LOCUS NP_689631 395 aa linear PRI 01-JUN-2024
DEFINITION DDB1- and CUL4-associated factor 4-like protein 2 [Homo sapiens].
ACCESSION NP_689631
VERSION NP_689631.1
DBSOURCE REFSEQ: accession NM_152418.4
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 395)
AUTHORS Zhang,X., Xu,S., Hu,C., Fang,K., Zhou,J., Guo,Z., Zhu,G. and Li,L.
TITLE LncRNA ST8SIA6-AS1 promotes hepatocellular carcinoma progression by
regulating MAGEA3 and DCAF4L2 expression
JOURNAL Biochem Biophys Res Commun 533 (4), 1039-1047 (2020)
PUBMED 33012505
REMARK GeneRIF: LncRNA ST8SIA6-AS1 promotes hepatocellular carcinoma
progression by regulating MAGEA3 and DCAF4L2 expression.
REFERENCE 2 (residues 1 to 395)
AUTHORS Beaty,T.H., Taub,M.A., Scott,A.F., Murray,J.C., Marazita,M.L.,
Schwender,H., Parker,M.M., Hetmanski,J.B., Balakrishnan,P.,
Mansilla,M.A., Mangold,E., Ludwig,K.U., Noethen,M.M., Rubini,M.,
Elcioglu,N. and Ruczinski,I.
TITLE Confirming genes influencing risk to cleft lip with/without cleft
palate in a case-parent trio study
JOURNAL Hum Genet 132 (7), 771-781 (2013)
PUBMED 23512105
REMARK GeneRIF: In addition, eight genes classified as 'second tier' hits
in the original study (PAX7, THADA, COL8A1/FILIP1L, DCAF4L2,
GADD45G, NTN1, RBFOX3 and FOXE1) showed evidence of linkage and
association in this replication sample.
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK093094.1, AL833507.1, AC005066.1 and BC035011.2.
##Evidence-Data-START##
Transcript is intronless :: AL833507.1, BC035011.2 [ECO:0000345]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000319675.5/ ENSP00000316496.3
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..395
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="8"
/map="8q21.3"
Protein 1..395
/product="DDB1- and CUL4-associated factor 4-like protein
2"
/note="WD repeat domain 21C; WD repeat-containing protein
21C"
/calculated_mol_wt=43616
Region 223..267
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 268..307
/region_name="WD 1"
/note="propagated from UniProtKB/Swiss-Prot (Q8NA75.1)"
Region <269..>369
/region_name="WD40"
/note="WD40 domain, found in a number of eukaryotic
proteins that cover a wide variety of functions including
adaptor/regulatory modules in signal transduction,
pre-mRNA processing and cytoskeleton assembly; typically
contains a GH dipeptide 11-24 residues from...; cl29593"
/db_xref="CDD:475233"
Region 273..309
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 312..351
/region_name="WD 2"
/note="propagated from UniProtKB/Swiss-Prot (Q8NA75.1)"
Region 317..353
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
CDS 1..395
/gene="DCAF4L2"
/gene_synonym="WDR21C"
/coded_by="NM_152418.4:45..1232"
/db_xref="CCDS:CCDS6245.1"
/db_xref="GeneID:138009"
/db_xref="HGNC:HGNC:26657"
/db_xref="MIM:620421"
ORIGIN
1 meskrprlle eadkqkktvr vglnapsmlr knqlgflrfa nycriarelr vscmqrkkvq
61 ihswdpssla sdrfnrilan tntdqlftvn qveaggskyg iitmrglttp elrvyphktl
121 yvpnrkvnsm cwaslnhlds hlllcfvgla dtpscavllp aslfigsfpg mrrpgmlcsf
181 qipdawscaw slsihayhsf stglsqqvll tnvvtghqqs fgtssdvlaq qfaimtpllf
241 ngcrsgeifg idlrcgnqgs gwkaiclshd savtslqilq dgqflvssdm tgtiklwdlr
301 atkcvtqyeg hvnnsaylpv hvneeegvva avgqdcytri wslrhghllt tipspypase
361 ndipsvafss rlggfrgapg llmavredly cfsyg
//