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DDB1- and CUL4-associated factor 4-like protein 2 [Homo sapiens]

NCBI Reference Sequence: NP_689631.1

Identical Proteins FASTA Graphics 

LOCUS       NP_689631                395 aa            linear   PRI 01-JUN-2024
DEFINITION  DDB1- and CUL4-associated factor 4-like protein 2 [Homo sapiens].
ACCESSION   NP_689631
VERSION     NP_689631.1
DBSOURCE    REFSEQ: accession NM_152418.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 395)
  AUTHORS   Zhang,X., Xu,S., Hu,C., Fang,K., Zhou,J., Guo,Z., Zhu,G. and Li,L.
  TITLE     LncRNA ST8SIA6-AS1 promotes hepatocellular carcinoma progression by
            regulating MAGEA3 and DCAF4L2 expression
  JOURNAL   Biochem Biophys Res Commun 533 (4), 1039-1047 (2020)
   PUBMED   33012505
  REMARK    GeneRIF: LncRNA ST8SIA6-AS1 promotes hepatocellular carcinoma
            progression by regulating MAGEA3 and DCAF4L2 expression.
REFERENCE   2  (residues 1 to 395)
  AUTHORS   Beaty,T.H., Taub,M.A., Scott,A.F., Murray,J.C., Marazita,M.L.,
            Schwender,H., Parker,M.M., Hetmanski,J.B., Balakrishnan,P.,
            Mansilla,M.A., Mangold,E., Ludwig,K.U., Noethen,M.M., Rubini,M.,
            Elcioglu,N. and Ruczinski,I.
  TITLE     Confirming genes influencing risk to cleft lip with/without cleft
            palate in a case-parent trio study
  JOURNAL   Hum Genet 132 (7), 771-781 (2013)
   PUBMED   23512105
  REMARK    GeneRIF: In addition, eight genes classified as 'second tier' hits
            in the original study (PAX7, THADA, COL8A1/FILIP1L, DCAF4L2,
            GADD45G, NTN1, RBFOX3 and FOXE1) showed evidence of linkage and
            association in this replication sample.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK093094.1, AL833507.1, AC005066.1 and BC035011.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AL833507.1, BC035011.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319675.5/ ENSP00000316496.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..395
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.3"
     Protein         1..395
                     /product="DDB1- and CUL4-associated factor 4-like protein
                     2"
                     /note="WD repeat domain 21C; WD repeat-containing protein
                     21C"
                     /calculated_mol_wt=43616
     Region          223..267
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          268..307
                     /region_name="WD 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NA75.1)"
     Region          <269..>369
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          273..309
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          312..351
                     /region_name="WD 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NA75.1)"
     Region          317..353
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..395
                     /gene="DCAF4L2"
                     /gene_synonym="WDR21C"
                     /coded_by="NM_152418.4:45..1232"
                     /db_xref="CCDS:CCDS6245.1"
                     /db_xref="GeneID:138009"
                     /db_xref="HGNC:HGNC:26657"
                     /db_xref="MIM:620421"
ORIGIN      
        1 meskrprlle eadkqkktvr vglnapsmlr knqlgflrfa nycriarelr vscmqrkkvq
       61 ihswdpssla sdrfnrilan tntdqlftvn qveaggskyg iitmrglttp elrvyphktl
      121 yvpnrkvnsm cwaslnhlds hlllcfvgla dtpscavllp aslfigsfpg mrrpgmlcsf
      181 qipdawscaw slsihayhsf stglsqqvll tnvvtghqqs fgtssdvlaq qfaimtpllf
      241 ngcrsgeifg idlrcgnqgs gwkaiclshd savtslqilq dgqflvssdm tgtiklwdlr
      301 atkcvtqyeg hvnnsaylpv hvneeegvva avgqdcytri wslrhghllt tipspypase
      361 ndipsvafss rlggfrgapg llmavredly cfsyg
//
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