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NCBI Reference Sequence: XP_054225724.1
Identical Proteins FASTA Graphics
LOCUS XP_054225724 2390 aa linear PRI 26-AUG-2024 DEFINITION spectrin beta chain, non-erythrocytic 2 isoform X1 [Homo sapiens]. ACCESSION XP_054225724 VERSION XP_054225724.1 DBLINK BioProject: PRJNA807723 DBSOURCE REFSEQ: accession XM_054369749.1 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_060935) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Updated annotation Annotation Name :: GCF_009914755.1-RS_2024_08 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; RefSeqFE; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 08/23/2024 ##Genome-Annotation-Data-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..2390 /organism="Homo sapiens" /isolate="CHM13" /db_xref="taxon:9606" /chromosome="11" /sex="female" /cell_line="CHM13htert" /tissue_type="hydatidiform mole" /note="haploid cell line" Protein 1..2390 /product="spectrin beta chain, non-erythrocytic 2 isoform X1" /calculated_mol_wt=271165 Region 43..159 /region_name="CH_SPTB-like_rpt1" /note="first calponin homology (CH) domain found in the beta-I spectrin-like subfamily; cd21246" /db_xref="CDD:409095" Site order(44,47..48,51..52,55..56,59,113,116..117,120,127, 132..140,147..148,150..151,154..155,158..159) /site_type="other" /note="actin binding site [polypeptide binding]" /db_xref="CDD:409095" Region 173..291 /region_name="CH_SPTBN2_rpt2" /note="second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 2 (SPTBN2) and similar proteins; cd21321" /db_xref="CDD:409170" Site order(178,182,232,234..235,238,245,250..258,267..268, 270..271,274..275,278) /site_type="other" /note="putative actin binding site [polypeptide binding]" /db_xref="CDD:409170" Region 305..414 /region_name="Spectrin" /note="Spectrin repeat; pfam00435" /db_xref="CDD:395348" Site 416..421 /site_type="active" /note="linker region [active]" /db_xref="CDD:238103" Region 429..522 /region_name="Spectrin" /note="Spectrin repeat; pfam00435" /db_xref="CDD:395348" Region 534..746 /region_name="SPEC" /note="Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176" /db_xref="CDD:238103" Site 640..645 /site_type="active" /note="linker region [active]" /db_xref="CDD:238103" Region 749..958 /region_name="SPEC" /note="Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176" /db_xref="CDD:238103" Site 851..856 /site_type="active" /note="linker region [active]" /db_xref="CDD:238103" Region 961..1172 /region_name="SPEC" /note="Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176" /db_xref="CDD:238103" Site 1064..1069 /site_type="active" /note="linker region [active]" /db_xref="CDD:238103" Region 1174..1383 /region_name="SPEC" /note="Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176" /db_xref="CDD:238103" Site 1277..1282 /site_type="active" /note="linker region [active]" /db_xref="CDD:238103" Region 1384..1588 /region_name="SPEC" /note="Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176" /db_xref="CDD:238103" Site 1487..1492 /site_type="active" /note="linker region [active]" /db_xref="CDD:238103" Region 1589..1801 /region_name="SPEC" /note="Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176" /db_xref="CDD:238103" Site 1693..1698 /site_type="active" /note="linker region [active]" /db_xref="CDD:238103" Region 1802..2010 /region_name="SPEC" /note="Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176" /db_xref="CDD:238103" Site 1906..1911 /site_type="active" /note="linker region [active]" /db_xref="CDD:238103" Region 2018..>2075 /region_name="SPEC" /note="Spectrin repeats; smart00150" /db_xref="CDD:197544" Region <2097..>2241 /region_name="dnaA" /note="chromosomal replication initiator protein DnaA; cl42516" /db_xref="CDD:455861" Region 2221..2324 /region_name="PH_beta_spectrin" /note="Beta-spectrin pleckstrin homology (PH) domain; cd10571" /db_xref="CDD:269975" Site order(2228,2241..2243,2289) /site_type="other" /note="non-cannonical phosphoinositide binding site [chemical binding]" /db_xref="CDD:269975" CDS 1..2390 /gene="SPTBN2" /gene_synonym="GTRAP41; SCA5; SCAR14" /coded_by="XM_054369749.1:261..7433" /db_xref="GeneID:6712" /db_xref="HGNC:HGNC:11276" /db_xref="MIM:604985" ORIGIN 1 msstlsptdf dsleiqgqys dinnrwdlpd sdwdndsssa rlfersrika ladereavqk 61 ktftkwvnsh larvtcrvgd lysdlrdgrn llrllevlsg eilpkptkgr mrihclenvd 121 kalqflkeqk vhlenmgshd ivdgnhrltl glvwtiilrf qiqdisvete dnkekksakd 181 alllwcqmkt agypnvnvhn fttswrdgla fnaivhkhrp dlldfeslkk cnahynlqna 241 fnlaekelgl tklldpedvn vdqpdeksii tyvatyyhyf skmkalaveg krigkvldha 301 meaerlveky eslasellqw ieqtivtlnd rqlanslsgv qnqlqsfnsy rtvekppkft 361 ekgnlevllf tiqsklrann qkvytpregr lisdinkawe rlekaehere lalrtelirq 421 ekleqlaarf drkaamretw lsenqrlvsq dnfglelaav eaavrkheai etdivaysgr 481 vqavdavaae laaeryhdik riaarqhnva rlwdflrqmv aarrerllln lelqkvfqdl 541 lylmdwmeem kgrlqsqdlg rhlagvedll qlhelveadi avqaervrav sasalrfcnp 601 gkeyrpcdpq lvservakle qsyealcela aarrarlees rrlwrflwev geaeawvreq 661 qhllasadtg rdltgalrll nkhtalrgem sgrlgplklt leqgqqlvae ghpgasqasa 721 raaelqaqwe rlealaeera qrlaqaasly qfqadandme awlvdalrlv sspelghdef 781 stqalarqhr aleeeirshr ptldalreqa aalpptlsrt pevqgrvptl erhyeelqar 841 ageraralea alalytmlse agacglwvee keqwlnglal perledlevv qqrfetlepe 901 mntlaaqita vndiaeqllk anppgkdriv ntqeqlnhrw qqfrrladgk kaaltsalsi 961 qnyhlectet qawmrektkv iestqglgnd lagvlalqrk lagterdlea iaarvgeltr 1021 eanalaaghp aqavainarl revqtgwedl ratmrrrees lgearrlqdf lrslddfqaw 1081 lgrtqtavas eegpatlpea eallaqhaal rgeveraqse ysrlralgee vtrdqadpqc 1141 lflrqrleal gtgweelgrm wesrqgrlaq ahgfqgflrd arqaegvlss qeyvlshtem 1201 pgtlqaadaa ikkledfmst mdangerihg lleagrqlvs egnihadkir ekadsierrh 1261 kknqdaaqqf lgrlrdnreq qhflqdchel klwidekmlt aqdvsydear nlhtkwqkhq 1321 afmaelaank dwldkvdkeg reltlekpel kalvseklrd lhrrwdelet ttqakarslf 1381 danraelfaq sccaleswle slqaqlhsdd ygkdltsvni llkkqqmlew emavrekeve 1441 aiqaqakala qedqgageve rtsraveekf ralcqpmrer crrlqasreq hqfhrdvede 1501 ilwvterlpm assmehgkdl psvqllmkkn qtlqkeiqgh epriadlrer qralgaaaag 1561 pelaelqemw krlghelelr gkrledalra qqfyrdaaea eawmgeqelh mmgqekakde 1621 lsaqaevkkh qvleqalady aqtihqlaas sqdmidhehp estrisirqa qvdklyaglk 1681 elagerrerl qehlrlcqlr relddleqwi qerevvaash elgqdyehvt mlrdkfrefs 1741 rdtstigqer vdsanalang liagghaara tvaewkdsln eawadllell dtrgqvlaaa 1801 yelqrflhga rqalarvqhk qqqlpdgtgr dlnaaealqr rhcayehdiq alspqvqqvq 1861 ddghrlqkay agdkaeeigr hmqavaeawa qlqgssaarr qllldttdkf rffkavrelm 1921 lwmdevnlqm daqerprdvs sadlviknqq gikaeieara drfsscidmg kellarshya 1981 aeeiseklsq lqarrqetae kwqekmdwlq lvlevlvfgr dagmaeawlc sqeplvrsae 2041 lgctvdeves likrheafqk savaweerfc alekltalee rekerkrkre eeerrkqppa 2101 peptasvppg dlvggqtasd ttwdgtqprp ppstqapsvn gvctdgepsq pllgqqrleh 2161 ssfpegpgpg sgdeangprg erqtrtrgpa psampqsrst esahaatlpp rgpepsaqeq 2221 megmlcrkqe meafgkkaan rswqnvycvl rrgslgfykd akaasagvpy hgevpvslar 2281 aqgsvafdyr krkhvfklgl qdgkeylfqa kdeaemsswl rvvnaaiata ssasgepeep 2341 vvpsttrgmt ramtmppvsp vgaegpvvlr skdgrerere krfsffkknk //
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