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RecName: Full=Zinc finger protein 595

UniProtKB/Swiss-Prot: Q8IYB9.2

Identical Proteins FASTA Graphics 

LOCUS       ZN595_HUMAN              648 aa            linear   PRI 27-NOV-2024
DEFINITION  RecName: Full=Zinc finger protein 595.
ACCESSION   Q8IYB9
VERSION     Q8IYB9.2
DBSOURCE    UniProtKB: locus ZN595_HUMAN, accession Q8IYB9;
            class: standard.
            extra accessions:Q7Z3I0
            created: Nov 23, 2004.
            sequence updated: Mar 28, 2018.
            annotation updated: Nov 27, 2024.
            xrefs: BX537887.1, CAD97883.1, AC253576.2, BC036110.1, AAH36110.1,
            BC043151.1, AAH43151.1, NP_001272981.1, NP_001272982.1,
            NP_001272983.1, NP_872330.1
            xrefs (non-sequence databases): CCDS:CCDS75075.1,
            AlphaFoldDB:Q8IYB9, SMR:Q8IYB9, IntAct:Q8IYB9, MINT:Q8IYB9,
            STRING:9606.ENSP00000477392, iPTMnet:Q8IYB9,
            PhosphoSitePlus:Q8IYB9, BioMuta:ZNF595, jPOST:Q8IYB9,
            MassIVE:Q8IYB9, PaxDb:9606-ENSP00000477392, PeptideAtlas:Q8IYB9,
            ProteomicsDB:71154, Pumba:Q8IYB9, Antibodypedia:74373,
            DNASU:152687, Ensembl:ENST00000610261.6, Ensembl:ENSP00000477392.1,
            Ensembl:ENSG00000272602.6, GeneID:152687, KEGG:hsa:152687,
            MANE-Select:ENST00000610261.6, UCSC:uc032szy.1, AGR:HGNC:27196,
            CTD:152687, DisGeNET:152687, GeneCards:ZNF595, HGNC:27196,
            HPA:ENSG00000272602, neXtProt:NX_Q8IYB9,
            OpenTargets:ENSG00000272602, VEuPathDB:HostDB:ENSG00000272602,
            eggNOG:KOG1721, GeneTree:ENSGT00940000161765, InParanoid:Q8IYB9,
            OMA:CEKVISW, OrthoDB:5398495at2759, PhylomeDB:Q8IYB9,
            PathwayCommons:Q8IYB9, Reactome:R-HSA-212436, SignaLink:Q8IYB9,
            BioGRID-ORCS:152687, ChiTaRS:ZNF595, GenomeRNAi:152687,
            Pharos:Q8IYB9, PRO:PR:Q8IYB9, Proteomes:UP000005640, RNAct:Q8IYB9,
            Bgee:ENSG00000272602, ExpressionAtlas:Q8IYB9, GO:0005634,
            GO:0000981, GO:0046872, GO:0000978, GO:0006357, CDD:cd07765,
            FunFam:3.30.160.60:FF:000688, FunFam:3.30.160.60:FF:001702,
            FunFam:3.30.160.60:FF:000034, FunFam:3.30.160.60:FF:001868,
            FunFam:3.30.160.60:FF:002259, FunFam:3.30.160.60:FF:002254,
            FunFam:3.30.160.60:FF:000737, FunFam:3.30.160.60:FF:000015,
            FunFam:3.30.160.60:FF:000362, FunFam:3.30.160.60:FF:000307,
            Gene3D:6.10.140.140, Gene3D:3.30.160.60, InterPro:IPR001909,
            InterPro:IPR036051, InterPro:IPR050826, InterPro:IPR036236,
            InterPro:IPR013087, PANTHER:PTHR24377, PANTHER:PTHR24377:SF938,
            Pfam:PF01352, Pfam:PF00096, SMART:SM00349, SMART:SM00355,
            SUPFAM:SSF57667, SUPFAM:SSF109640, PROSITE:PS50805,
            PROSITE:PS00028, PROSITE:PS50157
KEYWORDS    DNA-binding; Metal-binding; Nucleus; Proteomics identification;
            Reference proteome; Repeat; Transcription; Transcription
            regulation; Zinc; Zinc-finger.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 648)
  AUTHORS   Bechtel,S., Rosenfelder,H., Duda,A., Schmidt,C.P., Ernst,U.,
            Wellenreuther,R., Mehrle,A., Schuster,C., Bahr,A., Blocker,H.,
            Heubner,D., Hoerlein,A., Michel,G., Wedler,H., Kohrer,K.,
            Ottenwalder,B., Poustka,A., Wiemann,S. and Schupp,I.
  TITLE     The full-ORF clone resource of the German cDNA Consortium
  JOURNAL   BMC Genomics 8, 399 (2007)
   PUBMED   17974005
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].;
            TISSUE=Bone marrow {ECO:0000312|EMBL:CAD97883.1}
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 648)
  AUTHORS   Hillier,L.W., Graves,T.A., Fulton,R.S., Fulton,L.A., Pepin,K.H.,
            Minx,P., Wagner-McPherson,C., Layman,D., Wylie,K., Sekhon,M.,
            Becker,M.C., Fewell,G.A., Delehaunty,K.D., Miner,T.L., Nash,W.E.,
            Kremitzki,C., Oddy,L., Du,H., Sun,H., Bradshaw-Cordum,H., Ali,J.,
            Carter,J., Cordes,M., Harris,A., Isak,A., van Brunt,A., Nguyen,C.,
            Du,F., Courtney,L., Kalicki,J., Ozersky,P., Abbott,S.,
            Armstrong,J., Belter,E.A., Caruso,L., Cedroni,M., Cotton,M.,
            Davidson,T., Desai,A., Elliott,G., Erb,T., Fronick,C., Gaige,T.,
            Haakenson,W., Haglund,K., Holmes,A., Harkins,R., Kim,K.,
            Kruchowski,S.S., Strong,C.M., Grewal,N., Goyea,E., Hou,S., Levy,A.,
            Martinka,S., Mead,K., McLellan,M.D., Meyer,R., Randall-Maher,J.,
            Tomlinson,C., Dauphin-Kohlberg,S., Kozlowicz-Reilly,A., Shah,N.,
            Swearengen-Shahid,S., Snider,J., Strong,J.T., Thompson,J.,
            Yoakum,M., Leonard,S., Pearman,C., Trani,L., Radionenko,M.,
            Waligorski,J.E., Wang,C., Rock,S.M., Tin-Wollam,A.M., Maupin,R.,
            Latreille,P., Wendl,M.C., Yang,S.P., Pohl,C., Wallis,J.W.,
            Spieth,J., Bieri,T.A., Berkowicz,N., Nelson,J.O., Osborne,J.,
            Ding,L., Meyer,R., Sabo,A., Shotland,Y., Sinha,P., Wohldmann,P.E.,
            Cook,L.L., Hickenbotham,M.T., Eldred,J., Williams,D., Jones,T.A.,
            She,X., Ciccarelli,F.D., Izaurralde,E., Taylor,J., Schmutz,J.,
            Myers,R.M., Cox,D.R., Huang,X., McPherson,J.D., Mardis,E.R.,
            Clifton,S.W., Warren,W.C., Chinwalla,A.T., Eddy,S.R., Marra,M.A.,
            Ovcharenko,I., Furey,T.S., Miller,W., Eichler,E.E., Bork,P.,
            Suyama,M., Torrents,D., Waterston,R.H. and Wilson,R.K.
  TITLE     Generation and annotation of the DNA sequences of human chromosomes
            2 and 4
  JOURNAL   Nature 434 (7034), 724-731 (2005)
   PUBMED   15815621
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
REFERENCE   3  (residues 1 to 648)
  AUTHORS   Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
            Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
            Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
            Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
            Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
            Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
            Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
            Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
            Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
            Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
            Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
            Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
            Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
            Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
            Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
            Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
            Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
            Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
            Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
            Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
            Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
            Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
            Makowski,K.A., Bosak,S. and Malek,J.
  CONSRTM   MGC Project Team
  TITLE     The status, quality, and expansion of the NIH full-length cDNA
            project: the Mammalian Gene Collection (MGC)
  JOURNAL   Genome Res 14 (10B), 2121-2127 (2004)
   PUBMED   15489334
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].;
            TISSUE=Testis
            Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
            Morin, Ryan]]
COMMENT     On or before Apr 2, 2018 this sequence version replaced
            gi:74762428, Q8IYB9.1.
            [FUNCTION] May be involved in transcriptional regulation.
            [INTERACTION] Q8IYB9; P60371: KRTAP10-6; NbExp=3;
            IntAct=EBI-2682172, EBI-12012928.
            [SUBCELLULAR LOCATION] Nucleus {ECO:0000305}.
            [SIMILARITY] Belongs to the krueppel C2H2-type zinc-finger protein
            family. {ECO:0000305}.
FEATURES             Location/Qualifiers
     source          1..648
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
     gene            1..648
                     /gene="ZNF595"
     Protein         1..648
                     /product="Zinc finger protein 595"
                     /UniProtKB_evidence="Evidence at protein level"
     Region          1..648
                     /region_name="Mature chain"
                     /note="Zinc finger protein 595. /id=PRO_0000047686."
     Region          4..75
                     /region_name="Domain"
                     /note="KRAB.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00119."
     Region          4..64
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          145..167
                     /region_name="Zinc finger region"
                     /note="C2H2-type 1.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
     Region          147..167
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          173..194
                     /region_name="Zinc finger region"
                     /note="C2H2-type 2.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
     Region          175..194
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(175,178,190,194)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Region          198..599
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          200..222
                     /region_name="Zinc finger region"
                     /note="C2H2-type 3.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
     Region          202..222
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(202,205,218,222)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Site            order(207,209,211,213..214,217..218,221,235,237,241..242,
                     245..246,249,263,265,267,269..270,273..274,277)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          228..250
                     /region_name="Zinc finger region"
                     /note="C2H2-type 4.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
     Region          230..250
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          256..278
                     /region_name="Zinc finger region"
                     /note="C2H2-type 5.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
     Region          258..278
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          284..306
                     /region_name="Zinc finger region"
                     /note="C2H2-type 6.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
     Region          286..306
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          299
                     /region_name="Conflict"
                     /note="L -> M (in Ref. 3; AAH36110/AAH43151)."
     Region          312..334
                     /region_name="Zinc finger region"
                     /note="C2H2-type 7.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
     Region          314..334
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          340..362
                     /region_name="Zinc finger region"
                     /note="C2H2-type 8.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
     Region          342..362
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(342,345,358,362)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Region          368..390
                     /region_name="Zinc finger region"
                     /note="C2H2-type 9.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
     Region          370..390
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(370,373,386,390)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Site            order(375,377,379,381..382,385..386,389,403,405,409..410,
                     413..414,417,431,433,435,437..438,441..442,445)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          396..418
                     /region_name="Zinc finger region"
                     /note="C2H2-type 10.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
     Region          397
                     /region_name="Conflict"
                     /note="T -> A (in Ref. 3; AAH36110/AAH43151)."
     Region          398..418
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          424..446
                     /region_name="Zinc finger region"
                     /note="C2H2-type 11.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
     Region          426..446
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          452..474
                     /region_name="Zinc finger region"
                     /note="C2H2-type 12.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
     Region          454..474
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          480..502
                     /region_name="Zinc finger region"
                     /note="C2H2-type 13.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
     Region          482..502
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          508..530
                     /region_name="Zinc finger region"
                     /note="C2H2-type 14.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
     Region          510..530
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          536..558
                     /region_name="Zinc finger region"
                     /note="C2H2-type 15.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
     Region          538..558
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(538,541,554,558)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Region          564..586
                     /region_name="Zinc finger region"
                     /note="C2H2-type 16.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
     Region          566..586
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(566,569,582,586)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Site            order(571,573,575,577..578,581..582,585,599,601,605..606,
                     609..610,613,627,629,631,633..634,637..638,641)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          592..614
                     /region_name="Zinc finger region"
                     /note="C2H2-type 17.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
     Region          594..614
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          606..631
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          620..642
                     /region_name="Zinc finger region"
                     /note="C2H2-type 18.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
     Region          622..642
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          628
                     /region_name="Variant"
                     /note="A -> G (in dbSNP:rs2006764). /id=VAR_061958."
ORIGIN      
        1 melvtfrdva iefspeewkc ldpaqqnlyr dvmlenyrnl vslgfvisnp dlvtcleqik
       61 epcnlkihet aakppaicsp fsqdlspvqg iedsfhklil kryekcghen lqlrkgckrv
      121 neckvqkgvn ngvyqclstt qskifqcntc vkvfskfsns nkhkirhtge kpfkctecgr
      181 sfymshltqh tgihagekpy kcekcgkafn rstslskhkr ihtgekpytc eecgkafrrs
      241 tvlnehkkih tgekpykcee cgkaftrstt lnehkkihtg ekpykckecg kafrwstsln
      301 ehknihtgek pykckecgka frqsrslneh knihtgekpy tcekcgkafn qsssliihrs
      361 ihseqklykc eecgkaftws sslnkhkrih tgekpytcee cgkafyrssh lakhkrihtg
      421 ekpytceecg kafnqsstli lhkrihsgqk pykceecgka ftrsttlneh kkihtgekpy
      481 kceecgkafi wsaslnehkn ihtgekpykc kecgkafnqs sgliihrsih seqklykcee
      541 cgkaftrsta lnehkkihsg ekpykckecg kaynlsstlt khkrihtgek pftceecgka
      601 fnwsssltkh kiihtgeksy kceecgkafn rpstltvhkr ihtgkehs
//
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