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phosphogluconate dehydrogenase (decarboxylating) GND2 [Saccharomyces cerevisiae S288C]

NCBI Reference Sequence: NP_011772.3

Identical Proteins FASTA Graphics 

LOCUS       NP_011772                492 aa            linear   PLN 17-DEC-2024
DEFINITION  phosphogluconate dehydrogenase (decarboxylating) GND2
            [Saccharomyces cerevisiae S288C].
ACCESSION   NP_011772
VERSION     NP_011772.3
DBLINK      BioProject: PRJNA128
DBSOURCE    REFSEQ: accession NM_001181385.3
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (residues 1 to 492)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (residues 1 to 492)
  AUTHORS   Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M.,
            Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J.,
            Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E.,
            Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E.,
            Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B.,
            Kleine,K. et al.
  TITLE     The nucleotide sequence of Saccharomyces cerevisiae chromosome VII
  JOURNAL   Nature 387 (6632 SUPPL), 81-84 (1997)
   PUBMED   9169869
REFERENCE   3  (residues 1 to 492)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   4  (residues 1 to 492)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 492)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JAN-2015) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (residues 1 to 492)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   7  (residues 1 to 492)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   8  (residues 1 to 492)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (11-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. The reference
            sequence is identical to DAA08347.
            
            On Jul 30, 2012 this sequence version replaced NP_011772.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Saccharomyces cerevisiae S288C"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="VII"
     Protein         1..492
                     /product="phosphogluconate dehydrogenase (decarboxylating)
                     GND2"
                     /EC_number="1.1.1.44"
                     /calculated_mol_wt=53792
     Region          7..480
                     /region_name="gnd"
                     /note="6-phosphogluconate dehydrogenase (decarboxylating);
                     TIGR00873"
                     /db_xref="CDD:273314"
     CDS             1..492
                     /gene="GND2"
                     /locus_tag="YGR256W"
                     /coded_by="NM_001181385.3:1..1479"
                     /experiment="EXISTENCE:direct assay:GO:0005886 plasma
                     membrane [PMID:16622836]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0004616
                     phosphogluconate dehydrogenase (decarboxylating) activity
                     [PMID:1328471]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0009051
                     pentose-phosphate shunt, oxidative branch [PMID:1328471]"
                     /note="6-phosphogluconate dehydrogenase (decarboxylating);
                     catalyzes an NADPH regenerating reaction in the pentose
                     phosphate pathway; required for growth on
                     D-glucono-delta-lactone; GND2 has a paralog, GND1, that
                     arose from the whole genome duplication"
                     /db_xref="GeneID:853172"
                     /db_xref="SGD:S000003488"
ORIGIN      
        1 mskavgdlgl vglavmgqnl ilnaadhgft vvaynrtqsk vdrflaneak gksiigatsi
       61 edlvaklkkp rkimllikag apvdtlikel vphldkgdii idggnshfpd tnrryeeltk
      121 qgilfvgsgv sggedgarfg pslmpggsae awphiknifq siaaksngep ccewvgpags
      181 ghyvkmvhng ieygdmqlic eaydimkrig rftdkeisev fdkwntgvld sflieitrdi
      241 lkfddvdgkp lvekimdtag qkgtgkwtai naldlgmpvt ligeavfarc lsaikderkr
      301 askllagptv pkdaihdreq fvydleqaly askiisyaqg fmlireaars ygwklnnpai
      361 almwrggcii rsvflaeitk ayrddpdlen llfneffasa vtkaqsgwrr tialaatygi
      421 ptpafstala fydgyrserl panllqaqrd yfgahtfril pecasahlpv dkdihinwtg
      481 hggnisssty qa
//
Feature
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Reference sequence information

  • RefSeq mRNA
    See reference mRNA sequence for the GND2 gene (NM_001181385.3).

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