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serum amyloid A-1 protein preproprotein [Homo sapiens]

NCBI Reference Sequence: NP_954630.2

Identical Proteins FASTA Graphics 

LOCUS       NP_954630                122 aa            linear   PRI 12-DEC-2024
DEFINITION  serum amyloid A-1 protein preproprotein [Homo sapiens].
ACCESSION   NP_954630
VERSION     NP_954630.2
DBSOURCE    REFSEQ: accession NM_199161.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 122)
  AUTHORS   Bilog,M., Vedad,J., Capadona,C., Profit,A.A. and Desamero,R.Z.B.
  TITLE     Key charged residues influence the amyloidogenic propensity of the
            helix-1 region of serum amyloid A
  JOURNAL   Biochim Biophys Acta Gen Subj 1868 (11), 130690 (2024)
   PUBMED   39117048
  REMARK    GeneRIF: Key charged residues influence the amyloidogenic
            propensity of the helix-1 region of serum amyloid A.
REFERENCE   2  (residues 1 to 122)
  AUTHORS   Rybinska,I., Mangano,N., Romero-Cordoba,S.L., Regondi,V.,
            Ciravolo,V., De Cecco,L., Maffioli,E., Paolini,B., Bianchi,F.,
            Sfondrini,L., Tedeschi,G., Agresti,R., Tagliabue,E. and Triulzi,T.
  TITLE     SAA1-dependent reprogramming of adipocytes by tumor cells is
            associated with triple negative breast cancer aggressiveness
  JOURNAL   Int J Cancer 154 (10), 1842-1856 (2024)
   PUBMED   38289016
  REMARK    GeneRIF: SAA1-dependent reprogramming of adipocytes by tumor cells
            is associated with triple negative breast cancer aggressiveness.
REFERENCE   3  (residues 1 to 122)
  AUTHORS   Huang,X., An,X., Gao,X., Wang,N., Liu,J., Zhang,Y., Qi,G. and
            Zhang,C.
  TITLE     Serum amyloid A facilitates expansion of CD4+ T cell and CD19+ B
            cell subsets implicated in the severity of myasthenia gravis
            patients
  JOURNAL   J Neurochem 168 (3), 224-237 (2024)
   PUBMED   38214332
  REMARK    GeneRIF: Serum amyloid A facilitates expansion of CD4[+] T cell and
            CD19[+] B cell subsets implicated in the severity of myasthenia
            gravis patients.
REFERENCE   4  (residues 1 to 122)
  AUTHORS   Zheng,H., Li,H., Zhang,J., Fan,H., Jia,L., Ma,W., Ma,S., Wang,S.,
            You,H., Yin,Z. and Li,X.
  TITLE     Serum amyloid A exhibits pH dependent antibacterial action and
            contributes to host defense against Staphylococcus aureus cutaneous
            infection
  JOURNAL   J Biol Chem 295 (9), 2570-2581 (2020)
   PUBMED   31819008
  REMARK    GeneRIF: SAA1 displays antimicrobial activity against S. aureus and
            E. coli.
REFERENCE   5  (residues 1 to 122)
  AUTHORS   Beach,C.M., De Beer,M.C., Sipe,J.D., Loose,L.D. and De Beer,F.C.
  TITLE     Human serum amyloid A protein. Complete amino acid sequence of a
            new variant
  JOURNAL   Biochem J 282 (Pt 2) (Pt 2), 615-620 (1992)
   PUBMED   1546977
REFERENCE   6  (residues 1 to 122)
  AUTHORS   Betts,J.C., Edbrooke,M.R., Thakker,R.V. and Woo,P.
  TITLE     The human acute-phase serum amyloid A gene family: structure,
            evolution and expression in hepatoma cells
  JOURNAL   Scand J Immunol 34 (4), 471-482 (1991)
   PUBMED   1656519
REFERENCE   7  (residues 1 to 122)
  AUTHORS   Zimlichman,S., Danon,A., Nathan,I., Mozes,G. and
            Shainkin-Kestenbaum,R.
  TITLE     Serum amyloid A, an acute phase protein, inhibits platelet
            activation
  JOURNAL   J Lab Clin Med 116 (2), 180-186 (1990)
   PUBMED   1697614
REFERENCE   8  (residues 1 to 122)
  AUTHORS   Woo,P., Sipe,J., Dinarello,C.A. and Colten,H.R.
  TITLE     Structure of a human serum amyloid A gene and modulation of its
            expression in transfected L cells
  JOURNAL   J Biol Chem 262 (32), 15790-15795 (1987)
   PUBMED   2890635
REFERENCE   9  (residues 1 to 122)
  AUTHORS   Sipe,J.D., Colten,H.R., Goldberger,G., Edge,M.D., Tack,B.F.,
            Cohen,A.S. and Whitehead,A.S.
  TITLE     Human serum amyloid A (SAA): biosynthesis and postsynthetic
            processing of preSAA and structural variants defined by
            complementary DNA
  JOURNAL   Biochemistry 24 (12), 2931-2936 (1985)
   PUBMED   3839415
REFERENCE   10 (residues 1 to 122)
  AUTHORS   Sletten,K., Husby,G. and Natvig,J.B.
  TITLE     The complete amino acid sequence of an amyloid fibril protein AA1
            of unusual size (64 residues)
  JOURNAL   Biochem Biophys Res Commun 69 (1), 19-25 (1976)
   PUBMED   1259755
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC107948.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NP_954630.1.
            
            Summary: This gene encodes a member of the serum amyloid A family
            of apolipoproteins. The encoded preproprotein is proteolytically
            processed to generate the mature protein. This protein is a major
            acute phase protein that is highly expressed in response to
            inflammation and tissue injury. This protein also plays an
            important role in HDL metabolism and cholesterol homeostasis. High
            levels of this protein are associated with chronic inflammatory
            diseases including atherosclerosis, rheumatoid arthritis,
            Alzheimer's disease and Crohn's disease. This protein may also be a
            potential biomarker for certain tumors. Finally, antimicrobial
            activity against S. aureus and E. coli resides in the N-terminal
            portion of the mature protein. Alternate splicing results in
            multiple transcript variants that encode the same protein. A
            pseudogene of this gene is found on chromosome 11. [provided by
            RefSeq, Jul 2020].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX490424.1, SRR5189664.126194.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000356524.9/
                                                  ENSP00000348918.4
            Protein has antimicrobial activity :: PMID: 31819008
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..122
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     Protein         1..122
                     /product="serum amyloid A-1 protein preproprotein"
                     /note="tumor protein p53 inducible protein 4; serum
                     amyloid A protein; serum amyloid A-1 protein"
                     /calculated_mol_wt=11697
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1867
     Region          19..45
                     /region_name="Important for amyloid formation, forms
                     amyloid fibrils in vitro"
                     /note="propagated from UniProtKB/Swiss-Prot (P0DJI8.2)"
     Region          22..122
                     /region_name="SAA"
                     /note="Serum amyloid A protein; pfam00277"
                     /db_xref="CDD:459744"
     mat_peptide     25..122
                     /product="serum amyloid A-1 protein"
                     /name="serum amyloid antimicrobial protein"
                     /calculated_mol_wt=10925
     Region          98..122
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P0DJI8.2)"
     Site            101
                     /site_type="methylation"
                     /note="N4,N4-dimethylasparagine.
                     /evidence=ECO:0000305|PubMed:8783012; propagated from
                     UniProtKB/Swiss-Prot (P0DJI8.2)"
     CDS             1..122
                     /gene="SAA1"
                     /gene_synonym="PIG4; SAA; SAA2; TP53I4"
                     /coded_by="NM_199161.5:38..406"
                     /db_xref="CCDS:CCDS7835.1"
                     /db_xref="GeneID:6288"
                     /db_xref="HGNC:HGNC:10513"
                     /db_xref="MIM:104750"
ORIGIN      
        1 mklltglvfc slvlgvssrs ffsflgeafd gardmwrays dmreanyigs dkyfhargny
       61 daakrgpgga waaevitdar eniqrffghg aedsladqaa newgrsgkdp nhfrpaglpe
      121 ky
//
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