LOCUS NP_001381926 182 aa linear PRI 08-APR-2024
DEFINITION kappa-casein precursor [Homo sapiens].
ACCESSION NP_001381926
VERSION NP_001381926.1
DBSOURCE REFSEQ: accession NM_001394997.1
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 182)
AUTHORS Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 2 (residues 1 to 182)
AUTHORS Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
Clark,A.G. and Yu,H.
TITLE Extensive disruption of protein interactions by genetic variants
across the allele frequency spectrum in human populations
JOURNAL Nat Commun 10 (1), 4141 (2019)
PUBMED 31515488
REMARK Publication Status: Online-Only
REFERENCE 3 (residues 1 to 182)
AUTHORS Cole,J.W., Stine,O.C., Liu,X., Pratap,A., Cheng,Y., Tallon,L.J.,
Sadzewicz,L.K., Dueker,N., Wozniak,M.A., Stern,B.J., Meschia,J.F.,
Mitchell,B.D., Kittner,S.J. and O'Connell,J.R.
TITLE Rare variants in ischemic stroke: an exome pilot study
JOURNAL PLoS One 7 (4), e35591 (2012)
PUBMED 22536414
REMARK GeneRIF: CSN3 was found to contain an interesting coding
polymorphism as well as containing excess rare variation as
compared with the other genes evaluated in cerebral ischemia
patients.
REFERENCE 4 (residues 1 to 182)
AUTHORS Satoh,J., Obayashi,S., Misawa,T., Sumiyoshi,K., Oosumi,K. and
Tabunoki,H.
TITLE Protein microarray analysis identifies human cellular prion protein
interactors
JOURNAL Neuropathol Appl Neurobiol 35 (1), 16-35 (2009)
PUBMED 18482256
REFERENCE 5 (residues 1 to 182)
AUTHORS Nekipelaya,V.V., Semenov,D.V., Potapenko,M.O., Kuligina,E.V.,
Kit,Yu., Romanova,I.V. and Richter,V.A.
TITLE Lactaptin is a human milk protein inducing apoptosis of MCF-7
adenocarcinoma cells
JOURNAL Dokl Biochem Biophys 419, 58-61 (2008)
PUBMED 18505157
REMARK GeneRIF: human milk plasma protein exterts an apoptotic effect on
MCF-7 adenocarcinoma cells.
REFERENCE 6 (residues 1 to 182)
AUTHORS Edlund,A., Johansson,T., Leidvik,B. and Hansson,L.
TITLE Structure of the human kappa-casein gene
JOURNAL Gene 174 (1), 65-69 (1996)
PUBMED 8863730
REFERENCE 7 (residues 1 to 182)
AUTHORS Dev,B.C., Sood,S.M., DeWind,S. and Slattery,C.W.
TITLE Kappa-casein and beta-caseins in human milk micelles: structural
studies
JOURNAL Arch Biochem Biophys 314 (2), 329-336 (1994)
PUBMED 7979373
REFERENCE 8 (residues 1 to 182)
AUTHORS Bergstrom,S., Hansson,L., Hernell,O., Lonnerdal,B., Nilsson,A.K.
and Stromqvist,M.
TITLE Cloning and sequencing of human kappa-casein cDNA
JOURNAL DNA Seq 3 (4), 245-246 (1992)
PUBMED 1296818
REFERENCE 9 (residues 1 to 182)
AUTHORS Brignon,G., Chtourou,A. and Ribadeau-Dumas,B.
TITLE Preparation and amino acid sequence of human kappa-casein
JOURNAL FEBS Lett 188 (1), 48-54 (1985)
PUBMED 4018271
REFERENCE 10 (residues 1 to 182)
AUTHORS Fiat,A.M., Jolles,J., Aubert,J.P., Loucheux-Lefebvre,M.H. and
Jolles,P.
TITLE Localisation and importance of the sugar part of human casein
JOURNAL Eur J Biochem 111 (2), 333-339 (1980)
PUBMED 7460900
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC105347.4.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC010935.1, X66417.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1968832, SAMEA2150585
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000304954.4/ ENSP00000304822.3
RefSeq Select criteria :: based on manual assertion, expression,
longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..182
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="4"
/map="4q13.3"
Protein 1..182
/product="kappa-casein precursor"
/note="kappa-casein"
/calculated_mol_wt=18163
sig_peptide 1..20
/note="propagated from UniProtKB/Swiss-Prot (P07498.3)"
/calculated_mol_wt=2161
mat_peptide 21..182
/product="Kappa-casein. /id=PRO_0000004498"
/note="propagated from UniProtKB/Swiss-Prot (P07498.3)"
/calculated_mol_wt=18163
Region 21..171
/region_name="Casein_kappa"
/note="Kappa casein; pfam00997"
/db_xref="CDD:460021"
Site 117..118
/site_type="cleavage"
/note="Cleavage, by chymosin/rennin; propagated from
UniProtKB/Swiss-Prot (P07498.3)"
Site 133
/site_type="glycosylation"
/note="O-linked (GalNAc...) threonine.
/evidence=ECO:0000269|PubMed:7460900; propagated from
UniProtKB/Swiss-Prot (P07498.3)"
Site 143
/site_type="glycosylation"
/note="O-linked (GalNAc...) threonine.
/evidence=ECO:0000269|PubMed:7460900; propagated from
UniProtKB/Swiss-Prot (P07498.3)"
Site 148
/site_type="glycosylation"
/note="O-linked (GalNAc...) threonine.
/evidence=ECO:0000269|PubMed:7460900; propagated from
UniProtKB/Swiss-Prot (P07498.3)"
Site 151
/site_type="glycosylation"
/note="O-linked (GalNAc...) threonine.
/evidence=ECO:0000269|PubMed:7460900; propagated from
UniProtKB/Swiss-Prot (P07498.3)"
Site 157
/site_type="glycosylation"
/note="O-linked (GalNAc...) threonine, alternate.
/evidence=ECO:0000269|PubMed:7460900; propagated from
UniProtKB/Swiss-Prot (P07498.3)"
Site 157
/site_type="phosphorylation"
/note="Phosphothreonine, alternate.
/evidence=ECO:0000250|UniProtKB:P02668; propagated from
UniProtKB/Swiss-Prot (P07498.3)"
Site 167
/site_type="glycosylation"
/note="O-linked (GalNAc...) threonine.
/evidence=ECO:0000269|PubMed:7460900; propagated from
UniProtKB/Swiss-Prot (P07498.3)"
Site 169
/site_type="glycosylation"
/note="O-linked (GalNAc...) threonine.
/evidence=ECO:0000269|PubMed:7460900; propagated from
UniProtKB/Swiss-Prot (P07498.3)"
Site 178
/site_type="glycosylation"
/note="O-linked (GalNAc...) threonine.
/evidence=ECO:0000250|UniProtKB:P02668; propagated from
UniProtKB/Swiss-Prot (P07498.3)"
CDS 1..182
/gene="CSN3"
/gene_synonym="CNS10; CSN10; CSNK; KCA"
/coded_by="NM_001394997.1:78..626"
/db_xref="CCDS:CCDS3538.1"
/db_xref="GeneID:1448"
/db_xref="HGNC:HGNC:2446"
/db_xref="MIM:601695"
ORIGIN
1 mksfllvvna laltlpflav evqnqkqpac henderpfyq ktapyvpmyy vpnsypyygt
61 nlyqrrpaia innpyvprty yanpavvrph aqipqrqylp nshpptvvrr pnlhpsfiai
121 ppkkiqdkii iptintiatv eptpapatep tvdsvvtpea fsesiitstp etttvavtpp
181 ta
//