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kappa-casein precursor [Homo sapiens]

NCBI Reference Sequence: NP_001381926.1

Identical Proteins FASTA Graphics 

LOCUS       NP_001381926             182 aa            linear   PRI 08-APR-2024
DEFINITION  kappa-casein precursor [Homo sapiens].
ACCESSION   NP_001381926
VERSION     NP_001381926.1
DBSOURCE    REFSEQ: accession NM_001394997.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 182)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (residues 1 to 182)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 182)
  AUTHORS   Cole,J.W., Stine,O.C., Liu,X., Pratap,A., Cheng,Y., Tallon,L.J.,
            Sadzewicz,L.K., Dueker,N., Wozniak,M.A., Stern,B.J., Meschia,J.F.,
            Mitchell,B.D., Kittner,S.J. and O'Connell,J.R.
  TITLE     Rare variants in ischemic stroke: an exome pilot study
  JOURNAL   PLoS One 7 (4), e35591 (2012)
   PUBMED   22536414
  REMARK    GeneRIF: CSN3 was found to contain an interesting coding
            polymorphism as well as containing excess rare variation as
            compared with the other genes evaluated in cerebral ischemia
            patients.
REFERENCE   4  (residues 1 to 182)
  AUTHORS   Satoh,J., Obayashi,S., Misawa,T., Sumiyoshi,K., Oosumi,K. and
            Tabunoki,H.
  TITLE     Protein microarray analysis identifies human cellular prion protein
            interactors
  JOURNAL   Neuropathol Appl Neurobiol 35 (1), 16-35 (2009)
   PUBMED   18482256
REFERENCE   5  (residues 1 to 182)
  AUTHORS   Nekipelaya,V.V., Semenov,D.V., Potapenko,M.O., Kuligina,E.V.,
            Kit,Yu., Romanova,I.V. and Richter,V.A.
  TITLE     Lactaptin is a human milk protein inducing apoptosis of MCF-7
            adenocarcinoma cells
  JOURNAL   Dokl Biochem Biophys 419, 58-61 (2008)
   PUBMED   18505157
  REMARK    GeneRIF: human milk plasma protein exterts an apoptotic effect on
            MCF-7 adenocarcinoma cells.
REFERENCE   6  (residues 1 to 182)
  AUTHORS   Edlund,A., Johansson,T., Leidvik,B. and Hansson,L.
  TITLE     Structure of the human kappa-casein gene
  JOURNAL   Gene 174 (1), 65-69 (1996)
   PUBMED   8863730
REFERENCE   7  (residues 1 to 182)
  AUTHORS   Dev,B.C., Sood,S.M., DeWind,S. and Slattery,C.W.
  TITLE     Kappa-casein and beta-caseins in human milk micelles: structural
            studies
  JOURNAL   Arch Biochem Biophys 314 (2), 329-336 (1994)
   PUBMED   7979373
REFERENCE   8  (residues 1 to 182)
  AUTHORS   Bergstrom,S., Hansson,L., Hernell,O., Lonnerdal,B., Nilsson,A.K.
            and Stromqvist,M.
  TITLE     Cloning and sequencing of human kappa-casein cDNA
  JOURNAL   DNA Seq 3 (4), 245-246 (1992)
   PUBMED   1296818
REFERENCE   9  (residues 1 to 182)
  AUTHORS   Brignon,G., Chtourou,A. and Ribadeau-Dumas,B.
  TITLE     Preparation and amino acid sequence of human kappa-casein
  JOURNAL   FEBS Lett 188 (1), 48-54 (1985)
   PUBMED   4018271
REFERENCE   10 (residues 1 to 182)
  AUTHORS   Fiat,A.M., Jolles,J., Aubert,J.P., Loucheux-Lefebvre,M.H. and
            Jolles,P.
  TITLE     Localisation and importance of the sugar part of human casein
  JOURNAL   Eur J Biochem 111 (2), 333-339 (1980)
   PUBMED   7460900
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105347.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010935.1, X66417.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2150585
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304954.4/ ENSP00000304822.3
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..182
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     Protein         1..182
                     /product="kappa-casein precursor"
                     /note="kappa-casein"
                     /calculated_mol_wt=18163
     sig_peptide     1..20
                     /note="propagated from UniProtKB/Swiss-Prot (P07498.3)"
                     /calculated_mol_wt=2161
     mat_peptide     21..182
                     /product="Kappa-casein. /id=PRO_0000004498"
                     /note="propagated from UniProtKB/Swiss-Prot (P07498.3)"
                     /calculated_mol_wt=18163
     Region          21..171
                     /region_name="Casein_kappa"
                     /note="Kappa casein; pfam00997"
                     /db_xref="CDD:460021"
     Site            117..118
                     /site_type="cleavage"
                     /note="Cleavage, by chymosin/rennin; propagated from
                     UniProtKB/Swiss-Prot (P07498.3)"
     Site            133
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000269|PubMed:7460900; propagated from
                     UniProtKB/Swiss-Prot (P07498.3)"
     Site            143
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000269|PubMed:7460900; propagated from
                     UniProtKB/Swiss-Prot (P07498.3)"
     Site            148
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000269|PubMed:7460900; propagated from
                     UniProtKB/Swiss-Prot (P07498.3)"
     Site            151
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000269|PubMed:7460900; propagated from
                     UniProtKB/Swiss-Prot (P07498.3)"
     Site            157
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine, alternate.
                     /evidence=ECO:0000269|PubMed:7460900; propagated from
                     UniProtKB/Swiss-Prot (P07498.3)"
     Site            157
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P02668; propagated from
                     UniProtKB/Swiss-Prot (P07498.3)"
     Site            167
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000269|PubMed:7460900; propagated from
                     UniProtKB/Swiss-Prot (P07498.3)"
     Site            169
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000269|PubMed:7460900; propagated from
                     UniProtKB/Swiss-Prot (P07498.3)"
     Site            178
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000250|UniProtKB:P02668; propagated from
                     UniProtKB/Swiss-Prot (P07498.3)"
     CDS             1..182
                     /gene="CSN3"
                     /gene_synonym="CNS10; CSN10; CSNK; KCA"
                     /coded_by="NM_001394997.1:78..626"
                     /db_xref="CCDS:CCDS3538.1"
                     /db_xref="GeneID:1448"
                     /db_xref="HGNC:HGNC:2446"
                     /db_xref="MIM:601695"
ORIGIN      
        1 mksfllvvna laltlpflav evqnqkqpac henderpfyq ktapyvpmyy vpnsypyygt
       61 nlyqrrpaia innpyvprty yanpavvrph aqipqrqylp nshpptvvrr pnlhpsfiai
      121 ppkkiqdkii iptintiatv eptpapatep tvdsvvtpea fsesiitstp etttvavtpp
      181 ta
//
Feature
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