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spectrin beta chain, non-erythrocytic 2 isoform X1 [Homo sapiens]

NCBI Reference Sequence: XP_054225724.1

Identical Proteins FASTA Graphics 

LOCUS       XP_054225724            2390 aa            linear   PRI 26-AUG-2024
DEFINITION  spectrin beta chain, non-erythrocytic 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054225724
VERSION     XP_054225724.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369749.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2390
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2390
                     /product="spectrin beta chain, non-erythrocytic 2 isoform
                     X1"
                     /calculated_mol_wt=271165
     Region          43..159
                     /region_name="CH_SPTB-like_rpt1"
                     /note="first calponin homology (CH) domain found in the
                     beta-I spectrin-like subfamily; cd21246"
                     /db_xref="CDD:409095"
     Site            order(44,47..48,51..52,55..56,59,113,116..117,120,127,
                     132..140,147..148,150..151,154..155,158..159)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409095"
     Region          173..291
                     /region_name="CH_SPTBN2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     spectrin beta chain, non-erythrocytic 2 (SPTBN2) and
                     similar proteins; cd21321"
                     /db_xref="CDD:409170"
     Site            order(178,182,232,234..235,238,245,250..258,267..268,
                     270..271,274..275,278)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409170"
     Region          305..414
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Site            416..421
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          429..522
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          534..746
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            640..645
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          749..958
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            851..856
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          961..1172
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1064..1069
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1174..1383
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1277..1282
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1384..1588
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1487..1492
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1589..1801
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1693..1698
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1802..2010
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1906..1911
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2018..>2075
                     /region_name="SPEC"
                     /note="Spectrin repeats; smart00150"
                     /db_xref="CDD:197544"
     Region          <2097..>2241
                     /region_name="dnaA"
                     /note="chromosomal replication initiator protein DnaA;
                     cl42516"
                     /db_xref="CDD:455861"
     Region          2221..2324
                     /region_name="PH_beta_spectrin"
                     /note="Beta-spectrin pleckstrin homology (PH) domain;
                     cd10571"
                     /db_xref="CDD:269975"
     Site            order(2228,2241..2243,2289)
                     /site_type="other"
                     /note="non-cannonical phosphoinositide binding site
                     [chemical binding]"
                     /db_xref="CDD:269975"
     CDS             1..2390
                     /gene="SPTBN2"
                     /gene_synonym="GTRAP41; SCA5; SCAR14"
                     /coded_by="XM_054369749.1:261..7433"
                     /db_xref="GeneID:6712"
                     /db_xref="HGNC:HGNC:11276"
                     /db_xref="MIM:604985"
ORIGIN      
        1 msstlsptdf dsleiqgqys dinnrwdlpd sdwdndsssa rlfersrika ladereavqk
       61 ktftkwvnsh larvtcrvgd lysdlrdgrn llrllevlsg eilpkptkgr mrihclenvd
      121 kalqflkeqk vhlenmgshd ivdgnhrltl glvwtiilrf qiqdisvete dnkekksakd
      181 alllwcqmkt agypnvnvhn fttswrdgla fnaivhkhrp dlldfeslkk cnahynlqna
      241 fnlaekelgl tklldpedvn vdqpdeksii tyvatyyhyf skmkalaveg krigkvldha
      301 meaerlveky eslasellqw ieqtivtlnd rqlanslsgv qnqlqsfnsy rtvekppkft
      361 ekgnlevllf tiqsklrann qkvytpregr lisdinkawe rlekaehere lalrtelirq
      421 ekleqlaarf drkaamretw lsenqrlvsq dnfglelaav eaavrkheai etdivaysgr
      481 vqavdavaae laaeryhdik riaarqhnva rlwdflrqmv aarrerllln lelqkvfqdl
      541 lylmdwmeem kgrlqsqdlg rhlagvedll qlhelveadi avqaervrav sasalrfcnp
      601 gkeyrpcdpq lvservakle qsyealcela aarrarlees rrlwrflwev geaeawvreq
      661 qhllasadtg rdltgalrll nkhtalrgem sgrlgplklt leqgqqlvae ghpgasqasa
      721 raaelqaqwe rlealaeera qrlaqaasly qfqadandme awlvdalrlv sspelghdef
      781 stqalarqhr aleeeirshr ptldalreqa aalpptlsrt pevqgrvptl erhyeelqar
      841 ageraralea alalytmlse agacglwvee keqwlnglal perledlevv qqrfetlepe
      901 mntlaaqita vndiaeqllk anppgkdriv ntqeqlnhrw qqfrrladgk kaaltsalsi
      961 qnyhlectet qawmrektkv iestqglgnd lagvlalqrk lagterdlea iaarvgeltr
     1021 eanalaaghp aqavainarl revqtgwedl ratmrrrees lgearrlqdf lrslddfqaw
     1081 lgrtqtavas eegpatlpea eallaqhaal rgeveraqse ysrlralgee vtrdqadpqc
     1141 lflrqrleal gtgweelgrm wesrqgrlaq ahgfqgflrd arqaegvlss qeyvlshtem
     1201 pgtlqaadaa ikkledfmst mdangerihg lleagrqlvs egnihadkir ekadsierrh
     1261 kknqdaaqqf lgrlrdnreq qhflqdchel klwidekmlt aqdvsydear nlhtkwqkhq
     1321 afmaelaank dwldkvdkeg reltlekpel kalvseklrd lhrrwdelet ttqakarslf
     1381 danraelfaq sccaleswle slqaqlhsdd ygkdltsvni llkkqqmlew emavrekeve
     1441 aiqaqakala qedqgageve rtsraveekf ralcqpmrer crrlqasreq hqfhrdvede
     1501 ilwvterlpm assmehgkdl psvqllmkkn qtlqkeiqgh epriadlrer qralgaaaag
     1561 pelaelqemw krlghelelr gkrledalra qqfyrdaaea eawmgeqelh mmgqekakde
     1621 lsaqaevkkh qvleqalady aqtihqlaas sqdmidhehp estrisirqa qvdklyaglk
     1681 elagerrerl qehlrlcqlr relddleqwi qerevvaash elgqdyehvt mlrdkfrefs
     1741 rdtstigqer vdsanalang liagghaara tvaewkdsln eawadllell dtrgqvlaaa
     1801 yelqrflhga rqalarvqhk qqqlpdgtgr dlnaaealqr rhcayehdiq alspqvqqvq
     1861 ddghrlqkay agdkaeeigr hmqavaeawa qlqgssaarr qllldttdkf rffkavrelm
     1921 lwmdevnlqm daqerprdvs sadlviknqq gikaeieara drfsscidmg kellarshya
     1981 aeeiseklsq lqarrqetae kwqekmdwlq lvlevlvfgr dagmaeawlc sqeplvrsae
     2041 lgctvdeves likrheafqk savaweerfc alekltalee rekerkrkre eeerrkqppa
     2101 peptasvppg dlvggqtasd ttwdgtqprp ppstqapsvn gvctdgepsq pllgqqrleh
     2161 ssfpegpgpg sgdeangprg erqtrtrgpa psampqsrst esahaatlpp rgpepsaqeq
     2221 megmlcrkqe meafgkkaan rswqnvycvl rrgslgfykd akaasagvpy hgevpvslar
     2281 aqgsvafdyr krkhvfklgl qdgkeylfqa kdeaemsswl rvvnaaiata ssasgepeep
     2341 vvpsttrgmt ramtmppvsp vgaegpvvlr skdgrerere krfsffkknk
//
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