LOCUS HXC11_MOUSE 304 aa linear ROD 27-NOV-2024
DEFINITION RecName: Full=Homeobox protein Hox-C11; AltName: Full=Homeobox
protein Hox-3.7.
ACCESSION P31313
VERSION P31313.3
DBSOURCE UniProtKB: locus HXC11_MOUSE, accession P31313;
class: standard.
extra accessions:B9EI74
created: Jul 1, 1993.
sequence updated: Oct 3, 2012.
annotation updated: Nov 27, 2024.
xrefs: AC160979.2, CH466550.2, EDL03950.1, BC139233.1, AAI39234.1,
BC139269.1, AAI39270.1, I37290, NP_001020013.1
xrefs (non-sequence databases): CCDS:CCDS27892.1,
AlphaFoldDB:P31313, SMR:P31313, BioGRID:224942,
STRING:10090.ENSMUSP00000001701, PhosphoSitePlus:P31313,
PaxDb:10090-ENSMUSP00000001701, ProteomicsDB:266932,
Antibodypedia:15309, Ensembl:ENSMUST00000001701.4,
Ensembl:ENSMUSP00000001701.4, Ensembl:ENSMUSG00000001656.4,
GeneID:109663, KEGG:mmu:109663, UCSC:uc007xwy.1, AGR:MGI:96193,
CTD:3227, MGI:96193, VEuPathDB:HostDB:ENSMUSG00000001656,
eggNOG:KOG0487, GeneTree:ENSGT00940000160009,
HOGENOM:CLU_079662_0_0_1, InParanoid:P31313, OMA:AYCGADN,
OrthoDB:728401at2759, PhylomeDB:P31313, TreeFam:TF350668,
BioGRID-ORCS:109663, PRO:PR:P31313, Proteomes:UP000000589,
RNAct:P31313, Bgee:ENSMUSG00000001656, GO:0005829, GO:0005654,
GO:0001228, GO:0000978, GO:0009952, GO:0042733, GO:0060272,
GO:0001656, GO:0001759, GO:0009954, GO:0001501, CDD:cd00086,
FunFam:1.10.10.60:FF:000166, Gene3D:1.10.10.60, InterPro:IPR021918,
InterPro:IPR001356, InterPro:IPR020479, InterPro:IPR017970,
InterPro:IPR009057, PANTHER:PTHR46092, PANTHER:PTHR46092:SF1,
Pfam:PF12045, Pfam:PF00046, PRINTS:PR00024, SMART:SM00389,
SUPFAM:SSF46689, PROSITE:PS00027, PROSITE:PS50071
KEYWORDS Developmental protein; DNA-binding; Homeobox; Isopeptide bond;
Nucleus; Reference proteome; Transcription; Transcription
regulation; Ubl conjugation.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 304)
AUTHORS Church,D.M., Goodstadt,L., Hillier,L.W., Zody,M.C., Goldstein,S.,
She,X., Bult,C.J., Agarwala,R., Cherry,J.L., DiCuccio,M.,
Hlavina,W., Kapustin,Y., Meric,P., Maglott,D., Birtle,Z.,
Marques,A.C., Graves,T., Zhou,S., Teague,B., Potamousis,K.,
Churas,C., Place,M., Herschleb,J., Runnheim,R., Forrest,D.,
Amos-Landgraf,J., Schwartz,D.C., Cheng,Z., Lindblad-Toh,K.,
Eichler,E.E. and Ponting,C.P.
CONSRTM Mouse Genome Sequencing Consortium
TITLE Lineage-specific biology revealed by a finished genome assembly of
the mouse
JOURNAL PLoS Biol 7 (5), e1000112 (2009)
PUBMED 19468303
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
STRAIN=C57BL/6J
REFERENCE 2 (residues 1 to 304)
AUTHORS Mural,R.J., Adams,M.D., Myers,E.W., Smith,H.O. and Venter,J.C.
TITLE Direct Submission
JOURNAL Submitted (??-JUL-2005) to the EMBL/GenBank/DDBJ databases
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
REFERENCE 3 (residues 1 to 304)
AUTHORS Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
Makowski,K.A., Bosak,S. and Malek,J.
CONSRTM MGC Project Team
TITLE The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC)
JOURNAL Genome Res 14 (10B), 2121-2127 (2004)
PUBMED 15489334
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].;
TISSUE=Brain
Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
Morin, Ryan]]
REFERENCE 4 (residues 1 to 304)
AUTHORS Singh,G., Kaur,S., Stock,J.L., Jenkins,N.A., Gilbert,D.J.,
Copeland,N.G. and Potter,S.S.
TITLE Identification of 10 murine homeobox genes
JOURNAL Proc Natl Acad Sci U S A 88 (23), 10706-10710 (1991)
PUBMED 1683707
REMARK NUCLEOTIDE SEQUENCE OF 232-291.
COMMENT On Oct 5, 2012 this sequence version replaced P31313.2.
[FUNCTION] Sequence-specific transcription factor which is part of
a developmental regulatory system that provides cells with specific
positional identities on the anterior-posterior axis.
[SUBCELLULAR LOCATION] Nucleus.
[SIMILARITY] Belongs to the Abd-B homeobox family. {ECO:0000305}.
FEATURES Location/Qualifiers
source 1..304
/organism="Mus musculus"
/db_xref="taxon:10090"
gene 1..304
/gene="Hoxc11"
/gene_synonym="Hox-3.7"
/gene_synonym="Hoxc-11"
Protein 1..304
/product="Homeobox protein Hox-C11"
/note="Homeobox protein Hox-3.7"
/UniProtKB_evidence="Evidence at transcript level"
Region 1..304
/region_name="Mature chain"
/note="Homeobox protein Hox-C11. /id=PRO_0000200195."
Region 42..161
/region_name="DUF3528"
/note="Protein of unknown function (DUF3528); pfam12045"
/db_xref="CDD:432284"
Bond bond(82)
/bond_type="xlink"
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO2). /evidence=ECO:0000250|UniProtKB:O43248."
Bond bond(116)
/bond_type="xlink"
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO2). /evidence=ECO:0000250|UniProtKB:O43248."
Region 167..237
/region_name="Region of interest in the sequence"
/note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
Bond bond(178)
/bond_type="xlink"
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO2). /evidence=ECO:0000250|UniProtKB:O43248."
Region 203..218
/region_name="Compositionally biased region"
/note="Polar residues.
/evidence=ECO:0000256|SAM:MobiDB-lite."
Site 232..291
/site_type="DNA binding"
/note="Homeobox.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00108."
Region 233..289
/region_name="Homeodomain"
/note="pfam00046"
/db_xref="CDD:459649"
ORIGIN
1 mfnsvnlgnf cspsrkerga dfgergscts nlylpsctyy vpefstvssf lpqapsrqis
61 ypysaqvppv revsygleps gkwhhrnsys scyaaadelm hreclppstv teilmknegs
121 ygghhhpsap haapagfyss vnknsvlpqa fdrffdnayc gggdapaepp csgkgeakge
181 peappasgla sraeagaeae aeeentnpss sgsshsatke pakgaapnap rtrkkrcpys
241 kfqirelere fffnvyinke krlqlsrmln ltdrqvkiwf qnrrmkekkl srdrlqyfsg
301 npll
//