LOCUS AAH51676 459 aa linear ROD 15-JUL-2006
DEFINITION Interleukin-1 receptor-associated kinase 4 [Mus musculus].
ACCESSION AAH51676
VERSION AAH51676.1
DBSOURCE accession BC051676.1
KEYWORDS MGC.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 459)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (residues 1 to 459)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (30-APR-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Minoru Ko
cDNA Library Preparation: Yulan Piao and Minoru Ko (National
Institute on Aging, NIH: http://lgsun.grc.nia.nih.gov/cDNA/)
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Baylor College of Medicine Human Genome
Sequencing Center
Center code: BCM-HGSC
Web site: http://www.hgsc.bcm.tmc.edu/cdna/
Contact: amg@bcm.tmc.edu
Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
A.N., Gibbs, R.A.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 111 Row: i Column: 20
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 31559901.
Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..459
/organism="Mus musculus"
/strain="C57BL/6J"
/db_xref="taxon:10090"
/clone="MGC:60994 IMAGE:30017484"
/tissue_type="Embryo, whole, mouse, 7.5-dpc"
/clone_lib="NIA Mouse 7.5-dpc Whole Embryo cDNA Library
(Long)"
/lab_host="DH10B"
/note="Vector: pSPORT1"
Protein 1..459
/product="interleukin-1 receptor-associated kinase 4"
Region 9..108
/region_name="Death_IRAK4"
/note="Death domain of Interleukin-1 Receptor-Associated
Kinase 4; cd08793"
/db_xref="CDD:260060"
Site order(12,14,16..17,20,47..48,52,55..56,59,69,72..73,76,78)
/site_type="other"
/note="IRAK4-MyD88 interaction site [polypeptide binding]"
/db_xref="CDD:260060"
Site order(25,28..30,34,37,46,50,54,92..96,98,108)
/site_type="other"
/note="IRAK4-IRAK2 interaction site [polypeptide binding]"
/db_xref="CDD:260060"
Region 170..457
/region_name="STKc_IRAK4"
/note="Catalytic domain of the Serine/Threonine kinase,
Interleukin-1 Receptor Associated Kinase 4; cd14158"
/db_xref="CDD:271060"
Site order(192..196,200,211,213,246,262..265,269,271,311,313,
315..316,318,329,332,350..353)
/site_type="active"
/db_xref="CDD:271060"
Site order(192..196,200,211,213,246,262..265,269,311,313,
315..316,318,329)
/site_type="other"
/note="ATP binding site [chemical binding]"
/db_xref="CDD:271060"
Site order(196,269,271,311,313,315,332,350..353)
/site_type="other"
/note="polypeptide substrate binding site [polypeptide
binding]"
/db_xref="CDD:271060"
Site order(328..340,342..353)
/site_type="other"
/note="activation loop (A-loop)"
/db_xref="CDD:271060"
CDS 1..459
/gene="Irak4"
/gene_synonym="IRAK-4"
/gene_synonym="NY-REN-64"
/coded_by="BC051676.1:168..1547"
/db_xref="GeneID:266632"
/db_xref="MGI:MGI:2182474"
ORIGIN
1 mnkpltpsty irnlnvgilr klsdfidpqe gwkklavaik kpsgddrynq fhirrfeall
61 qtgksptcel lfdwgttnct vgdlvdllvq ielfapatll lpdavpqtvk slppreaatv
121 aqthgpcqek drtsvmpmpk lehsceppds sspdnrsves sdtrfhsfsf helksitnnf
181 deqpasaggn rmgeggfgvv ykgcvnntiv avkklgamve isteelkqqf dqeikvmatc
241 qhenlvellg fssdsdnlcl vyaympngsl ldrlscldgt pplswhtrck vaqgtangir
301 flhenhhihr diksanilld rdftakisdf glarasarla qtvmtsrivg ttaymapeal
361 rgeitpksdi ysfgvvllel itglaavden repqllldik eeiedeekti edytdekmsd
421 adpasveamy saasqclhek knrrpdiakv qqllqemsa
//