LOCUS NP_689929 770 aa linear PRI 19-SEP-2024
DEFINITION protein PAT1 homolog 1 [Homo sapiens].
ACCESSION NP_689929
VERSION NP_689929.2
DBSOURCE REFSEQ: accession NM_152716.3
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 770)
AUTHORS Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
and Leonetti,M.D.
TITLE OpenCell: Endogenous tagging for the cartography of human cellular
organization
JOURNAL Science 375 (6585), eabi6983 (2022)
PUBMED 35271311
REFERENCE 2 (residues 1 to 770)
AUTHORS Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
Harper,J.W. and Gygi,S.P.
TITLE Dual proteome-scale networks reveal cell-specific remodeling of the
human interactome
JOURNAL Cell 184 (11), 3022-3040 (2021)
PUBMED 33961781
REFERENCE 3 (residues 1 to 770)
AUTHORS Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 4 (residues 1 to 770)
AUTHORS Peter,D., Ruscica,V., Bawankar,P., Weber,R., Helms,S., Valkov,E.,
Igreja,C. and Izaurralde,E.
TITLE Molecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated
translational repression
JOURNAL Genes Dev 33 (19-20), 1355-1360 (2019)
PUBMED 31439631
REFERENCE 5 (residues 1 to 770)
AUTHORS Balak,C., Benard,M., Schaefer,E., Iqbal,S., Ramsey,K.,
Ernoult-Lange,M., Mattioli,F., Llaci,L., Geoffroy,V., Courel,M.,
Naymik,M., Bachman,K.K., Pfundt,R., Rump,P., Ter Beest,J.,
Wentzensen,I.M., Monaghan,K.G., McWalter,K., Richholt,R., Le
Bechec,A., Jepsen,W., De Both,M., Belnap,N., Boland,A., Piras,I.S.,
Deleuze,J.F., Szelinger,S., Dollfus,H., Chelly,J., Muller,J.,
Campbell,A., Lal,D., Rangasamy,S., Mandel,J.L., Narayanan,V.,
Huentelman,M., Weil,D. and Piton,A.
TITLE Rare De Novo Missense Variants in RNA Helicase DDX6 Cause
Intellectual Disability and Dysmorphic Features and Lead to P-Body
Defects and RNA Dysregulation
JOURNAL Am J Hum Genet 105 (3), 509-525 (2019)
PUBMED 31422817
REFERENCE 6 (residues 1 to 770)
AUTHORS Marnef,A., Maldonado,M., Bugaut,A., Balasubramanian,S., Kress,M.,
Weil,D. and Standart,N.
TITLE Distinct functions of maternal and somatic Pat1 protein paralogs
JOURNAL RNA 16 (11), 2094-2107 (2010)
PUBMED 20826699
REMARK GeneRIF: hPat1b localizes to P-bodies, while mPat1a-GFP is either
found weakly in P-bodies or disperses P-bodies in a
dominant-negative fashion.
REFERENCE 7 (residues 1 to 770)
AUTHORS Ozgur,S., Chekulaeva,M. and Stoecklin,G.
TITLE Human Pat1b connects deadenylation with mRNA decapping and controls
the assembly of processing bodies
JOURNAL Mol Cell Biol 30 (17), 4308-4323 (2010)
PUBMED 20584987
REMARK GeneRIF: By tethering Pat1b to a reporter mRNA, the study provides
evidence that Pat1b is also functionally linked to both
deadenylation and decapping.
REFERENCE 8 (residues 1 to 770)
AUTHORS Braun,J.E., Tritschler,F., Haas,G., Igreja,C., Truffault,V.,
Weichenrieder,O. and Izaurralde,E.
TITLE The C-terminal alpha-alpha superhelix of Pat is required for mRNA
decapping in metazoa
JOURNAL EMBO J 29 (14), 2368-2380 (2010)
PUBMED 20543818
REMARK GeneRIF: Data show that PatL1 is essential for the interaction with
mRNA decapping factors (i.e. DCP2, EDC4 and LSm1-7), whereas the
P-rich region and Mid domain have distinct functions in modulating
these interactions.
REFERENCE 9 (residues 1 to 770)
AUTHORS Scheller,N., Resa-Infante,P., de la Luna,S., Galao,R.P.,
Albrecht,M., Kaestner,L., Lipp,P., Lengauer,T., Meyerhans,A. and
Diez,J.
TITLE Identification of PatL1, a human homolog to yeast P body component
Pat1
JOURNAL Biochim Biophys Acta 1773 (12), 1786-1792 (2007)
PUBMED 17936923
REMARK GeneRIF: The identification of two human PAT1 genes is described
and one of them, PATL1, codes for an open reading frame with
similar features as the yeast PAT1.
REFERENCE 10 (residues 1 to 770)
AUTHORS Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
TITLE Large-scale characterization of HeLa cell nuclear phosphoproteins
JOURNAL Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
PUBMED 15302935
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DC409866.1 and BC111047.1.
On May 31, 2008 this sequence version replaced NP_689929.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1163658.423178.1, AL831992.2
[ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000300146.10/ ENSP00000300146.9
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..770
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q12.1"
Protein 1..770
/product="protein PAT1 homolog 1"
/note="PAT1-like protein 1; protein PAT1 homolog b;
protein associated with topoisomerase II homolog 1"
/calculated_mol_wt=86719
Region 1..397
/region_name="Involved in nuclear foci localization"
/note="propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
Region 1..84
/region_name="Region A, interaction with DDX6/RCK"
/note="propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
Region 1..26
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
Region 16..>613
/region_name="PAT1"
/note="Topoisomerase II-associated protein PAT1;
pfam09770"
/db_xref="CDD:401645"
Region 85..388
/region_name="Region N, interaction with decapping
machinery"
/note="propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
Region 86..95
/region_name="Nuclear export signal"
/note="propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
Site 177
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:18669648; propagated from
UniProtKB/Swiss-Prot (Q86TB9.2)"
Site 178
/site_type="phosphorylation"
/note="Phosphothreonine.
/evidence=ECO:0000250|UniProtKB:Q3TC46; propagated from
UniProtKB/Swiss-Prot (Q86TB9.2)"
Site 179
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:18669648,
ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163;
propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
Site 184
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:18669648,
ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163;
propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
Site 194
/site_type="phosphorylation"
/note="Phosphothreonine.
/evidence=ECO:0007744|PubMed:23186163; propagated from
UniProtKB/Swiss-Prot (Q86TB9.2)"
Site 217
/site_type="methylation"
/note="Asymmetric dimethylarginine.
/evidence=ECO:0007744|PubMed:24129315; propagated from
UniProtKB/Swiss-Prot (Q86TB9.2)"
Region 223..397
/region_name="Involved in RNA-binding"
/note="propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
Site 223
/site_type="methylation"
/note="Asymmetric dimethylarginine.
/evidence=ECO:0007744|PubMed:24129315; propagated from
UniProtKB/Swiss-Prot (Q86TB9.2)"
Site 263
/site_type="methylation"
/note="Asymmetric dimethylarginine.
/evidence=ECO:0007744|PubMed:24129315; propagated from
UniProtKB/Swiss-Prot (Q86TB9.2)"
Site 278
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:23186163; propagated from
UniProtKB/Swiss-Prot (Q86TB9.2)"
Site 284
/site_type="methylation"
/note="Asymmetric dimethylarginine.
/evidence=ECO:0000250|UniProtKB:Q3TC46; propagated from
UniProtKB/Swiss-Prot (Q86TB9.2)"
Region 314..344
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
Region 360..399
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
Site 385
/site_type="methylation"
/note="Omega-N-methylarginine.
/evidence=ECO:0000250|UniProtKB:Q3TC46; propagated from
UniProtKB/Swiss-Prot (Q86TB9.2)"
Region 389..448
/region_name="Region H"
/note="propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
Region 398..770
/region_name="Involved in nuclear speckle localization"
/note="propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
Region 449..770
/region_name="Region C"
/note="propagated from UniProtKB/Swiss-Prot (Q86TB9.2)"
CDS 1..770
/gene="PATL1"
/gene_synonym="hPat1b; Pat1b"
/coded_by="NM_152716.3:143..2455"
/db_xref="CCDS:CCDS44613.1"
/db_xref="GeneID:219988"
/db_xref="HGNC:HGNC:26721"
/db_xref="MIM:614660"
ORIGIN
1 mfryesledc pldededafq glgeedeeid qfnddtfgsg avdddwqeah erlaeleekl
61 pvavneqtgn gerdemdllg dheenlaerl skmvienele dpaimravqt rpvlqpqpgs
121 lnssiwdgse vlrrirgpll aqemptvsvl eyalpqrppq gpeddrdlse ralprrstsp
181 iigsppvrav pigtppkqma vpsftqqilc pkpvhvrppm pprypapyge rmspnqlcsv
241 pnssllghpf ppsvppvlsp lqraqllgga qlqpgrmsps qfarvpgfvg splaamnpkl
301 lqgrvgqmlp papgfraffs appsatpppq qhppgpgphl qnlrsqapmf rpdtthlhpq
361 hrrllhqrqq qnrsqhrnln gagdrgshrs shqdhlrkdp yanlmlqrek dwvskiqmmq
421 lqstdpyldd fyyqnyfekl eklsaaeeiq gdgpkkertk litpqvakle haykpvqfeg
481 slgkltvssv nnprkmidav vtsrseddet kekqvrdkrr ktlviiekty sllldvedye
541 rryllsleee rpalmddrkh kicsmydnlr gklpgqerps ddhfvqimci rkgkrmvari
601 lpflsteqaa dilmttarnl pflikkdaqd evlpcllspf slllyhlpsv sitsllrqlm
661 nlpqsaatpa lsnphltavl qnkfglslll illsrgedlq ssdpatestq nnqwtevmfm
721 atrellripq aalakpisip tnlvslfsry vdrqklnlle tklqlvqgir
//