U.S. flag

An official website of the United States government

RecName: Full=Keratin-associated protein 10-6; AltName: Full=High sulfur keratin-associated protein 10.6; AltName: Full=Keratin-associated protein 10.6; AltName: Full=Keratin-associated protein 18-6; AltName: Full=Keratin-associated protein 18.6

UniProtKB/Swiss-Prot: P60371.3

Identical Proteins FASTA Graphics 

LOCUS       KR106_HUMAN              365 aa            linear   PRI 02-OCT-2024
DEFINITION  RecName: Full=Keratin-associated protein 10-6; AltName: Full=High
            sulfur keratin-associated protein 10.6; AltName:
            Full=Keratin-associated protein 10.6; AltName:
            Full=Keratin-associated protein 18-6; AltName:
            Full=Keratin-associated protein 18.6.
ACCESSION   P60371
VERSION     P60371.3
DBSOURCE    UniProtKB: locus KR106_HUMAN, accession P60371;
            class: standard.
            created: Feb 16, 2004.
            sequence updated: Feb 23, 2022.
            annotation updated: Oct 2, 2024.
            xrefs: AB076353.1, BAD01540.1, AL773602.1, NP_941961.3
            xrefs (non-sequence databases): CCDS:CCDS42959.1,
            AlphaFoldDB:P60371, BioGRID:132125, IntAct:P60371,
            STRING:9606.ENSP00000383219, iPTMnet:P60371,
            PhosphoSitePlus:P60371, BioMuta:KRTAP10-6, DMDM:288558812,
            MassIVE:P60371, PaxDb:9606-ENSP00000383219, PeptideAtlas:P60371,
            Antibodypedia:78046, DNASU:386674, Ensembl:ENST00000400368.1,
            Ensembl:ENSP00000383219.1, Ensembl:ENSG00000188155.11,
            GeneID:386674, KEGG:hsa:386674, MANE-Select:ENST00000400368.1,
            UCSC:uc032qbq.1, AGR:HGNC:20523, CTD:386674, DisGeNET:386674,
            GeneCards:KRTAP10-6, HGNC:20523, HPA:ENSG00000188155,
            neXtProt:NX_P60371, PharmGKB:PA134871340,
            VEuPathDB:HostDB:ENSG00000188155, eggNOG:KOG4726,
            GeneTree:ENSGT00940000164049, InParanoid:P60371, OMA:DDPTVCP,
            OrthoDB:5267189at2759, PhylomeDB:P60371, PathwayCommons:P60371,
            Reactome:R-HSA-6805567, SignaLink:P60371, BioGRID-ORCS:386674,
            GenomeRNAi:386674, Pharos:P60371, PRO:PR:P60371,
            Proteomes:UP000005640, RNAct:P60371, Bgee:ENSG00000188155,
            GO:0005829, GO:0045095, InterPro:IPR002494, PANTHER:PTHR23262,
            PANTHER:PTHR23262:SF256, Pfam:PF13885
KEYWORDS    Keratin; Reference proteome; Repeat.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 365)
  AUTHORS   Shibuya,K., Obayashi,I., Asakawa,S., Minoshima,S., Kudoh,J. and
            Shimizu,N.
  TITLE     A cluster of 21 keratin-associated protein genes within introns of
            another gene on human chromosome 21q22.3
  JOURNAL   Genomics 83 (4), 679-693 (2004)
   PUBMED   15028290
  REMARK    NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT
            PRO-SER-CYS-CYS-ALA-81 INS.;
            TISSUE=Hair root
REFERENCE   2  (residues 1 to 365)
  AUTHORS   Hattori,M., Fujiyama,A., Taylor,T.D., Watanabe,H., Yada,T.,
            Park,H.S., Toyoda,A., Ishii,K., Totoki,Y., Choi,D.K., Groner,Y.,
            Soeda,E., Ohki,M., Takagi,T., Sakaki,Y., Taudien,S.,
            Blechschmidt,K., Polley,A., Menzel,U., Delabar,J., Kumpf,K.,
            Lehmann,R., Patterson,D., Reichwald,K., Rump,A., Schillhabel,M.,
            Schudy,A., Zimmermann,W., Rosenthal,A., Kudoh,J., Schibuya,K.,
            Kawasaki,K., Asakawa,S., Shintani,A., Sasaki,T., Nagamine,K.,
            Mitsuyama,S., Antonarakis,S.E., Minoshima,S., Shimizu,N.,
            Nordsiek,G., Hornischer,K., Brant,P., Scharfe,M., Schon,O.,
            Desario,A., Reichelt,J., Kauer,G., Blocker,H., Ramser,J., Beck,A.,
            Klages,S., Hennig,S., Riesselmann,L., Dagand,E., Haaf,T.,
            Wehrmeyer,S., Borzym,K., Gardiner,K., Nizetic,D., Francis,F.,
            Lehrach,H., Reinhardt,R. and Yaspo,M.L.
  CONSRTM   Chromosome 21 mapping and sequencing consortium
  TITLE     The DNA sequence of human chromosome 21
  JOURNAL   Nature 405 (6784), 311-319 (2000)
   PUBMED   10830953
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
            Erratum:[Nature 2000 Sep 7;407(6800):110]
REFERENCE   3  (residues 1 to 365)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Beckmann,I., Praetzel,S. and
            Schweizer,J.
  TITLE     Hair keratin associated proteins: characterization of a second high
            sulfur KAP gene domain on human chromosome 21
  JOURNAL   J Invest Dermatol 122 (1), 147-158 (2004)
   PUBMED   14962103
  REMARK    TISSUE SPECIFICITY.
COMMENT     On Mar 4, 2022 this sequence version replaced P60371.2.
            [FUNCTION] In the hair cortex, hair keratin intermediate filaments
            are embedded in an interfilamentous matrix, consisting of hair
            keratin-associated proteins (KRTAP), which are essential for the
            formation of a rigid and resistant hair shaft through their
            extensive disulfide bond cross-linking with abundant cysteine
            residues of hair keratins. The matrix proteins include the
            high-sulfur and high-glycine-tyrosine keratins.
            [SUBUNIT] Interacts with hair keratins.
            [INTERACTION] P60371; P82987: ADAMTSL3; NbExp=3;
            IntAct=EBI-12012928, EBI-10221726; P60371; Q5T686: AVPI1; NbExp=3;
            IntAct=EBI-12012928, EBI-8640233; P60371; P49759-3: CLK1; NbExp=3;
            IntAct=EBI-12012928, EBI-11981867; P60371; Q9HAZ1: CLK4; NbExp=3;
            IntAct=EBI-12012928, EBI-633400; P60371; Q6P158: DHX57; NbExp=3;
            IntAct=EBI-12012928, EBI-1051531; P60371; Q9UBU2: DKK2; NbExp=3;
            IntAct=EBI-12012928, EBI-13274770; P60371; Q12950: FOXD4; NbExp=3;
            IntAct=EBI-12012928, EBI-11317801; P60371; O96004: HAND1; NbExp=3;
            IntAct=EBI-12012928, EBI-11320290; P60371; Q03014: HHEX; NbExp=3;
            IntAct=EBI-12012928, EBI-747421; P60371; P09067: HOXB5; NbExp=3;
            IntAct=EBI-12012928, EBI-3893317; P60371; A0A384DVV8: KIAA0040;
            NbExp=3; IntAct=EBI-12012928, EBI-20764875; P60371; Q9HAQ2: KIF9;
            NbExp=3; IntAct=EBI-12012928, EBI-8472129; P60371; P60370:
            KRTAP10-5; NbExp=3; IntAct=EBI-12012928, EBI-10172150; P60371;
            Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-12012928, EBI-10172511;
            P60371; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-12012928,
            EBI-11958132; P60371; Q9BYR2: KRTAP4-5; NbExp=3;
            IntAct=EBI-12012928, EBI-11993254; P60371; Q6L8G4: KRTAP5-11;
            NbExp=3; IntAct=EBI-12012928, EBI-11993296; P60371; Q701N4:
            KRTAP5-2; NbExp=3; IntAct=EBI-12012928, EBI-11958178; P60371;
            P26371: KRTAP5-9; NbExp=3; IntAct=EBI-12012928, EBI-3958099;
            P60371; Q5T753: LCE1E; NbExp=3; IntAct=EBI-12012928, EBI-11955335;
            P60371; Q5T754: LCE1F; NbExp=3; IntAct=EBI-12012928, EBI-11958008;
            P60371; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-12012928, EBI-11973993;
            P60371; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-12012928, EBI-10246750;
            P60371; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-12012928, EBI-11974495;
            P60371; Q5T5B0: LCE3E; NbExp=3; IntAct=EBI-12012928, EBI-10245456;
            P60371; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-12012928, EBI-10246358;
            P60371; Q96ES6: MFSD3; NbExp=3; IntAct=EBI-12012928, EBI-745345;
            P60371; Q13875-3: MOBP; NbExp=3; IntAct=EBI-12012928, EBI-12013470;
            P60371; P07438: MT1B; NbExp=3; IntAct=EBI-12012928, EBI-12015462;
            P60371; P41227: NAA10; NbExp=3; IntAct=EBI-12012928, EBI-747693;
            P60371; Q8IW45: NAXD; NbExp=3; IntAct=EBI-12012928, EBI-8650724;
            P60371; Q969G9: NKD1; NbExp=3; IntAct=EBI-12012928, EBI-1538217;
            P60371; P48645: NMU; NbExp=3; IntAct=EBI-12012928, EBI-10210351;
            P60371; Q9UGY1: NOL12; NbExp=3; IntAct=EBI-12012928, EBI-716098;
            P60371; Q9NQX5: NPDC1; NbExp=3; IntAct=EBI-12012928, EBI-748927;
            P60371; Q96AQ6: PBXIP1; NbExp=3; IntAct=EBI-12012928, EBI-740845;
            P60371; Q13526: PIN1; NbExp=3; IntAct=EBI-12012928, EBI-714158;
            P60371; Q6UXX9-2: RSPO2; NbExp=3; IntAct=EBI-12012928,
            EBI-12009390; P60371; Q8TAD8: SNIP1; NbExp=3; IntAct=EBI-12012928,
            EBI-749336; P60371; Q9BX79-6: STRA6; NbExp=3; IntAct=EBI-12012928,
            EBI-12140683; P60371; Q6EMK4: VASN; NbExp=3; IntAct=EBI-12012928,
            EBI-10249550; P60371; P19544-6: WT1; NbExp=3; IntAct=EBI-12012928,
            EBI-11745701; P60371; Q96MU7: YTHDC1; NbExp=3; IntAct=EBI-12012928,
            EBI-2849854; P60371; O43167: ZBTB24; NbExp=3; IntAct=EBI-12012928,
            EBI-744471; P60371; Q7Z2W4: ZC3HAV1; NbExp=3; IntAct=EBI-12012928,
            EBI-922540; P60371; Q9NZV7: ZIM2; NbExp=3; IntAct=EBI-12012928,
            EBI-11962760; P60371; Q8NC26: ZNF114; NbExp=3; IntAct=EBI-12012928,
            EBI-10265237; P60371; P52744: ZNF138; NbExp=3; IntAct=EBI-12012928,
            EBI-10746567; P60371; Q12901: ZNF155; NbExp=3; IntAct=EBI-12012928,
            EBI-10747670; P60371; Q14929: ZNF169; NbExp=3; IntAct=EBI-12012928,
            EBI-10234472; P60371; Q9UK13: ZNF221; NbExp=3; IntAct=EBI-12012928,
            EBI-14513896; P60371; Q16600: ZNF239; NbExp=3; IntAct=EBI-12012928,
            EBI-8787052; P60371; O43296: ZNF264; NbExp=3; IntAct=EBI-12012928,
            EBI-4395808; P60371; Q8ND82: ZNF280C; NbExp=3; IntAct=EBI-12012928,
            EBI-8831272; P60371; Q9NR11-2: ZNF302; NbExp=3;
            IntAct=EBI-12012928, EBI-12988373; P60371; Q9P2F9: ZNF319; NbExp=3;
            IntAct=EBI-12012928, EBI-11993110; P60371; Q8TF45: ZNF418; NbExp=3;
            IntAct=EBI-12012928, EBI-3446851; P60371; Q8IYI8: ZNF440; NbExp=3;
            IntAct=EBI-12012928, EBI-726439; P60371; Q96JC4: ZNF479; NbExp=3;
            IntAct=EBI-12012928, EBI-10820574; P60371; Q9ULM2: ZNF490; NbExp=3;
            IntAct=EBI-12012928, EBI-1105370; P60371; Q08ER8: ZNF543; NbExp=3;
            IntAct=EBI-12012928, EBI-10226133; P60371; Q8TA94: ZNF563; NbExp=3;
            IntAct=EBI-12012928, EBI-11792334; P60371; Q8IYB9: ZNF595; NbExp=3;
            IntAct=EBI-12012928, EBI-2682172; P60371; Q6ZNG1: ZNF600; NbExp=3;
            IntAct=EBI-12012928, EBI-3444696; P60371; Q96BR6: ZNF669; NbExp=3;
            IntAct=EBI-12012928, EBI-12006574; P60371; Q499Z4: ZNF672; NbExp=3;
            IntAct=EBI-12012928, EBI-12146251; P60371; Q8IYX0: ZNF679; NbExp=3;
            IntAct=EBI-12012928, EBI-745567; P60371; Q9H7X3: ZNF696; NbExp=3;
            IntAct=EBI-12012928, EBI-11090299; P60371; Q6NX45: ZNF774; NbExp=3;
            IntAct=EBI-12012928, EBI-10251462; P60371; Q68DI1: ZNF776; NbExp=3;
            IntAct=EBI-12012928, EBI-12878746; P60371; Q3KQV3: ZNF792; NbExp=3;
            IntAct=EBI-12012928, EBI-10240849; P60371; O43257: ZNHIT1; NbExp=3;
            IntAct=EBI-12012928, EBI-347522.
            [TISSUE SPECIFICITY] Restricted to a narrow region of the hair
            fiber cuticle, lying approximately 20 cell layers above the apex of
            the dermal papilla of the hair root; not detected in any other
            tissues. {ECO:0000269|PubMed:14962103,
            ECO:0000269|PubMed:15028290}.
            [SIMILARITY] Belongs to the KRTAP type 10 family. {ECO:0000305}.
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
     gene            1..365
                     /gene="KRTAP10-6"
                     /gene_synonym="KAP10.6"
                     /gene_synonym="KAP18-6"
                     /gene_synonym="KRTAP10.6"
                     /gene_synonym="KRTAP18-6"
                     /gene_synonym="KRTAP18.6"
     Protein         1..365
                     /product="Keratin-associated protein 10-6"
                     /note="High sulfur keratin-associated protein 10.6;
                     Keratin-associated protein 10.6; Keratin-associated
                     protein 18-6; Keratin-associated protein 18.6"
                     /UniProtKB_evidence="Evidence at protein level"
     Region          1..365
                     /region_name="Mature chain"
                     /note="Keratin-associated protein 10-6.
                     /id=PRO_0000185214."
     Region          41..338
                     /region_name="Region of interest in the sequence"
                     /note="29 X 5 AA repeats of C-C-X(3)."
     Region          41..45
                     /region_name="Repetitive region"
                     /note="1."
     Region          46..209
                     /region_name="Keratin_B2"
                     /note="Keratin, high sulfur B2 protein; pfam01500"
                     /db_xref="CDD:366678"
     Region          46..50
                     /region_name="Repetitive region"
                     /note="2."
     Region          67..71
                     /region_name="Repetitive region"
                     /note="3."
     Region          68
                     /region_name="Variant"
                     /note="C -> S (in dbSNP:rs13051409). /id=VAR_060049."
     Region          74
                     /region_name="Variant"
                     /note="P -> S (in dbSNP:rs13050443). /id=VAR_060050."
     Region          81
                     /region_name="Variant"
                     /note="C -> CPSCCA. /id=VAR_017699."
     Region          89..130
                     /region_name="Keratin_B2_2"
                     /note="Keratin, high sulfur B2 protein; pfam13885"
                     /db_xref="CDD:464017"
     Region          89..93
                     /region_name="Repetitive region"
                     /note="4."
     Region          99..103
                     /region_name="Repetitive region"
                     /note="5."
     Region          109..113
                     /region_name="Repetitive region"
                     /note="6."
     Region          114..118
                     /region_name="Repetitive region"
                     /note="7."
     Region          119..123
                     /region_name="Repetitive region"
                     /note="8."
     Region          124..128
                     /region_name="Repetitive region"
                     /note="9."
     Region          129..291
                     /region_name="Keratin_B2"
                     /note="Keratin, high sulfur B2 protein; pfam01500"
                     /db_xref="CDD:366678"
     Region          129..133
                     /region_name="Repetitive region"
                     /note="10."
     Region          135..139
                     /region_name="Repetitive region"
                     /note="11."
     Region          145..149
                     /region_name="Repetitive region"
                     /note="12."
     Region          155..159
                     /region_name="Repetitive region"
                     /note="13."
     Region          159
                     /region_name="Variant"
                     /note="V -> I (in dbSNP:rs233306). /id=VAR_057649."
     Region          160..164
                     /region_name="Repetitive region"
                     /note="14."
     Region          172..176
                     /region_name="Repetitive region"
                     /note="15."
     Region          186..190
                     /region_name="Repetitive region"
                     /note="16."
     Region          208..212
                     /region_name="Repetitive region"
                     /note="17."
     Region          218..222
                     /region_name="Repetitive region"
                     /note="18."
     Region          228..232
                     /region_name="Repetitive region"
                     /note="19."
     Region          233..237
                     /region_name="Repetitive region"
                     /note="20."
     Region          238..242
                     /region_name="Repetitive region"
                     /note="21."
     Region          250..254
                     /region_name="Repetitive region"
                     /note="22."
     Region          260..264
                     /region_name="Repetitive region"
                     /note="23."
     Region          270..274
                     /region_name="Repetitive region"
                     /note="24."
     Region          282..286
                     /region_name="Repetitive region"
                     /note="25."
     Region          292..296
                     /region_name="Repetitive region"
                     /note="26."
     Region          297..301
                     /region_name="Repetitive region"
                     /note="27."
     Region          300
                     /region_name="Variant"
                     /note="S -> P (in dbSNP:rs465279). /id=VAR_062533."
     Region          316..320
                     /region_name="Repetitive region"
                     /note="28."
     Region          334..338
                     /region_name="Repetitive region"
                     /note="29."
ORIGIN      
        1 maastmsvcs sdlsygsrvc lpgscdscsd swqvddcpes cceppccapa pclslvctpv
       61 srvsspccpv tcepspcqsg ctssctpscc qqsscqlacc asspcqqacc vpvccktvcc
      121 kpvccvsvcc gdssccqqss cqsacctssp cqqaccvpvc ckpvcsgiss sccqqsscvs
      181 cvsspccqav cepspcqsgc tssctpsccq qsscqptcct sspcqqaccv pvccvpvccv
      241 ptcsedsssc cqqsscqpac ctsspcqhac cvpvcsgast sccqqsscqp acctasccrs
      301 sssvsllchp vckstccvpv pscgasassc qpsccrtasc vsllcrpmcs rpacyslcsg
      361 qkssc
//
Feature
Display: FASTA GenBank Help
Details

Supplemental Content

Change region shown

Customize view

Reference sequence information

  • RefSeq genomic sequence
    See the genomic reference sequence for the KRTAP10-6 gene (NG_033806.2).
  • RefSeq protein
    See the reference protein sequence for keratin-associated protein 10-6 (NP_941961.3).

More about the KRTAP10-6 gene

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
External link. Please review our privacy policy.