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centlein isoform 2 [Homo sapiens]

NCBI Reference Sequence: NP_001107867.1

Identical Proteins FASTA Graphics 

LOCUS       NP_001107867             391 aa            linear   PRI 21-SEP-2024
DEFINITION  centlein isoform 2 [Homo sapiens].
ACCESSION   NP_001107867
VERSION     NP_001107867.1
DBSOURCE    REFSEQ: accession NM_001114395.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 391)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (residues 1 to 391)
  AUTHORS   Jing,Z., Yin,H., Wang,P., Gao,J. and Yuan,L.
  TITLE     Centlein, a novel microtubule-associated protein stabilizing
            microtubules and involved in neurite formation
  JOURNAL   Biochem Biophys Res Commun 472 (2), 360-365 (2016)
   PUBMED   26915804
  REMARK    GeneRIF: Taken together, we propose that centlein is involved in MT
            stability and neuritogenesis in vivo.
REFERENCE   3  (residues 1 to 391)
  AUTHORS   Fang,G., Zhang,D., Yin,H., Zheng,L., Bi,X. and Yuan,L.
  TITLE     Centlein mediates an interaction between C-Nap1 and Cep68 to
            maintain centrosome cohesion
  JOURNAL   J Cell Sci 127 (Pt 8), 1631-1639 (2014)
   PUBMED   24554434
  REMARK    GeneRIF: Centlein complexes with C-Nap1 and Cep68 at the proximal
            ends of centrioles during interphase.
REFERENCE   4  (residues 1 to 391)
  AUTHORS   Menni,C., Boffi,L., Cesana,F., Viviani Anselmi,C., Nava,S.,
            Bertola,F., Blasio,A.M., Roncarati,R., Trimarco,V., Marino,M.,
            Trimarco,B., Grassi,G., Giannattasio,C. and Mancia,G.
  TITLE     Variant on chromosome 9p is associated with left ventricular mass:
            results from two cohorts of essential hypertensive individuals
  JOURNAL   J Hypertens 30 (11), 2144-2150 (2012)
   PUBMED   22940680
  REMARK    GeneRIF: identified a SNP (rs894379) in the intronic region of the
            centlein, centrosomal protein (CNTLN) gene on chromosome 9p22,
            whose minor allele G is associated with an increased left
            ventricular mass
REFERENCE   5  (residues 1 to 391)
  AUTHORS   Imboden,M., Bouzigon,E., Curjuric,I., Ramasamy,A., Kumar,A.,
            Hancock,D.B., Wilk,J.B., Vonk,J.M., Thun,G.A., Siroux,V., Nadif,R.,
            Monier,F., Gonzalez,J.R., Wjst,M., Heinrich,J., Loehr,L.R.,
            Franceschini,N., North,K.E., Altmuller,J., Koppelman,G.H.,
            Guerra,S., Kronenberg,F., Lathrop,M., Moffatt,M.F., O'Connor,G.T.,
            Strachan,D.P., Postma,D.S., London,S.J., Schindler,C.,
            Kogevinas,M., Kauffmann,F., Jarvis,D.L., Demenais,F. and
            Probst-Hensch,N.M.
  TITLE     Genome-wide association study of lung function decline in adults
            with and without asthma
  JOURNAL   J Allergy Clin Immunol 129 (5), 1218-1228 (2012)
   PUBMED   22424883
REFERENCE   6  (residues 1 to 391)
  AUTHORS   Hart,A.B., Engelhardt,B.E., Wardle,M.C., Sokoloff,G., Stephens,M.,
            de Wit,H. and Palmer,A.A.
  TITLE     Genome-wide association study of d-amphetamine response in healthy
            volunteers identifies putative associations, including cadherin 13
            (CDH13)
  JOURNAL   PLoS One 7 (8), e42646 (2012)
   PUBMED   22952603
REFERENCE   7  (residues 1 to 391)
  AUTHORS   Song,H., Ramus,S.J., Tyrer,J., Bolton,K.L., Gentry-Maharaj,A.,
            Wozniak,E., Anton-Culver,H., Chang-Claude,J., Cramer,D.W.,
            DiCioccio,R., Dork,T., Goode,E.L., Goodman,M.T., Schildkraut,J.M.,
            Sellers,T., Baglietto,L., Beckmann,M.W., Beesley,J., Blaakaer,J.,
            Carney,M.E., Chanock,S., Chen,Z., Cunningham,J.M., Dicks,E.,
            Doherty,J.A., Durst,M., Ekici,A.B., Fenstermacher,D., Fridley,B.L.,
            Giles,G., Gore,M.E., De Vivo,I., Hillemanns,P., Hogdall,C.,
            Hogdall,E., Iversen,E.S., Jacobs,I.J., Jakubowska,A., Li,D.,
            Lissowska,J., Lubinski,J., Lurie,G., McGuire,V., McLaughlin,J.,
            Medrek,K., Moorman,P.G., Moysich,K., Narod,S., Phelan,C., Pye,C.,
            Risch,H., Runnebaum,I.B., Severi,G., Southey,M., Stram,D.O.,
            Thiel,F.C., Terry,K.L., Tsai,Y.Y., Tworoger,S.S., Van Den
            Berg,D.J., Vierkant,R.A., Wang-Gohrke,S., Webb,P.M., Wilkens,L.R.,
            Wu,A.H., Yang,H., Brewster,W., Ziogas,A., Houlston,R.,
            Tomlinson,I., Whittemore,A.S., Rossing,M.A., Ponder,B.A.,
            Pearce,C.L., Ness,R.B., Menon,U., Kjaer,S.K., Gronwald,J.,
            Garcia-Closas,M., Fasching,P.A., Easton,D.F., Chenevix-Trench,G.,
            Berchuck,A., Pharoah,P.D. and Gayther,S.A.
  CONSRTM   Australian Cancer (Ovarian) Study; Australian Ovarian Cancer Study
            Group; Ovarian Cancer Association Consortium
  TITLE     A genome-wide association study identifies a new ovarian cancer
            susceptibility locus on 9p22.2
  JOURNAL   Nat Genet 41 (9), 996-1000 (2009)
   PUBMED   19648919
REFERENCE   8  (residues 1 to 391)
  AUTHORS   Kim,Y.C., Wu,Q., Chen,J., Xuan,Z., Jung,Y.C., Zhang,M.Q.,
            Rowley,J.D. and Wang,S.M.
  TITLE     The transcriptome of human CD34+ hematopoietic stem-progenitor
            cells
  JOURNAL   Proc Natl Acad Sci U S A 106 (20), 8278-8283 (2009)
   PUBMED   19416867
REFERENCE   9  (residues 1 to 391)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   10 (residues 1 to 391)
  AUTHORS   Makino,K., Umeda,K., Uezu,A., Hiragami,Y., Sakamoto,T., Ihn,H. and
            Nakanishi,H.
  TITLE     Identification and characterization of the novel centrosomal
            protein centlein
  JOURNAL   Biochem Biophys Res Commun 366 (4), 958-962 (2008)
   PUBMED   18086554
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK098502.1, AL354711.24 and AW136479.1.
            
            Transcript Variant: This variant (2) lacks several exons in the
            central and 3' regions but includes an alternate 3' terminal exon,
            and it thus differs in its 3' coding region and 3' UTR, compared to
            variant 1. The encoded isoform (2) has a distinct C-terminus and is
            significantly shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK098502.1, SRR3476690.735304.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..391
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p22.2"
     Protein         1..391
                     /product="centlein isoform 2"
                     /note="centrosomal protein; centlein, centrosomal protein"
                     /calculated_mol_wt=44456
     Region          1..79
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NXG0.6)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:A2AM05; propagated from
                     UniProtKB/Swiss-Prot (Q9NXG0.6)"
     Site            5
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:A2AM05; propagated from
                     UniProtKB/Swiss-Prot (Q9NXG0.6)"
     Site            22
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9NXG0.6)"
     Region          131..>364
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..391
                     /gene="CNTLN"
                     /gene_synonym="bA340N12.1; C9orf101; C9orf39"
                     /coded_by="NM_001114395.3:27..1202"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS47953.1"
                     /db_xref="GeneID:54875"
                     /db_xref="HGNC:HGNC:23432"
                     /db_xref="MIM:611870"
ORIGIN      
        1 maarsppsph pspparqlgp rsprvgrgae vhamrseasg fagaarevva desdkiwvge
       61 egsggrrgpg gaapahapll sapmgsrrle gisveeamvt rtqlleeels slkeelalcq
      121 adkefvwslw krlqvtnpdl tqvvslvver ekqkseakdr kvleilqvkd akiqefeqre
      181 svlkqeindl vkrkiavdee naflrkefsd lekkfkdksq eikdtkecvq nkeeqnrlvi
      241 knleeenkkl strctdllnd leklrkqeah lrkekystda kiktfednli earkevevsq
      301 skynalslql snkqteliqk dmditlvrke lqelqnlykq nsthtaqqae liqqlqvlnm
      361 dtqkvlrnqe dvhtaesisy qkvcfysvik m
//
Feature
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