LOCUS NP_839994 377 aa linear ROD 30-JUL-2024
DEFINITION ankyrin repeat domain-containing protein 27 isoform 2 [Mus
musculus].
ACCESSION NP_839994 XP_001002181
VERSION NP_839994.1
DBSOURCE REFSEQ: accession NM_178263.3
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 377)
AUTHORS Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
Jackson,S.P. and Balmus,G.
CONSRTM Sanger Mouse Genetics Project
TITLE Genetic determinants of micronucleus formation in vivo
JOURNAL Nature 627 (8002), 130-136 (2024)
PUBMED 38355793
REFERENCE 2 (residues 1 to 377)
AUTHORS Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
Murray,S.A.
CONSRTM International Mouse Phenotyping Consortium; Jackson Laboratory;
Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
(ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
Center
TITLE High-throughput discovery of novel developmental phenotypes
JOURNAL Nature 537 (7621), 508-514 (2016)
PUBMED 27626380
REMARK Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
10.1038/nature24643. PMID: 29144450]
REFERENCE 3 (residues 1 to 377)
AUTHORS Marubashi,S., Ohbayashi,N. and Fukuda,M.
TITLE A Varp-Binding Protein, RACK1, Regulates Dendrite Outgrowth through
Stabilization of Varp Protein in Mouse Melanocytes
JOURNAL J Invest Dermatol 136 (8), 1672-1680 (2016)
PUBMED 27066885
REMARK GeneRIF: RACK1 competes with Rab40C for binding to the ANKR2 domain
of Varp and regulates dendrite outgrowth through stabilization of
Varp in mouse melanocytes
REFERENCE 4 (residues 1 to 377)
AUTHORS Yatsu,A., Shimada,H., Ohbayashi,N. and Fukuda,M.
TITLE Rab40C is a novel Varp-binding protein that promotes proteasomal
degradation of Varp in melanocytes
JOURNAL Biol Open 4 (3), 267-275 (2015)
PUBMED 25661869
REMARK Publication Status: Online-Only
REFERENCE 5 (residues 1 to 377)
AUTHORS Ohbayashi,N., Yatsu,A., Tamura,K. and Fukuda,M.
TITLE The Rab21-GEF activity of Varp, but not its Rab32/38 effector
function, is required for dendrite formation in melanocytes
JOURNAL Mol Biol Cell 23 (4), 669-678 (2012)
PUBMED 22171327
REFERENCE 6 (residues 1 to 377)
AUTHORS Tamura,K., Ohbayashi,N., Maruta,Y., Kanno,E., Itoh,T. and Fukuda,M.
TITLE Varp is a novel Rab32/38-binding protein that regulates Tyrp1
trafficking in melanocytes
JOURNAL Mol Biol Cell 20 (12), 2900-2908 (2009)
PUBMED 19403694
REMARK GeneRIF: Varp functions as the Rab32/38 effector that controls
trafficking of Tyrp1 in melanocytes.
REFERENCE 7 (residues 1 to 377)
AUTHORS Wang,F., Zhang,H., Zhang,X., Wang,Y., Ren,F., Zhang,X., Zhai,Y. and
Chang,Z.
TITLE Varp interacts with Rab38 and functions as its potential effector
JOURNAL Biochem Biophys Res Commun 372 (1), 162-167 (2008)
PUBMED 18477474
REFERENCE 8 (residues 1 to 377)
AUTHORS Zhang,X., He,X., Fu,X.Y. and Chang,Z.
TITLE Varp is a Rab21 guanine nucleotide exchange factor and regulates
endosome dynamics
JOURNAL J Cell Sci 119 (Pt 6), 1053-1062 (2006)
PUBMED 16525121
REMARK GeneRIF: Varp is a potential Rab21 guanine nucleotide exchange
factor and might regulate endosome dynamics in vivo
REFERENCE 9 (residues 1 to 377)
AUTHORS Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
TITLE Prediction of the coding sequences of mouse homologues of FLJ
genes: the complete nucleotide sequences of 110 mouse
FLJ-homologous cDnas identified by screening of terminal sequences
of cDNA clones randomly sampled from size-fractionated libraries
JOURNAL DNA Res 11 (2), 127-135 (2004)
PUBMED 15449545
REFERENCE 10 (residues 1 to 377)
AUTHORS Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
Saga,Y., Nagase,T., Ohara,O. and Koga,H.
TITLE Prediction of the coding sequences of mouse homologues of KIAA
gene: III. the complete nucleotide sequences of 500 mouse
KIAA-homologous cDNAs identified by screening of terminal sequences
of cDNA clones randomly sampled from size-fractionated libraries
JOURNAL DNA Res 10 (4), 167-180 (2003)
PUBMED 14621295
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BY070464.1, AK085796.1, AK144733.1 and AI429389.1.
On Aug 25, 2006 this sequence version replaced XP_001002181.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC016493.1, AK085796.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849374, SAMN00849375
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..377
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="7"
/map="7 21.37 cM"
Protein 1..377
/product="ankyrin repeat domain-containing protein 27
isoform 2"
/note="VPS9-ankyrin repeat-containing protein; ankyrin
repeat domain-containing protein 27; VPS9-ankyrin-repeat
protein; mFLJ00040 protein; VPS9 domain-containing
protein; ankyrin repeat domain 27 (VPS9 domain)"
/calculated_mol_wt=42837
Region 1..372
/region_name="Sufficient for GEF activity towards RAB21.
/evidence=ECO:0000250|UniProtKB:Q96NW4"
/note="propagated from UniProtKB/Swiss-Prot (Q3UMR0.2)"
Region 264..363
/region_name="VPS9"
/note="Vacuolar sorting protein 9 (VPS9) domain; cl19569"
/db_xref="CDD:473191"
CDS 1..377
/gene="Ankrd27"
/gene_synonym="D330003H11Rik; Varp"
/coded_by="NM_178263.3:153..1286"
/note="isoform 2 is encoded by transcript variant 2"
/db_xref="CCDS:CCDS80706.1"
/db_xref="GeneID:245886"
/db_xref="MGI:MGI:2444103"
ORIGIN
1 malydedllk npfylalqkw rpdlcskvaq ihgivlvpcr gslpgsvqas cqfesyvlvp
61 teghfqtldg kavviegnri klgagfacll svpilfeetf ynekeesfsi lciahplerr
121 etseepsapa dpfslktied vreflgrhse kfdkniasfh rtfrecerks lrhhidsvna
181 lytkclqqll rdshlkvlak qeaqmnlmkq avemyvhhdi ydlifkyvgt measedaafn
241 kitrslqdlq qkdigvkpef sfniprakre lgqlnkctsp qqkllclrkv vqlmtqspsq
301 rvnletmcad dllsvllyll vkteipnwma nlsyiknfrf sssakdelgy cltsveaaie
361 yirqgslstk tpvrspc
//