LOCUS NP_859074 530 aa linear PRI 19-SEP-2024
DEFINITION calcium uptake protein 3, mitochondrial isoform 1 [Homo sapiens].
ACCESSION NP_859074
VERSION NP_859074.1
DBSOURCE REFSEQ: accession NM_181723.3
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 530)
AUTHORS Roman,B., Mastoor,Y., Sun,J., Chapoy Villanueva,H., Hinojosa,G.,
Springer,D., Liu,J.C. and Murphy,E.
TITLE MICU3 Regulates Mitochondrial Calcium and Cardiac Hypertrophy
JOURNAL Circ Res 135 (1), 26-40 (2024)
PUBMED 38747181
REMARK GeneRIF: MICU3 Regulates Mitochondrial Calcium and Cardiac
Hypertrophy.
REFERENCE 2 (residues 1 to 530)
AUTHORS Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
Warscheid,B.
TITLE Quantitative high-confidence human mitochondrial proteome and its
dynamics in cellular context
JOURNAL Cell Metab 33 (12), 2464-2483 (2021)
PUBMED 34800366
REFERENCE 3 (residues 1 to 530)
AUTHORS Ashrafi,G., de Juan-Sanz,J., Farrell,R.J. and Ryan,T.A.
TITLE Molecular Tuning of the Axonal Mitochondrial Ca2+ Uniporter Ensures
Metabolic Flexibility of Neurotransmission
JOURNAL Neuron 105 (4), 678-687 (2020)
PUBMED 31862210
REFERENCE 4 (residues 1 to 530)
AUTHORS Xing,Y., Wang,M., Wang,J., Nie,Z., Wu,G., Yang,X. and Shen,Y.
TITLE Dimerization of MICU Proteins Controls Ca2+ Influx through the
Mitochondrial Ca2+ Uniporter
JOURNAL Cell Rep 26 (5), 1203-1212 (2019)
PUBMED 30699349
REMARK GeneRIF: multiple crystal structures of MICU2 and MICU3 from Homo
sapiens, were determined.
REFERENCE 5 (residues 1 to 530)
AUTHORS Patron,M., Granatiero,V., Espino,J., Rizzuto,R. and De Stefani,D.
TITLE MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake
JOURNAL Cell Death Differ 26 (1), 179-195 (2019)
PUBMED 29725115
REFERENCE 6 (residues 1 to 530)
AUTHORS Plovanich,M., Bogorad,R.L., Sancak,Y., Kamer,K.J., Strittmatter,L.,
Li,A.A., Girgis,H.S., Kuchimanchi,S., De Groot,J., Speciner,L.,
Taneja,N., Oshea,J., Koteliansky,V. and Mootha,V.K.
TITLE MICU2, a paralog of MICU1, resides within the mitochondrial
uniporter complex to regulate calcium handling
JOURNAL PLoS One 8 (2), e55785 (2013)
PUBMED 23409044
REFERENCE 7 (residues 1 to 530)
AUTHORS Edwards,A.C., Aliev,F., Bierut,L.J., Bucholz,K.K., Edenberg,H.,
Hesselbrock,V., Kramer,J., Kuperman,S., Nurnberger,J.I. Jr.,
Schuckit,M.A., Porjesz,B. and Dick,D.M.
TITLE Genome-wide association study of comorbid depressive syndrome and
alcohol dependence
JOURNAL Psychiatr Genet 22 (1), 31-41 (2012)
PUBMED 22064162
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BI546243.1, BC045553.1, BX953026.1, DB548272.1 and AC079193.10.
Transcript Variant: This variant (1) encodes the longer isoform
(1).
##Evidence-Data-START##
Transcript exon combination :: SRR1660805.257112.1, BC045553.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1968540, SAMEA2142586
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
gene product(s) localized to mito. :: inferred from homology
MANE Ensembl match :: ENST00000318063.10/
ENSP00000321455.5
RefSeq Select criteria :: based on conservation,
expression, longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..530
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="8"
/map="8p22"
Protein 1..530
/product="calcium uptake protein 3, mitochondrial isoform
1"
/note="EF hand domain family A2; EF-hand domain-containing
family member A2; EF-hand domain family, member A2;
mitochondrial uptake family, member 3; calcium uptake
protein 3, mitochondrial"
/calculated_mol_wt=56035
transit_peptide 1..43
/note="Mitochondrion. /evidence=ECO:0000255; propagated
from UniProtKB/Swiss-Prot (Q86XE3.1)"
/calculated_mol_wt=4695
mat_peptide 44..530
/product="Calcium uptake protein 3, mitochondrial.
/evidence=ECO:0000255. /id=PRO_0000251230"
/note="propagated from UniProtKB/Swiss-Prot (Q86XE3.1)"
/calculated_mol_wt=56035
Region 92..115
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q86XE3.1)"
Region 236..503
/region_name="EFh_MICU3"
/note="EF-hand, calcium binding motif, found in calcium
uptake protein 3, mitochondrial (MICU3) and similar
proteins; cd16175"
/db_xref="CDD:320083"
Region 236..265
/region_name="EF-hand motif"
/note="EF-hand motif [structural motif]"
/db_xref="CDD:320083"
Region 238..366
/region_name="PTZ00183"
/note="centrin; Provisional"
/db_xref="CDD:185503"
Site order(245,247,249,256,483,485,487,494)
/site_type="other"
/note="Ca binding site [ion binding]"
/db_xref="CDD:320083"
Region 341..371
/region_name="EF-hand motif"
/note="EF-hand motif [structural motif]"
/db_xref="CDD:320083"
Region 437..466
/region_name="EF-hand motif"
/note="EF-hand motif [structural motif]"
/db_xref="CDD:320083"
Region 474..503
/region_name="EF-hand motif"
/note="EF-hand motif [structural motif]"
/db_xref="CDD:320083"
CDS 1..530
/gene="MICU3"
/gene_synonym="EFHA2; hMICU3"
/coded_by="NM_181723.3:43..1635"
/note="isoform 1 is encoded by transcript variant 1"
/db_xref="CCDS:CCDS5999.1"
/db_xref="GeneID:286097"
/db_xref="HGNC:HGNC:27820"
/db_xref="MIM:610633"
ORIGIN
1 maalrrllwp pprvspplca hqpllgpwgr pavttlglpg rpfssredee ravaeaawrr
61 rrrwgelsva aaaggglvgl vcyqlygdpr agspatgrps ksaatepedp prgrgmlpip
121 vaaaketvai grtdiedldl yatsrerrfr lfasiecegq lfmtpydfil avttdepkva
181 ktwkslskqe lnqmlaetpp vwkgssklfr nlkekgvisy teylfllcil tkphagfria
241 fnmfdtdgne mvdkkeflvl qeifrkknek reikgdeekr amlrlqlygy hsptnsvlkt
301 daeelvsrsy wdtlrrntsq alfsdlaera dditslvtdt tllvhffgkk gkaelnfedf
361 yrfmdnlqte vleieflsys ngmntiseed fahillrytn ventsvflen vrysipeekg
421 itfdefrsff qflnnledfa ialnmynfas rsigqdefkr avyvatglkf sphlvntvfk
481 ifdvdkddql sykefigimk drlhrgfrgy ktvqkyptfk sclkkelhsr
//