RecName: Full=Cyclic GMP-AMP phosphodiesterase SMPDL3A; Short=2',3'-cG - Protein

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SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing. [Immunity. 2023]
SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing.
Hou Y, Wang Z, Liu P, Wei X, Zhang Z, Fan S, Zhang L, Han F, Song Y, Chu L, et al. Immunity. 2023 Nov 14; 56(11):2492-2507.e10. Epub 2023 Oct 26.
Structural Basis for Nucleotide Hydrolysis by the Acid Sphingomyelinase-like Phosphodiesterase SMPDL3A. [J Biol Chem. 2016]
Structural Basis for Nucleotide Hydrolysis by the Acid Sphingomyelinase-like Phosphodiesterase SMPDL3A.
Gorelik A, Illes K, Superti-Furga G, Nagar B. J Biol Chem. 2016 Mar 18; 291(12):6376-85. Epub 2016 Jan 20.
Sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophages. [J Biol Chem. 2014]
Sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophages.
Traini M, Quinn CM, Sandoval C, Johansson E, Schroder K, Kockx M, Meikle PJ, Jessup W, Kritharides L. J Biol Chem. 2014 Nov 21; 289(47):32895-913. Epub 2014 Oct 6.

RefSeq protein
See the reference protein sequence for cyclic GMP-AMP phosphodiesterase SMPDL3A precursor (NP_065586.3).

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RecName: Full=Cyclic GMP-AMP phosphodiesterase SMPDL3A; Short=2',3'-cGAMP phosph...
RecName: Full=Cyclic GMP-AMP phosphodiesterase SMPDL3A; Short=2',3'-cGAMP phosphodiesterase SMPDL3A; AltName: Full=Acid sphingomyelinase-like phosphodiesterase 3a; Short=ASM-like phosphodiesterase 3a; Flags: Precursor
gi|341940248|sp|P70158.2|ASM3A_MOUS

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