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RecName: Full=Synaptotagmin-like protein 1; AltName: Full=Exophilin-7

UniProtKB/Swiss-Prot: Q99N80.2

Identical Proteins FASTA Graphics 

LOCUS       SYTL1_MOUSE              567 aa            linear   ROD 27-NOV-2024
DEFINITION  RecName: Full=Synaptotagmin-like protein 1; AltName:
            Full=Exophilin-7.
ACCESSION   Q99N80
VERSION     Q99N80.2
DBSOURCE    UniProtKB: locus SYTL1_MOUSE, accession Q99N80;
            class: standard.
            extra accessions:Q99J26
            created: Jul 25, 2003.
            sequence updated: Jul 25, 2003.
            annotation updated: Nov 27, 2024.
            xrefs: AB050741.1, BAB32651.1, BC005623.1, AAH05623.1
            xrefs (non-sequence databases): AlphaFoldDB:Q99N80, SMR:Q99N80,
            IntAct:Q99N80, STRING:10090.ENSMUSP00000030674, iPTMnet:Q99N80,
            PhosphoSitePlus:Q99N80, PaxDb:10090-ENSMUSP00000030674,
            ProteomicsDB:263197, AGR:MGI:1933365, MGI:1933365, eggNOG:KOG1028,
            InParanoid:Q99N80, Reactome:R-MMU-8854214, PRO:PR:Q99N80,
            Proteomes:UP000000589, RNAct:Q99N80, GO:0012505, GO:0042470,
            GO:0016020, GO:0005886, GO:0042043, GO:0031267, GO:0006887,
            GO:0006886, GO:0016192, CDD:cd04020, FunFam:2.60.40.150:FF:000108,
            FunFam:2.60.40.150:FF:000006, Gene3D:6.10.250.3000,
            Gene3D:2.60.40.150, InterPro:IPR000008, InterPro:IPR035892,
            InterPro:IPR010911, InterPro:IPR043567, PANTHER:PTHR45716,
            PANTHER:PTHR45716:SF3, Pfam:PF00168, SMART:SM00239,
            SUPFAM:SSF49562, PROSITE:PS50004, PROSITE:PS50916
KEYWORDS    Cell membrane; Exocytosis; Membrane; Phosphoprotein; Reference
            proteome; Repeat.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 567)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     Synaptotagmin-like protein 1-3: a novel family of C-terminal-type
            tandem C2 proteins
  JOURNAL   Biochem Biophys Res Commun 281 (5), 1226-1233 (2001)
   PUBMED   11243866
  REMARK    NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH NRXN1.;
            STRAIN=BALB/cJ; TISSUE=Brain
REFERENCE   2  (residues 1 to 567)
  AUTHORS   Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
            Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
            Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
            Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
            Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
            Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
            Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
            Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
            Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
            Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
            Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
            Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
            Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
            Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
            Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
            Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
            Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
            Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
            Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
            Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
            Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
            Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
            Makowski,K.A., Bosak,S. and Malek,J.
  CONSRTM   MGC Project Team
  TITLE     The status, quality, and expansion of the NIH full-length cDNA
            project: the Mammalian Gene Collection (MGC)
  JOURNAL   Genome Res 14 (10B), 2121-2127 (2004)
   PUBMED   15489334
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].;
            TISSUE=Mammary cancer
            Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
            Morin, Ryan]]
REFERENCE   3  (residues 1 to 567)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
  REMARK    INTERACTION WITH RAB27A.
REFERENCE   4  (residues 1 to 567)
  AUTHORS   Holt,O., Kanno,E., Bossi,G., Booth,S., Daniele,T., Santoro,A.,
            Arico,M., Saegusa,C., Fukuda,M. and Griffiths,G.M.
  TITLE     Slp1 and Slp2-a localize to the plasma membrane of CTL and
            contribute to secretion from the immunological synapse
  JOURNAL   Traffic 9 (4), 446-457 (2008)
   PUBMED   18266782
  REMARK    FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RAB27A, AND TISSUE
            SPECIFICITY.
REFERENCE   5  (residues 1 to 567)
  AUTHORS   Huttlin,E.L., Jedrychowski,M.P., Elias,J.E., Goswami,T., Rad,R.,
            Beausoleil,S.A., Villen,J., Haas,W., Sowa,M.E. and Gygi,S.P.
  TITLE     A tissue-specific atlas of mouse protein phosphorylation and
            expression
  JOURNAL   Cell 143 (7), 1174-1189 (2010)
   PUBMED   21183079
  REMARK    PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120, AND
            IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].;
            TISSUE=Pancreas
COMMENT     [FUNCTION] Binds phosphatidylinositol 3,4,5-trisphosphate (By
            similarity). May play a role in vesicle trafficking. Acts as a
            RAB27A effector protein and may play a role in cytotoxic granule
            exocytosis in lymphocytes. {ECO:0000250,
            ECO:0000269|PubMed:18266782}.
            [SUBUNIT] Monomer. Binds NCF2 and NRXN1 (By similarity). Binds
            RAB27A that has been activated by GTP-binding via its N-terminus.
            {ECO:0000250}.
            [SUBCELLULAR LOCATION] Endomembrane system
            {ECO:0000269|PubMed:18266782}; Peripheral membrane protein
            {ECO:0000269|PubMed:18266782}. Cell membrane
            {ECO:0000269|PubMed:18266782}.
            [TISSUE SPECIFICITY] Highly expressed in lung. Detected at lower
            levels in spleen, liver and kidney, and at very low levels in
            heart, brain and skeletal muscle. Expressed in cytotoxic
            T-lymphocytes (CTL). {ECO:0000269|PubMed:18266782}.
FEATURES             Location/Qualifiers
     source          1..567
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
     gene            1..567
                     /gene="Sytl1"
                     /gene_synonym="Slp1"
     Protein         1..567
                     /product="Synaptotagmin-like protein 1"
                     /note="Exophilin-7"
                     /UniProtKB_evidence="Evidence at protein level"
     Region          1..567
                     /region_name="Mature chain"
                     /note="Synaptotagmin-like protein 1. /id=PRO_0000190212."
     Region          31..87
                     /region_name="Domain"
                     /note="RabBD.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00234."
     Region          35..>90
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Region          103..255
                     /region_name="Region of interest in the sequence"
                     /note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          <111..>238
                     /region_name="PHA03169"
                     /note="hypothetical protein; Provisional"
                     /db_xref="CDD:223003"
     Site            120
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079."
     Region          152..166
                     /region_name="Compositionally biased region"
                     /note="Polar residues.
                     /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          178
                     /region_name="Conflict"
                     /note="H -> Q (in Ref. 1; BAB32651).
                     /evidence=ECO:0000305."
     Region          206..222
                     /region_name="Compositionally biased region"
                     /note="Polar residues.
                     /evidence=ECO:0000256|SAM:MobiDB-lite."
     Site            220
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8IYJ3."
     Region          237..255
                     /region_name="Compositionally biased region"
                     /note="Polar residues.
                     /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          271..390
                     /region_name="Domain"
                     /note="C2 1.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00041."
     Region          272..391
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          403..532
                     /region_name="Domain"
                     /note="C2 2.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00041."
     Region          404..560
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
ORIGIN      
        1 mpqrghpsqe rlwalpslpm ahgpgseveg lldlsfltee eqeaisdvlk rdahlrqlee
       61 grvsklrasl edpwqlkilt gdwfqearsq rhhhahfgsd lvrasirrkk spkgdqalgs
      121 dgeaeaaged tiegepesrv sievaapers tetqgpdlss pyvpskaseg qeeepqdhec
      181 eleapgeggv qvaeadpeld peqkaeqesq ptpaqskats kilengeeap glgpsldrml
      241 sssssvssln sstlsgslms lsgeeagtvq vrgsvlfslh yepgtselrv qviqcqglaa
      301 arrrrsdpyv ksyllpdkqs krktsvkkrn lnpifnetlr hsvqqadlpg rvlslsvwhr
      361 eslgrniflg evevpldtwn wdseatwlpl qprvppspde lpsrgllsls lkyvpagseg
      421 ggqpqsgelh fwvkeaqslv plrpgsldty iqcsvlpdds rasrqrtrvv rrslspvfnh
      481 tmvydgfgpa dlrqacaels lwdhgalasr qlggtrlslg tgssyglqvp wmdstpeekq
      541 lwqtllerpc ewvdgllplr tnlvpra
//
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