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electrogenic sodium bicarbonate cotransporter 4 isoform a [Homo sapiens]

NCBI Reference Sequence: NP_067019.3

Identical Proteins FASTA Graphics 

LOCUS       NP_067019               1137 aa            linear   PRI 19-SEP-2024
DEFINITION  electrogenic sodium bicarbonate cotransporter 4 isoform a [Homo
            sapiens].
ACCESSION   NP_067019
VERSION     NP_067019.3
DBSOURCE    REFSEQ: accession NM_021196.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1137)
  AUTHORS   Gildea,J.J., Xu,P., Kemp,B.A., Carlson,J.M., Tran,H.T., Bigler
            Wang,D., Langouet-Astrie,C.J., McGrath,H.E., Carey,R.M., Jose,P.A.
            and Felder,R.A.
  TITLE     Sodium bicarbonate cotransporter NBCe2 gene variants increase
            sodium and bicarbonate transport in human renal proximal tubule
            cells
  JOURNAL   PLoS One 13 (4), e0189464 (2018)
   PUBMED   29642240
  REMARK    GeneRIF: NBCe2 activity is stimulated by an increase in
            intracellular sodium and is hyper-responsive in hRPTCs carrying HV
            SLC4A5 rs7571842 through an aberrant HNF4A-mediated mechanism
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1137)
  AUTHORS   Gildea,J.J., Xu,P., Carlson,J.M., Gaglione,R.T., Bigler Wang,D.,
            Kemp,B.A., Reyes,C.M., McGrath,H.E., Carey,R.M., Jose,P.A. and
            Felder,R.A.
  TITLE     The sodium-bicarbonate cotransporter NBCe2 (slc4a5) expressed in
            human renal proximal tubules shows increased apical expression
            under high-salt conditions
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 309 (11), R1447-R1459 (2015)
   PUBMED   26447209
  REMARK    GeneRIF: NBCe2 could be important in proximal kidney tubule apical
            sodium and bicarbonate cotransport under high-salt conditions.
REFERENCE   3  (residues 1 to 1137)
  AUTHORS   Wen,D. and Sansom,S.C.
  TITLE     Physiological role of NBCe2 in the regulation of electrolyte
            transport in the distal nephron
  JOURNAL   Am J Physiol Renal Physiol 309 (6), F489-F491 (2015)
   PUBMED   26136555
  REMARK    GeneRIF: we summarize the potential function of NBCe2 in the
            regulation of blood pressure, acid-base, and K(+) and Ca(2+)
            transport in the distal nephron--{REVIEW}
            Review article
REFERENCE   4  (residues 1 to 1137)
  AUTHORS   Xie,P., Kranzler,H.R., Yang,C., Zhao,H., Farrer,L.A. and
            Gelernter,J.
  TITLE     Genome-wide association study identifies new susceptibility loci
            for posttraumatic stress disorder
  JOURNAL   Biol Psychiatry 74 (9), 656-663 (2013)
   PUBMED   23726511
REFERENCE   5  (residues 1 to 1137)
  AUTHORS   Carey,R.M., Schoeffel,C.D., Gildea,J.J., Jones,J.E., McGrath,H.E.,
            Gordon,L.N., Park,M.J., Sobota,R.S., Underwood,P.C., Williams,J.,
            Sun,B., Raby,B., Lasky-Su,J., Hopkins,P.N., Adler,G.K.,
            Williams,S.M., Jose,P.A. and Felder,R.A.
  TITLE     Salt sensitivity of blood pressure is associated with polymorphisms
            in the sodium-bicarbonate cotransporter
  JOURNAL   Hypertension 60 (5), 1359-1366 (2012)
   PUBMED   22987918
  REMARK    GeneRIF: Data indicate that 2 SNPs in SLC4A5 (rs7571842 and
            rs10177833) showed highly significant results and large effects
            sizes.
REFERENCE   6  (residues 1 to 1137)
  AUTHORS   Virkki,L.V., Wilson,D.A., Vaughan-Jones,R.D. and Boron,W.F.
  TITLE     Functional characterization of human NBC4 as an electrogenic
            Na+-HCO cotransporter (NBCe2)
  JOURNAL   Am J Physiol Cell Physiol 282 (6), C1278-C1289 (2002)
   PUBMED   11997242
REFERENCE   7  (residues 1 to 1137)
  AUTHORS   Sassani,P., Pushkin,A., Gross,E., Gomer,A., Abuladze,N.,
            Dukkipati,R., Carpenito,G. and Kurtz,I.
  TITLE     Functional characterization of NBC4: a new electrogenic
            sodium-bicarbonate cotransporter
  JOURNAL   Am J Physiol Cell Physiol 282 (2), C408-C416 (2002)
   PUBMED   11788353
REFERENCE   8  (residues 1 to 1137)
  AUTHORS   Soleimani,M. and Burnham,C.E.
  TITLE     Na+:HCO(3-) cotransporters (NBC): cloning and characterization
  JOURNAL   J Membr Biol 183 (2), 71-84 (2001)
   PUBMED   11562789
  REMARK    Review article
REFERENCE   9  (residues 1 to 1137)
  AUTHORS   Pushkin,A., Abuladze,N., Newman,D., Lee,I., Xu,G. and Kurtz,I.
  TITLE     Cloning, characterization and chromosomal assignment of NBC4, a new
            member of the sodium bicarbonate cotransporter family
  JOURNAL   Biochim Biophys Acta 1493 (1-2), 215-218 (2000)
   PUBMED   10978526
REFERENCE   10 (residues 1 to 1137)
  AUTHORS   Pushkin,A., Abuladze,N., Newman,D., Lee,I., Xu,G. and Kurtz,I.
  TITLE     Two C-terminal variants of NBC4, a new member of the sodium
            bicarbonate cotransporter family: cloning, characterization, and
            localization
  JOURNAL   IUBMB Life 50 (1), 13-19 (2000)
   PUBMED   11087115
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF293337.2 and AF243499.2.
            
            On Feb 16, 2007 this sequence version replaced NP_067019.2.
            
            Summary: This gene encodes a member of the sodium bicarbonate
            cotransporter (NBC) family, part of the bicarbonate transporter
            superfamily. Sodium bicarbonate cotransporters are involved in
            intracellular pH regulation and electroneural or electrogenic
            sodium bicarbonate transport. This protein is thought to be an
            integral membrane protein. Multiple transcript variants encoding
            different isoforms have been found for this gene, but the
            biological validity of some variants has not been determined.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (a) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF243499.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1137
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.1"
     Protein         1..1137
                     /product="electrogenic sodium bicarbonate cotransporter 4
                     isoform a"
                     /note="electrogenic sodium bicarbonate cotransporter 4;
                     solute carrier family 4 (sodium bicarbonate
                     cotransporter), member 5"
                     /calculated_mol_wt=126125
     Region          1..52
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BY07.2)"
     Region          64..94
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BY07.2)"
     Region          114..1070
                     /region_name="Band_3_cyto"
                     /note="Band 3 cytoplasmic domain; cl26877"
                     /db_xref="CDD:452680"
     Region          221..255
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BY07.2)"
     Region          438..478
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BY07.2)"
     Site            522..544
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BY07.2)"
     Site            556..587
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BY07.2)"
     Site            607..628
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BY07.2)"
     Site            743..762
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BY07.2)"
     Site            774..795
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BY07.2)"
     Site            829..847
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BY07.2)"
     Site            867..883
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BY07.2)"
     Site            889..908
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BY07.2)"
     Site            929..948
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BY07.2)"
     Site            954..971
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BY07.2)"
     Site            1017..1034
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BY07.2)"
     Site            1040..1057
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BY07.2)"
     Region          1079..1137
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BY07.2)"
     CDS             1..1137
                     /gene="SLC4A5"
                     /gene_synonym="NBC4; NBCe2"
                     /coded_by="NM_021196.3:3..3416"
                     /note="isoform a is encoded by transcript variant a"
                     /db_xref="CCDS:CCDS1936.1"
                     /db_xref="GeneID:57835"
                     /db_xref="HGNC:HGNC:18168"
                     /db_xref="MIM:606757"
ORIGIN      
        1 mkvkeekagv gkldhtnhrr rfpdqkecpp ihiglpvpty pqrktdqkgh lsglqkvhwg
       61 lrpdqpqqel tgpgsgassq dssmdlisrt rspaaeqlqd ilgeedeapn ptlftemdtl
      121 qhdgdqmewk esarwikfee kveeggerws kphvstlslh slfelrtclq tgtvlldlds
      181 gslpqiiddv iekqiedgll rpelrervsy vllrrhrhqt kkpihrslad igksvsttnr
      241 sparspgagp slhhstedlr mrqsanygrl chaqsrsmnd isltpntdqr knkfmkkipk
      301 dseasnvlvg evdfldqpfi afvrliqsam lggvtevpvp trflfillgp sgraksynei
      361 graiatlmvd dlfsdvayka rnredliagi defldevivl ppgewdpnir ieppkkvpsa
      421 dkrksvfsla elgqmngsvg ggggapgggn gggggggsgg gagsggaggt ssgddgempa
      481 mheigeeliw tgrffgglcl dikrklpwfp sdfydgfhiq sisailfiyl gcitnaitfg
      541 gllgdatdny qgvmesflgt amagslfclf sgqpliilss tgpilifekl lfdfskgngl
      601 dymefrlwig lhsavqclil vatdasfiik yitrfteegf stlisfifiy daikkmigaf
      661 kyypinmdfk pnfittykce cvapdtvntt vfnasaplap dtnaslynll nltaldwsll
      721 skkeclsygg rllgnsckfi pdlalmsfil ffgtysmtlt lkkfkfsryf ptkvralvad
      781 fsivfsilmf cgidacfgle tpklhvpsvi kptrpdrgwf vapfgknpww vypasilpal
      841 lvtilifmdq qitavivnrk enklkkaagy hldlfwvgil malcsfmglp wyvaatvisi
      901 ahidslkmet etsapgeqpq flgvreqrvt giivfiltgi svflapilkc iplpvlygvf
      961 lymgvaslng iqmgtggsef kiqkkltpfw ercklflmpa khqpdhaflr hvplrrihlf
     1021 tlvqilclav lwilkstvaa iifpvmilgl iivrrlldfi fsqhdlawid nilpekekke
     1081 tdkkrkrkkg ahedcdeepq fpppsvikip mesvqsdpqn gihciarkrs sswsysl
//
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