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ankyrin repeat domain-containing protein 27 isoform 2 [Mus musculus]

NCBI Reference Sequence: NP_839994.1

Identical Proteins FASTA Graphics 

LOCUS       NP_839994                377 aa            linear   ROD 30-JUL-2024
DEFINITION  ankyrin repeat domain-containing protein 27 isoform 2 [Mus
            musculus].
ACCESSION   NP_839994 XP_001002181
VERSION     NP_839994.1
DBSOURCE    REFSEQ: accession NM_178263.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 377)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 377)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   3  (residues 1 to 377)
  AUTHORS   Marubashi,S., Ohbayashi,N. and Fukuda,M.
  TITLE     A Varp-Binding Protein, RACK1, Regulates Dendrite Outgrowth through
            Stabilization of Varp Protein in Mouse Melanocytes
  JOURNAL   J Invest Dermatol 136 (8), 1672-1680 (2016)
   PUBMED   27066885
  REMARK    GeneRIF: RACK1 competes with Rab40C for binding to the ANKR2 domain
            of Varp and regulates dendrite outgrowth through stabilization of
            Varp in mouse melanocytes
REFERENCE   4  (residues 1 to 377)
  AUTHORS   Yatsu,A., Shimada,H., Ohbayashi,N. and Fukuda,M.
  TITLE     Rab40C is a novel Varp-binding protein that promotes proteasomal
            degradation of Varp in melanocytes
  JOURNAL   Biol Open 4 (3), 267-275 (2015)
   PUBMED   25661869
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 377)
  AUTHORS   Ohbayashi,N., Yatsu,A., Tamura,K. and Fukuda,M.
  TITLE     The Rab21-GEF activity of Varp, but not its Rab32/38 effector
            function, is required for dendrite formation in melanocytes
  JOURNAL   Mol Biol Cell 23 (4), 669-678 (2012)
   PUBMED   22171327
REFERENCE   6  (residues 1 to 377)
  AUTHORS   Tamura,K., Ohbayashi,N., Maruta,Y., Kanno,E., Itoh,T. and Fukuda,M.
  TITLE     Varp is a novel Rab32/38-binding protein that regulates Tyrp1
            trafficking in melanocytes
  JOURNAL   Mol Biol Cell 20 (12), 2900-2908 (2009)
   PUBMED   19403694
  REMARK    GeneRIF: Varp functions as the Rab32/38 effector that controls
            trafficking of Tyrp1 in melanocytes.
REFERENCE   7  (residues 1 to 377)
  AUTHORS   Wang,F., Zhang,H., Zhang,X., Wang,Y., Ren,F., Zhang,X., Zhai,Y. and
            Chang,Z.
  TITLE     Varp interacts with Rab38 and functions as its potential effector
  JOURNAL   Biochem Biophys Res Commun 372 (1), 162-167 (2008)
   PUBMED   18477474
REFERENCE   8  (residues 1 to 377)
  AUTHORS   Zhang,X., He,X., Fu,X.Y. and Chang,Z.
  TITLE     Varp is a Rab21 guanine nucleotide exchange factor and regulates
            endosome dynamics
  JOURNAL   J Cell Sci 119 (Pt 6), 1053-1062 (2006)
   PUBMED   16525121
  REMARK    GeneRIF: Varp is a potential Rab21 guanine nucleotide exchange
            factor and might regulate endosome dynamics in vivo
REFERENCE   9  (residues 1 to 377)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
REFERENCE   10 (residues 1 to 377)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY070464.1, AK085796.1, AK144733.1 and AI429389.1.
            
            On Aug 25, 2006 this sequence version replaced XP_001002181.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016493.1, AK085796.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..377
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 21.37 cM"
     Protein         1..377
                     /product="ankyrin repeat domain-containing protein 27
                     isoform 2"
                     /note="VPS9-ankyrin repeat-containing protein; ankyrin
                     repeat domain-containing protein 27; VPS9-ankyrin-repeat
                     protein; mFLJ00040 protein; VPS9 domain-containing
                     protein; ankyrin repeat domain 27 (VPS9 domain)"
                     /calculated_mol_wt=42837
     Region          1..372
                     /region_name="Sufficient for GEF activity towards RAB21.
                     /evidence=ECO:0000250|UniProtKB:Q96NW4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UMR0.2)"
     Region          264..363
                     /region_name="VPS9"
                     /note="Vacuolar sorting protein 9 (VPS9) domain; cl19569"
                     /db_xref="CDD:473191"
     CDS             1..377
                     /gene="Ankrd27"
                     /gene_synonym="D330003H11Rik; Varp"
                     /coded_by="NM_178263.3:153..1286"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS80706.1"
                     /db_xref="GeneID:245886"
                     /db_xref="MGI:MGI:2444103"
ORIGIN      
        1 malydedllk npfylalqkw rpdlcskvaq ihgivlvpcr gslpgsvqas cqfesyvlvp
       61 teghfqtldg kavviegnri klgagfacll svpilfeetf ynekeesfsi lciahplerr
      121 etseepsapa dpfslktied vreflgrhse kfdkniasfh rtfrecerks lrhhidsvna
      181 lytkclqqll rdshlkvlak qeaqmnlmkq avemyvhhdi ydlifkyvgt measedaafn
      241 kitrslqdlq qkdigvkpef sfniprakre lgqlnkctsp qqkllclrkv vqlmtqspsq
      301 rvnletmcad dllsvllyll vkteipnwma nlsyiknfrf sssakdelgy cltsveaaie
      361 yirqgslstk tpvrspc
//
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