LOCUS NP_011772 492 aa linear PLN 17-DEC-2024
DEFINITION phosphogluconate dehydrogenase (decarboxylating) GND2
[Saccharomyces cerevisiae S288C].
ACCESSION NP_011772
VERSION NP_011772.3
DBLINK BioProject: PRJNA128
DBSOURCE REFSEQ: accession NM_001181385.3
KEYWORDS RefSeq.
SOURCE Saccharomyces cerevisiae S288C
ORGANISM Saccharomyces cerevisiae S288C
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
Saccharomyces.
REFERENCE 1 (residues 1 to 492)
AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
Weng,S. and Cherry,J.M.
TITLE New data and collaborations at the Saccharomyces Genome Database:
updated reference genome, alleles, and the Alliance of Genome
Resources
JOURNAL Genetics 220 (4) (2022)
PUBMED 34897464
REFERENCE 2 (residues 1 to 492)
AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M.,
Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J.,
Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E.,
Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E.,
Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B.,
Kleine,K. et al.
TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII
JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997)
PUBMED 9169869
REFERENCE 3 (residues 1 to 492)
AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
Oliver,S.G.
TITLE Life with 6000 genes
JOURNAL Science 274 (5287), 546 (1996)
PUBMED 8849441
REFERENCE 4 (residues 1 to 492)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (17-DEC-2024) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 5 (residues 1 to 492)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 6 (residues 1 to 492)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 7 (residues 1 to 492)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Sequence update by submitter
REFERENCE 8 (residues 1 to 492)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
COMMENT REVIEWED REFSEQ: This record has been curated by SGD. The reference
sequence is identical to DAA08347.
On Jul 30, 2012 this sequence version replaced NP_011772.2.
##Genome-Annotation-Data-START##
Annotation Provider :: SGD
Annotation Status :: Full Annotation
Annotation Version :: R64-4-1
URL :: http://www.yeastgenome.org/
##Genome-Annotation-Data-END##
Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..492
/organism="Saccharomyces cerevisiae S288C"
/strain="S288C"
/db_xref="taxon:559292"
/chromosome="VII"
Protein 1..492
/product="phosphogluconate dehydrogenase (decarboxylating)
GND2"
/EC_number="1.1.1.44"
/calculated_mol_wt=53792
Region 7..480
/region_name="gnd"
/note="6-phosphogluconate dehydrogenase (decarboxylating);
TIGR00873"
/db_xref="CDD:273314"
CDS 1..492
/gene="GND2"
/locus_tag="YGR256W"
/coded_by="NM_001181385.3:1..1479"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:16622836]"
/experiment="EXISTENCE:mutant phenotype:GO:0004616
phosphogluconate dehydrogenase (decarboxylating) activity
[PMID:1328471]"
/experiment="EXISTENCE:mutant phenotype:GO:0009051
pentose-phosphate shunt, oxidative branch [PMID:1328471]"
/note="6-phosphogluconate dehydrogenase (decarboxylating);
catalyzes an NADPH regenerating reaction in the pentose
phosphate pathway; required for growth on
D-glucono-delta-lactone; GND2 has a paralog, GND1, that
arose from the whole genome duplication"
/db_xref="GeneID:853172"
/db_xref="SGD:S000003488"
ORIGIN
1 mskavgdlgl vglavmgqnl ilnaadhgft vvaynrtqsk vdrflaneak gksiigatsi
61 edlvaklkkp rkimllikag apvdtlikel vphldkgdii idggnshfpd tnrryeeltk
121 qgilfvgsgv sggedgarfg pslmpggsae awphiknifq siaaksngep ccewvgpags
181 ghyvkmvhng ieygdmqlic eaydimkrig rftdkeisev fdkwntgvld sflieitrdi
241 lkfddvdgkp lvekimdtag qkgtgkwtai naldlgmpvt ligeavfarc lsaikderkr
301 askllagptv pkdaihdreq fvydleqaly askiisyaqg fmlireaars ygwklnnpai
361 almwrggcii rsvflaeitk ayrddpdlen llfneffasa vtkaqsgwrr tialaatygi
421 ptpafstala fydgyrserl panllqaqrd yfgahtfril pecasahlpv dkdihinwtg
481 hggnisssty qa
//