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RecName: Full=Homeobox protein unc-4 homolog; AltName: Full=Homeobox protein Uncx4.1

UniProtKB/Swiss-Prot: A6NJT0.1

Identical Proteins FASTA Graphics 

LOCUS       UNC4_HUMAN               531 aa            linear   PRI 27-NOV-2024
DEFINITION  RecName: Full=Homeobox protein unc-4 homolog; AltName:
            Full=Homeobox protein Uncx4.1.
ACCESSION   A6NJT0
VERSION     A6NJT0.1
DBSOURCE    UniProtKB: locus UNC4_HUMAN, accession A6NJT0;
            class: standard.
            extra accessions:A4D221
            created: May 20, 2008.
            sequence updated: Jul 24, 2007.
            annotation updated: Nov 27, 2024.
            xrefs: AC073094.11, CH236953.1, EAL23940.1, NP_001073930.1
            xrefs (non-sequence databases): CCDS:CCDS34583.1,
            AlphaFoldDB:A6NJT0, BioGRID:131024, STRING:9606.ENSP00000314480,
            iPTMnet:A6NJT0, PhosphoSitePlus:A6NJT0, BioMuta:UNCX,
            MassIVE:A6NJT0, PaxDb:9606-ENSP00000314480, PeptideAtlas:A6NJT0,
            ProteomicsDB:1352, Antibodypedia:24186, DNASU:340260,
            Ensembl:ENST00000316333.9, Ensembl:ENSP00000314480.8,
            Ensembl:ENSG00000164853.9, GeneID:340260, KEGG:hsa:340260,
            MANE-Select:ENST00000316333.9, UCSC:uc011jvw.3, AGR:HGNC:33194,
            CTD:340260, DisGeNET:340260, GeneCards:UNCX, HGNC:33194,
            HPA:ENSG00000164853, neXtProt:NX_A6NJT0,
            OpenTargets:ENSG00000164853, PharmGKB:PA162408642,
            VEuPathDB:HostDB:ENSG00000164853, eggNOG:KOG0490,
            GeneTree:ENSGT00940000161420, HOGENOM:CLU_041996_0_0_1,
            InParanoid:A6NJT0, OMA:DKDAAPC, OrthoDB:2902937at2759,
            PhylomeDB:A6NJT0, TreeFam:TF315554, PathwayCommons:A6NJT0,
            BioGRID-ORCS:340260, GenomeRNAi:340260, Pharos:A6NJT0,
            PRO:PR:A6NJT0, Proteomes:UP000005640, RNAct:A6NJT0,
            Bgee:ENSG00000164853, GO:0000785, GO:0005634, GO:0000981,
            GO:1990837, GO:0001502, GO:0035726, GO:0021516, GO:0021889,
            GO:0007389, GO:0045595, GO:0010468, CDD:cd00086,
            FunFam:1.10.10.60:FF:000057, Gene3D:1.10.10.60, InterPro:IPR001356,
            InterPro:IPR017970, InterPro:IPR009057, PANTHER:PTHR46799,
            PANTHER:PTHR46799:SF1, Pfam:PF00046, SMART:SM00389,
            SUPFAM:SSF46689, PROSITE:PS00027, PROSITE:PS50071
KEYWORDS    Developmental protein; Differentiation; DNA-binding; Homeobox;
            Neurogenesis; Nucleus; Proteomics identification; Reference
            proteome; Transcription; Transcription regulation.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 531)
  AUTHORS   Hillier,L.W., Fulton,R.S., Fulton,L.A., Graves,T.A., Pepin,K.H.,
            Wagner-McPherson,C., Layman,D., Maas,J., Jaeger,S., Walker,R.,
            Wylie,K., Sekhon,M., Becker,M.C., O'Laughlin,M.D., Schaller,M.E.,
            Fewell,G.A., Delehaunty,K.D., Miner,T.L., Nash,W.E., Cordes,M.,
            Du,H., Sun,H., Edwards,J., Bradshaw-Cordum,H., Ali,J., Andrews,S.,
            Isak,A., Vanbrunt,A., Nguyen,C., Du,F., Lamar,B., Courtney,L.,
            Kalicki,J., Ozersky,P., Bielicki,L., Scott,K., Holmes,A.,
            Harkins,R., Harris,A., Strong,C.M., Hou,S., Tomlinson,C.,
            Dauphin-Kohlberg,S., Kozlowicz-Reilly,A., Leonard,S., Rohlfing,T.,
            Rock,S.M., Tin-Wollam,A.M., Abbott,A., Minx,P., Maupin,R.,
            Strowmatt,C., Latreille,P., Miller,N., Johnson,D., Murray,J.,
            Woessner,J.P., Wendl,M.C., Yang,S.P., Schultz,B.R., Wallis,J.W.,
            Spieth,J., Bieri,T.A., Nelson,J.O., Berkowicz,N., Wohldmann,P.E.,
            Cook,L.L., Hickenbotham,M.T., Eldred,J., Williams,D., Bedell,J.A.,
            Mardis,E.R., Clifton,S.W., Chissoe,S.L., Marra,M.A., Raymond,C.,
            Haugen,E., Gillett,W., Zhou,Y., James,R., Phelps,K., Iadanoto,S.,
            Bubb,K., Simms,E., Levy,R., Clendenning,J., Kaul,R., Kent,W.J.,
            Furey,T.S., Baertsch,R.A., Brent,M.R., Keibler,E., Flicek,P.,
            Bork,P., Suyama,M., Bailey,J.A., Portnoy,M.E., Torrents,D.,
            Chinwalla,A.T., Gish,W.R., Eddy,S.R., McPherson,J.D., Olson,M.V.,
            Eichler,E.E., Green,E.D., Waterston,R.H. and Wilson,R.K.
  TITLE     The DNA sequence of human chromosome 7
  JOURNAL   Nature 424 (6945), 157-164 (2003)
   PUBMED   12853948
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
REFERENCE   2  (residues 1 to 531)
  AUTHORS   Scherer,S.W., Cheung,J., MacDonald,J.R., Osborne,L.R.,
            Nakabayashi,K., Herbrick,J.A., Carson,A.R., Parker-Katiraee,L.,
            Skaug,J., Khaja,R., Zhang,J., Hudek,A.K., Li,M., Haddad,M.,
            Duggan,G.E., Fernandez,B.A., Kanematsu,E., Gentles,S.,
            Christopoulos,C.C., Choufani,S., Kwasnicka,D., Zheng,X.H., Lai,Z.,
            Nusskern,D., Zhang,Q., Gu,Z., Lu,F., Zeesman,S., Nowaczyk,M.J.,
            Teshima,I., Chitayat,D., Shuman,C., Weksberg,R., Zackai,E.H.,
            Grebe,T.A., Cox,S.R., Kirkpatrick,S.J., Rahman,N., Friedman,J.M.,
            Heng,H.H., Pelicci,P.G., Lo-Coco,F., Belloni,E., Shaffer,L.G.,
            Pober,B., Morton,C.C., Gusella,J.F., Bruns,G.A., Korf,B.R.,
            Quade,B.J., Ligon,A.H., Ferguson,H., Higgins,A.W., Leach,N.T.,
            Herrick,S.R., Lemyre,E., Farra,C.G., Kim,H.G., Summers,A.M.,
            Gripp,K.W., Roberts,W., Szatmari,P., Winsor,E.J., Grzeschik,K.H.,
            Teebi,A., Minassian,B.A., Kere,J., Armengol,L., Pujana,M.A.,
            Estivill,X., Wilson,M.D., Koop,B.F., Tosi,S., Moore,G.E.,
            Boright,A.P., Zlotorynski,E., Kerem,B., Kroisel,P.M., Petek,E.,
            Oscier,D.G., Mould,S.J., Dohner,H., Dohner,K., Rommens,J.M.,
            Vincent,J.B., Venter,J.C., Li,P.W., Mural,R.J., Adams,M.D. and
            Tsui,L.C.
  TITLE     Human chromosome 7: DNA sequence and biology
  JOURNAL   Science 300 (5620), 767-772 (2003)
   PUBMED   12690205
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
COMMENT     [FUNCTION] Transcription factor involved in somitogenesis and
            neurogenesis. Required for the maintenance and differentiation of
            particular elements of the axial skeleton. May act upstream of
            PAX9. Plays a role in controlling the development of connections of
            hypothalamic neurons to pituitary elements, allowing central
            neurons to reach the peripheral blood circulation and to deliver
            hormones for control of peripheral functions (By similarity).
            {ECO:0000250}.
            [SUBCELLULAR LOCATION] Nucleus
            {ECO:0000255|PROSITE-ProRule:PRU00108}.
            [SIMILARITY] Belongs to the paired homeobox family. Unc-4
            subfamily. {ECO:0000305}.
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
     gene            1..531
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
     Protein         1..531
                     /product="Homeobox protein unc-4 homolog"
                     /note="Homeobox protein Uncx4.1"
                     /UniProtKB_evidence="Evidence at protein level"
     Region          1..531
                     /region_name="Mature chain"
                     /note="Homeobox protein unc-4 homolog.
                     /id=PRO_0000334624."
     Region          87..107
                     /region_name="Region of interest in the sequence"
                     /note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          91..106
                     /region_name="Compositionally biased region"
                     /note="Basic and acidic residues.
                     /evidence=ECO:0000256|SAM:MobiDB-lite."
     Site            105..164
                     /site_type="DNA binding"
                     /note="Homeobox.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00108."
     Region          106..162
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          161..312
                     /region_name="Region of interest in the sequence"
                     /note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          188..203
                     /region_name="Compositionally biased region"
                     /note="Basic and acidic residues.
                     /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          324..344
                     /region_name="Region of interest in the sequence"
                     /note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          401..531
                     /region_name="Region of interest in the sequence"
                     /note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          406..420
                     /region_name="Compositionally biased region"
                     /note="Pro residues.
                     /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          482..507
                     /region_name="Compositionally biased region"
                     /note="Pro residues.
                     /evidence=ECO:0000256|SAM:MobiDB-lite."
ORIGIN      
        1 mmdgrllehp haqfggslgg vvgfpyplgh hhvyelaghq lqsaaaaasv pfsidgllgg
       61 scaaaasvvn ptpllpaacg vggdgqpfkl sdsgdpdkes pgckrrrtrt nftgwqleel
      121 ekafneshyp dvfmrealal rldlvesrvq vwfqnrrakw rkkentkkgp grpahnshpt
      181 tcsgepmdpe eiarkelekm ekkkrkhekk llksqgrhlh spgglslhsa pssdsdsggg
      241 glspeppepp ppaakgpgah asgaagtapa ppgeppapgt cdpafypsqr sgagpqprpg
      301 rpadkdaasc gpgaavaave rgaaglpkas pfsvesllsd spprrkaasn aaaaaaagld
      361 fapglpcapr tligkghfll ypitqplgfl vpqaalkgga glepapkdap papavppapp
      421 aqasfgafsg pggapdsafa rrspdavasp gapapapapf rdlasaaate ggggdcadag
      481 tagpappppa psprpgprpp spaeepatcg vpepgaaagp sppegeeldm d
//
Feature
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Reference sequence information

  • RefSeq protein
    See the reference protein sequence for homeobox protein unc-4 homolog (NP_001073930.1).

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