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basic helix-loop-helix ARNT-like protein 2 isoform X6 [Homo sapiens]

NCBI Reference Sequence: XP_054228574.1

Identical Proteins FASTA Graphics 

LOCUS       XP_054228574             534 aa            linear   PRI 26-AUG-2024
DEFINITION  basic helix-loop-helix ARNT-like protein 2 isoform X6 [Homo
            sapiens].
ACCESSION   XP_054228574
VERSION     XP_054228574.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054372599.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..534
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..534
                     /product="basic helix-loop-helix ARNT-like protein 2
                     isoform X6"
                     /calculated_mol_wt=59800
     Region          8..65
                     /region_name="bHLH-PAS_ARNTL2_PASD9"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in aryl hydrocarbon receptor nuclear
                     translocator-like protein 2 (ARNTL2) and similar proteins;
                     cd11469"
                     /db_xref="CDD:381475"
     Site            order(10..11,14,17..18,22,43..44)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381475"
     Site            order(21,24,27..28,45,48..49,52,54..56,58)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381475"
     Region          90..185
                     /region_name="PAS"
                     /note="PAS domain; PAS motifs appear in archaea,
                     eubacteria and eukarya. Probably the most surprising
                     identification of a PAS domain was that in EAG-like
                     K+-channels. PAS domains have been found to bind ligands,
                     and to act as sensors for light and oxygen in...; cd00130"
                     /db_xref="CDD:238075"
     Site            order(105,109,115,128..131,153,158)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(125,129,137,140..141,165,167)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          268..370
                     /region_name="PAS_11"
                     /note="PAS domain; pfam14598"
                     /db_xref="CDD:464214"
     CDS             1..534
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /coded_by="XM_054372599.1:340..1944"
                     /db_xref="GeneID:56938"
                     /db_xref="HGNC:HGNC:18984"
                     /db_xref="MIM:614517"
ORIGIN      
        1 millvrveah sqtekrrrdk mnnlieelsa mipqcnpmar kldkltvlrm avqhlrslkg
       61 ltnsyvgsny rpsflqdnel rhlilktaeg flfvvgcerg kilfvsksvs kilnydqasl
      121 tgqslfdflh pkdvakvkeq lssfdispre klidaktglq vhsnlhagrt rvysgsrrsf
      181 fcriksckis vkeehgclpn skkkehrkfy tihctgylrs wppnivgmee ernskkdnsn
      241 ftclvaigrl qpyivpqnsg einvkptefi trfavngkfv yvdqratail gylpqellgt
      301 scyeyfhqdd hnnltdkhka vlqskekilt dsykfrakdg sfvtlksqwf sftnpwtkel
      361 eyivsvntlv lghsepgeas flpcssqsse essrqscmsv pgmstgtvlg agsigtdian
      421 eildlqrlqs ssylddsspt glmkdthtvn crsmsnkelf ppspsemgel eatrqnqstv
      481 avhsheplls dgaqldfdal cdnddtamaa fmnyleaegg lgdpgdfsdi qwtl
//
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