LOCUS KR106_HUMAN 365 aa linear PRI 02-OCT-2024
DEFINITION RecName: Full=Keratin-associated protein 10-6; AltName: Full=High
sulfur keratin-associated protein 10.6; AltName:
Full=Keratin-associated protein 10.6; AltName:
Full=Keratin-associated protein 18-6; AltName:
Full=Keratin-associated protein 18.6.
ACCESSION P60371
VERSION P60371.3
DBSOURCE UniProtKB: locus KR106_HUMAN, accession P60371;
class: standard.
created: Feb 16, 2004.
sequence updated: Feb 23, 2022.
annotation updated: Oct 2, 2024.
xrefs: AB076353.1, BAD01540.1, AL773602.1, NP_941961.3
xrefs (non-sequence databases): CCDS:CCDS42959.1,
AlphaFoldDB:P60371, BioGRID:132125, IntAct:P60371,
STRING:9606.ENSP00000383219, iPTMnet:P60371,
PhosphoSitePlus:P60371, BioMuta:KRTAP10-6, DMDM:288558812,
MassIVE:P60371, PaxDb:9606-ENSP00000383219, PeptideAtlas:P60371,
Antibodypedia:78046, DNASU:386674, Ensembl:ENST00000400368.1,
Ensembl:ENSP00000383219.1, Ensembl:ENSG00000188155.11,
GeneID:386674, KEGG:hsa:386674, MANE-Select:ENST00000400368.1,
UCSC:uc032qbq.1, AGR:HGNC:20523, CTD:386674, DisGeNET:386674,
GeneCards:KRTAP10-6, HGNC:20523, HPA:ENSG00000188155,
neXtProt:NX_P60371, PharmGKB:PA134871340,
VEuPathDB:HostDB:ENSG00000188155, eggNOG:KOG4726,
GeneTree:ENSGT00940000164049, InParanoid:P60371, OMA:DDPTVCP,
OrthoDB:5267189at2759, PhylomeDB:P60371, PathwayCommons:P60371,
Reactome:R-HSA-6805567, SignaLink:P60371, BioGRID-ORCS:386674,
GenomeRNAi:386674, Pharos:P60371, PRO:PR:P60371,
Proteomes:UP000005640, RNAct:P60371, Bgee:ENSG00000188155,
GO:0005829, GO:0045095, InterPro:IPR002494, PANTHER:PTHR23262,
PANTHER:PTHR23262:SF256, Pfam:PF13885
KEYWORDS Keratin; Reference proteome; Repeat.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 365)
AUTHORS Shibuya,K., Obayashi,I., Asakawa,S., Minoshima,S., Kudoh,J. and
Shimizu,N.
TITLE A cluster of 21 keratin-associated protein genes within introns of
another gene on human chromosome 21q22.3
JOURNAL Genomics 83 (4), 679-693 (2004)
PUBMED 15028290
REMARK NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT
PRO-SER-CYS-CYS-ALA-81 INS.;
TISSUE=Hair root
REFERENCE 2 (residues 1 to 365)
AUTHORS Hattori,M., Fujiyama,A., Taylor,T.D., Watanabe,H., Yada,T.,
Park,H.S., Toyoda,A., Ishii,K., Totoki,Y., Choi,D.K., Groner,Y.,
Soeda,E., Ohki,M., Takagi,T., Sakaki,Y., Taudien,S.,
Blechschmidt,K., Polley,A., Menzel,U., Delabar,J., Kumpf,K.,
Lehmann,R., Patterson,D., Reichwald,K., Rump,A., Schillhabel,M.,
Schudy,A., Zimmermann,W., Rosenthal,A., Kudoh,J., Schibuya,K.,
Kawasaki,K., Asakawa,S., Shintani,A., Sasaki,T., Nagamine,K.,
Mitsuyama,S., Antonarakis,S.E., Minoshima,S., Shimizu,N.,
Nordsiek,G., Hornischer,K., Brant,P., Scharfe,M., Schon,O.,
Desario,A., Reichelt,J., Kauer,G., Blocker,H., Ramser,J., Beck,A.,
Klages,S., Hennig,S., Riesselmann,L., Dagand,E., Haaf,T.,
Wehrmeyer,S., Borzym,K., Gardiner,K., Nizetic,D., Francis,F.,
Lehrach,H., Reinhardt,R. and Yaspo,M.L.
CONSRTM Chromosome 21 mapping and sequencing consortium
TITLE The DNA sequence of human chromosome 21
JOURNAL Nature 405 (6784), 311-319 (2000)
PUBMED 10830953
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Erratum:[Nature 2000 Sep 7;407(6800):110]
REFERENCE 3 (residues 1 to 365)
AUTHORS Rogers,M.A., Langbein,L., Winter,H., Beckmann,I., Praetzel,S. and
Schweizer,J.
TITLE Hair keratin associated proteins: characterization of a second high
sulfur KAP gene domain on human chromosome 21
JOURNAL J Invest Dermatol 122 (1), 147-158 (2004)
PUBMED 14962103
REMARK TISSUE SPECIFICITY.
COMMENT On Mar 4, 2022 this sequence version replaced P60371.2.
[FUNCTION] In the hair cortex, hair keratin intermediate filaments
are embedded in an interfilamentous matrix, consisting of hair
keratin-associated proteins (KRTAP), which are essential for the
formation of a rigid and resistant hair shaft through their
extensive disulfide bond cross-linking with abundant cysteine
residues of hair keratins. The matrix proteins include the
high-sulfur and high-glycine-tyrosine keratins.
[SUBUNIT] Interacts with hair keratins.
[INTERACTION] P60371; P82987: ADAMTSL3; NbExp=3;
IntAct=EBI-12012928, EBI-10221726; P60371; Q5T686: AVPI1; NbExp=3;
IntAct=EBI-12012928, EBI-8640233; P60371; P49759-3: CLK1; NbExp=3;
IntAct=EBI-12012928, EBI-11981867; P60371; Q9HAZ1: CLK4; NbExp=3;
IntAct=EBI-12012928, EBI-633400; P60371; Q6P158: DHX57; NbExp=3;
IntAct=EBI-12012928, EBI-1051531; P60371; Q9UBU2: DKK2; NbExp=3;
IntAct=EBI-12012928, EBI-13274770; P60371; Q12950: FOXD4; NbExp=3;
IntAct=EBI-12012928, EBI-11317801; P60371; O96004: HAND1; NbExp=3;
IntAct=EBI-12012928, EBI-11320290; P60371; Q03014: HHEX; NbExp=3;
IntAct=EBI-12012928, EBI-747421; P60371; P09067: HOXB5; NbExp=3;
IntAct=EBI-12012928, EBI-3893317; P60371; A0A384DVV8: KIAA0040;
NbExp=3; IntAct=EBI-12012928, EBI-20764875; P60371; Q9HAQ2: KIF9;
NbExp=3; IntAct=EBI-12012928, EBI-8472129; P60371; P60370:
KRTAP10-5; NbExp=3; IntAct=EBI-12012928, EBI-10172150; P60371;
Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-12012928, EBI-10172511;
P60371; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-12012928,
EBI-11958132; P60371; Q9BYR2: KRTAP4-5; NbExp=3;
IntAct=EBI-12012928, EBI-11993254; P60371; Q6L8G4: KRTAP5-11;
NbExp=3; IntAct=EBI-12012928, EBI-11993296; P60371; Q701N4:
KRTAP5-2; NbExp=3; IntAct=EBI-12012928, EBI-11958178; P60371;
P26371: KRTAP5-9; NbExp=3; IntAct=EBI-12012928, EBI-3958099;
P60371; Q5T753: LCE1E; NbExp=3; IntAct=EBI-12012928, EBI-11955335;
P60371; Q5T754: LCE1F; NbExp=3; IntAct=EBI-12012928, EBI-11958008;
P60371; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-12012928, EBI-11973993;
P60371; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-12012928, EBI-10246750;
P60371; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-12012928, EBI-11974495;
P60371; Q5T5B0: LCE3E; NbExp=3; IntAct=EBI-12012928, EBI-10245456;
P60371; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-12012928, EBI-10246358;
P60371; Q96ES6: MFSD3; NbExp=3; IntAct=EBI-12012928, EBI-745345;
P60371; Q13875-3: MOBP; NbExp=3; IntAct=EBI-12012928, EBI-12013470;
P60371; P07438: MT1B; NbExp=3; IntAct=EBI-12012928, EBI-12015462;
P60371; P41227: NAA10; NbExp=3; IntAct=EBI-12012928, EBI-747693;
P60371; Q8IW45: NAXD; NbExp=3; IntAct=EBI-12012928, EBI-8650724;
P60371; Q969G9: NKD1; NbExp=3; IntAct=EBI-12012928, EBI-1538217;
P60371; P48645: NMU; NbExp=3; IntAct=EBI-12012928, EBI-10210351;
P60371; Q9UGY1: NOL12; NbExp=3; IntAct=EBI-12012928, EBI-716098;
P60371; Q9NQX5: NPDC1; NbExp=3; IntAct=EBI-12012928, EBI-748927;
P60371; Q96AQ6: PBXIP1; NbExp=3; IntAct=EBI-12012928, EBI-740845;
P60371; Q13526: PIN1; NbExp=3; IntAct=EBI-12012928, EBI-714158;
P60371; Q6UXX9-2: RSPO2; NbExp=3; IntAct=EBI-12012928,
EBI-12009390; P60371; Q8TAD8: SNIP1; NbExp=3; IntAct=EBI-12012928,
EBI-749336; P60371; Q9BX79-6: STRA6; NbExp=3; IntAct=EBI-12012928,
EBI-12140683; P60371; Q6EMK4: VASN; NbExp=3; IntAct=EBI-12012928,
EBI-10249550; P60371; P19544-6: WT1; NbExp=3; IntAct=EBI-12012928,
EBI-11745701; P60371; Q96MU7: YTHDC1; NbExp=3; IntAct=EBI-12012928,
EBI-2849854; P60371; O43167: ZBTB24; NbExp=3; IntAct=EBI-12012928,
EBI-744471; P60371; Q7Z2W4: ZC3HAV1; NbExp=3; IntAct=EBI-12012928,
EBI-922540; P60371; Q9NZV7: ZIM2; NbExp=3; IntAct=EBI-12012928,
EBI-11962760; P60371; Q8NC26: ZNF114; NbExp=3; IntAct=EBI-12012928,
EBI-10265237; P60371; P52744: ZNF138; NbExp=3; IntAct=EBI-12012928,
EBI-10746567; P60371; Q12901: ZNF155; NbExp=3; IntAct=EBI-12012928,
EBI-10747670; P60371; Q14929: ZNF169; NbExp=3; IntAct=EBI-12012928,
EBI-10234472; P60371; Q9UK13: ZNF221; NbExp=3; IntAct=EBI-12012928,
EBI-14513896; P60371; Q16600: ZNF239; NbExp=3; IntAct=EBI-12012928,
EBI-8787052; P60371; O43296: ZNF264; NbExp=3; IntAct=EBI-12012928,
EBI-4395808; P60371; Q8ND82: ZNF280C; NbExp=3; IntAct=EBI-12012928,
EBI-8831272; P60371; Q9NR11-2: ZNF302; NbExp=3;
IntAct=EBI-12012928, EBI-12988373; P60371; Q9P2F9: ZNF319; NbExp=3;
IntAct=EBI-12012928, EBI-11993110; P60371; Q8TF45: ZNF418; NbExp=3;
IntAct=EBI-12012928, EBI-3446851; P60371; Q8IYI8: ZNF440; NbExp=3;
IntAct=EBI-12012928, EBI-726439; P60371; Q96JC4: ZNF479; NbExp=3;
IntAct=EBI-12012928, EBI-10820574; P60371; Q9ULM2: ZNF490; NbExp=3;
IntAct=EBI-12012928, EBI-1105370; P60371; Q08ER8: ZNF543; NbExp=3;
IntAct=EBI-12012928, EBI-10226133; P60371; Q8TA94: ZNF563; NbExp=3;
IntAct=EBI-12012928, EBI-11792334; P60371; Q8IYB9: ZNF595; NbExp=3;
IntAct=EBI-12012928, EBI-2682172; P60371; Q6ZNG1: ZNF600; NbExp=3;
IntAct=EBI-12012928, EBI-3444696; P60371; Q96BR6: ZNF669; NbExp=3;
IntAct=EBI-12012928, EBI-12006574; P60371; Q499Z4: ZNF672; NbExp=3;
IntAct=EBI-12012928, EBI-12146251; P60371; Q8IYX0: ZNF679; NbExp=3;
IntAct=EBI-12012928, EBI-745567; P60371; Q9H7X3: ZNF696; NbExp=3;
IntAct=EBI-12012928, EBI-11090299; P60371; Q6NX45: ZNF774; NbExp=3;
IntAct=EBI-12012928, EBI-10251462; P60371; Q68DI1: ZNF776; NbExp=3;
IntAct=EBI-12012928, EBI-12878746; P60371; Q3KQV3: ZNF792; NbExp=3;
IntAct=EBI-12012928, EBI-10240849; P60371; O43257: ZNHIT1; NbExp=3;
IntAct=EBI-12012928, EBI-347522.
[TISSUE SPECIFICITY] Restricted to a narrow region of the hair
fiber cuticle, lying approximately 20 cell layers above the apex of
the dermal papilla of the hair root; not detected in any other
tissues. {ECO:0000269|PubMed:14962103,
ECO:0000269|PubMed:15028290}.
[SIMILARITY] Belongs to the KRTAP type 10 family. {ECO:0000305}.
FEATURES Location/Qualifiers
source 1..365
/organism="Homo sapiens"
/db_xref="taxon:9606"
gene 1..365
/gene="KRTAP10-6"
/gene_synonym="KAP10.6"
/gene_synonym="KAP18-6"
/gene_synonym="KRTAP10.6"
/gene_synonym="KRTAP18-6"
/gene_synonym="KRTAP18.6"
Protein 1..365
/product="Keratin-associated protein 10-6"
/note="High sulfur keratin-associated protein 10.6;
Keratin-associated protein 10.6; Keratin-associated
protein 18-6; Keratin-associated protein 18.6"
/UniProtKB_evidence="Evidence at protein level"
Region 1..365
/region_name="Mature chain"
/note="Keratin-associated protein 10-6.
/id=PRO_0000185214."
Region 41..338
/region_name="Region of interest in the sequence"
/note="29 X 5 AA repeats of C-C-X(3)."
Region 41..45
/region_name="Repetitive region"
/note="1."
Region 46..209
/region_name="Keratin_B2"
/note="Keratin, high sulfur B2 protein; pfam01500"
/db_xref="CDD:366678"
Region 46..50
/region_name="Repetitive region"
/note="2."
Region 67..71
/region_name="Repetitive region"
/note="3."
Region 68
/region_name="Variant"
/note="C -> S (in dbSNP:rs13051409). /id=VAR_060049."
Region 74
/region_name="Variant"
/note="P -> S (in dbSNP:rs13050443). /id=VAR_060050."
Region 81
/region_name="Variant"
/note="C -> CPSCCA. /id=VAR_017699."
Region 89..130
/region_name="Keratin_B2_2"
/note="Keratin, high sulfur B2 protein; pfam13885"
/db_xref="CDD:464017"
Region 89..93
/region_name="Repetitive region"
/note="4."
Region 99..103
/region_name="Repetitive region"
/note="5."
Region 109..113
/region_name="Repetitive region"
/note="6."
Region 114..118
/region_name="Repetitive region"
/note="7."
Region 119..123
/region_name="Repetitive region"
/note="8."
Region 124..128
/region_name="Repetitive region"
/note="9."
Region 129..291
/region_name="Keratin_B2"
/note="Keratin, high sulfur B2 protein; pfam01500"
/db_xref="CDD:366678"
Region 129..133
/region_name="Repetitive region"
/note="10."
Region 135..139
/region_name="Repetitive region"
/note="11."
Region 145..149
/region_name="Repetitive region"
/note="12."
Region 155..159
/region_name="Repetitive region"
/note="13."
Region 159
/region_name="Variant"
/note="V -> I (in dbSNP:rs233306). /id=VAR_057649."
Region 160..164
/region_name="Repetitive region"
/note="14."
Region 172..176
/region_name="Repetitive region"
/note="15."
Region 186..190
/region_name="Repetitive region"
/note="16."
Region 208..212
/region_name="Repetitive region"
/note="17."
Region 218..222
/region_name="Repetitive region"
/note="18."
Region 228..232
/region_name="Repetitive region"
/note="19."
Region 233..237
/region_name="Repetitive region"
/note="20."
Region 238..242
/region_name="Repetitive region"
/note="21."
Region 250..254
/region_name="Repetitive region"
/note="22."
Region 260..264
/region_name="Repetitive region"
/note="23."
Region 270..274
/region_name="Repetitive region"
/note="24."
Region 282..286
/region_name="Repetitive region"
/note="25."
Region 292..296
/region_name="Repetitive region"
/note="26."
Region 297..301
/region_name="Repetitive region"
/note="27."
Region 300
/region_name="Variant"
/note="S -> P (in dbSNP:rs465279). /id=VAR_062533."
Region 316..320
/region_name="Repetitive region"
/note="28."
Region 334..338
/region_name="Repetitive region"
/note="29."
ORIGIN
1 maastmsvcs sdlsygsrvc lpgscdscsd swqvddcpes cceppccapa pclslvctpv
61 srvsspccpv tcepspcqsg ctssctpscc qqsscqlacc asspcqqacc vpvccktvcc
121 kpvccvsvcc gdssccqqss cqsacctssp cqqaccvpvc ckpvcsgiss sccqqsscvs
181 cvsspccqav cepspcqsgc tssctpsccq qsscqptcct sspcqqaccv pvccvpvccv
241 ptcsedsssc cqqsscqpac ctsspcqhac cvpvcsgast sccqqsscqp acctasccrs
301 sssvsllchp vckstccvpv pscgasassc qpsccrtasc vsllcrpmcs rpacyslcsg
361 qkssc
//