_116243.2, XP_005258104.1, XP_005258113.1, 7KYX_A
            xrefs (non-sequence databases): CCDS:CCDS11252.2, PDBsum:7KYX,
            AlphaFoldDB:Q6QEF8, SMR:Q6QEF8, BioGRID:124374, IntAct:Q6QEF8,
            MINT:Q6QEF8, STRING:9606.ENSP00000344562, GlyGen:Q6QEF8,
            iPTMnet:Q6QEF8, PhosphoSitePlus:Q6QEF8, BioMuta:CORO6,
            DMDM:119369490, jPOST:Q6QEF8, MassIVE:Q6QEF8,
            PaxDb:9606-ENSP00000344562, PeptideAtlas:Q6QEF8,
            ProteomicsDB:67283, ProteomicsDB:67284, ProteomicsDB:67285,
            ProteomicsDB:67286, ProteomicsDB:67287, Antibodypedia:54318,
            DNASU:84940, Ensembl:ENST00000345068.9, Ensembl:ENSP00000344562.5,
            Ensembl:ENSG00000167549.19, Ensembl:ENST00000388767.8,
            Ensembl:ENSP00000373419.3, GeneID:84940, KEGG:hsa:84940,
            MANE-Select:ENST00000388767.8, UCSC:uc002hel.2, AGR:HGNC:21356,
            CTD:84940, DisGeNET:84940, GeneCards:CORO6, HGNC:21356,
            HPA:ENSG00000167549, neXtProt:NX_Q6QEF8,
            OpenTargets:ENSG00000167549, PharmGKB:PA134869901,
            VEuPathDB:HostDB:ENSG00000167549, eggNOG:KOG0303,
            GeneTree:ENSGT00940000159328, InParanoid:Q6QEF8, OMA:FRHSTGH,
            OrthoDB:5474889at2759, PhylomeDB:Q6QEF8, TreeFam:TF314280,
            PathwayCommons:Q6QEF8, SignaLink:Q6QEF8, BioGRID-ORCS:84940,
            ChiTaRS:CORO6, GenomeRNAi:84940, Pharos:Q6QEF8, PRO:PR:Q6QEF8,
            Proteomes:UP000005640, RNAct:Q6QEF8, Bgee:ENSG00000167549,
            ExpressionAtlas:Q6QEF8, GO:0051015, GO:0007015, GO:0016477,
            FunFam:2.130.10.10:FF:000003, Gene3D:2.130.10.10,
            InterPro:IPR015505, InterPro:IPR015048, InterPro:IPR015943,
            InterPro:IPR019775, InterPro:IPR036322, InterPro:IPR001680,
            PANTHER:PTHR10856, PANTHER:PTHR10856:SF23, Pfam:PF08953,
            Pfam:PF00400, Pfam:PF16300, SMART:SM01166, SMART:SM01167,
            SMART:SM00320, SUPFAM:SSF50978, PROSITE:PS00678, PROSITE:PS50082,
            PROSITE:PS50294
KEYWORDS    3D-structure; Alternative splicing; Coiled coil; Proteomics
            identification; Reference proteome; Repeat; WD repeat.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 472)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
            Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   2  (residues 1 to 472)
  AUTHORS   Shen,C., Wang,C., Li,H., Zhou,G., Ke,R., Zhong,G., Lin,L. and
            Yang,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (??-FEB-2004) to the EMBL/GenBank/DDBJ databases
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
REFERENCE   3  (residues 1 to 472)
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat Genet 36 (1), 40-45 (2004)
   PUBMED   14702039
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE
            SEQUENCE [LARGE SCALE MRNA] OF 32-472 (ISOFORM 5).;
            TISSUE=Placenta, and Tongue
REFERENCE   4  (residues 1 to 472)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
REFERENCE   5  (residues 1 to 472)
  AUTHORS   Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
            Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
            Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
            Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
            Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
            Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
            Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
            Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
            Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
            Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
            Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
            Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
            Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
            Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
            Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
            Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
            Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
            Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
            Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
            Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
            Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
            Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
            Makowski,K.A., Bosak,S. and Malek,J.
  CONSRTM   MGC Project Team
  TITLE     The status, quality, and expansion of the NIH full-length cDNA
            project: the Mammalian Gene Collection (MGC)
  JOURNAL   Genome Res 14 (10B), 2121-2127 (2004)
   PUBMED   15489334
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).;
            TISSUE=Lymph
            Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
            Morin, Ryan]]
COMMENT     On or before Dec 12, 2006 this sequence version replaced
            gi:74738340, gi:74716455, gi:74716885, gi:74749291.
            [INTERACTION] Q6QEF8; Q9UL45: BLOC1S6; NbExp=3;
            IntAct=EBI-10254194, EBI-465781; Q6QEF8-4; P23560-2: BDNF; NbExp=3;
            IntAct=EBI-10699285, EBI-12275524; Q6QEF8-4; P02511: CRYAB;
            NbExp=3; IntAct=EBI-10699285, EBI-739060; Q6QEF8-4; P07900:
            HSP90AA1; NbExp=3; IntAct=EBI-10699285, EBI-296047.
            [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named
            isoforms=5; Name=1; IsoId=Q6QEF8-1; Sequence=Displayed; Name=2;
            IsoId=Q6QEF8-2; Sequence=VSP_021484; Name=3; IsoId=Q6QEF8-3;
            Sequence=VSP_021484, VSP_021486; Name=4; IsoId=Q6QEF8-4;
            Sequence=VSP_021485, VSP_021486; Name=5; IsoId=Q6QEF8-5;
            Sequence=VSP_039874.
            [SEQUENCE CAUTION] Sequence=AAG22467.1; Type=Erroneous translation;
            Note=Wrong choice of frame.; Evidence={ECO:0000305};
            Sequence=BAG53288.1; Type=Erroneous initiation; Note=Truncated
            N-terminus.; Evidence={ECO:0000305}.
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
     gene            1..472
                     /gene="CORO6"
                     /locus_tag="PP1009"
                     /gene_synonym="PP1782"
                     /gene_synonym="PP1881"
     Protein         1..472
                     /product="Coronin-6"
                     /note="Coronin-like protein E; Clipin-E"
                     /UniProtKB_evidence="Evidence at protein level"
     Region          1..472
                     /region_name="Mature chain"
                     /note="Coronin-6. /id=PRO_0000259596."
     Region          1..251
                     /region_name="Splicing variant"
                     /note="MSRRVVRQSKFRHVFGQAAKADQAYEDIRVSKVTWDSSFCAVNPKFLAIIV
                     EAGGGGAFIVLPLAKTGRVDKNYPLVTGHTAPVLDIDWCPHNDNVIASASDDTTIMVW
                     QIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVL
                     LSLDDMHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAEQARPHEGARPLRA
                     VFTADGKLLSTGFSRMSERQLALWDP ->
                     MCRGGGAMCAGEEERCAQGRGLQLWSLEVWGIGFGKARKRKGASGGPEVAREGGAGLV
                     TPPVLGQ (in isoform 2 and isoform 3).
                     /evidence=ECO:0000303|PubMed:14702039,
                     ECO:0000303|PubMed:15498874, ECO:0000303|Ref.2.
                     /id=VSP_021484."
     Region          1..251
                     /region_name="Splicing variant"
                     /note="MSRRVVRQSKFRHVFGQAAKADQAYEDIRVSKVTWDSSFCAVNPKFLAIIV
                     EAGGGGAFIVLPLAKTGRVDKNYPLVTGHTAPVLDIDWCPHNDNVIASASDDTTIMVW
                     QIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVL
                     LSLDDMHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAEQARPHEGARPLRA
                     VFTADGKLLSTGFSRMSERQLALWDP -> MPSPWGWFAVTACGAQR (in
                     isoform 4). /evidence=ECO:0000303|PubMed:15489334,
                     ECO:0000303|PubMed:15498874. /id=VSP_021485."
     Region          9..454
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          10..13
                     /region_name="Hydrogen bonded turn"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          15..18
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          21..23
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          23..64
                     /region_name="Repetitive region"
                     /note="WD 1."
     Region          24..27
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          37..79
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          39..42
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          44..51
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          58..63
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          72..111
                     /region_name="Repetitive region"
                     /note="WD 2."
     Region          84..89
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          85..129
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          96..101
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          106..110
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          122..161
                     /region_name="Repetitive region"
                     /note="WD 3."
     Region          124..127
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          134..171
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          134..139
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          141..143
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          146..151
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          156..160
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          161..163
                     /region_name="Hydrogen bonded turn"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          165..204
                     /region_name="Repetitive region"
                     /note="WD 4."
     Region          166..170
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          172..176
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          178..183
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          179..215
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          190..194
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          199..203
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          204..207
                     /region_name="Hydrogen bonded turn"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          208..212
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          210..251
                     /region_name="Repetitive region"
                     /note="WD 5."
     Region          213..247
                     /region_name="Splicing variant"
                     /note="QARPHEGARPLRAVFTADGKLLSTGFSRMSERQLA ->
                     RFAAHEGMRPMRAVFTRQGHIFTTGFTRMSQRELG (in isoform 5).
                     /evidence=ECO:0000303|PubMed:14702039. /id=VSP_039874."
     Region          221..227
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          222..262
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          233..238
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          244..249
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          256..296
                     /region_name="Repetitive region"
                     /note="WD 6."
     Region          258..262
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          266
                     /region_name="Conflict"
                     /note="S -> I (in Ref. 3; BAG53288).
                     /evidence=ECO:0000305."
     Region          269..310
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          271..275
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          276..279
                     /region_name="Hydrogen bonded turn"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          280..284
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          291..296
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          302..309
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          316..320
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          323..325
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          328..330
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          332..339
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          341..350
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          360..362
                     /region_name="Hydrogen bonded turn"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          375..379
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          391..393
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
     Region          407..433
                     /region_name="Region of interest in the sequence"
                     /note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          419..433
                     /region_name="Compositionally biased region"
                     /note="Polar residues.
                     /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          430..464
                     /region_name="Coiled-coil region"
                     /note="/evidence=ECO:0000255."
     Region          433
                     /region_name="Splicing variant"
                     /note="Missing (in isoform 3 and isoform 4).
                     /evidence=ECO:0000303|PubMed:14702039,
                     ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:15498874.
                     /id=VSP_021486."
ORIGIN      
        1 msrrvvrqsk frhvfgqaak adqayedirv skvtwdssfc avnpkflaii veaggggafi
       61 vlplaktgrv dknyplvtgh tapvldidwc phndnviasa sddttimvwq ipdytpmrni
      121 tepiitlegh skrvgilswh ptarnvllsa ggdnviiiwn vgtgevllsl ddmhpdvihs
      181 vcwnsngsll attckdktlr iidprkgqvv aeqarphega rplravftad gkllstgfsr
      241 mserqlalwd pnnfeepval qemdtsngvl lpfydpdssi vylcgkgdss iryfeitdep
      301 pfvhylntfs skepqrgmgf mpkrgldvsk ceiarfyklh erkcepiimt vprksdlfqd
      361 dlypdtpgpe paleadewls gqdaepvlis lrdgyvppkh relrvtkrni ldvrppsgpr
      421 rsqsasdapl sqqhtletll eeikalrerv qaqeqrital enmlcelvdg td
//
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