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calcium uptake protein 3, mitochondrial isoform 1 [Homo sapiens]

NCBI Reference Sequence: NP_859074.1

Identical Proteins FASTA Graphics 

LOCUS       NP_859074                530 aa            linear   PRI 19-SEP-2024
DEFINITION  calcium uptake protein 3, mitochondrial isoform 1 [Homo sapiens].
ACCESSION   NP_859074
VERSION     NP_859074.1
DBSOURCE    REFSEQ: accession NM_181723.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 530)
  AUTHORS   Roman,B., Mastoor,Y., Sun,J., Chapoy Villanueva,H., Hinojosa,G.,
            Springer,D., Liu,J.C. and Murphy,E.
  TITLE     MICU3 Regulates Mitochondrial Calcium and Cardiac Hypertrophy
  JOURNAL   Circ Res 135 (1), 26-40 (2024)
   PUBMED   38747181
  REMARK    GeneRIF: MICU3 Regulates Mitochondrial Calcium and Cardiac
            Hypertrophy.
REFERENCE   2  (residues 1 to 530)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (residues 1 to 530)
  AUTHORS   Ashrafi,G., de Juan-Sanz,J., Farrell,R.J. and Ryan,T.A.
  TITLE     Molecular Tuning of the Axonal Mitochondrial Ca2+ Uniporter Ensures
            Metabolic Flexibility of Neurotransmission
  JOURNAL   Neuron 105 (4), 678-687 (2020)
   PUBMED   31862210
REFERENCE   4  (residues 1 to 530)
  AUTHORS   Xing,Y., Wang,M., Wang,J., Nie,Z., Wu,G., Yang,X. and Shen,Y.
  TITLE     Dimerization of MICU Proteins Controls Ca2+ Influx through the
            Mitochondrial Ca2+ Uniporter
  JOURNAL   Cell Rep 26 (5), 1203-1212 (2019)
   PUBMED   30699349
  REMARK    GeneRIF: multiple crystal structures of MICU2 and MICU3 from Homo
            sapiens, were determined.
REFERENCE   5  (residues 1 to 530)
  AUTHORS   Patron,M., Granatiero,V., Espino,J., Rizzuto,R. and De Stefani,D.
  TITLE     MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake
  JOURNAL   Cell Death Differ 26 (1), 179-195 (2019)
   PUBMED   29725115
REFERENCE   6  (residues 1 to 530)
  AUTHORS   Plovanich,M., Bogorad,R.L., Sancak,Y., Kamer,K.J., Strittmatter,L.,
            Li,A.A., Girgis,H.S., Kuchimanchi,S., De Groot,J., Speciner,L.,
            Taneja,N., Oshea,J., Koteliansky,V. and Mootha,V.K.
  TITLE     MICU2, a paralog of MICU1, resides within the mitochondrial
            uniporter complex to regulate calcium handling
  JOURNAL   PLoS One 8 (2), e55785 (2013)
   PUBMED   23409044
REFERENCE   7  (residues 1 to 530)
  AUTHORS   Edwards,A.C., Aliev,F., Bierut,L.J., Bucholz,K.K., Edenberg,H.,
            Hesselbrock,V., Kramer,J., Kuperman,S., Nurnberger,J.I. Jr.,
            Schuckit,M.A., Porjesz,B. and Dick,D.M.
  TITLE     Genome-wide association study of comorbid depressive syndrome and
            alcohol dependence
  JOURNAL   Psychiatr Genet 22 (1), 31-41 (2012)
   PUBMED   22064162
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI546243.1, BC045553.1, BX953026.1, DB548272.1 and AC079193.10.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.257112.1, BC045553.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000318063.10/
                                                  ENSP00000321455.5
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..530
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p22"
     Protein         1..530
                     /product="calcium uptake protein 3, mitochondrial isoform
                     1"
                     /note="EF hand domain family A2; EF-hand domain-containing
                     family member A2; EF-hand domain family, member A2;
                     mitochondrial uptake family, member 3; calcium uptake
                     protein 3, mitochondrial"
                     /calculated_mol_wt=56035
     transit_peptide 1..43
                     /note="Mitochondrion. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q86XE3.1)"
                     /calculated_mol_wt=4695
     mat_peptide     44..530
                     /product="Calcium uptake protein 3, mitochondrial.
                     /evidence=ECO:0000255. /id=PRO_0000251230"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86XE3.1)"
                     /calculated_mol_wt=56035
     Region          92..115
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86XE3.1)"
     Region          236..503
                     /region_name="EFh_MICU3"
                     /note="EF-hand, calcium binding motif, found in calcium
                     uptake protein 3, mitochondrial (MICU3) and similar
                     proteins; cd16175"
                     /db_xref="CDD:320083"
     Region          236..265
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320083"
     Region          238..366
                     /region_name="PTZ00183"
                     /note="centrin; Provisional"
                     /db_xref="CDD:185503"
     Site            order(245,247,249,256,483,485,487,494)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:320083"
     Region          341..371
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320083"
     Region          437..466
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320083"
     Region          474..503
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320083"
     CDS             1..530
                     /gene="MICU3"
                     /gene_synonym="EFHA2; hMICU3"
                     /coded_by="NM_181723.3:43..1635"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS5999.1"
                     /db_xref="GeneID:286097"
                     /db_xref="HGNC:HGNC:27820"
                     /db_xref="MIM:610633"
ORIGIN      
        1 maalrrllwp pprvspplca hqpllgpwgr pavttlglpg rpfssredee ravaeaawrr
       61 rrrwgelsva aaaggglvgl vcyqlygdpr agspatgrps ksaatepedp prgrgmlpip
      121 vaaaketvai grtdiedldl yatsrerrfr lfasiecegq lfmtpydfil avttdepkva
      181 ktwkslskqe lnqmlaetpp vwkgssklfr nlkekgvisy teylfllcil tkphagfria
      241 fnmfdtdgne mvdkkeflvl qeifrkknek reikgdeekr amlrlqlygy hsptnsvlkt
      301 daeelvsrsy wdtlrrntsq alfsdlaera dditslvtdt tllvhffgkk gkaelnfedf
      361 yrfmdnlqte vleieflsys ngmntiseed fahillrytn ventsvflen vrysipeekg
      421 itfdefrsff qflnnledfa ialnmynfas rsigqdefkr avyvatglkf sphlvntvfk
      481 ifdvdkddql sykefigimk drlhrgfrgy ktvqkyptfk sclkkelhsr
//
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