LOCUS UNC4_HUMAN 531 aa linear PRI 27-NOV-2024
DEFINITION RecName: Full=Homeobox protein unc-4 homolog; AltName:
Full=Homeobox protein Uncx4.1.
ACCESSION A6NJT0
VERSION A6NJT0.1
DBSOURCE UniProtKB: locus UNC4_HUMAN, accession A6NJT0;
class: standard.
extra accessions:A4D221
created: May 20, 2008.
sequence updated: Jul 24, 2007.
annotation updated: Nov 27, 2024.
xrefs: AC073094.11, CH236953.1, EAL23940.1, NP_001073930.1
xrefs (non-sequence databases): CCDS:CCDS34583.1,
AlphaFoldDB:A6NJT0, BioGRID:131024, STRING:9606.ENSP00000314480,
iPTMnet:A6NJT0, PhosphoSitePlus:A6NJT0, BioMuta:UNCX,
MassIVE:A6NJT0, PaxDb:9606-ENSP00000314480, PeptideAtlas:A6NJT0,
ProteomicsDB:1352, Antibodypedia:24186, DNASU:340260,
Ensembl:ENST00000316333.9, Ensembl:ENSP00000314480.8,
Ensembl:ENSG00000164853.9, GeneID:340260, KEGG:hsa:340260,
MANE-Select:ENST00000316333.9, UCSC:uc011jvw.3, AGR:HGNC:33194,
CTD:340260, DisGeNET:340260, GeneCards:UNCX, HGNC:33194,
HPA:ENSG00000164853, neXtProt:NX_A6NJT0,
OpenTargets:ENSG00000164853, PharmGKB:PA162408642,
VEuPathDB:HostDB:ENSG00000164853, eggNOG:KOG0490,
GeneTree:ENSGT00940000161420, HOGENOM:CLU_041996_0_0_1,
InParanoid:A6NJT0, OMA:DKDAAPC, OrthoDB:2902937at2759,
PhylomeDB:A6NJT0, TreeFam:TF315554, PathwayCommons:A6NJT0,
BioGRID-ORCS:340260, GenomeRNAi:340260, Pharos:A6NJT0,
PRO:PR:A6NJT0, Proteomes:UP000005640, RNAct:A6NJT0,
Bgee:ENSG00000164853, GO:0000785, GO:0005634, GO:0000981,
GO:1990837, GO:0001502, GO:0035726, GO:0021516, GO:0021889,
GO:0007389, GO:0045595, GO:0010468, CDD:cd00086,
FunFam:1.10.10.60:FF:000057, Gene3D:1.10.10.60, InterPro:IPR001356,
InterPro:IPR017970, InterPro:IPR009057, PANTHER:PTHR46799,
PANTHER:PTHR46799:SF1, Pfam:PF00046, SMART:SM00389,
SUPFAM:SSF46689, PROSITE:PS00027, PROSITE:PS50071
KEYWORDS Developmental protein; Differentiation; DNA-binding; Homeobox;
Neurogenesis; Nucleus; Proteomics identification; Reference
proteome; Transcription; Transcription regulation.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 531)
AUTHORS Hillier,L.W., Fulton,R.S., Fulton,L.A., Graves,T.A., Pepin,K.H.,
Wagner-McPherson,C., Layman,D., Maas,J., Jaeger,S., Walker,R.,
Wylie,K., Sekhon,M., Becker,M.C., O'Laughlin,M.D., Schaller,M.E.,
Fewell,G.A., Delehaunty,K.D., Miner,T.L., Nash,W.E., Cordes,M.,
Du,H., Sun,H., Edwards,J., Bradshaw-Cordum,H., Ali,J., Andrews,S.,
Isak,A., Vanbrunt,A., Nguyen,C., Du,F., Lamar,B., Courtney,L.,
Kalicki,J., Ozersky,P., Bielicki,L., Scott,K., Holmes,A.,
Harkins,R., Harris,A., Strong,C.M., Hou,S., Tomlinson,C.,
Dauphin-Kohlberg,S., Kozlowicz-Reilly,A., Leonard,S., Rohlfing,T.,
Rock,S.M., Tin-Wollam,A.M., Abbott,A., Minx,P., Maupin,R.,
Strowmatt,C., Latreille,P., Miller,N., Johnson,D., Murray,J.,
Woessner,J.P., Wendl,M.C., Yang,S.P., Schultz,B.R., Wallis,J.W.,
Spieth,J., Bieri,T.A., Nelson,J.O., Berkowicz,N., Wohldmann,P.E.,
Cook,L.L., Hickenbotham,M.T., Eldred,J., Williams,D., Bedell,J.A.,
Mardis,E.R., Clifton,S.W., Chissoe,S.L., Marra,M.A., Raymond,C.,
Haugen,E., Gillett,W., Zhou,Y., James,R., Phelps,K., Iadanoto,S.,
Bubb,K., Simms,E., Levy,R., Clendenning,J., Kaul,R., Kent,W.J.,
Furey,T.S., Baertsch,R.A., Brent,M.R., Keibler,E., Flicek,P.,
Bork,P., Suyama,M., Bailey,J.A., Portnoy,M.E., Torrents,D.,
Chinwalla,A.T., Gish,W.R., Eddy,S.R., McPherson,J.D., Olson,M.V.,
Eichler,E.E., Green,E.D., Waterston,R.H. and Wilson,R.K.
TITLE The DNA sequence of human chromosome 7
JOURNAL Nature 424 (6945), 157-164 (2003)
PUBMED 12853948
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
REFERENCE 2 (residues 1 to 531)
AUTHORS Scherer,S.W., Cheung,J., MacDonald,J.R., Osborne,L.R.,
Nakabayashi,K., Herbrick,J.A., Carson,A.R., Parker-Katiraee,L.,
Skaug,J., Khaja,R., Zhang,J., Hudek,A.K., Li,M., Haddad,M.,
Duggan,G.E., Fernandez,B.A., Kanematsu,E., Gentles,S.,
Christopoulos,C.C., Choufani,S., Kwasnicka,D., Zheng,X.H., Lai,Z.,
Nusskern,D., Zhang,Q., Gu,Z., Lu,F., Zeesman,S., Nowaczyk,M.J.,
Teshima,I., Chitayat,D., Shuman,C., Weksberg,R., Zackai,E.H.,
Grebe,T.A., Cox,S.R., Kirkpatrick,S.J., Rahman,N., Friedman,J.M.,
Heng,H.H., Pelicci,P.G., Lo-Coco,F., Belloni,E., Shaffer,L.G.,
Pober,B., Morton,C.C., Gusella,J.F., Bruns,G.A., Korf,B.R.,
Quade,B.J., Ligon,A.H., Ferguson,H., Higgins,A.W., Leach,N.T.,
Herrick,S.R., Lemyre,E., Farra,C.G., Kim,H.G., Summers,A.M.,
Gripp,K.W., Roberts,W., Szatmari,P., Winsor,E.J., Grzeschik,K.H.,
Teebi,A., Minassian,B.A., Kere,J., Armengol,L., Pujana,M.A.,
Estivill,X., Wilson,M.D., Koop,B.F., Tosi,S., Moore,G.E.,
Boright,A.P., Zlotorynski,E., Kerem,B., Kroisel,P.M., Petek,E.,
Oscier,D.G., Mould,S.J., Dohner,H., Dohner,K., Rommens,J.M.,
Vincent,J.B., Venter,J.C., Li,P.W., Mural,R.J., Adams,M.D. and
Tsui,L.C.
TITLE Human chromosome 7: DNA sequence and biology
JOURNAL Science 300 (5620), 767-772 (2003)
PUBMED 12690205
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
COMMENT [FUNCTION] Transcription factor involved in somitogenesis and
neurogenesis. Required for the maintenance and differentiation of
particular elements of the axial skeleton. May act upstream of
PAX9. Plays a role in controlling the development of connections of
hypothalamic neurons to pituitary elements, allowing central
neurons to reach the peripheral blood circulation and to deliver
hormones for control of peripheral functions (By similarity).
{ECO:0000250}.
[SUBCELLULAR LOCATION] Nucleus
{ECO:0000255|PROSITE-ProRule:PRU00108}.
[SIMILARITY] Belongs to the paired homeobox family. Unc-4
subfamily. {ECO:0000305}.
FEATURES Location/Qualifiers
source 1..531
/organism="Homo sapiens"
/db_xref="taxon:9606"
gene 1..531
/gene="UNCX"
/gene_synonym="UNCX4.1"
Protein 1..531
/product="Homeobox protein unc-4 homolog"
/note="Homeobox protein Uncx4.1"
/UniProtKB_evidence="Evidence at protein level"
Region 1..531
/region_name="Mature chain"
/note="Homeobox protein unc-4 homolog.
/id=PRO_0000334624."
Region 87..107
/region_name="Region of interest in the sequence"
/note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
Region 91..106
/region_name="Compositionally biased region"
/note="Basic and acidic residues.
/evidence=ECO:0000256|SAM:MobiDB-lite."
Site 105..164
/site_type="DNA binding"
/note="Homeobox.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00108."
Region 106..162
/region_name="Homeodomain"
/note="pfam00046"
/db_xref="CDD:459649"
Region 161..312
/region_name="Region of interest in the sequence"
/note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
Region 188..203
/region_name="Compositionally biased region"
/note="Basic and acidic residues.
/evidence=ECO:0000256|SAM:MobiDB-lite."
Region 324..344
/region_name="Region of interest in the sequence"
/note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
Region 401..531
/region_name="Region of interest in the sequence"
/note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
Region 406..420
/region_name="Compositionally biased region"
/note="Pro residues.
/evidence=ECO:0000256|SAM:MobiDB-lite."
Region 482..507
/region_name="Compositionally biased region"
/note="Pro residues.
/evidence=ECO:0000256|SAM:MobiDB-lite."
ORIGIN
1 mmdgrllehp haqfggslgg vvgfpyplgh hhvyelaghq lqsaaaaasv pfsidgllgg
61 scaaaasvvn ptpllpaacg vggdgqpfkl sdsgdpdkes pgckrrrtrt nftgwqleel
121 ekafneshyp dvfmrealal rldlvesrvq vwfqnrrakw rkkentkkgp grpahnshpt
181 tcsgepmdpe eiarkelekm ekkkrkhekk llksqgrhlh spgglslhsa pssdsdsggg
241 glspeppepp ppaakgpgah asgaagtapa ppgeppapgt cdpafypsqr sgagpqprpg
301 rpadkdaasc gpgaavaave rgaaglpkas pfsvesllsd spprrkaasn aaaaaaagld
361 fapglpcapr tligkghfll ypitqplgfl vpqaalkgga glepapkdap papavppapp
421 aqasfgafsg pggapdsafa rrspdavasp gapapapapf rdlasaaate ggggdcadag
481 tagpappppa psprpgprpp spaeepatcg vpepgaaagp sppegeeldm d
//