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Interleukin-1 receptor-associated kinase 4 [Mus musculus]

GenBank: AAH51676.1

Identical Proteins FASTA Graphics 

LOCUS       AAH51676                 459 aa            linear   ROD 15-JUL-2006
DEFINITION  Interleukin-1 receptor-associated kinase 4 [Mus musculus].
ACCESSION   AAH51676
VERSION     AAH51676.1
DBSOURCE    accession BC051676.1
KEYWORDS    MGC.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 459)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (residues 1 to 459)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (30-APR-2003) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: Minoru Ko
            cDNA Library Preparation: Yulan Piao and Minoru Ko (National
            Institute on Aging, NIH: http://lgsun.grc.nia.nih.gov/cDNA/)
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: Baylor College of Medicine Human Genome
            Sequencing Center
            Center code: BCM-HGSC
            Web site: http://www.hgsc.bcm.tmc.edu/cdna/
            Contact: amg@bcm.tmc.edu
            Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
            Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
            A.N., Gibbs, R.A.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAK Plate: 111 Row: i Column: 20
            This clone was selected for full length sequencing because it
            passed the following selection criteria: matched mRNA gi: 31559901.
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Mus musculus"
                     /strain="C57BL/6J"
                     /db_xref="taxon:10090"
                     /clone="MGC:60994 IMAGE:30017484"
                     /tissue_type="Embryo, whole, mouse, 7.5-dpc"
                     /clone_lib="NIA Mouse 7.5-dpc Whole Embryo cDNA Library
                     (Long)"
                     /lab_host="DH10B"
                     /note="Vector: pSPORT1"
     Protein         1..459
                     /product="interleukin-1 receptor-associated kinase 4"
     Region          9..108
                     /region_name="Death_IRAK4"
                     /note="Death domain of Interleukin-1 Receptor-Associated
                     Kinase 4; cd08793"
                     /db_xref="CDD:260060"
     Site            order(12,14,16..17,20,47..48,52,55..56,59,69,72..73,76,78)
                     /site_type="other"
                     /note="IRAK4-MyD88 interaction site [polypeptide binding]"
                     /db_xref="CDD:260060"
     Site            order(25,28..30,34,37,46,50,54,92..96,98,108)
                     /site_type="other"
                     /note="IRAK4-IRAK2 interaction site [polypeptide binding]"
                     /db_xref="CDD:260060"
     Region          170..457
                     /region_name="STKc_IRAK4"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Interleukin-1 Receptor Associated Kinase 4; cd14158"
                     /db_xref="CDD:271060"
     Site            order(192..196,200,211,213,246,262..265,269,271,311,313,
                     315..316,318,329,332,350..353)
                     /site_type="active"
                     /db_xref="CDD:271060"
     Site            order(192..196,200,211,213,246,262..265,269,311,313,
                     315..316,318,329)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271060"
     Site            order(196,269,271,311,313,315,332,350..353)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271060"
     Site            order(328..340,342..353)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271060"
     CDS             1..459
                     /gene="Irak4"
                     /gene_synonym="IRAK-4"
                     /gene_synonym="NY-REN-64"
                     /coded_by="BC051676.1:168..1547"
                     /db_xref="GeneID:266632"
                     /db_xref="MGI:MGI:2182474"
ORIGIN      
        1 mnkpltpsty irnlnvgilr klsdfidpqe gwkklavaik kpsgddrynq fhirrfeall
       61 qtgksptcel lfdwgttnct vgdlvdllvq ielfapatll lpdavpqtvk slppreaatv
      121 aqthgpcqek drtsvmpmpk lehsceppds sspdnrsves sdtrfhsfsf helksitnnf
      181 deqpasaggn rmgeggfgvv ykgcvnntiv avkklgamve isteelkqqf dqeikvmatc
      241 qhenlvellg fssdsdnlcl vyaympngsl ldrlscldgt pplswhtrck vaqgtangir
      301 flhenhhihr diksanilld rdftakisdf glarasarla qtvmtsrivg ttaymapeal
      361 rgeitpksdi ysfgvvllel itglaavden repqllldik eeiedeekti edytdekmsd
      421 adpasveamy saasqclhek knrrpdiakv qqllqemsa
//
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