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docking protein 3 [Rattus norvegicus]

NCBI Reference Sequence: NP_001100806.1

Identical Proteins FASTA Graphics 

LOCUS       NP_001100806             444 aa            linear   ROD 03-APR-2024
DEFINITION  docking protein 3 [Rattus norvegicus].
ACCESSION   NP_001100806 XP_001069255 XP_225170
VERSION     NP_001100806.1
DBSOURCE    REFSEQ: accession NM_001107336.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 444)
  AUTHORS   Kang,B.W., Jeon,H.S., Chae,Y.S., Lee,S.J., Park,J.S., Choi,G.S. and
            Kim,J.G.
  TITLE     Impact of Genetic Variation in MicroRNA-binding Site on
            Susceptibility to Colorectal Cancer
  JOURNAL   Anticancer Res 36 (7), 3353-3361 (2016)
   PUBMED   27354594
REFERENCE   2  (residues 1 to 444)
  AUTHORS   Berger,A.H., Niki,M., Morotti,A., Taylor,B.S., Socci,N.D.,
            Viale,A., Brennan,C., Szoke,J., Motoi,N., Rothman,P.B.,
            Teruya-Feldstein,J., Gerald,W.L., Ladanyi,M. and Pandolfi,P.P.
  TITLE     Identification of DOK genes as lung tumor suppressors
  JOURNAL   Nat Genet 42 (3), 216-223 (2010)
   PUBMED   20139980
REFERENCE   3  (residues 1 to 444)
  AUTHORS   Cong,F., Yuan,B. and Goff,S.P.
  TITLE     Characterization of a novel member of the DOK family that binds and
            modulates Abl signaling
  JOURNAL   Mol Cell Biol 19 (12), 8314-8325 (1999)
   PUBMED   10567556
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474032.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_225170.3, XP_001069255.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166772.1, FQ235097.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132301, SAMD00132307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     Protein         1..444
                     /product="docking protein 3"
                     /note="downstream of tyrosine kinase 3"
                     /calculated_mol_wt=48059
     Region          9..123
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          47..66
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (B2RYG7.1)"
     Site            138
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7L591; propagated from
                     UniProtKB/Swiss-Prot (B2RYG7.1)"
     Region          157..255
                     /region_name="PTB_DOK1_DOK2_DOK3"
                     /note="Downstream of tyrosine kinase 1, 2, and 3 proteins
                     phosphotyrosine-binding domain (PTBi); cd01203"
                     /db_xref="CDD:269914"
     Site            order(167,173)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269914"
     Site            order(205..213,219,223..224,244,251,254)
                     /site_type="other"
                     /note="phosphopeptide binding site [polypeptide binding]"
                     /db_xref="CDD:269914"
     Site            274
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (B2RYG7.1)"
     Site            308
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QZK7; propagated from
                     UniProtKB/Swiss-Prot (B2RYG7.1)"
     Site            314
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QZK7; propagated from
                     UniProtKB/Swiss-Prot (B2RYG7.1)"
     Site            325
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q9QZK7; propagated from
                     UniProtKB/Swiss-Prot (B2RYG7.1)"
     Region          354..390
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (B2RYG7.1)"
     Site            371
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QZK7; propagated from
                     UniProtKB/Swiss-Prot (B2RYG7.1)"
     CDS             1..444
                     /gene="Dok3"
                     /coded_by="NM_001107336.1:25..1359"
                     /db_xref="GeneID:306760"
                     /db_xref="RGD:1311840"
ORIGIN      
        1 mesvetpvkd gllyqqhmkf gkkcwrkvwa llyaggpsgv arleswdvrd gglgpggdrp
       61 agpgrrgerr iirladcvsv lpadgescpr dtgaflittt ershllaaqh rqswmdpicq
      121 lafpstgecs sgsgqaespk rgfvpmeens iysswqevae fpvvvqrtea ttrcqlkgpy
      181 llvlgqddiq lretskpqac yswpyrflrk fgsdkgvfsf eagrrcdsge glfafsspra
      241 pdicgavaaa iarqrerlpe lamsppcplp ralslpslep pgelrevape yelapsrklp
      301 ltdpgpqslp lllsptqdgt asslyasvck qtskhkatve hlyenvfmle aspglsnggp
      361 eaqegppggr splgspiyhn seelswpgsa hdsnleaqyr rlleleldda ggagrpgaqt
      421 gikaklvtll trerkkgpap cdrp
//
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