LOCUS NP_001381066 1145 aa linear PRI 22-SEP-2024
DEFINITION nonsense-mediated mRNA decay factor SMG7 isoform 5 [Homo sapiens].
ACCESSION NP_001381066
VERSION NP_001381066.1
DBSOURCE REFSEQ: accession NM_001394137.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 1145)
AUTHORS Song,X., Ru,M., Steinsnyder,Z., Tkachuk,K., Kopp,R.P., Sullivan,J.,
Gumus,Z.H., Offit,K., Joseph,V. and Klein,R.J.
TITLE SNPs at SMG7 Associated with Time from Biochemical Recurrence to
Prostate Cancer Death
JOURNAL Cancer Epidemiol Biomarkers Prev 31 (7), 1466-1472 (2022)
PUBMED 35511739
REMARK GeneRIF: SNPs at SMG7 Associated with Time from Biochemical
Recurrence to Prostate Cancer Death.
REFERENCE 2 (residues 1 to 1145)
AUTHORS Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
and Leonetti,M.D.
TITLE OpenCell: Endogenous tagging for the cartography of human cellular
organization
JOURNAL Science 375 (6585), eabi6983 (2022)
PUBMED 35271311
REFERENCE 3 (residues 1 to 1145)
AUTHORS Boehm,V., Kueckelmann,S., Gerbracht,J.V., Kallabis,S.,
Britto-Borges,T., Altmuller,J., Kruger,M., Dieterich,C. and
Gehring,N.H.
TITLE SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6
endonucleolytic activity
JOURNAL Nat Commun 12 (1), 3965 (2021)
PUBMED 34172724
REMARK GeneRIF: SMG5-SMG7 authorize nonsense-mediated mRNA decay by
enabling SMG6 endonucleolytic activity.
Publication Status: Online-Only
REFERENCE 4 (residues 1 to 1145)
AUTHORS Ho,K., Luo,H., Zhu,W. and Tang,Y.
TITLE Critical role of SMG7 in activation of the ATR-CHK1 axis in
response to genotoxic stress
JOURNAL Sci Rep 11 (1), 7502 (2021)
PUBMED 33820915
REMARK GeneRIF: Critical role of SMG7 in activation of the ATR-CHK1 axis
in response to genotoxic stress.
Publication Status: Online-Only
REFERENCE 5 (residues 1 to 1145)
AUTHORS Yang,L., Kraft,V.A.N., Pfeiffer,S., Merl-Pham,J., Bao,X., An,Y.,
Hauck,S.M. and Schick,J.A.
TITLE Nonsense-mediated decay factor SMG7 sensitizes cells to
TNFalpha-induced apoptosis via CYLD tumor suppressor and the
noncoding oncogene Pvt1
JOURNAL Mol Oncol 14 (10), 2420-2435 (2020)
PUBMED 32602581
REMARK GeneRIF: Nonsense-mediated decay factor SMG7 sensitizes cells to
TNFalpha-induced apoptosis via CYLD tumor suppressor and the
noncoding oncogene Pvt1.
REFERENCE 6 (residues 1 to 1145)
AUTHORS Unterholzner,L. and Izaurralde,E.
TITLE SMG7 acts as a molecular link between mRNA surveillance and mRNA
decay
JOURNAL Mol Cell 16 (4), 587-596 (2004)
PUBMED 15546618
REFERENCE 7 (residues 1 to 1145)
AUTHORS Ohnishi,T., Yamashita,A., Kashima,I., Schell,T., Anders,K.R.,
Grimson,A., Hachiya,T., Hentze,M.W., Anderson,P. and Ohno,S.
TITLE Phosphorylation of hUPF1 induces formation of mRNA surveillance
complexes containing hSMG-5 and hSMG-7
JOURNAL Mol Cell 12 (5), 1187-1200 (2003)
PUBMED 14636577
REMARK GeneRIF: Data show that phosphorylated hUPF1, the human ortholog of
UPF1/SMG-2, forms a complex with human orthologs of the
Caenorhabditis elegans proteins SMG-5 and SMG-7.
REFERENCE 8 (residues 1 to 1145)
AUTHORS Snow,B.E., Erdmann,N., Cruickshank,J., Goldman,H., Gill,R.M.,
Robinson,M.O. and Harrington,L.
TITLE Functional conservation of the telomerase protein Est1p in humans
JOURNAL Curr Biol 13 (8), 698-704 (2003)
PUBMED 12699629
REFERENCE 9 (residues 1 to 1145)
AUTHORS Reichenbach,P., Hoss,M., Azzalin,C.M., Nabholz,M., Bucher,P. and
Lingner,J.
TITLE A human homolog of yeast Est1 associates with telomerase and uncaps
chromosome ends when overexpressed
JOURNAL Curr Biol 13 (7), 568-574 (2003)
PUBMED 12676087
REFERENCE 10 (residues 1 to 1145)
AUTHORS Sood,R., Bonner,T.I., Makalowska,I., Stephan,D.A., Robbins,C.M.,
Connors,T.D., Morgenbesser,S.D., Su,K., Faruque,M.U., Pinkett,H.,
Graham,C., Baxevanis,A.D., Klinger,K.W., Landes,G.M., Trent,J.M.
and Carpten,J.D.
TITLE Cloning and characterization of 13 novel transcripts and the human
RGS8 gene from the 1q25 region encompassing the hereditary prostate
cancer (HPC1) locus
JOURNAL Genomics 73 (2), 211-222 (2001)
PUBMED 11318611
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL449223.7 and AL137800.12.
Summary: This gene encodes a protein that is essential for
nonsense-mediated mRNA decay (NMD); a process whereby transcripts
with premature termination codons are targeted for rapid
degradation by a mRNA decay complex. The mRNA decay complex
consists, in part, of this protein along with proteins SMG5 and
UPF1. The N-terminal domain of this protein is thought to mediate
its association with SMG5 or UPF1 while the C-terminal domain
interacts with the mRNA decay complex. This protein may therefore
couple changes in UPF1 phosphorylation state to the degradation of
NMD-candidate transcripts. Alternative splicing results in multiple
transcript variants encoding distinct isoforms. [provided by
RefSeq, Aug 2011].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
FEATURES Location/Qualifiers
source 1..1145
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q25.3"
Protein 1..1145
/product="nonsense-mediated mRNA decay factor SMG7 isoform
5"
/EC_number="2.7.11.1"
/note="ever shorter telomeres 1C; EST1 telomerase
component homolog C; breast cancer-associated antigen
SGA-56M; EST1-like protein C; smg-7 homolog, nonsense
mediated mRNA decay factor; nonsense-mediated mRNA decay
factor SMG7"
/calculated_mol_wt=127724
Region 13..125
/region_name="EST1"
/note="Telomerase activating protein Est1; pfam10374"
/db_xref="CDD:463062"
Region 112..138
/region_name="TPR repeat"
/note="TPR repeat [structural motif]"
/db_xref="CDD:276809"
Site order(114..115,118..119,121,145,148..149,152..153,
155..156,179,182..183,186..187,190)
/site_type="other"
/note="putative protein binding surface [polypeptide
binding]"
/db_xref="CDD:276809"
Region 129..389
/region_name="EST1_DNA_bind"
/note="Est1 DNA/RNA binding domain; pfam10373"
/db_xref="CDD:431239"
Region 143..173
/region_name="TPR repeat"
/note="TPR repeat [structural motif]"
/db_xref="CDD:276809"
Region <644..819
/region_name="PABP-1234"
/note="polyadenylate binding protein, human types 1, 2, 3,
4 family; TIGR01628"
/db_xref="CDD:130689"
CDS 1..1145
/gene="SMG7"
/gene_synonym="C1orf16; EST1C; SGA56M"
/coded_by="NM_001394137.1:493..3930"
/note="isoform 5 is encoded by transcript variant 17"
/db_xref="CCDS:CCDS53445.1"
/db_xref="GeneID:9887"
/db_xref="HGNC:HGNC:16792"
/db_xref="MIM:610964"
ORIGIN
1 mlvtdleyal dkkveqdlwn hafknqittl qgqaknranp nrsevqanls lfleaasgfy
61 tqllqelctv fnvdlpcrvk ssqlgiisnk qthtsaivkp qssscsyicq hclvhlgdia
121 ryrnqtsqae syyrhaaqlv psngqpynql ailasskgdh lttifyycrs iavkfpfpaa
181 stnlqkalsk alesrdevkt kwgvsdfika fikfhghvyl sksleklspl rekleeqfkr
241 llfqkafnsq qlvhvtvinl fqlhhlrdfs neteqhtysq deqlcwtqll alfmsflgil
301 ckcplqnesq eesynayplp avkvsmdwlr lrprvfqeav vderqyiwpw lisllnsfhp
361 heedlssisa tplpeefelq gflalrpsfr nldfskghqg itgdkegqqr rirqqrlisi
421 gkwiadnqpr liqcenevgk llfiteipel iledpseake nlilqetsvi eslaadgspg
481 lksvlstsrn lsnncdtgek pvvtfkenik trevnrdqgr sfppkevrrd yskgitvtkn
541 dgkkdnnkrk tetkkctlek lqetgkqnva vqvksqtelr ktpvsearkt pvtqtptqas
601 nsqfipihhp gafpplpsrp gfppptyvip ppvafsmgsg ytfpagvsvp gtflqptahs
661 pagnqvqagk qshipysqqr psgpgpmnqg pqqsqppsqq pltslpaqpt aqstsqlqvq
721 altqqqqspt kavpalgksp phhsgfqqyq qadaskqlwn ppqvqgplgk impvkqpyyl
781 qtqdpiklfe pslqppvmqq qplekkmkpf pmepynhnps evkvpefywd ssysmadnrs
841 vmaqqanidr rgkrspgvfr peqdpvprmp fedpksspll ppdllkslaa leeeeelifs
901 nppdlypall gplaslpgrs lfksllekps elmshsssfl sltgfslnqe rypnnsmfne
961 vygknltsss kaelspsmap qetslyslfe gtpwspslpa ssdhstpasq sphssnpssl
1021 pssppthnhn svpfsnfgpi gtpdnrdrrt adrwktdkpa mggfgidyls atsssesswh
1081 qastpsgtwt ghgpsmedss avlmeslksi wsssmmhpgp saleqllmqq kqkqqrgqgt
1141 mnpph
//