LOCUS NP_001073886 869 aa linear PRI 04-APR-2024
DEFINITION zinc finger protein 629 isoform 1 [Homo sapiens].
ACCESSION NP_001073886 XP_034819
VERSION NP_001073886.1
DBSOURCE REFSEQ: accession NM_001080417.3
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 869)
AUTHORS Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 2 (residues 1 to 869)
AUTHORS Lichter,P., Bray,P., Ried,T., Dawid,I.B. and Ward,D.C.
TITLE Clustering of C2-H2 zinc finger motif sequences within telomeric
and fragile site regions of human chromosomes
JOURNAL Genomics 13 (4), 999-1007 (1992)
PUBMED 1505991
REFERENCE 3 (residues 1 to 869)
AUTHORS Bray,P., Lichter,P., Thiesen,H.J., Ward,D.C. and Dawid,I.B.
TITLE Characterization and mapping of human genes encoding zinc finger
proteins
JOURNAL Proc Natl Acad Sci U S A 88 (21), 9563-9567 (1991)
PUBMED 1946370
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC106886.3.
On Jan 18, 2007 this sequence version replaced XP_034819.4.
Transcript Variant: This variant (1) encodes the longer isoform
(1).
##Evidence-Data-START##
Transcript exon combination :: AB002324.1, DA796162.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1966682, SAMEA1968189
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000262525.6/ ENSP00000262525.4
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..869
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="16"
/map="16p11.2"
Protein 1..869
/product="zinc finger protein 629 isoform 1"
/note="zinc finger protein 65; DNA-binding protein"
/calculated_mol_wt=96490
Region 1..105
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q9UEG4.2)"
Region <3..>149
/region_name="PTZ00449"
/note="104 kDa microneme/rhoptry antigen; Provisional"
/db_xref="CDD:185628"
Site 18
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:23186163,
ECO:0007744|PubMed:24275569; propagated from
UniProtKB/Swiss-Prot (Q9UEG4.2)"
Region 150..172
/region_name="zf-C2H2"
/note="Zinc finger, C2H2 type; pfam00096"
/db_xref="CDD:395048"
Region 152..172
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 179..200
/region_name="zf-C2H2"
/note="Zinc finger, C2H2 type; pfam00096"
/db_xref="CDD:395048"
Region 180..200
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Site order(185,187,189,191..192,195..196,199,213,215,219..220,
223..224,227,241,243,245,247..248,251..252,255)
/site_type="other"
/note="putative nucleic acid binding site [nucleotide
binding]"
/db_xref="CDD:275368"
Region 204..512
/region_name="COG5048"
/note="FOG: Zn-finger [General function prediction only]"
/db_xref="CDD:227381"
Region 208..228
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 236..256
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 264..284
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 292..312
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Site order(297,299,301,303..304,307..308,311,325,327,331..332,
335..336,339,353,355,357,359..360,363..364,367)
/site_type="other"
/note="putative nucleic acid binding site [nucleotide
binding]"
/db_xref="CDD:275368"
Region 320..340
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 348..368
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 376..396
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 404..424
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 432..452
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Site order(437,439,441,443..444,447..448,451,465,467,471..472,
475..476,479,493,495,497,499..500,503..504,507)
/site_type="other"
/note="putative nucleic acid binding site [nucleotide
binding]"
/db_xref="CDD:275368"
Region 460..480
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 488..508
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 516..536
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 571..591
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 607..651
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q9UEG4.2)"
Site 616
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:20068231,
ECO:0007744|PubMed:23186163; propagated from
UniProtKB/Swiss-Prot (Q9UEG4.2)"
Region 664..684
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Site order(669,671,673,675..676,679..680,683,721,723,727..728,
731..732,735,775,777,779,781..782,785..786,789)
/site_type="other"
/note="putative nucleic acid binding site [nucleotide
binding]"
/db_xref="CDD:275368"
Region 716..736
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 770..790
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 787..837
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q9UEG4.2)"
Region 844..864
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
CDS 1..869
/gene="ZNF629"
/gene_synonym="ZNF; ZNF65"
/coded_by="NM_001080417.3:212..2821"
/note="isoform 1 is encoded by transcript variant 1"
/db_xref="CCDS:CCDS45463.1"
/db_xref="GeneID:23361"
/db_xref="HGNC:HGNC:29008"
/db_xref="MIM:619587"
ORIGIN
1 mepetalwgp dlqgpeqspn dahrgaesen eeesprqess geeiimgdpa qspeskdste
61 mslerssqdp svpqnpptpl ghsnpldhqi pldppapevv ptpsdwtkac easwqwgalt
121 twnsppvvpa nepslrelvq grpagaekpy icnecgksfs qwskllrhqr ihtgerpntc
181 secgksftqs shlvqhqrth tgekpykcpd cgkcfswssn lvqhqrthtg ekpykctece
241 kaftqstnli khqrshtgek pykcgecrra fyrssdliqh qathtgekpy kcpecgkrfg
301 qnhnllkhqk ihagekpyrc tecgksfiqs seltqhqrth tgekpyecle cgksfghsst
361 likhqrthlr edpfkcpvcg ktftlsatll rhqrthtger pykcpecgks fsvssnlinh
421 qrihrgerpy icadcgksfi msstlirhqr ihtgekpykc sdcgksfirs shliqhrrth
481 tgekpykcpe cgksfsqssn lithvrthmd enlfvcsdcg kafleahele qhrvihergk
541 tparraqgds llglgdpsll tpppgakphk clvcgkgfnd egifmqhqri higenpykna
601 dgliahaapk ppqlrsprlp frgnsypgaa egraeapgqp lkppegqegf sqrrgllssk
661 tyicshcges fldrsvllqh qlthgnekpf lfpdyriglg egagpspfls gkpfkcpeck
721 qsfglssell lhqkvhaggk ssqkspelgk sssvllehlr splgarpyrc sdcrasfldr
781 valtrhqeth tqekppnped pppeavtlst dqegegetpt ptessshgeg qnpktlveek
841 pylcpecgag ftevaalllh rschpgvsl
//