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RecName: Full=Homeobox protein Hox-C11; AltName: Full=Homeobox protein Hox-3.7

UniProtKB/Swiss-Prot: P31313.3

Identical Proteins FASTA Graphics 

LOCUS       HXC11_MOUSE              304 aa            linear   ROD 27-NOV-2024
DEFINITION  RecName: Full=Homeobox protein Hox-C11; AltName: Full=Homeobox
            protein Hox-3.7.
ACCESSION   P31313
VERSION     P31313.3
DBSOURCE    UniProtKB: locus HXC11_MOUSE, accession P31313;
            class: standard.
            extra accessions:B9EI74
            created: Jul 1, 1993.
            sequence updated: Oct 3, 2012.
            annotation updated: Nov 27, 2024.
            xrefs: AC160979.2, CH466550.2, EDL03950.1, BC139233.1, AAI39234.1,
            BC139269.1, AAI39270.1, I37290, NP_001020013.1
            xrefs (non-sequence databases): CCDS:CCDS27892.1,
            AlphaFoldDB:P31313, SMR:P31313, BioGRID:224942,
            STRING:10090.ENSMUSP00000001701, PhosphoSitePlus:P31313,
            PaxDb:10090-ENSMUSP00000001701, ProteomicsDB:266932,
            Antibodypedia:15309, Ensembl:ENSMUST00000001701.4,
            Ensembl:ENSMUSP00000001701.4, Ensembl:ENSMUSG00000001656.4,
            GeneID:109663, KEGG:mmu:109663, UCSC:uc007xwy.1, AGR:MGI:96193,
            CTD:3227, MGI:96193, VEuPathDB:HostDB:ENSMUSG00000001656,
            eggNOG:KOG0487, GeneTree:ENSGT00940000160009,
            HOGENOM:CLU_079662_0_0_1, InParanoid:P31313, OMA:AYCGADN,
            OrthoDB:728401at2759, PhylomeDB:P31313, TreeFam:TF350668,
            BioGRID-ORCS:109663, PRO:PR:P31313, Proteomes:UP000000589,
            RNAct:P31313, Bgee:ENSMUSG00000001656, GO:0005829, GO:0005654,
            GO:0001228, GO:0000978, GO:0009952, GO:0042733, GO:0060272,
            GO:0001656, GO:0001759, GO:0009954, GO:0001501, CDD:cd00086,
            FunFam:1.10.10.60:FF:000166, Gene3D:1.10.10.60, InterPro:IPR021918,
            InterPro:IPR001356, InterPro:IPR020479, InterPro:IPR017970,
            InterPro:IPR009057, PANTHER:PTHR46092, PANTHER:PTHR46092:SF1,
            Pfam:PF12045, Pfam:PF00046, PRINTS:PR00024, SMART:SM00389,
            SUPFAM:SSF46689, PROSITE:PS00027, PROSITE:PS50071
KEYWORDS    Developmental protein; DNA-binding; Homeobox; Isopeptide bond;
            Nucleus; Reference proteome; Transcription; Transcription
            regulation; Ubl conjugation.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 304)
  AUTHORS   Church,D.M., Goodstadt,L., Hillier,L.W., Zody,M.C., Goldstein,S.,
            She,X., Bult,C.J., Agarwala,R., Cherry,J.L., DiCuccio,M.,
            Hlavina,W., Kapustin,Y., Meric,P., Maglott,D., Birtle,Z.,
            Marques,A.C., Graves,T., Zhou,S., Teague,B., Potamousis,K.,
            Churas,C., Place,M., Herschleb,J., Runnheim,R., Forrest,D.,
            Amos-Landgraf,J., Schwartz,D.C., Cheng,Z., Lindblad-Toh,K.,
            Eichler,E.E. and Ponting,C.P.
  CONSRTM   Mouse Genome Sequencing Consortium
  TITLE     Lineage-specific biology revealed by a finished genome assembly of
            the mouse
  JOURNAL   PLoS Biol 7 (5), e1000112 (2009)
   PUBMED   19468303
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
            STRAIN=C57BL/6J
REFERENCE   2  (residues 1 to 304)
  AUTHORS   Mural,R.J., Adams,M.D., Myers,E.W., Smith,H.O. and Venter,J.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (??-JUL-2005) to the EMBL/GenBank/DDBJ databases
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
REFERENCE   3  (residues 1 to 304)
  AUTHORS   Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
            Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
            Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
            Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
            Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
            Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
            Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
            Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
            Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
            Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
            Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
            Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
            Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
            Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
            Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
            Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
            Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
            Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
            Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
            Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
            Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
            Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
            Makowski,K.A., Bosak,S. and Malek,J.
  CONSRTM   MGC Project Team
  TITLE     The status, quality, and expansion of the NIH full-length cDNA
            project: the Mammalian Gene Collection (MGC)
  JOURNAL   Genome Res 14 (10B), 2121-2127 (2004)
   PUBMED   15489334
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].;
            TISSUE=Brain
            Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
            Morin, Ryan]]
REFERENCE   4  (residues 1 to 304)
  AUTHORS   Singh,G., Kaur,S., Stock,J.L., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Potter,S.S.
  TITLE     Identification of 10 murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10706-10710 (1991)
   PUBMED   1683707
  REMARK    NUCLEOTIDE SEQUENCE OF 232-291.
COMMENT     On Oct 5, 2012 this sequence version replaced P31313.2.
            [FUNCTION] Sequence-specific transcription factor which is part of
            a developmental regulatory system that provides cells with specific
            positional identities on the anterior-posterior axis.
            [SUBCELLULAR LOCATION] Nucleus.
            [SIMILARITY] Belongs to the Abd-B homeobox family. {ECO:0000305}.
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
     gene            1..304
                     /gene="Hoxc11"
                     /gene_synonym="Hox-3.7"
                     /gene_synonym="Hoxc-11"
     Protein         1..304
                     /product="Homeobox protein Hox-C11"
                     /note="Homeobox protein Hox-3.7"
                     /UniProtKB_evidence="Evidence at transcript level"
     Region          1..304
                     /region_name="Mature chain"
                     /note="Homeobox protein Hox-C11. /id=PRO_0000200195."
     Region          42..161
                     /region_name="DUF3528"
                     /note="Protein of unknown function (DUF3528); pfam12045"
                     /db_xref="CDD:432284"
     Bond            bond(82)
                     /bond_type="xlink"
                     /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
                     G-Cter in SUMO2). /evidence=ECO:0000250|UniProtKB:O43248."
     Bond            bond(116)
                     /bond_type="xlink"
                     /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
                     G-Cter in SUMO2). /evidence=ECO:0000250|UniProtKB:O43248."
     Region          167..237
                     /region_name="Region of interest in the sequence"
                     /note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
     Bond            bond(178)
                     /bond_type="xlink"
                     /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
                     G-Cter in SUMO2). /evidence=ECO:0000250|UniProtKB:O43248."
     Region          203..218
                     /region_name="Compositionally biased region"
                     /note="Polar residues.
                     /evidence=ECO:0000256|SAM:MobiDB-lite."
     Site            232..291
                     /site_type="DNA binding"
                     /note="Homeobox.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00108."
     Region          233..289
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
ORIGIN      
        1 mfnsvnlgnf cspsrkerga dfgergscts nlylpsctyy vpefstvssf lpqapsrqis
       61 ypysaqvppv revsygleps gkwhhrnsys scyaaadelm hreclppstv teilmknegs
      121 ygghhhpsap haapagfyss vnknsvlpqa fdrffdnayc gggdapaepp csgkgeakge
      181 peappasgla sraeagaeae aeeentnpss sgsshsatke pakgaapnap rtrkkrcpys
      241 kfqirelere fffnvyinke krlqlsrmln ltdrqvkiwf qnrrmkekkl srdrlqyfsg
      301 npll
//
Feature
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Reference sequence information

  • RefSeq protein
    See the reference protein sequence for homeobox protein Hox-C11 (NP_001020013.1).

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