LOCUS NP_001100806 444 aa linear ROD 03-APR-2024
DEFINITION docking protein 3 [Rattus norvegicus].
ACCESSION NP_001100806 XP_001069255 XP_225170
VERSION NP_001100806.1
DBSOURCE REFSEQ: accession NM_001107336.1
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (residues 1 to 444)
AUTHORS Kang,B.W., Jeon,H.S., Chae,Y.S., Lee,S.J., Park,J.S., Choi,G.S. and
Kim,J.G.
TITLE Impact of Genetic Variation in MicroRNA-binding Site on
Susceptibility to Colorectal Cancer
JOURNAL Anticancer Res 36 (7), 3353-3361 (2016)
PUBMED 27354594
REFERENCE 2 (residues 1 to 444)
AUTHORS Berger,A.H., Niki,M., Morotti,A., Taylor,B.S., Socci,N.D.,
Viale,A., Brennan,C., Szoke,J., Motoi,N., Rothman,P.B.,
Teruya-Feldstein,J., Gerald,W.L., Ladanyi,M. and Pandolfi,P.P.
TITLE Identification of DOK genes as lung tumor suppressors
JOURNAL Nat Genet 42 (3), 216-223 (2010)
PUBMED 20139980
REFERENCE 3 (residues 1 to 444)
AUTHORS Cong,F., Yuan,B. and Goff,S.P.
TITLE Characterization of a novel member of the DOK family that binds and
modulates Abl signaling
JOURNAL Mol Cell Biol 19 (12), 8314-8325 (1999)
PUBMED 10567556
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from CH474032.1.
On or before Oct 4, 2007 this sequence version replaced
XP_225170.3, XP_001069255.1.
##Evidence-Data-START##
Transcript exon combination :: BC166772.1, FQ235097.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMD00132301, SAMD00132307
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..444
/organism="Rattus norvegicus"
/db_xref="taxon:10116"
/chromosome="17"
/map="17p14"
Protein 1..444
/product="docking protein 3"
/note="downstream of tyrosine kinase 3"
/calculated_mol_wt=48059
Region 9..123
/region_name="PH-like"
/note="Pleckstrin homology-like domain; cl17171"
/db_xref="CDD:473070"
Region 47..66
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (B2RYG7.1)"
Site 138
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q7L591; propagated from
UniProtKB/Swiss-Prot (B2RYG7.1)"
Region 157..255
/region_name="PTB_DOK1_DOK2_DOK3"
/note="Downstream of tyrosine kinase 1, 2, and 3 proteins
phosphotyrosine-binding domain (PTBi); cd01203"
/db_xref="CDD:269914"
Site order(167,173)
/site_type="other"
/note="putative phosphoinositide binding site [chemical
binding]"
/db_xref="CDD:269914"
Site order(205..213,219,223..224,244,251,254)
/site_type="other"
/note="phosphopeptide binding site [polypeptide binding]"
/db_xref="CDD:269914"
Site 274
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (B2RYG7.1)"
Site 308
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q9QZK7; propagated from
UniProtKB/Swiss-Prot (B2RYG7.1)"
Site 314
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q9QZK7; propagated from
UniProtKB/Swiss-Prot (B2RYG7.1)"
Site 325
/site_type="phosphorylation"
/note="Phosphotyrosine.
/evidence=ECO:0000250|UniProtKB:Q9QZK7; propagated from
UniProtKB/Swiss-Prot (B2RYG7.1)"
Region 354..390
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (B2RYG7.1)"
Site 371
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q9QZK7; propagated from
UniProtKB/Swiss-Prot (B2RYG7.1)"
CDS 1..444
/gene="Dok3"
/coded_by="NM_001107336.1:25..1359"
/db_xref="GeneID:306760"
/db_xref="RGD:1311840"
ORIGIN
1 mesvetpvkd gllyqqhmkf gkkcwrkvwa llyaggpsgv arleswdvrd gglgpggdrp
61 agpgrrgerr iirladcvsv lpadgescpr dtgaflittt ershllaaqh rqswmdpicq
121 lafpstgecs sgsgqaespk rgfvpmeens iysswqevae fpvvvqrtea ttrcqlkgpy
181 llvlgqddiq lretskpqac yswpyrflrk fgsdkgvfsf eagrrcdsge glfafsspra
241 pdicgavaaa iarqrerlpe lamsppcplp ralslpslep pgelrevape yelapsrklp
301 ltdpgpqslp lllsptqdgt asslyasvck qtskhkatve hlyenvfmle aspglsnggp
361 eaqegppggr splgspiyhn seelswpgsa hdsnleaqyr rlleleldda ggagrpgaqt
421 gikaklvtll trerkkgpap cdrp
//