LOCUS SYTL1_MOUSE 567 aa linear ROD 27-NOV-2024
DEFINITION RecName: Full=Synaptotagmin-like protein 1; AltName:
Full=Exophilin-7.
ACCESSION Q99N80
VERSION Q99N80.2
DBSOURCE UniProtKB: locus SYTL1_MOUSE, accession Q99N80;
class: standard.
extra accessions:Q99J26
created: Jul 25, 2003.
sequence updated: Jul 25, 2003.
annotation updated: Nov 27, 2024.
xrefs: AB050741.1, BAB32651.1, BC005623.1, AAH05623.1
xrefs (non-sequence databases): AlphaFoldDB:Q99N80, SMR:Q99N80,
IntAct:Q99N80, STRING:10090.ENSMUSP00000030674, iPTMnet:Q99N80,
PhosphoSitePlus:Q99N80, PaxDb:10090-ENSMUSP00000030674,
ProteomicsDB:263197, AGR:MGI:1933365, MGI:1933365, eggNOG:KOG1028,
InParanoid:Q99N80, Reactome:R-MMU-8854214, PRO:PR:Q99N80,
Proteomes:UP000000589, RNAct:Q99N80, GO:0012505, GO:0042470,
GO:0016020, GO:0005886, GO:0042043, GO:0031267, GO:0006887,
GO:0006886, GO:0016192, CDD:cd04020, FunFam:2.60.40.150:FF:000108,
FunFam:2.60.40.150:FF:000006, Gene3D:6.10.250.3000,
Gene3D:2.60.40.150, InterPro:IPR000008, InterPro:IPR035892,
InterPro:IPR010911, InterPro:IPR043567, PANTHER:PTHR45716,
PANTHER:PTHR45716:SF3, Pfam:PF00168, SMART:SM00239,
SUPFAM:SSF49562, PROSITE:PS50004, PROSITE:PS50916
KEYWORDS Cell membrane; Exocytosis; Membrane; Phosphoprotein; Reference
proteome; Repeat.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 567)
AUTHORS Fukuda,M. and Mikoshiba,K.
TITLE Synaptotagmin-like protein 1-3: a novel family of C-terminal-type
tandem C2 proteins
JOURNAL Biochem Biophys Res Commun 281 (5), 1226-1233 (2001)
PUBMED 11243866
REMARK NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH NRXN1.;
STRAIN=BALB/cJ; TISSUE=Brain
REFERENCE 2 (residues 1 to 567)
AUTHORS Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
Makowski,K.A., Bosak,S. and Malek,J.
CONSRTM MGC Project Team
TITLE The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC)
JOURNAL Genome Res 14 (10B), 2121-2127 (2004)
PUBMED 15489334
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].;
TISSUE=Mammary cancer
Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
Morin, Ryan]]
REFERENCE 3 (residues 1 to 567)
AUTHORS Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
TITLE The Slp homology domain of synaptotagmin-like proteins 1-4 and
Slac2 functions as a novel Rab27A binding domain
JOURNAL J Biol Chem 277 (11), 9212-9218 (2002)
PUBMED 11773082
REMARK INTERACTION WITH RAB27A.
REFERENCE 4 (residues 1 to 567)
AUTHORS Holt,O., Kanno,E., Bossi,G., Booth,S., Daniele,T., Santoro,A.,
Arico,M., Saegusa,C., Fukuda,M. and Griffiths,G.M.
TITLE Slp1 and Slp2-a localize to the plasma membrane of CTL and
contribute to secretion from the immunological synapse
JOURNAL Traffic 9 (4), 446-457 (2008)
PUBMED 18266782
REMARK FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RAB27A, AND TISSUE
SPECIFICITY.
REFERENCE 5 (residues 1 to 567)
AUTHORS Huttlin,E.L., Jedrychowski,M.P., Elias,J.E., Goswami,T., Rad,R.,
Beausoleil,S.A., Villen,J., Haas,W., Sowa,M.E. and Gygi,S.P.
TITLE A tissue-specific atlas of mouse protein phosphorylation and
expression
JOURNAL Cell 143 (7), 1174-1189 (2010)
PUBMED 21183079
REMARK PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].;
TISSUE=Pancreas
COMMENT [FUNCTION] Binds phosphatidylinositol 3,4,5-trisphosphate (By
similarity). May play a role in vesicle trafficking. Acts as a
RAB27A effector protein and may play a role in cytotoxic granule
exocytosis in lymphocytes. {ECO:0000250,
ECO:0000269|PubMed:18266782}.
[SUBUNIT] Monomer. Binds NCF2 and NRXN1 (By similarity). Binds
RAB27A that has been activated by GTP-binding via its N-terminus.
{ECO:0000250}.
[SUBCELLULAR LOCATION] Endomembrane system
{ECO:0000269|PubMed:18266782}; Peripheral membrane protein
{ECO:0000269|PubMed:18266782}. Cell membrane
{ECO:0000269|PubMed:18266782}.
[TISSUE SPECIFICITY] Highly expressed in lung. Detected at lower
levels in spleen, liver and kidney, and at very low levels in
heart, brain and skeletal muscle. Expressed in cytotoxic
T-lymphocytes (CTL). {ECO:0000269|PubMed:18266782}.
FEATURES Location/Qualifiers
source 1..567
/organism="Mus musculus"
/db_xref="taxon:10090"
gene 1..567
/gene="Sytl1"
/gene_synonym="Slp1"
Protein 1..567
/product="Synaptotagmin-like protein 1"
/note="Exophilin-7"
/UniProtKB_evidence="Evidence at protein level"
Region 1..567
/region_name="Mature chain"
/note="Synaptotagmin-like protein 1. /id=PRO_0000190212."
Region 31..87
/region_name="Domain"
/note="RabBD.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00234."
Region 35..>90
/region_name="PHD_SF"
/note="PHD finger superfamily; cl22851"
/db_xref="CDD:473978"
Region 103..255
/region_name="Region of interest in the sequence"
/note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
Region <111..>238
/region_name="PHA03169"
/note="hypothetical protein; Provisional"
/db_xref="CDD:223003"
Site 120
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:21183079."
Region 152..166
/region_name="Compositionally biased region"
/note="Polar residues.
/evidence=ECO:0000256|SAM:MobiDB-lite."
Region 178
/region_name="Conflict"
/note="H -> Q (in Ref. 1; BAB32651).
/evidence=ECO:0000305."
Region 206..222
/region_name="Compositionally biased region"
/note="Polar residues.
/evidence=ECO:0000256|SAM:MobiDB-lite."
Site 220
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q8IYJ3."
Region 237..255
/region_name="Compositionally biased region"
/note="Polar residues.
/evidence=ECO:0000256|SAM:MobiDB-lite."
Region 271..390
/region_name="Domain"
/note="C2 1.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00041."
Region 272..391
/region_name="C2"
/note="C2 domain; cl14603"
/db_xref="CDD:472691"
Region 403..532
/region_name="Domain"
/note="C2 2.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00041."
Region 404..560
/region_name="C2B_SLP_1-2-3-4"
/note="C2 domain second repeat present in
Synaptotagmin-like proteins 1-4; cd04020"
/db_xref="CDD:175987"
ORIGIN
1 mpqrghpsqe rlwalpslpm ahgpgseveg lldlsfltee eqeaisdvlk rdahlrqlee
61 grvsklrasl edpwqlkilt gdwfqearsq rhhhahfgsd lvrasirrkk spkgdqalgs
121 dgeaeaaged tiegepesrv sievaapers tetqgpdlss pyvpskaseg qeeepqdhec
181 eleapgeggv qvaeadpeld peqkaeqesq ptpaqskats kilengeeap glgpsldrml
241 sssssvssln sstlsgslms lsgeeagtvq vrgsvlfslh yepgtselrv qviqcqglaa
301 arrrrsdpyv ksyllpdkqs krktsvkkrn lnpifnetlr hsvqqadlpg rvlslsvwhr
361 eslgrniflg evevpldtwn wdseatwlpl qprvppspde lpsrgllsls lkyvpagseg
421 ggqpqsgelh fwvkeaqslv plrpgsldty iqcsvlpdds rasrqrtrvv rrslspvfnh
481 tmvydgfgpa dlrqacaels lwdhgalasr qlggtrlslg tgssyglqvp wmdstpeekq
541 lwqtllerpc ewvdgllplr tnlvpra
//