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protein PAT1 homolog 1 [Homo sapiens]

NCBI Reference Sequence: NP_689929.2

Identical Proteins FASTA Graphics 

LOCUS       NP_689929                770 aa            linear   PRI 19-SEP-2024
DEFINITION  protein PAT1 homolog 1 [Homo sapiens].
ACCESSION   NP_689929
VERSION     NP_689929.2
DBSOURCE    REFSEQ: accession NM_152716.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 770)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (residues 1 to 770)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (residues 1 to 770)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (residues 1 to 770)
  AUTHORS   Peter,D., Ruscica,V., Bawankar,P., Weber,R., Helms,S., Valkov,E.,
            Igreja,C. and Izaurralde,E.
  TITLE     Molecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated
            translational repression
  JOURNAL   Genes Dev 33 (19-20), 1355-1360 (2019)
   PUBMED   31439631
REFERENCE   5  (residues 1 to 770)
  AUTHORS   Balak,C., Benard,M., Schaefer,E., Iqbal,S., Ramsey,K.,
            Ernoult-Lange,M., Mattioli,F., Llaci,L., Geoffroy,V., Courel,M.,
            Naymik,M., Bachman,K.K., Pfundt,R., Rump,P., Ter Beest,J.,
            Wentzensen,I.M., Monaghan,K.G., McWalter,K., Richholt,R., Le
            Bechec,A., Jepsen,W., De Both,M., Belnap,N., Boland,A., Piras,I.S.,
            Deleuze,J.F., Szelinger,S., Dollfus,H., Chelly,J., Muller,J.,
            Campbell,A., Lal,D., Rangasamy,S., Mandel,J.L., Narayanan,V.,
            Huentelman,M., Weil,D. and Piton,A.
  TITLE     Rare De Novo Missense Variants in RNA Helicase DDX6 Cause
            Intellectual Disability and Dysmorphic Features and Lead to P-Body
            Defects and RNA Dysregulation
  JOURNAL   Am J Hum Genet 105 (3), 509-525 (2019)
   PUBMED   31422817
REFERENCE   6  (residues 1 to 770)
  AUTHORS   Marnef,A., Maldonado,M., Bugaut,A., Balasubramanian,S., Kress,M.,
            Weil,D. and Standart,N.
  TITLE     Distinct functions of maternal and somatic Pat1 protein paralogs
  JOURNAL   RNA 16 (11), 2094-2107 (2010)
   PUBMED   20826699
  REMARK    GeneRIF: hPat1b localizes to P-bodies, while mPat1a-GFP is either
            found weakly in P-bodies or disperses P-bodies in a
            dominant-negative fashion.
REFERENCE   7  (residues 1 to 770)
  AUTHORS   Ozgur,S., Chekulaeva,M. and Stoecklin,G.
  TITLE     Human Pat1b connects deadenylation with mRNA decapping and controls
            the assembly of processing bodies
  JOURNAL   Mol Cell Biol 30 (17), 4308-4323 (2010)
   PUBMED   20584987
  REMARK    GeneRIF: By tethering Pat1b to a reporter mRNA, the study provides
            evidence that Pat1b is also functionally linked to both
            deadenylation and decapping.
REFERENCE   8  (residues 1 to 770)
  AUTHORS   Braun,J.E., Tritschler,F., Haas,G., Igreja,C., Truffault,V.,
            Weichenrieder,O. and Izaurralde,E.
  TITLE     The C-terminal alpha-alpha superhelix of Pat is required for mRNA
            decapping in metazoa
  JOURNAL   EMBO J 29 (14), 2368-2380 (2010)
   PUBMED   20543818
  REMARK    GeneRIF: Data show that PatL1 is essential for the interaction with
            mRNA decapping factors (i.e. DCP2, EDC4 and LSm1-7), whereas the
            P-rich region and Mid domain have distinct functions in modulating
            these interactions.
REFERENCE   9  (residues 1 to 770)
  AUTHORS   Scheller,N., Resa-Infante,P., de la Luna,S., Galao,R.P.,
            Albrecht,M., Kaestner,L., Lipp,P., Lengauer,T., Meyerhans,A. and
            Diez,J.
  TITLE     Identification of PatL1, a human homolog to yeast P body component
            Pat1
  JOURNAL   Biochim Biophys Acta 1773 (12), 1786-1792 (2007)
   PUBMED   17936923
  REMARK    GeneRIF: The identification of two human PAT1 genes is described
            and one of them, PATL1, codes for an open reading frame with
            similar features as the yeast PAT1.
REFERENCE   10 (residues 1 to 770)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC409866.1 and BC111047.1.
            
            On May 31, 2008 this sequence version replaced NP_689929.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.423178.1, AL831992.2
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300146.10/ ENSP00000300146.9
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..770
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     Protein         1..770
                     /product="protein PAT1 homolog 1"
                     /note="PAT1-like protein 1; protein PAT1 homolog b;
                     protein associated with topoisomerase II homolog 1"
                     /calculated_mol_wt=86719
     Region          1..397
                     /region_name="Involved in nuclear foci localization"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
     Region          1..84
                     /region_name="Region A, interaction with DDX6/RCK"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
     Region          1..26
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
     Region          16..>613
                     /region_name="PAT1"
                     /note="Topoisomerase II-associated protein PAT1;
                     pfam09770"
                     /db_xref="CDD:401645"
     Region          85..388
                     /region_name="Region N, interaction with decapping
                     machinery"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
     Region          86..95
                     /region_name="Nuclear export signal"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
     Site            177
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q86TB9.2)"
     Site            178
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q3TC46; propagated from
                     UniProtKB/Swiss-Prot (Q86TB9.2)"
     Site            179
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
     Site            184
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
     Site            194
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q86TB9.2)"
     Site            217
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q86TB9.2)"
     Region          223..397
                     /region_name="Involved in RNA-binding"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
     Site            223
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q86TB9.2)"
     Site            263
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q86TB9.2)"
     Site            278
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q86TB9.2)"
     Site            284
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q3TC46; propagated from
                     UniProtKB/Swiss-Prot (Q86TB9.2)"
     Region          314..344
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
     Region          360..399
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
     Site            385
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q3TC46; propagated from
                     UniProtKB/Swiss-Prot (Q86TB9.2)"
     Region          389..448
                     /region_name="Region H"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
     Region          398..770
                     /region_name="Involved in nuclear speckle localization"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
     Region          449..770
                     /region_name="Region C"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
     CDS             1..770
                     /gene="PATL1"
                     /gene_synonym="hPat1b; Pat1b"
                     /coded_by="NM_152716.3:143..2455"
                     /db_xref="CCDS:CCDS44613.1"
                     /db_xref="GeneID:219988"
                     /db_xref="HGNC:HGNC:26721"
                     /db_xref="MIM:614660"
ORIGIN      
        1 mfryesledc pldededafq glgeedeeid qfnddtfgsg avdddwqeah erlaeleekl
       61 pvavneqtgn gerdemdllg dheenlaerl skmvienele dpaimravqt rpvlqpqpgs
      121 lnssiwdgse vlrrirgpll aqemptvsvl eyalpqrppq gpeddrdlse ralprrstsp
      181 iigsppvrav pigtppkqma vpsftqqilc pkpvhvrppm pprypapyge rmspnqlcsv
      241 pnssllghpf ppsvppvlsp lqraqllgga qlqpgrmsps qfarvpgfvg splaamnpkl
      301 lqgrvgqmlp papgfraffs appsatpppq qhppgpgphl qnlrsqapmf rpdtthlhpq
      361 hrrllhqrqq qnrsqhrnln gagdrgshrs shqdhlrkdp yanlmlqrek dwvskiqmmq
      421 lqstdpyldd fyyqnyfekl eklsaaeeiq gdgpkkertk litpqvakle haykpvqfeg
      481 slgkltvssv nnprkmidav vtsrseddet kekqvrdkrr ktlviiekty sllldvedye
      541 rryllsleee rpalmddrkh kicsmydnlr gklpgqerps ddhfvqimci rkgkrmvari
      601 lpflsteqaa dilmttarnl pflikkdaqd evlpcllspf slllyhlpsv sitsllrqlm
      661 nlpqsaatpa lsnphltavl qnkfglslll illsrgedlq ssdpatestq nnqwtevmfm
      721 atrellripq aalakpisip tnlvslfsry vdrqklnlle tklqlvqgir
//
Feature
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Protein 3D Structure

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Reference sequence information

  • RefSeq mRNA
    See reference mRNA sequence for the PATL1 gene (NM_152716.3).

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