LOCUS XP_036356975 1123 aa linear INV 08-OCT-2020
DEFINITION G-protein coupled receptor GRL101 isoform X1 [Octopus sinensis].
ACCESSION XP_036356975
VERSION XP_036356975.1
DBLINK BioProject: PRJNA551489
DBSOURCE REFSEQ: accession XM_036501082.1
KEYWORDS RefSeq.
SOURCE Octopus sinensis (East Asian common octopus)
ORGANISM Octopus sinensis
Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca;
Cephalopoda; Coleoidea; Octopodiformes; Octopoda; Incirrata;
Octopodidae; Octopus.
COMMENT MODEL REFSEQ: This record is predicted by automated computational
analysis. This record is derived from a genomic sequence
(NC_042999.1) annotated using gene prediction method: Gnomon.
Also see:
Documentation of NCBI's Annotation Process
##Genome-Annotation-Data-START##
Annotation Provider :: NCBI
Annotation Status :: Full annotation
Annotation Name :: Octopus sinensis Annotation Release
101
Annotation Version :: 101
Annotation Pipeline :: NCBI eukaryotic genome annotation
pipeline
Annotation Software Version :: 8.5
Annotation Method :: Best-placed RefSeq; Gnomon
Features Annotated :: Gene; mRNA; CDS; ncRNA
##Genome-Annotation-Data-END##
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..1123
/organism="Octopus sinensis"
/db_xref="taxon:2607531"
/linkage_group="LG3"
Protein 1..1123
/product="G-protein coupled receptor GRL101 isoform X1"
/calculated_mol_wt=127624
Region 67..101
/region_name="LDLa"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; cd00112"
/db_xref="CDD:238060"
Site order(72,80,91..92)
/site_type="active"
/note="putative binding surface [active]"
/db_xref="CDD:238060"
Site order(84,87,91,97..98)
/site_type="other"
/note="calcium-binding site [ion binding]"
/db_xref="CDD:238060"
Site 94..98
/site_type="other"
/note="D-X-S-D-E motif"
/db_xref="CDD:238060"
Region 106..140
/region_name="LDLa"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; cd00112"
/db_xref="CDD:238060"
Site order(111,119,130..131)
/site_type="active"
/note="putative binding surface [active]"
/db_xref="CDD:238060"
Site order(123,126,130,136..137)
/site_type="other"
/note="calcium-binding site [ion binding]"
/db_xref="CDD:238060"
Site 133..137
/site_type="other"
/note="D-X-S-D-E motif"
/db_xref="CDD:238060"
Region 145..179
/region_name="LDLa"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; cd00112"
/db_xref="CDD:238060"
Site order(150,158,169..170)
/site_type="active"
/note="putative binding surface [active]"
/db_xref="CDD:238060"
Site order(162,165,169,175..176)
/site_type="other"
/note="calcium-binding site [ion binding]"
/db_xref="CDD:238060"
Site 172..176
/site_type="other"
/note="D-X-S-D-E motif"
/db_xref="CDD:238060"
Region 180..213
/region_name="LDLa"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; cd00112"
/db_xref="CDD:238060"
Site order(183,191,202..203)
/site_type="active"
/note="putative binding surface [active]"
/db_xref="CDD:238060"
Site order(195,198,202,209..210)
/site_type="other"
/note="calcium-binding site [ion binding]"
/db_xref="CDD:238060"
Site 206..210
/site_type="other"
/note="D-X-S-D-E motif"
/db_xref="CDD:238060"
Region 215..242
/region_name="LDLa"
/note="Low-density lipoprotein receptor domain class A;
smart00192"
/db_xref="CDD:197566"
Site order(221,229,240..241)
/site_type="active"
/note="putative binding surface [active]"
/db_xref="CDD:238060"
Site order(233,236,240,247..248)
/site_type="other"
/note="calcium-binding site [ion binding]"
/db_xref="CDD:238060"
Site order(243,245..248)
/site_type="other"
/note="D-X-S-D-E motif"
/db_xref="CDD:238060"
Region 256..295
/region_name="LDLa"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; cd00112"
/db_xref="CDD:238060"
Site order(262,271,282..283)
/site_type="active"
/note="putative binding surface [active]"
/db_xref="CDD:238060"
Site order(275,278,282,291..292)
/site_type="other"
/note="calcium-binding site [ion binding]"
/db_xref="CDD:238060"
Site order(285,289..292)
/site_type="other"
/note="D-X-S-D-E motif"
/db_xref="CDD:238060"
Region 309..338
/region_name="LDLa"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; cd00112"
/db_xref="CDD:238060"
Site order(309,317,328..329)
/site_type="active"
/note="putative binding surface [active]"
/db_xref="CDD:238060"
Site order(321,324,328,334..335)
/site_type="other"
/note="calcium-binding site [ion binding]"
/db_xref="CDD:238060"
Site 331..335
/site_type="other"
/note="D-X-S-D-E motif"
/db_xref="CDD:238060"
Region 343..377
/region_name="LDLa"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; cd00112"
/db_xref="CDD:238060"
Site order(348,356,367..368)
/site_type="active"
/note="putative binding surface [active]"
/db_xref="CDD:238060"
Site order(360,363,367,373..374)
/site_type="other"
/note="calcium-binding site [ion binding]"
/db_xref="CDD:238060"
Site 370..374
/site_type="other"
/note="D-X-S-D-E motif"
/db_xref="CDD:238060"
Region 382..416
/region_name="LDLa"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; cd00112"
/db_xref="CDD:238060"
Site order(387,395,406..407)
/site_type="active"
/note="putative binding surface [active]"
/db_xref="CDD:238060"
Site order(399,402,406,412..413)
/site_type="other"
/note="calcium-binding site [ion binding]"
/db_xref="CDD:238060"
Site 409..413
/site_type="other"
/note="D-X-S-D-E motif"
/db_xref="CDD:238060"
Region 465..500
/region_name="LDLa"
/note="Low Density Lipoprotein Receptor Class A domain, a
cysteine-rich repeat that plays a central role in
mammalian cholesterol metabolism; the receptor protein
binds LDL and transports it into cells by endocytosis; 7
successive cysteine-rich repeats of about...; cd00112"
/db_xref="CDD:238060"
Site order(470,478,489..490)
/site_type="active"
/note="putative binding surface [active]"
/db_xref="CDD:238060"
Site order(482,485,489,496..497)
/site_type="other"
/note="calcium-binding site [ion binding]"
/db_xref="CDD:238060"
Site 493..497
/site_type="other"
/note="D-X-S-D-E motif"
/db_xref="CDD:238060"
Region 536..558
/region_name="leucine-rich repeat"
/note="leucine-rich repeat [structural motif]"
/db_xref="CDD:275380"
Region <545..>707
/region_name="LRR"
/note="Leucine-rich repeat (LRR) protein [Transcription];
COG4886"
/db_xref="CDD:443914"
Region 559..582
/region_name="leucine-rich repeat"
/note="leucine-rich repeat [structural motif]"
/db_xref="CDD:275380"
Region 583..606
/region_name="leucine-rich repeat"
/note="leucine-rich repeat [structural motif]"
/db_xref="CDD:275380"
Region 607..630
/region_name="leucine-rich repeat"
/note="leucine-rich repeat [structural motif]"
/db_xref="CDD:275380"
Region 631..654
/region_name="leucine-rich repeat"
/note="leucine-rich repeat [structural motif]"
/db_xref="CDD:275380"
Region 655..678
/region_name="leucine-rich repeat"
/note="leucine-rich repeat [structural motif]"
/db_xref="CDD:275380"
Region 679..702
/region_name="leucine-rich repeat"
/note="leucine-rich repeat [structural motif]"
/db_xref="CDD:275380"
Region 741..1023
/region_name="7tmA_Relaxin_R"
/note="relaxin family peptide receptors, member of the
class A family of seven-transmembrane G protein-coupled
receptors; cd15137"
/db_xref="CDD:320265"
Region 741..767
/region_name="TM helix 1"
/note="TM helix 1 [structural motif]"
/db_xref="CDD:320265"
Region 774..799
/region_name="TM helix 2"
/note="TM helix 2 [structural motif]"
/db_xref="CDD:320265"
Site order(795,798..799,819..824,826..827,830,874,876..880,909,
912..914,916..918,920..921,972,975..976,978..979,982,
990..991,993..995,998,1001..1002)
/site_type="other"
/note="putative peptide ligand binding pocket [polypeptide
binding]"
/db_xref="CDD:320265"
Region 819..849
/region_name="TM helix 3"
/note="TM helix 3 [structural motif]"
/db_xref="CDD:320265"
Region 860..882
/region_name="TM helix 4"
/note="TM helix 4 [structural motif]"
/db_xref="CDD:320265"
Region 909..938
/region_name="TM helix 5"
/note="TM helix 5 [structural motif]"
/db_xref="CDD:320265"
Region 952..982
/region_name="TM helix 6"
/note="TM helix 6 [structural motif]"
/db_xref="CDD:320265"
Region 991..1016
/region_name="TM helix 7"
/note="TM helix 7 [structural motif]"
/db_xref="CDD:320265"
CDS 1..1123
/gene="LOC115209347"
/coded_by="XM_036501082.1:854..4225"
/db_xref="GeneID:115209347"
ORIGIN
1 meshllvfiv lisatatiya sflipcqten aftcdeaske cisaeqkcng isecsngfde
61 svktcgclph efqcnetncv dlvkrcdtvq dcdagedein cesyvcpvhr tkcknylcvp
121 stamcnfidd cgdnsdeenc kyrscylaef rcnnsecipe sllcdgiqdc vdgsdetece
181 shfqcsngly ihkdkvcdfh rdclidhdde tncgkcperk yqcqsgecid isnqcdgicd
241 cahtcddenk cgsmwcqage qfmcpknyrc ikkeflcdgf ndckntwrgt desfcvnssn
301 scnifksnfm cqegrclpsl lqcntfidcl ngedesnctl qlctknefrc sdnrcidkky
361 rcdgkgncyd rsdehgcety dcppghrkcr ggqciaenkw cdfwrdcpdn sdeedcelrp
421 ckrdefkcdn gqcipgylrc fkgpntdrlg cadyshlkqc qntkcesdqf kcrnaycitq
481 kqvcngktdc lmskwdefhc aykcpyptde cvcfdismnc tnrglfhvpn nnegsiqfhl
541 agnflnytls adtfkiydlt tldisnnsls tippdcfagl wrlqslnlad nqlteiendt
601 fvglsglrsl niernniqti lpnafrglss lstldlskqr ltfieknvfn glrklrflnl
661 sgnqitnied gafnglknll tldisnnmli tigenvfhgl tnlhtlytde yrfcclakgv
721 pdcnpkpdef sscedlmsny vlrasiwilg itasfgnviv iiwrtrdkrs gkvhsflitn
781 lalgdmfmgv ylmiiavadt yyrgsyilyd klwrssilch fagfiatfss elsvftltvi
841 tldrlicilf pfrshrmglk eaqlamlalw ifvfflsavp lfgieyfkdf ysrsgvclal
901 hitpdrprgw eysvmiflav nllsfliifi sylwmfivak ktrsavrtae tktdsamakr
961 itlivltdff cwipiiilgi aslcgqripp evyawvavfi lpvnsainpv lytlstapfl
1021 gnvrkratkf rksfmtsltf dtkhsyvedr tsgnywertn snyrqfeimr mrpmtkcsss
1081 qtpanngikv eeyipkdmkl eklkseqdsa hsqvevtqte dfv
//