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nonsense-mediated mRNA decay factor SMG7 isoform 5 [Homo sapiens]

NCBI Reference Sequence: NP_001381066.1

Identical Proteins FASTA Graphics 

LOCUS       NP_001381066            1145 aa            linear   PRI 22-SEP-2024
DEFINITION  nonsense-mediated mRNA decay factor SMG7 isoform 5 [Homo sapiens].
ACCESSION   NP_001381066
VERSION     NP_001381066.1
DBSOURCE    REFSEQ: accession NM_001394137.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1145)
  AUTHORS   Song,X., Ru,M., Steinsnyder,Z., Tkachuk,K., Kopp,R.P., Sullivan,J.,
            Gumus,Z.H., Offit,K., Joseph,V. and Klein,R.J.
  TITLE     SNPs at SMG7 Associated with Time from Biochemical Recurrence to
            Prostate Cancer Death
  JOURNAL   Cancer Epidemiol Biomarkers Prev 31 (7), 1466-1472 (2022)
   PUBMED   35511739
  REMARK    GeneRIF: SNPs at SMG7 Associated with Time from Biochemical
            Recurrence to Prostate Cancer Death.
REFERENCE   2  (residues 1 to 1145)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (residues 1 to 1145)
  AUTHORS   Boehm,V., Kueckelmann,S., Gerbracht,J.V., Kallabis,S.,
            Britto-Borges,T., Altmuller,J., Kruger,M., Dieterich,C. and
            Gehring,N.H.
  TITLE     SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6
            endonucleolytic activity
  JOURNAL   Nat Commun 12 (1), 3965 (2021)
   PUBMED   34172724
  REMARK    GeneRIF: SMG5-SMG7 authorize nonsense-mediated mRNA decay by
            enabling SMG6 endonucleolytic activity.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1145)
  AUTHORS   Ho,K., Luo,H., Zhu,W. and Tang,Y.
  TITLE     Critical role of SMG7 in activation of the ATR-CHK1 axis in
            response to genotoxic stress
  JOURNAL   Sci Rep 11 (1), 7502 (2021)
   PUBMED   33820915
  REMARK    GeneRIF: Critical role of SMG7 in activation of the ATR-CHK1 axis
            in response to genotoxic stress.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1145)
  AUTHORS   Yang,L., Kraft,V.A.N., Pfeiffer,S., Merl-Pham,J., Bao,X., An,Y.,
            Hauck,S.M. and Schick,J.A.
  TITLE     Nonsense-mediated decay factor SMG7 sensitizes cells to
            TNFalpha-induced apoptosis via CYLD tumor suppressor and the
            noncoding oncogene Pvt1
  JOURNAL   Mol Oncol 14 (10), 2420-2435 (2020)
   PUBMED   32602581
  REMARK    GeneRIF: Nonsense-mediated decay factor SMG7 sensitizes cells to
            TNFalpha-induced apoptosis via CYLD tumor suppressor and the
            noncoding oncogene Pvt1.
REFERENCE   6  (residues 1 to 1145)
  AUTHORS   Unterholzner,L. and Izaurralde,E.
  TITLE     SMG7 acts as a molecular link between mRNA surveillance and mRNA
            decay
  JOURNAL   Mol Cell 16 (4), 587-596 (2004)
   PUBMED   15546618
REFERENCE   7  (residues 1 to 1145)
  AUTHORS   Ohnishi,T., Yamashita,A., Kashima,I., Schell,T., Anders,K.R.,
            Grimson,A., Hachiya,T., Hentze,M.W., Anderson,P. and Ohno,S.
  TITLE     Phosphorylation of hUPF1 induces formation of mRNA surveillance
            complexes containing hSMG-5 and hSMG-7
  JOURNAL   Mol Cell 12 (5), 1187-1200 (2003)
   PUBMED   14636577
  REMARK    GeneRIF: Data show that phosphorylated hUPF1, the human ortholog of
            UPF1/SMG-2, forms a complex with human orthologs of the
            Caenorhabditis elegans proteins SMG-5 and SMG-7.
REFERENCE   8  (residues 1 to 1145)
  AUTHORS   Snow,B.E., Erdmann,N., Cruickshank,J., Goldman,H., Gill,R.M.,
            Robinson,M.O. and Harrington,L.
  TITLE     Functional conservation of the telomerase protein Est1p in humans
  JOURNAL   Curr Biol 13 (8), 698-704 (2003)
   PUBMED   12699629
REFERENCE   9  (residues 1 to 1145)
  AUTHORS   Reichenbach,P., Hoss,M., Azzalin,C.M., Nabholz,M., Bucher,P. and
            Lingner,J.
  TITLE     A human homolog of yeast Est1 associates with telomerase and uncaps
            chromosome ends when overexpressed
  JOURNAL   Curr Biol 13 (7), 568-574 (2003)
   PUBMED   12676087
REFERENCE   10 (residues 1 to 1145)
  AUTHORS   Sood,R., Bonner,T.I., Makalowska,I., Stephan,D.A., Robbins,C.M.,
            Connors,T.D., Morgenbesser,S.D., Su,K., Faruque,M.U., Pinkett,H.,
            Graham,C., Baxevanis,A.D., Klinger,K.W., Landes,G.M., Trent,J.M.
            and Carpten,J.D.
  TITLE     Cloning and characterization of 13 novel transcripts and the human
            RGS8 gene from the 1q25 region encompassing the hereditary prostate
            cancer (HPC1) locus
  JOURNAL   Genomics 73 (2), 211-222 (2001)
   PUBMED   11318611
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL449223.7 and AL137800.12.
            
            Summary: This gene encodes a protein that is essential for
            nonsense-mediated mRNA decay (NMD); a process whereby transcripts
            with premature termination codons are targeted for rapid
            degradation by a mRNA decay complex. The mRNA decay complex
            consists, in part, of this protein along with proteins SMG5 and
            UPF1. The N-terminal domain of this protein is thought to mediate
            its association with SMG5 or UPF1 while the C-terminal domain
            interacts with the mRNA decay complex. This protein may therefore
            couple changes in UPF1 phosphorylation state to the degradation of
            NMD-candidate transcripts. Alternative splicing results in multiple
            transcript variants encoding distinct isoforms. [provided by
            RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..1145
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.3"
     Protein         1..1145
                     /product="nonsense-mediated mRNA decay factor SMG7 isoform
                     5"
                     /EC_number="2.7.11.1"
                     /note="ever shorter telomeres 1C; EST1 telomerase
                     component homolog C; breast cancer-associated antigen
                     SGA-56M; EST1-like protein C; smg-7 homolog, nonsense
                     mediated mRNA decay factor; nonsense-mediated mRNA decay
                     factor SMG7"
                     /calculated_mol_wt=127724
     Region          13..125
                     /region_name="EST1"
                     /note="Telomerase activating protein Est1; pfam10374"
                     /db_xref="CDD:463062"
     Region          112..138
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(114..115,118..119,121,145,148..149,152..153,
                     155..156,179,182..183,186..187,190)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          129..389
                     /region_name="EST1_DNA_bind"
                     /note="Est1 DNA/RNA binding domain; pfam10373"
                     /db_xref="CDD:431239"
     Region          143..173
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          <644..819
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1145
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /coded_by="NM_001394137.1:493..3930"
                     /note="isoform 5 is encoded by transcript variant 17"
                     /db_xref="CCDS:CCDS53445.1"
                     /db_xref="GeneID:9887"
                     /db_xref="HGNC:HGNC:16792"
                     /db_xref="MIM:610964"
ORIGIN      
        1 mlvtdleyal dkkveqdlwn hafknqittl qgqaknranp nrsevqanls lfleaasgfy
       61 tqllqelctv fnvdlpcrvk ssqlgiisnk qthtsaivkp qssscsyicq hclvhlgdia
      121 ryrnqtsqae syyrhaaqlv psngqpynql ailasskgdh lttifyycrs iavkfpfpaa
      181 stnlqkalsk alesrdevkt kwgvsdfika fikfhghvyl sksleklspl rekleeqfkr
      241 llfqkafnsq qlvhvtvinl fqlhhlrdfs neteqhtysq deqlcwtqll alfmsflgil
      301 ckcplqnesq eesynayplp avkvsmdwlr lrprvfqeav vderqyiwpw lisllnsfhp
      361 heedlssisa tplpeefelq gflalrpsfr nldfskghqg itgdkegqqr rirqqrlisi
      421 gkwiadnqpr liqcenevgk llfiteipel iledpseake nlilqetsvi eslaadgspg
      481 lksvlstsrn lsnncdtgek pvvtfkenik trevnrdqgr sfppkevrrd yskgitvtkn
      541 dgkkdnnkrk tetkkctlek lqetgkqnva vqvksqtelr ktpvsearkt pvtqtptqas
      601 nsqfipihhp gafpplpsrp gfppptyvip ppvafsmgsg ytfpagvsvp gtflqptahs
      661 pagnqvqagk qshipysqqr psgpgpmnqg pqqsqppsqq pltslpaqpt aqstsqlqvq
      721 altqqqqspt kavpalgksp phhsgfqqyq qadaskqlwn ppqvqgplgk impvkqpyyl
      781 qtqdpiklfe pslqppvmqq qplekkmkpf pmepynhnps evkvpefywd ssysmadnrs
      841 vmaqqanidr rgkrspgvfr peqdpvprmp fedpksspll ppdllkslaa leeeeelifs
      901 nppdlypall gplaslpgrs lfksllekps elmshsssfl sltgfslnqe rypnnsmfne
      961 vygknltsss kaelspsmap qetslyslfe gtpwspslpa ssdhstpasq sphssnpssl
     1021 pssppthnhn svpfsnfgpi gtpdnrdrrt adrwktdkpa mggfgidyls atsssesswh
     1081 qastpsgtwt ghgpsmedss avlmeslksi wsssmmhpgp saleqllmqq kqkqqrgqgt
     1141 mnpph
//
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