LOCUS NP_001107867 391 aa linear PRI 21-SEP-2024
DEFINITION centlein isoform 2 [Homo sapiens].
ACCESSION NP_001107867
VERSION NP_001107867.1
DBSOURCE REFSEQ: accession NM_001114395.3
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 391)
AUTHORS Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 2 (residues 1 to 391)
AUTHORS Jing,Z., Yin,H., Wang,P., Gao,J. and Yuan,L.
TITLE Centlein, a novel microtubule-associated protein stabilizing
microtubules and involved in neurite formation
JOURNAL Biochem Biophys Res Commun 472 (2), 360-365 (2016)
PUBMED 26915804
REMARK GeneRIF: Taken together, we propose that centlein is involved in MT
stability and neuritogenesis in vivo.
REFERENCE 3 (residues 1 to 391)
AUTHORS Fang,G., Zhang,D., Yin,H., Zheng,L., Bi,X. and Yuan,L.
TITLE Centlein mediates an interaction between C-Nap1 and Cep68 to
maintain centrosome cohesion
JOURNAL J Cell Sci 127 (Pt 8), 1631-1639 (2014)
PUBMED 24554434
REMARK GeneRIF: Centlein complexes with C-Nap1 and Cep68 at the proximal
ends of centrioles during interphase.
REFERENCE 4 (residues 1 to 391)
AUTHORS Menni,C., Boffi,L., Cesana,F., Viviani Anselmi,C., Nava,S.,
Bertola,F., Blasio,A.M., Roncarati,R., Trimarco,V., Marino,M.,
Trimarco,B., Grassi,G., Giannattasio,C. and Mancia,G.
TITLE Variant on chromosome 9p is associated with left ventricular mass:
results from two cohorts of essential hypertensive individuals
JOURNAL J Hypertens 30 (11), 2144-2150 (2012)
PUBMED 22940680
REMARK GeneRIF: identified a SNP (rs894379) in the intronic region of the
centlein, centrosomal protein (CNTLN) gene on chromosome 9p22,
whose minor allele G is associated with an increased left
ventricular mass
REFERENCE 5 (residues 1 to 391)
AUTHORS Imboden,M., Bouzigon,E., Curjuric,I., Ramasamy,A., Kumar,A.,
Hancock,D.B., Wilk,J.B., Vonk,J.M., Thun,G.A., Siroux,V., Nadif,R.,
Monier,F., Gonzalez,J.R., Wjst,M., Heinrich,J., Loehr,L.R.,
Franceschini,N., North,K.E., Altmuller,J., Koppelman,G.H.,
Guerra,S., Kronenberg,F., Lathrop,M., Moffatt,M.F., O'Connor,G.T.,
Strachan,D.P., Postma,D.S., London,S.J., Schindler,C.,
Kogevinas,M., Kauffmann,F., Jarvis,D.L., Demenais,F. and
Probst-Hensch,N.M.
TITLE Genome-wide association study of lung function decline in adults
with and without asthma
JOURNAL J Allergy Clin Immunol 129 (5), 1218-1228 (2012)
PUBMED 22424883
REFERENCE 6 (residues 1 to 391)
AUTHORS Hart,A.B., Engelhardt,B.E., Wardle,M.C., Sokoloff,G., Stephens,M.,
de Wit,H. and Palmer,A.A.
TITLE Genome-wide association study of d-amphetamine response in healthy
volunteers identifies putative associations, including cadherin 13
(CDH13)
JOURNAL PLoS One 7 (8), e42646 (2012)
PUBMED 22952603
REFERENCE 7 (residues 1 to 391)
AUTHORS Song,H., Ramus,S.J., Tyrer,J., Bolton,K.L., Gentry-Maharaj,A.,
Wozniak,E., Anton-Culver,H., Chang-Claude,J., Cramer,D.W.,
DiCioccio,R., Dork,T., Goode,E.L., Goodman,M.T., Schildkraut,J.M.,
Sellers,T., Baglietto,L., Beckmann,M.W., Beesley,J., Blaakaer,J.,
Carney,M.E., Chanock,S., Chen,Z., Cunningham,J.M., Dicks,E.,
Doherty,J.A., Durst,M., Ekici,A.B., Fenstermacher,D., Fridley,B.L.,
Giles,G., Gore,M.E., De Vivo,I., Hillemanns,P., Hogdall,C.,
Hogdall,E., Iversen,E.S., Jacobs,I.J., Jakubowska,A., Li,D.,
Lissowska,J., Lubinski,J., Lurie,G., McGuire,V., McLaughlin,J.,
Medrek,K., Moorman,P.G., Moysich,K., Narod,S., Phelan,C., Pye,C.,
Risch,H., Runnebaum,I.B., Severi,G., Southey,M., Stram,D.O.,
Thiel,F.C., Terry,K.L., Tsai,Y.Y., Tworoger,S.S., Van Den
Berg,D.J., Vierkant,R.A., Wang-Gohrke,S., Webb,P.M., Wilkens,L.R.,
Wu,A.H., Yang,H., Brewster,W., Ziogas,A., Houlston,R.,
Tomlinson,I., Whittemore,A.S., Rossing,M.A., Ponder,B.A.,
Pearce,C.L., Ness,R.B., Menon,U., Kjaer,S.K., Gronwald,J.,
Garcia-Closas,M., Fasching,P.A., Easton,D.F., Chenevix-Trench,G.,
Berchuck,A., Pharoah,P.D. and Gayther,S.A.
CONSRTM Australian Cancer (Ovarian) Study; Australian Ovarian Cancer Study
Group; Ovarian Cancer Association Consortium
TITLE A genome-wide association study identifies a new ovarian cancer
susceptibility locus on 9p22.2
JOURNAL Nat Genet 41 (9), 996-1000 (2009)
PUBMED 19648919
REFERENCE 8 (residues 1 to 391)
AUTHORS Kim,Y.C., Wu,Q., Chen,J., Xuan,Z., Jung,Y.C., Zhang,M.Q.,
Rowley,J.D. and Wang,S.M.
TITLE The transcriptome of human CD34+ hematopoietic stem-progenitor
cells
JOURNAL Proc Natl Acad Sci U S A 106 (20), 8278-8283 (2009)
PUBMED 19416867
REFERENCE 9 (residues 1 to 391)
AUTHORS Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
TITLE Large-scale proteomics and phosphoproteomics of urinary exosomes
JOURNAL J Am Soc Nephrol 20 (2), 363-379 (2009)
PUBMED 19056867
REFERENCE 10 (residues 1 to 391)
AUTHORS Makino,K., Umeda,K., Uezu,A., Hiragami,Y., Sakamoto,T., Ihn,H. and
Nakanishi,H.
TITLE Identification and characterization of the novel centrosomal
protein centlein
JOURNAL Biochem Biophys Res Commun 366 (4), 958-962 (2008)
PUBMED 18086554
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK098502.1, AL354711.24 and AW136479.1.
Transcript Variant: This variant (2) lacks several exons in the
central and 3' regions but includes an alternate 3' terminal exon,
and it thus differs in its 3' coding region and 3' UTR, compared to
variant 1. The encoded isoform (2) has a distinct C-terminus and is
significantly shorter than isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
##Evidence-Data-START##
Transcript exon combination :: AK098502.1, SRR3476690.735304.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1968189
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..391
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="9"
/map="9p22.2"
Protein 1..391
/product="centlein isoform 2"
/note="centrosomal protein; centlein, centrosomal protein"
/calculated_mol_wt=44456
Region 1..79
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q9NXG0.6)"
Site 2
/site_type="acetylation"
/note="N-acetylalanine.
/evidence=ECO:0000250|UniProtKB:A2AM05; propagated from
UniProtKB/Swiss-Prot (Q9NXG0.6)"
Site 5
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:A2AM05; propagated from
UniProtKB/Swiss-Prot (Q9NXG0.6)"
Site 22
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:23186163; propagated from
UniProtKB/Swiss-Prot (Q9NXG0.6)"
Region 131..>364
/region_name="SMC_prok_B"
/note="chromosome segregation protein SMC, common
bacterial type; TIGR02168"
/db_xref="CDD:274008"
CDS 1..391
/gene="CNTLN"
/gene_synonym="bA340N12.1; C9orf101; C9orf39"
/coded_by="NM_001114395.3:27..1202"
/note="isoform 2 is encoded by transcript variant 2"
/db_xref="CCDS:CCDS47953.1"
/db_xref="GeneID:54875"
/db_xref="HGNC:HGNC:23432"
/db_xref="MIM:611870"
ORIGIN
1 maarsppsph pspparqlgp rsprvgrgae vhamrseasg fagaarevva desdkiwvge
61 egsggrrgpg gaapahapll sapmgsrrle gisveeamvt rtqlleeels slkeelalcq
121 adkefvwslw krlqvtnpdl tqvvslvver ekqkseakdr kvleilqvkd akiqefeqre
181 svlkqeindl vkrkiavdee naflrkefsd lekkfkdksq eikdtkecvq nkeeqnrlvi
241 knleeenkkl strctdllnd leklrkqeah lrkekystda kiktfednli earkevevsq
301 skynalslql snkqteliqk dmditlvrke lqelqnlykq nsthtaqqae liqqlqvlnm
361 dtqkvlrnqe dvhtaesisy qkvcfysvik m
//